Pill bottles have often been orange to help protect medication from UV light

In 2015, the FDA approved the first 3D-printed prescription tablet

Spritam, an epilepsy medication, had been too large and difficult to swallow, particularly due to its inability to dissolve easily. The new pill was designed with porous layers to enhance its dissolvability, paving the way for future 3D printing of drugs.

The Coca-Cola bottle was designed to be recognizable even when shattered

The contour bottle, which was designed and patented to prevent copycats in its distributed bottling system in 1915, would soon become one of the most identifiable shapes in commercial culture. The designers also made sure it could be easily identified even in the dark.

Power lines are dotted with large, brightly colored balls to improve the visibility of these thin wires to helicopters and small planes and help prevent potential crashes.

USP-verified label on supplements means a nonprofit confirmed what's in the bottle

The black-and-yellow USP-verified program seal on a dietary supplement bottle means that the nonprofit US Pharmacopeia tested a sample of the product and verified that it was made in a facility with good manufacturing practices and that it will dissolve in the body. Their certification also means they tested to confirm that the product contains the ingredients listed on the bottle at the specified levels, and that it doesn't contain harmful levels of certain dangerous contaminants.

Vitamin D supplement pills are linked to rising cases of vitamin D toxicity in the US

Vitamin D deficiency is common. But taking Vitamin D supplements in doses exceeding 4,000 IU/day (a measurement of vitamin biological activity) for prolonged periods can raise bodily concentrations of this vitamin to dangerous values. US National Poison Data indicates that the annual average of vitamin D poisonings from 2000-05 was 196, but this rose by 1,600% to 4,535 per year for the period of 2005-11.

How the placebo effect became mainstream

Contemporary patients and medical students take the placebo effect for granted, as its a standard element in most drug trials. But the concept was only first debated and standardized in the 1950s after a ground-breaking 1955 paper by medical...

Two-thirds of antibiotic classes were made between the 1940s and 1960s

The vast majority of bacterial treatments were developed during the "Golden Age of Antibiotics," an era of rapid innovation and drug discovery that led to the reduction of millions of deaths worldwide. Since 1970, only eight new antibiotic classes have been discovered.

Estée Lauder used wealthy people's bathrooms to curate the color of the jars her products were sold in

While Lauder herself was just starting her cosmetics empire, she knew wealthy people who could afford high-quality products would always be her target market. In order to make her products as appealing to this market as possible, Lauder held up different colors of glass bottles in people's bathrooms to see what would look best with their decorations before landing on a turquoise bottle with a gold cap.

Wood that changed the color of water was the earliest recorded example of fluorescence

Lignum nephriticum, a tea used to treat kidney and urinary illnesses, was described in the 16th century as derived from white wood that turned water a bluish hue. However, in the 17th century, accounts described the wood as reddish and creating a kaleidoscope of colors in water. In 1915, the sources were identified as two different woods, which absorb UV radiation and emit visible light.

Power lines are dotted with large, brightly colored balls to improve the visibility of these thin wires to helicopters and small planes and help prevent potential crashes.

The same mold behind penicillin also flavors blue cheese

There are over 300 species of Penicillium. The mold that produces the lifesaving antibiotic is a close relative to those used to make blue cheeses like Roquefort and Stilton and to flavor some types of ham.

What is orange wine?

You've heard of rosé, a so-called anomalous wine. But what about orange wine? Orange wine is made using white wine grapes and red wine production methods. This guide walks you through the history of these wines—now trendy in the global market after being produced for thousands of years in places like Georgia. It also explores the flavors typically found in orange wine and how to pair it with food.

Opium is a milky liquid substance extracted from unripe poppy plant seeds

It's been used for ages to reduce pain and induce euphoria, both of which are side effects of the plant's alkaloids—nitrogen-based compounds with pronounced physical effects. Isolating and synthesizing derivatives of these naturally occurring chemicals enabled the invention of morphine, heroin, and other opioids.

Modern media exposure may impact whether people dream in color or black and white

A 1942 study found that 70.7% of college sophomores rarely saw colors in their dreams, while a similar survey in 2003 showed that only 20% reported the same. The prevalence of color television and films may make color dreams or the recollection of color features easier to remember.

FDA has removed black box warnings from HRT for menopause

The agency removed the label in 2025, reversing its 2003 decision to warn women about HRT's links to stroke risk, developing cancer, and heart disease. Years of accumulating research have found that the risks had been overstated and unnecessarily deterred hormone therapy use. The agency still warns against using certain estrogen-alone products, however, due to elevated endometrial cancer risk.

Modern roll-on deodorant design was modeled on the ballpoint pen

Instead of a messy cream, which had been the norm in the 1940s, a new roll-on deodorant inspired by the easy flow of a ballpoint pen debuted in 1952.

The traditional colors of Advent are purple, rose, and white

Purple is Advent’s primary color, symbolizing preparation and prayer; rose appears on the third Sunday to signal joy; and white, used for the fifth Advent candle or Christmas liturgies, represents purity and celebration as Christmas arrives.

The five most common chemicals found in modern food

Most modern processed foods rely on a number of preservatives to stay fresh from production to our plates. The most common include citric acid (preservative and flavor), sodium benzoate (preservative), xanthan gum (thickening and stabilizing), carrageenan (thickening), and red dyes 3 and 4 (for color).

'Why'd I take speed for twenty years?': an exploration of stimulant ADHD medication

Many people with ADHD are prescribed stimulant medication to assist with symptoms ranging from time blindness to executive dysfunction. This hour-long podcast episode by Search Engine explores the host's experience with ADHD medication and the history of amphetamine and methylphenidate use in the US.

What did people do before eyeglasses were invented?

An estimated two-thirds of the world's adults use a form of prescription glasses or contacts, proof spectacles were a godsend when they were invented in 1286 CE. But what did people do before that? Different tools were used for distinct vision problems, but some would use magnifying lenses, clear emeralds, and more. Watch this video for a historical explanation.

A list of five everyday products that rely on radioactivity, including exit signs and gemstones

Like some glow-in-the-dark wristwatches, some exit signs contain sealed tubes of tritium—radioactive hydrogen gas—which emit low-energy beta particles that react with surrounding elements to produce light, making them visible without batteries. In smoke detectors, smoke particles disrupt the steady flow of ions generated by americium-241.

Without liver bile, human poop would be a pale silver color

Stomach acid and enzymes break down food into smaller particles, expelling a semi-fluid mass called chyme into the small intestine, where bile is added. As the intestines absorb nutrients and water, the chyme solidifies and changes color.

Some say baseball's drug problem goes back to the late 1800s

At age 32, pitcher James “Pud” Galvin was feeling tired and decided to take "the Brown-Séquard elixir," which contained a testicular fluid from dogs and guinea pigs, believed to invigorate tired bodies. It might've worked: Galvin pitched a two-hit shutout the next day.

Certain medications can make tinnitus worse

Certain antidepressants, antimalarial medications, antibiotics, ibuprofen, and cancer drugs have been linked with the condition. At higher doses, particularly, it seems they can trigger or worsen tinnitus in some individuals.

The legacy of Agent Orange: a photo gallery

An herbicide sprayed over the Vietnamese jungles during the war had a far greater impact than its supposed role as a defoliant, a chemical used to remove greenery. Agent Orange’s deleterious nature quickly impacted exposed people – and their children. This photo gallery, which includes graphic images, follows a photographer as they report on those affected by the chemical.

Light pollution is giving oysters insomnia

Oysters, bivalve mollusks that have light-detecting cells along their skin, can't sleep with all this artificial light. According to a 2022 study, oysters' sleep cycles are disturbed by light dimmer than that provided by the full moon. As with humans, it's possible that these bouts of insomnia could have adverse health effects and contribute to the development of disease over time.

See how fireworks are made and learn how metals like magnesium and copper are responsible for different colors.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

Coral reefs get their colors from zooxanthellae—microorganisms that line corals' digestive tracts and provide them with sugars in exchange for a home within this protective tissue.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

Budweiser stores yeast derived from the original 1800s strain in a secret bunker, which only the Head of Yeast Management can access—not even the CEO

Sony set the standard for cylinder-shaped batteries when it repurposed manufacturing equipment used to make rolls of magnetic recording tape.

When a Paris department store hesitated to sell Estée Lauder's perfume, she 'accidentally' broke a bottle, causing the smell to spread throughout the store and shoppers to start asking to buy the scent.

See images of medical cases of firework injuries shared on this 'Instagram for doctors.' (Warning: Graphic content)

The Great Salt Lake's distinct dual coloration results from high-salinity organisms that only live in the northern portion and produce a purple protein.

A century of Billboard issues documenting the evolution of popular music.

Doctors differentiate between a phobia and fear by asking patients whether their fear interferes with their day-to-day activities.

For centuries, it was common to sleep in two shifts: a few hours at the beginning of the night, and a longer period beginning around midnight

See the evolution of Ebola vaccine and treatment development.

Objects can be 3D printed with light by projecting 2D computerized tomography (CT) scans onto rotating cylinders of resin, which solidify upon exposure.

Dorothy's famous entrance into Oz in 'The Wizard of Oz' relied on analog tricks, including a body double and sepia-toned paint, as much as it did on technology

Sunflowers have long been a symbol of nuclear disarmament because they can extract large amounts of radioactive cesium from soil.

Mid-century modern graphic designers, known for their bright colors and bold lines in advertising, also found success with children's books.

While the first exchange-traded fund (a 'basket' of different assets that can be bought and sold on a stock exchange) in the US only launched in 1993, the global ETF market has grown to more than $10T in the short time since.

Some coin denominations have ridges etched on their sides, partly to prevent counterfeiting, in a practice called 'reeding.'

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

Trace how the Bill of Rights, inspired by centuries of political theory, took shape between 1774 and 1789.

The USPS spent $3.97B in 2024, accounting for .058% of the federal budget.

Graffiti dates back to at least ancient Pompeii, where citizens scrawled messages to one another on public walls