The same mold behind penicillin also flavors blue cheese

A moldy cantaloupe supercharged penicillin production

In 1943, a moldy cantaloupe found at a market in Peoria, Illinois, yielded a strain that produced six times more penicillin. Though often credited to lab worker “Moldy Mary” Hunt, accounts differ on who actually brought in the fruit.

Microbes are essential to creating the many varieties of cheese, influencing texture and taste

Microbes break down proteins and fats and produce compounds with distinct tastes. These microbes can include bacteria (like the one used to give Swiss its trademark holes), molds (like the ones that give blue cheese its distinctive veining), and countless other tiny organisms.

Penicillin’s pioneers were awarded the Nobel Prize in 1945

Alexander Fleming, Howard Florey, and Ernst Chain received the 1945 Nobel Prize in Physiology or Medicine for discovering and developing penicillin.

White powder on cheese is rarely mold

The white, powdery substance that forms on cheese is not mold but crystals that typically signal a well-aged cheese. There are two types: inorganic crystals, which result from the cheesemaking process, and organic crystals, which occur from the natural breakdown of amino acids.

Ancient Romans helped develop modern cheese production techniques

The ancient Romans loved cheese and experimented with different processes to elevate its flavor, like aging. Some of their innovations, like Pecorino Romano, you can still find today. Others, like the smoked goat-milk Caseus, we only know about through historical records.

Why Pabst Blue Ribbon switched from brewing beer to making cheese during Prohibition

The brewer marketed its product, Pabst-ett, as "whole milk cheese food," available in both block and spreadable forms, as well as various flavors.

Penicillin works by attacking the cell walls of bacteria

Penicillin targets bacteria at their weakest point—their cell walls. By blocking wall-building, it leaves microbes unable to survive, causing them to burst and die.

How scientists are using molecules found in acidophiles to develop new medical treatments

The Berkeley Pit, an open-pit copper mine in Butte, Montana, that ceased operations in 1982 and is now filled with highly acidic water, is home to various species of fungi and yeast. These extremophiles produce unique compounds that may have anti-inflammatory benefits and have already been used to create an antibiotic for staph infections.

Most penicillin allergy diagnoses are wrong

A Freakonomics Radio episode investigates why so many people mistakenly believe they’re allergic to penicillin. This widespread misdiagnosis leads to costlier, less effective treatments and contributes to the growing problem of antibiotic resistance.

Explore the history of antibiotics with 'This Podcast Will Kill You'

The show blends medical history with storytelling and science. In Episode 50, the hosts trace the dramatic origins of antibiotics—from Fleming’s moldy petri dish to Florey’s wartime labs—and explore their lasting impact on health.

The pharmaceutical industry evolved, in part, from the discovery of synthetic dyes

In 1856, a chemist accidentally discovered mauveine, the world’s first synthetic dye, while trying to make quinine to treat malaria. The synthetic dyes that followed helped reveal germs under microscopes, paving the way for modern imaging techniques and breakthrough treatments, such as antibiotics.

Bacteria rapidly evolve (and share) new defenses against drugs they encounter

Unlike humans, bacteria rapidly make genetic changes in response to their environment, including creating defense against antibiotics. Furthermore, these defenses are passed on to their future generations and can even be shared with neighboring bacteria through horizontal gene transfer.

An interactive periodic table maps every possible combination of cheese variables

Plotting milk type, texture, rind, mold, aging, and processing as intersecting axes, the tool shows which combinations already exist as named cheeses, which survive only as rare regional styles, and which remain entirely unexplored.

Black mold isn’t more worrisome than other colors of mold

Black mold typically refers to Stachybotrys chartarum, a mold that commonly appears in damp or water-damaged areas of the home. Black mold—and other molds—won’t typically make otherwise healthy people ill, and all molds should be treated the same with respect to health risks and removal. If you have mold allergies, mold can cause an allergic response, and it can trigger asthma attacks for people with asthma. If you have a compromised immune system, then black mold exposure can also cause a fungal infection in your airways or elsewhere in the body.

A delicious flavor used to be made from a beaver’s butt

Love vanilla-flavored foods? Well, it was once made from castoreum - a yellowish exudate from the castor sacs of mature beavers. And the FDA regards castoreum as “natural flavoring."

Mycotoxins are toxic compounds produced by fungi—some show up in food

About a quarter of the world’s agricultural products are contaminated with mycotoxins. Some of these compounds can cause serious health problems, including cancer, so the US government has set up monitoring programs to detect them in our food and in animal feed. Humans can become ill if they eat contaminated food, but also if they ingest products from animals that had previously consumed these toxic compounds, such as milk from a cow that ate contaminated corn.

How bitter taste receptors help guard against infection

Receptors for "bitter" tastes evolved to detect potentially harmful plant chemicals, such as nicotine. The receptors also trigger bacteria-fighting responses, including waving hairlike projections to bat away bacteria, ordering the release of bacteria-killing nitric oxide, and calling for antimicrobial protein reinforcements.

Serbian donkey cheese is the most expensive in the world

Only one farm in the world produces pule, a cheese made from rare Balkan donkey milk that can cost up to $600 per pound. Pule is special for a number of reasons, including the unusual ingredients and the amount of labor required to produce it. Everything, including milking the donkeys, must be done by hand.

Lyme disease-causing bacteria predate any suspected biological weapons testing

Borrelia bacteria existed long before any US biological weapons program—or human presence in North America. One study comparing genomes of the bacteria behind Lyme disease collected samples of the bacteria over three decades and calculated that the bacterium has been in North America longer than humans, at least 60,000 years. Other work found related bacteria preserved in amber from millions of years ago.

The five most common chemicals found in modern food

Most modern processed foods rely on a number of preservatives to stay fresh from production to our plates. The most common include citric acid (preservative and flavor), sodium benzoate (preservative), xanthan gum (thickening and stabilizing), carrageenan (thickening), and red dyes 3 and 4 (for color).

Budweiser stores yeast derived from the original 1800s strain in a secret bunker, which only the Head of Yeast Management can access—not even the CEO

LSD-like drugs may inspire new antidepressants

LSD and psilocybin have shown promise as antidepressants. Using a virtual library of similar chemical compounds, researchers determined via animal studies that two molecules inspired by LSD have antidepressant effects without any associated hallucinogenic experience. These molecules were found to be 40 times more potent than the common antidepressant fluoxetine, also known as Prozac, with antidepressant effects lasting up to 21 days.

Why your wine smells unpleasant

Ever had the experience of receiving a bottle of wine with a janky, less-than-favorable odor? This Esquire article ventures to answer this question and offers the explanation that the culprit is likely corked wine. Read to understand why corks can create a moldy or musty scent, and feel emboldened to send a corked bottle back for something with improved quality.

The mushrooms in 'Super Mario Bros.' are modeled after a real mushroom

Almost every mushroom in "Super Mario Bros." is based on the Amanita muscaria, sometimes referred to as the fly agaric, because it is known to attract flies. It's also the basis for the original mushroom emoji and the mushrooms from the popular game "Minecraft."

The US FDA defines peptides as being 40 amino acids or less

The US Food and Drug Administration regulates these short strings of amino acids as drugs and approves them for commercial use. These products may be produced naturally or synthesized via medicinal chemistry for therapeutic use.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

Probiotics, which are living bacteria and yeasts, are not recommended for most patients

The American Gastroenterological Association in 2020 concluded that although almost 4 million American adults have taken some form of probiotics, health claims about them are not backed in strong evidence. They only recommend their use for a few specific situations: to prevent Clostridioides difficile infection in people taking antibiotics that kill gut bacteria, to prevent necrotizing enterocolitis in preterm infants, and for the management of a complication of inflammatory bowel disease called pouchitis.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

Poison ivy is in the same family as mangoes, cashews, and pistachios—and they all produce oily urushiol in their raw, unprocessed state—but they are typically prepared in ways to avoid causing human discomfort.

Massive blooms of microscopic plankton called dinoflagellates produce the neon blue light seen in glowing tides.

Volcanic activity may have triggered the Black Death by spewing gases that led to crop failures in Europe, thus forcing the import of grain ships with plague-infested fleas.

Lesser-known phobias include turophobia, or the fear of cheese, and nomophobia, the fear of being without your cell phone.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

The use of fungi to detoxify land and water—a process known as mycoremediation—has been used to clean up natural resources affected by the 2025 California wildfires.

Some Pokémon have been named after real and fictional organisms, while some real-world species have been named after Pokémon, such as Chilicola charizard and Binburrum zapdos.

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

When a Paris department store hesitated to sell Estée Lauder's perfume, she 'accidentally' broke a bottle, causing the smell to spread throughout the store and shoppers to start asking to buy the scent.

The American cockroach is actually from Africa, an apparent hitchhiker aboard ships carrying enslaved people, with evidence suggesting the bug may have arrived in the New World as early as the 1600s.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

The Dracula character, now seen as the vampire archetype, was inspired by a seafood-induced nightmare its creator experienced.

While atoms are normally made of protons, neutrons, and electrons, exotic ones have been built with antimatter—alternate versions of normal matter that live for fractions of a second and are about a billion times as rare.

Elk Cloner, the first computer virus to spread in public, was written as a practical joke by Richard Skrenta, a Pittsburgh high school student.

Bone marrow (soft tissue found inside certain bones) generates roughly 500 billion new blood cells each day

Some coin denominations have ridges etched on their sides, partly to prevent counterfeiting, in a practice called 'reeding.'

Scientists can determine Earth's past climate conditions by analyzing air trapped in microscopic bubbles within ice cores—columns of compressed snow layers that build up over hundreds of thousands of years.

Massive 3D printers have been used to build homes by stacking layers of 'concrete toothpaste,' a fire-resistant material that effectively insulates against outside noise.

Prince's sexually explicit 1984 track 'Darling Nikki' attracted the ire of the Parents Music Resource Center, an advocacy group that inspired the Parental Advisory sticker, even though the song ends with a Christian message.

Georgia O'Keeffe's flower paintings are often assumed to be sexual, though the artist claimed she was simply interested in highlighting the beauty of flowers that most people neglect

Sony set the standard for cylinder-shaped batteries when it repurposed manufacturing equipment used to make rolls of magnetic recording tape.

Brandi Chastain, the star of the 1999 US victory over China in the 1999 Women's World Cup, was a last-second choice to take the penalty kick that sealed the victory.