Blood

Overview

The earliest evidence in the fossil record of a blood-like substance, found on the remains of an armored arthropod, dates back at least 520 million years.

Blood has evolved several times across the animal kingdom, giving rise to a rainbow of color, composition, and purpose. Some creatures can skip having blood entirely, a nearly heretical approach to humans who can't live without it.

In humans, there are two main blood groups. Blood group ABO refers to the presence of A and/or B antigens. The Rh blood group describes Rh antigens' presence (positive) or absence (negative). Groups describe the type of antigens that determines blood type, leading to four main types (A, B, AB, and O) with positive and negative variations. The combination of these types determines how the immune system responds to foreign blood, such as in the case of transfusions.

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