A moldy cantaloupe supercharged penicillin production

Penicillin was discovered by accident

In 1928, Alexander Fleming returned from vacation to find mold contaminating a petri dish of bacteria. Around the mold, the microbes had died—an accidental observation that led to the discovery of penicillin.

The 'Penicillin Girls' made mass production possible

In Oxford during the early 1940s, six female technicians—later dubbed the “Penicillin Girls”—worked long hours tending mold cultures and extracting tiny amounts of penicillin.

The same mold behind penicillin also flavors blue cheese

There are over 300 species of Penicillium. The mold that produces the lifesaving antibiotic is a close relative to those used to make blue cheeses like Roquefort and Stilton and to flavor some types of ham.

Oxford scientists turned Fleming’s mold discovery into medicine

In 1939, a team at Oxford—including Howard Florey, Ernst Chain, and Norman Heatley—revived Fleming’s forgotten discovery. Using makeshift equipment like bedpans and milk churns, they purified enough penicillin to prove it could treat deadly infections.

Watermelons were once neither red nor sweet

The gargantuan summer picnic staple has a fascinating story: 100 million tons are produced worldwide and they take up the most space of any vegetable crop in the world. But not long ago, the flesh of the melon was white and it had a bitter taste.

A World War I discovery about blocking ethylene, a plant hormone, now helps preserve our fruits

Listen to this in-depth podcast episode about discoveries that enabled fruits and vegetables to be preserved and appear fresh for months or longer and other scientific insights, including why iceberg lettuce was the salad staple people ate for most of the 20th century.

Cantaloupe’s textured skin boosts the risk of food poisoning

Food safety expert Darin Wetwiler says he prefers to stay clear of this fruit altogether since it’s so hard to keep the textured skin pathogen-free. He advises trying to avoid pre-cut cantaloupe in particular, since consumers won’t know when the fruit was sliced and pathogens on the outside could have been spread to the part we consume during slicing and multiplied.

Listen to how the 1902 'poison squad' experiments changed food safety in America

As part of government research, a group of young men were paid to eat standard American food—replete with food additives like borax and formaldehyde—which revealed the dangers of unregulated food. The work was led by the first FDA commissioner, Harvey Wiley, who helped end the "century of the great stomachache."

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

Monsanto got its start in the early 1900s producing saccharin

The company was originally called Monsanto Chemical Works and was founded in 1901 by John Francis Queeny who was then a wholesale drug buyer. He named the company Monsanto for his wife's maiden name. At first, the company began producing saccharin with borrowed equipment and secondhand machines, aiming to produce domestically what was then being imported from Germany. (Some users may encounter a paywall.)

Maryland required cholera researchers to fly a yellow warning flag—signifying quarantine dangers in the 1970s

University of Maryland Hospital researchers intentionally infected volunteers with the cholera bacterium in the late 1970s to further their understanding of the disease. They proceeded with this work following the recommendation of a US government panel. (Some users may encounter a paywall.)

Mold growth in space raises the hypothesis of life being brought to Earth

Panspermia suggests that life could be carried throughout the cosmos by asteroids, comets, and other objects, but it requires organisms that can withstand the extreme cold of space travel, stellar radiation, lack of water, and intense heat of planetary impacts. The discovery of mold on the International Space Station and experiments showing it can withstand radiation in outer space-like conditions increase the plausibility of the hypothesis.

Budweiser stores yeast derived from the original 1800s strain in a secret bunker, which only the Head of Yeast Management can access—not even the CEO

A New York farmer established the first cheese factory and revolutionized the industry

Jesse Williams, a farmer in New York state, had a passion for cheese but didn’t have the resources to produce it at the scale he desired. So, in 1851, Jesse and his son opened the first cheese factory, sourcing milk from multiple local farms and producing 100,000 pounds of cheddar—in their first season. Soon, Williams had hundreds of factories and created the prototype for cheesemaking as we know it today.

In 1951, a small French town was overtaken by the fungus that ultimately led to LSD

During the summer of 1951, the French town of Pont-Saint-Esprit appeared to go mad. Hundreds were treated for hallucinations and delirium, with some reporting ongoing hallucinations a month after the LSD-like symptoms appeared. Some historians argue it was a case of ergotism, better known in the Middle Ages as "burning disease" and "St. Anthony's Fire."

How the peach became Georgia's fruit, though it makes fewer than other states

After the Civil War, the state sought to redefine its agricultural traditions away from slave-dependent cotton. One innovator, Samuel Rumph, crossed two breeds of peach, resulting in the Elberta, which could travel farther without spoiling. The state embraced this delicious identity to transcend its earlier reputation.

'Johnny Appleseed' was the itinerant horticulturalist John Chapman

Born in 1774 in Massachusetts, Chapman planted apple orchards for pioneers across Pennsylvania, Ohio, and Indiana, to be sold to locals to produce hard cider. He became famous through a 'Harper's Weekly' profile in the late 1800s, cultivating the modern legend.

Some say baseball's drug problem goes back to the late 1800s

At age 32, pitcher James “Pud” Galvin was feeling tired and decided to take "the Brown-Séquard elixir," which contained a testicular fluid from dogs and guinea pigs, believed to invigorate tired bodies. It might've worked: Galvin pitched a two-hit shutout the next day.

Bacteria have been genetically engineered to bioluminesce when wine has spoiled

Developed by researchers at Hebrew University, the method involves the firefly enzyme luciferase, which emits light from within bacteria expressing when they are in the presence of acetic acid vapors produced by wine. The process provides affordable, on-site, real-time monitoring of fermentation quality.

What's so special about Mayan bees and their honey?

Melipona honey was utilized by the ancient Maya and produced by stingless bees located in Mexico's Yucatan peninsula. With a history dating over three millennia, this honey was traditionally used for medicinal purposes due to its high fructose content and antioxidant properties. Unlike regular honey, Melipona honey is less prone to crystallization and has a distinctive watery texture. Learn more about the honey here.

Distinct plant species evolved to produce caffeine as a pesticide

Although it provides a defense against insects trying to eat caffeine-bearing plants, the molecule is an example of exaptation, where its original function was repurposed over time. Studies show that some plants now produce caffeine-laced nectar to help pollinators move more quickly and pollinate more efficiently.

The ‘humongous fungus’ may be the largest organism on Earth at more than 2,300 acres

Discovered in 1988, when it was only covering 400 acres, this massive colony of Armillaria ostoyae, based in Oregon, has taken hold among the tree roots of the Malheur National Forest. It consists of a vast network of unique long black filaments of fungal tissue called rhizomorphs that grow under the soil and infect tree roots, nourishing the fungus but killing the trees. Researchers believe this fungal growth dates back more than 8,000 years and currently weighs approximately 35,000 tons.

View the model of the tobacco mosaic virus from the 1958 Brussels World's Fair

After she finished analyzing her X-ray diffraction data on DNA fibers, Rosalind Franklin explored plant virus structures. For her work on the TMV, she was invited to build this 5-foot model, modified from earlier versions made of ping pong balls and bicycle handlebar grips.

The ubiquitous 1990s “Got Milk?” ad campaign was intended to fix milk’s dwindling popularity in the late 20th century

Despite its success in spreading the word about milk, the sales numbers weren’t quite as impressive. This Mental Floss article details the marketing efforts themselves, as well as how milk lobbyists didn’t necessarily succeed despite their revolutionary ads.

Ancient Rome had an early version of macaroni and cheese

Called placenta (with a hard "c"), the holiday dish consisted of sheets of rolled-out dough layered with cheese. It is the first recipe documenting the combination of the two elements. While there is debate about whether the dough can be called pasta because it's not boiled, many scholars view the dish as a proto-lasagna.

An 18th-century woman tricked doctors into believing she gave birth to rabbits

Mary Toft was a poor servant in Surrey who reportedly sought fame and money by perpetuating the story of her "monstrous birth." After having a miscarriage a month earlier, Toft claimed to still be pregnant and called obstetrician John Howard to witness her give birth to animal parts, including a cat without a liver, a rabbit’s head, the legs of a cat, and nine dead baby rabbits. Eventually, after fooling the court physicians of King George I, she confessed to orchestrating the births.

Fremont, Ohio, produces over one billion pounds of Heinz ketchup every year, often sending the smell of the condiment through the small city

Most of the United States' Heinz ketchup is produced at the northeast Ohio plant, which has been open since 1937.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

After her fellow cult members tried to kill her with an LSD-infused hamburger, one member of the Manson Family, the murderous cult led by Charles Manson, decided to testify against the group's leader.

During the French Revolution, a botanist's letter asking about "dear Rhus" (poison ivy) was intercepted, leading authorities to suspect he was conspiring with the Russians.

When a Paris department store hesitated to sell Estée Lauder's perfume, she 'accidentally' broke a bottle, causing the smell to spread throughout the store and shoppers to start asking to buy the scent.

Volcanic activity may have triggered the Black Death by spewing gases that led to crop failures in Europe, thus forcing the import of grain ships with plague-infested fleas.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

The use of fungi to detoxify land and water—a process known as mycoremediation—has been used to clean up natural resources affected by the 2025 California wildfires.

The American cockroach is actually from Africa, an apparent hitchhiker aboard ships carrying enslaved people, with evidence suggesting the bug may have arrived in the New World as early as the 1600s.

Elk Cloner, the first computer virus to spread in public, was written as a practical joke by Richard Skrenta, a Pittsburgh high school student.

The story of Dollree Mapp, whose legal challenge over her 1957 conviction for possessing "obscene material" led to a major strengthening of the Fourth Amendment

Many legends about George Washington, including his supposed wooden teeth and the story of cutting down the cherry tree, lack evidence.

The first horror movie is believed to be George Méliès' 1986 short 'The Haunted Castle,' which pioneered the use of special effects

The Great Salt Lake's distinct dual coloration results from high-salinity organisms that only live in the northern portion and produce a purple protein.

Explore fun facts from the USPS, including unique post office buildings, a stamp that traveled past Pluto, and more.

Fear or disgust related to clusters of holes and cracks, called trypophobia, may stem from evolutionary processes to help us avoid pathogens.

In 1963, a basement renovation in Turkey revealed a passageway to a hidden, multilevel underground city that once housed as many as 20,000 people

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

Clever Hans was a 1900s horse that was believed to be able to solve math equations, tell time, and read and comprehend German, until a psychology student discovered how he got his answers.

While atoms are normally made of protons, neutrons, and electrons, exotic ones have been built with antimatter—alternate versions of normal matter that live for fractions of a second and are about a billion times as rare.

Double world record holder Hunter Ewen helped conquer his fear of balloons, called globophobia, by training to win Guinness World Record titles for balloon inflation.

Brandi Chastain, the star of the 1999 US victory over China in the 1999 Women's World Cup, was a last-second choice to take the penalty kick that sealed the victory.

Legendary architect Frank Lloyd Wright designed the SC Johnson headquarters in Wisconsin, aiming to make a cathedral-like workplace

One disco producer saw 'Star Wars' four times on its opening weekend and was so inspired that he recorded the album 'Star Wars and Other Intergalactic Funk,' which produced a chart-topping single.