Oxford scientists turned Fleming’s mold discovery into medicine

The 'Penicillin Girls' made mass production possible

In Oxford during the early 1940s, six female technicians—later dubbed the “Penicillin Girls”—worked long hours tending mold cultures and extracting tiny amounts of penicillin.

Penicillin’s pioneers were awarded the Nobel Prize in 1945

Alexander Fleming, Howard Florey, and Ernst Chain received the 1945 Nobel Prize in Physiology or Medicine for discovering and developing penicillin.

Penicillin was discovered by accident

In 1928, Alexander Fleming returned from vacation to find mold contaminating a petri dish of bacteria. Around the mold, the microbes had died—an accidental observation that led to the discovery of penicillin.

Penicillin’s discoverer predicted antibiotic resistance

Alexander Fleming’s discovery of penicillin revolutionized modern medicine. But the same man who pioneered the development of antibiotics also recognized that bacteria could make sntibiotics obsolete if they were used irresponsibly. This story sheds light on Fleming’s discovery—and on his prophetic warning about antibiotic resistance.

Penicillin was hailed as a 'wonder drug' upon its release

When penicillin became widely available in the 1940s, newspapers and doctors alike celebrated it as a “wonder drug” that could cure infections once considered fatal.

A moldy cantaloupe supercharged penicillin production

In 1943, a moldy cantaloupe found at a market in Peoria, Illinois, yielded a strain that produced six times more penicillin. Though often credited to lab worker “Moldy Mary” Hunt, accounts differ on who actually brought in the fruit.

Explore the history of antibiotics with 'This Podcast Will Kill You'

The show blends medical history with storytelling and science. In Episode 50, the hosts trace the dramatic origins of antibiotics—from Fleming’s moldy petri dish to Florey’s wartime labs—and explore their lasting impact on health.

The pharmaceutical industry evolved, in part, from the discovery of synthetic dyes

In 1856, a chemist accidentally discovered mauveine, the world’s first synthetic dye, while trying to make quinine to treat malaria. The synthetic dyes that followed helped reveal germs under microscopes, paving the way for modern imaging techniques and breakthrough treatments, such as antibiotics.

In 1933, the influenza virus was first identified through “ferret flu” experiments

In 1933, British researchers dripped filtered nasal fluids from a sick colleague into ferrets, which quickly developed “ferret flu.” This experiment proved influenza was viral, not bacterial, and established the basis for modern flu vaccines.

Rosalind Franklin’s work led to Nobel Prize-winning discoveries in DNA and virology

Her X-ray diffraction imaging helped uncover the structure of DNA, which earned James Watson, Francis Crick, and Maurice Wilkins a Nobel Prize. The same techniques enabled virus imaging, contributing to Aaron Klug's Nobel Prize in chemistry.

How scientists are using molecules found in acidophiles to develop new medical treatments

The Berkeley Pit, an open-pit copper mine in Butte, Montana, that ceased operations in 1982 and is now filled with highly acidic water, is home to various species of fungi and yeast. These extremophiles produce unique compounds that may have anti-inflammatory benefits and have already been used to create an antibiotic for staph infections.

The cholera bacteria was first isolated in 1854—but the discovery was largely ignored

The pathogen was isolated by the Italian physician Filippo Pacini in Florence, Italy, though his discovery was largely ignored in favor of the popular miasma—bad air—theory of disease at the time. The pathogen was separately isolated about three decades later by German microbiologist Robert Koch.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

Listen to how the 1902 'poison squad' experiments changed food safety in America

As part of government research, a group of young men were paid to eat standard American food—replete with food additives like borax and formaldehyde—which revealed the dangers of unregulated food. The work was led by the first FDA commissioner, Harvey Wiley, who helped end the "century of the great stomachache."

Merck developed MDMA in the early 1900s as part of its effort to create a blood clotting drug

The company's chemists were attempting to synthesize a substance that could compete with an existing patent for the best clot medicine of that time, hydrastinine. MDMA was the byproduct of that effort.

The birth of the multivitamin

In 1912, biochemist Kazimierz Funk, often anglicized as Casimir Funk, proposed that there existed an essential nutrient in food that could prevent deficiency diseases, such as scurvy or rickets. This article explores the origin of the multivitamin, an invention that has garnished...

Edward Jenner, the father of vaccinations

The British physician was the first to attempt to inoculate someone from smallpox using its milder cousin, cowpox. His innovations and documentations would prove crucial to the deployment of widespread vaccinations.

A man with organ failure used AI to speed discovery of his miracle drug

David Fajgenbaum had a few months to live after a diagnosis with a rare form of Castleman's disease. By studying his blood, medical records, and broader literature, he was able to identify the cause of his condition and a treatment. He's been in total relapse for ten years.

The history of chemistry, from alchemists to probing atoms before World War I

Those involved in the predecessor of the modern scientific discipline engaged in experimentation to develop recipes that would transform ordinary matter into gold and to create medicines, cosmetics, dyes, and alloys. Over the course of centuries, scientists identified unique elements, organized them based on their properties in the periodic table, and eventually developed the technology to discover the internal structure of atoms.

The first successful IVF pregnancy was in the United Kingdom in 1978

Gynecologist Patrick Steptoe and his collaborator Robert Edwards, a biologist, attempted to fertilize a human egg cell in a petri dish 101 times before finally succeeding. This resulted in the birth of Louise Brown—at the time referred to as a "test tube" baby—in 1978, who was born into the spotlight.

How the placebo effect became mainstream

Contemporary patients and medical students take the placebo effect for granted, as its a standard element in most drug trials. But the concept was only first debated and standardized in the 1950s after a ground-breaking 1955 paper by medical...

Research on bacterial cultures used in yogurt production led to CRISPR's discovery

Scientists learned it was a microbial immune system that could be repurposed to protect dairy cultures from viruses. Today, nearly all yogurt is made with CRISPRized bacteria, as are genetically modified crops like herbicide-resistant corn, wheat, and soy.

A history of treating frostbite

Amid Napoleon's invasion of bitterly cold Russia, soldiers succumbed to frostbite by the thousands. Nineteenth century doctors recommended walking and rubbing snow around the affected area. Fast forward to recent years, and the FDA has approved its first ever drug to treat frostbite. Listen to this podcast to learn the history of this wintry affliction.

The iron lung—a simple mechanical ventilator—was first used to treat polio

These breathing devices, developed in the late 1920s at Harvard, were used to treat polio patients with breathing difficulties. Watch this video describing how these negative pressure devices work.

Britain’s bottle innovation saved Champagne

Champagne wouldn’t be where it is today without a surprising partner: 17th-century British glassmakers. An energy crisis caused by deforestation—not enough trees to burn—led to the search for an alternative fuel source. Enter coal. The plentiful resource burned much hotter than wood, creating stronger glass that could stand up to the pressure of the carbon monoxide produced by the wine’s second fermentation and solving one of the fledgling industry’s most vexing problems.

Rome's herbal panacea may not be as extinct as we thought

Silphion: cure-all, aphrodisiac, birth control, tasty seasoning. Nero allegedly ate the last of this miracle plant. This article details how a researcher may have found more. Seven centuries after the yellow-flowered plant was first documented growing in what's now Libya, it vanished. Historians proposed that the loss of Silphion may have been the first recorded extinction of any species.

Poison ivy was sent to Europe in the 1600s as an exotic, ornamental oddity, where it was purposefully grown in the English royal gardens at Kew, the Faculty of Medicine in Paris, and a few other locations.

Budweiser stores yeast derived from the original 1800s strain in a secret bunker, which only the Head of Yeast Management can access—not even the CEO

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

The history of many kitchen appliances involves unexpected discoveries and applications, including wartime radar turned hamster defroster and replacing an 'ice king' with heat-stealing boxes.

See the evolution of Ebola vaccine and treatment development.

Against his wishes, Albert Einstein's brain was removed before his cremation, and the pathologist responsible stored it for decades in mason jars within a beer cooler.

Astronauts have repaired genetic damage in space using CRISPR—a molecular tool that can make precise changes to DNA and is used in single-celled organisms to attack invasive viruses.

When a Paris department store hesitated to sell Estée Lauder's perfume, she 'accidentally' broke a bottle, causing the smell to spread throughout the store and shoppers to start asking to buy the scent.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

Learn more about the history of fireworks, which dates back to an accidental invention during an alchemist's quest for information about immortality.

In 1915, workers recovered a submarine-like vessel from the Chicago River, prompting fears of German espionage

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

The use of fungi to detoxify land and water—a process known as mycoremediation—has been used to clean up natural resources affected by the 2025 California wildfires.

Explore the archaeological treasures of Pompeii, the city buried under volcanic ash when Mount Vesuvius erupted in 79 CE.

Elk Cloner, the first computer virus to spread in public, was written as a practical joke by Richard Skrenta, a Pittsburgh high school student.

Clever Hans was a 1900s horse that was believed to be able to solve math equations, tell time, and read and comprehend German, until a psychology student discovered how he got his answers.

The original copy of the Declaration of Independence is not a pristine document, and even features a smudged anonymous handprint in the bottom left corner.

Massive 3D printers have been used to build homes by stacking layers of 'concrete toothpaste,' a fire-resistant material that effectively insulates against outside noise.

Doctors differentiate between a phobia and fear by asking patients whether their fear interferes with their day-to-day activities.

Double world record holder Hunter Ewen helped conquer his fear of balloons, called globophobia, by training to win Guinness World Record titles for balloon inflation.

The distributor behind 'Rocky Horror' pulled the film from its scheduled national release, believing it would be a failure, though it eventually amassed a dedicated fanbase through midnight showings, a trend that continues over 50 years later.

Massive blooms of microscopic plankton called dinoflagellates produce the neon blue light seen in glowing tides.

Famed poet TS Eliot rejected the manuscript for George Orwell's political fable 'Animal Farm,' writing that its criticism of authoritarianism was not 'the right point of view.'