Listen to how the 1902 'poison squad' experiments changed food safety in America

How a government chemist founded the FDA—by poisoning people

The Poison Squad tells the story of government chemist Dr. Harvey Wiley who, determined to banish these dangerous substances from dinner tables, took on the powerful food manufacturers and their allies.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

Teddy Roosevelt was given a daily dose of saccharin

America's 26th president was prescribed a sugar-free diet by his clinician, so when the chief chemist for the US Department of Agriculture approached him with concerns about the product's safety in the early 1900s, the duo clashed over how to regulate it.

Learn the history of food science breakthroughs from the 20th century

Long after humans developed the means to produce sufficient food to feed civilizations, scientific research focused on a wide variety of objectives, such as developing methods to preserve food quality (accomplished via frozen food), speeding up cooking (leading to the microwave), and lowering the cost of sweetening food, which high fructose corn syrup provides.

Alexander the Great, Rudyard Kipling, and more may have died from food poisoning

Though it is hard to prove decades or centuries after their deaths, some researchers suspect that food poisoning killed a variety of historical figures, including US President Zachary Taylor in 1850: Some researchers believe he may have consumed food contaminated with *Salmonella*.

In the 19th century, ice-cream-related illnesses were somewhat regular in America

Ice cream was a popular dessert, but it was also a dangerous one, with numerous reports of vomiting, diarrhea, and—in some cases—death. Historians argue this was likely due to vendors' poor hygienic practices.

Michael Sveda discovered cyclamate by accident

When this lab researcher brought his hands to his lips to smoke his cigarette in 1937, he tasted something sweet, which he called cyclamate. It was quickly used in diet sodas, but it was banned from the US in 1969 after being linked to rodent bladder cancer in lab experiments.

Food poisoning investigations have led to more than 1 billion pounds of food recalls

PulseNet is the US government’s real-time foodborne illness tracking system for leading causes of food poisoning. There, a network of labs and scientists share DNA sequences for pathogens collected from contaminated food and also from sickened individuals, looking for patterns in the pathogens’ genome sequences that will help them hopefully finger a certain food, warehouse, producer, or restaurant.

Over the years, the USDA has changed its definitions of healthy eating

The US Department of Agriculture began offering eating advice in 1894 and has updated its guidance as both science and politics have evolved. In the early 20th century, its guidance emphasized recommended minimum servings of important foods; in later decades, its visual guides became more nuanced, illustrating the composition of a healthy diet and encouraging exercise.

Six of history's most unethical human experiments, from deliberate flu exposure to withholding syphilis treatment

Some of the progress made in mental health treatment, vaccines, blood transfusions, and more came about before the advent of consent and ethics committees, resulting in serious physical and psychological harm that participants in studies were not even anticipating.

The federal government allowed toxic chemicals into alcohol during Prohibition

Industrial alcohol was still legal during Prohibition, and was often used by bootleggers. In an attempt to disrupt the black market, the government required toxic additives to be included in industrial alcohol, leading to more than one death.

Mycotoxins are toxic compounds produced by fungi—some show up in food

About a quarter of the world’s agricultural products are contaminated with mycotoxins. Some of these compounds can cause serious health problems, including cancer, so the US government has set up monitoring programs to detect them in our food and in animal feed. Humans can become ill if they eat contaminated food, but also if they ingest products from animals that had previously consumed these toxic compounds, such as milk from a cow that ate contaminated corn.

Eduard Baltzer encouraged 'natural eating' in the 1860s

Historian Corinna Treitel credits the Protestant minister with inventing the concept of “natural eating” in Nordhausen, Germany, in the 19th century. Baltzer believed that people were consuming excessive amounts of schnapps, sugar, and meat, and that this behavior was having a detrimental impact on their lives. He encouraged a diet mostly of fruits and vegetables, though he was not opposed to food grown with artificial fertilizers.

Robert Koch won the Nobel for his tuberculosis work, but he also pioneered cholera research

Koch was one of the first scientists to isolate the bacterium that causes cholera while investigating an outbreak in Egypt in 1883. He went on to advise about rules to control cholera outbreaks, which formed the basis of the disease control approaches and water hygiene techniques still used today.

How the methods of catching fish for food affects their taste

Commercially caught fish are often killed through suffocation, allowing the causing the fish extreme stress and flooding their bodies with stress hormones and lactic acid. These chemicals cause the fish's flesh to become bitter where it was once rich and quickens the rotting process.

Dietary supplements are regulated like foods

This hour-long 2016 documentary from Frontline, the Canadian Broadcasting Corporation, and The New York Times examined the safety of dietary supplements. It noted that this then-$30B industry (it's at least doubled since then) suffers from irregularities and impurities. It warned that many Americans are unaware of the lack of regulatory oversight over these products.

The Love Canal disaster exposed the dangers of buried toxic waste

In the late 1970s, residents of Niagara Falls, New York, discovered their neighborhood was built atop 20,000 tons of chemical waste. Leaking toxins caused illness and birth defects, sparking nationwide outrage and leading to the creation of the EPA's Superfund cleanup program in 1980.

A moldy cantaloupe supercharged penicillin production

In 1943, a moldy cantaloupe found at a market in Peoria, Illinois, yielded a strain that produced six times more penicillin. Though often credited to lab worker “Moldy Mary” Hunt, accounts differ on who actually brought in the fruit.

A 1954 Senate subcommittee investigated the comics industry

Comic books were wildly popular in the '50s, especially with children, whom some politicians believed were being corrupted by crime and horror comics. A subcommittee convened and eventually determined that “this Nation cannot afford the calculated risk involved in the continued mass dissemination of crime and horror comic books to children.” The government didn't endorse censorship, but the comics industry did, creating its own Comics Code Authority.

A family's yearslong poisoning

Over 14 years, a southern Indian family slowly lost six members, several of whom were found foaming at their mouths. Upon the third death, a post-mortem examination was requested, revealing cyanide had been ingested, though it was ruled as self-inflicted. Several will edits and three deaths later, relatives turned a critical eye toward Joliyamma "Jolly" Joseph, who had married into the family and been present at each death.

Benjamin Franklin once wrote a satirical essay about passing gas

The Founding Father was asked to judge a contest for the Royal Academy of Brussels, but was incensed by one of the contest's questions, which he believed was highly impractical. In response, he wrote a piece suggesting that the most essential problem for scientists to solve was the "fetid Smell" that came with passing gas.

Before 1920, a single baseball was used throughout a game

During the Deadball Era, pitchers doctored a baseball with spit, nail files, and licorice for a competitive edge, leading to discolored, mangled, and lopsided baseballs by the game's end. This concluded in 1920 when Cleveland Indians star shortstop Ray Chapman was hit in the head by a ball too dirty to see and died. The rules were changed to require an umpire to replace a dirty baseball and outlawed the spitball.

The ubiquitous 1990s “Got Milk?” ad campaign was intended to fix milk’s dwindling popularity in the late 20th century

Despite its success in spreading the word about milk, the sales numbers weren’t quite as impressive. This Mental Floss article details the marketing efforts themselves, as well as how milk lobbyists didn’t necessarily succeed despite their revolutionary ads.

Soybean oil fraud almost decimated American Express in 1963

A New York commodities trader who had defrauded the American government over uninspected meat for school lunches, Anthony "Tino" De Angelis, used American Express warehouses to sell soybean oil. However, Angelis had actually filled the tanks with water and placed just enough soybean oil on top of the tanks to pass inspection. American Express was liable for many of the tanks and its stock faced a huge downturn, opening the door for a then 33-year-old Warren Buffett to make his first purchase in the company.

A delicious flavor used to be made from a beaver’s butt

Love vanilla-flavored foods? Well, it was once made from castoreum - a yellowish exudate from the castor sacs of mature beavers. And the FDA regards castoreum as “natural flavoring."

The Fair Labor Standards Act regulated child labor and introduced many protections

Child labor was widespread until the formation of the National Child Labor Committee, which hired photographer Lewis Hine to document conditions. His images spurred reform efforts like the Keating-Owen Act in 1916, which was overturned by the Supreme Court. Progress came in 1938 with the Fair Labor Standards Act.

Learn more about the history of fireworks, which dates back to an accidental invention during an alchemist's quest for information about immortality.

The history of many kitchen appliances involves unexpected discoveries and applications, including wartime radar turned hamster defroster and replacing an 'ice king' with heat-stealing boxes.

An investigation suggests a Scottish island became awash in forever chemicals via seafoam and seaspray—raising questions about what that means for the safety of other coastal areas.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

During the French Revolution, a botanist's letter asking about "dear Rhus" (poison ivy) was intercepted, leading authorities to suspect he was conspiring with the Russians.

After her fellow cult members tried to kill her with an LSD-infused hamburger, one member of the Manson Family, the murderous cult led by Charles Manson, decided to testify against the group's leader.

Hear about the 250-year history of the United States Postal Service, complete with some of its strangest deliveries, important innovations, and the figures that made it an American institution.

In 1915, workers recovered a submarine-like vessel from the Chicago River, prompting fears of German espionage

Against his wishes, Albert Einstein's brain was removed before his cremation, and the pathologist responsible stored it for decades in mason jars within a beer cooler.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

When a Paris department store hesitated to sell Estée Lauder's perfume, she 'accidentally' broke a bottle, causing the smell to spread throughout the store and shoppers to start asking to buy the scent.

'Shogun,' a 1980s TV series, helped popularize sushi in the US by stimulating an American interest in Japanese culture.

The story of Dollree Mapp, whose legal challenge over her 1957 conviction for possessing "obscene material" led to a major strengthening of the Fourth Amendment

See a ranking of the best (and worst) Federal Reserve Chairs since 1914 out of the 16 men and women who have held the office since.

The Dracula character, now seen as the vampire archetype, was inspired by a seafood-induced nightmare its creator experienced.

Many legends about George Washington, including his supposed wooden teeth and the story of cutting down the cherry tree, lack evidence.

The use of fungi to detoxify land and water—a process known as mycoremediation—has been used to clean up natural resources affected by the 2025 California wildfires.

70 years ago today, city officials in Santa Cruz, California, banned rock 'n' roll to protect its youth from corruption after witnessing a 'provocative' concert the night before.

Walt Disney's early film 'Alice's Wonderland' was a groundbreaking innovation in the silent film era

Jimmy Carter signed a 1978 bill that legalized home brewing, a move credited with kick-starting the craft beer industry.

US intelligence allegedly pursued more than 600 schemes to assassinate Cuban revolutionary Fidel Castro.

View the ten deadliest tornadoes in US history.

How the most famous Ebola book, The Hot Zone, which sold 3.5 million copies and was translated into 30 languages, got aspects of the disease so wrong.

Mid-century modern graphic designers, known for their bright colors and bold lines in advertising, also found success with children's books.