How the most famous Ebola book, The Hot Zone, which sold 3.5 million copies and was translated into 30 languages, got aspects of the disease so wrong.

Three Ebola species are responsible for most large outbreaks of the disease, yet the only approved Ebola vaccine is known to work against just one of them.

Ebola has an average fatality rate above 50%

The Ebola virus is one of the planet’s most feared bugs. Symptoms begin with fever and fatigue but quickly develop into severe vomiting, diarrhea, and internal and external bleeding. But why is it so deadly? In short, Ebola hijacks the immune system to rapidly make replicas of itself.

See how Ebola tore through Guinea, Sierra Leone, and Liberia in 2014-2016.

Watch what the Ebola virus does inside our cells and organs in order to spread and survive.

See how Ebola tore through Guinea, Sierra Leone, and Liberia in 2014-2016

Frontline traced how the outbreak started and spread across West Africa. documenting first-hand accounts and patient experiences. This Ebola outbreak was the deadliest to date, resulting in over 11,000 deaths.

The 2026 Ebola outbreak is hampered by a lack of vaccine against the species of the virus, heightening the need for rapid tests to aid in disease control

Clinics in the Democratic Republic of Congo saw patients with Ebola symptoms months before the disease was identified. The identification lag was due to inadequate diagnostics that could not accurately or quickly identify the virus's myriad species. Contact tracing and better diagnostics will be required to tamp down the outbreak.

The 2026 Ebola outbreak is hampered by a lack of vaccine against the species of the virus, heightening the need for rapid tests to aid in disease control.

Watch how viruses like Ebola can spill over from animals to humans—and vice-versa.

Learn how monoclonal antibodies, which mimic the body's antibodies, can fight diseases like Ebola.

Ebola is a filovirus, meaning it resembles a thread under a microscope, though it sometimes twists and can resemble a bowl of spaghetti.

Watch how viruses like Ebola can spill over from animals to humans—and vice-versa

More than 70% of all new infectious diseases originate in animals. Referred to as zoonotic diseases, these are diseases that originate in animals and occasionally spill over or jump from animals to humans. Bats, mosquitoes, and primates have all been linked to spillover events. As human populations push further into previously uninhabited wilderness, animal-human contact increases, and disease spillover is inevitable.

Cultural norms about how to handle the bodies of loved ones in communities in West Africa have hampered Ebola responses.

Watch the cumbersome, but necessary, precautions healthcare workers must take to care for and protect themselves while caring for Ebola patients

Treating someone with Ebola involves a painstaking process of suiting up (donning) and peeling off (doffing) protective gear. Doctors follow detailed CDC guidelines. Properly suiting up is key to protecting against fluids that transmit Ebola, and correctly removing a suit that could be contaminated with the virus is also critical.

Learn how monoclonal antibodies, which mimic the body's antibodies, can fight diseases like Ebola

Monoclonal Antibodies mimic the antibodies produced naturally by the immune system. These molecules target specific parts of the virus, preventing them from entering cells or interfering with their ability to cause harm or infection.

During the COVID-19 pandemic, readers returned to Camus' 'The Plague'

The 1947 novel, about a city in Algeria that enacts a city-wide quarantine to battle a deadly outbreak, captured readers' attention in the early months of 2020. In the UK, over 2,000 copies of the book were sold in March of that year, over six times what it had sold the month before.

Truman Capote's 'In Cold Blood,' a pioneer of the true crime genre, isn't wholly accurate

The nonfiction novel "In Cold Blood" influenced true crime's narrative and investigative bend and was supposedly only 92% accurate. Journalist Ben Yagoda reflects on its accuracy after finding the fact-checking file for the four-part series published before the story was converted into hardback. Yagoda says the inaccuracies are "especially striking" because the story was originally published in one of the magazines credited with establishing fact-checking as a practice. (Some users may experience a paywall.)

Hit show 'The Last of Us' was based on the real-life Cordyceps fungus

Though it depicted a fictional world with a collapsed society due to a fungal pandemic, this television series (based on an earlier video game) helped raise awareness about fungal threats. It even prompted the US Centers for Disease Control and Prevention to publicly comment on it—clarifying the show’s plausibility. The mind-controlling fungal species in the show is based on a real-life Cordyceps species, a fungus that modifies its host’s behavior before killing it.

Hundreds of vulnerable Chicago residents died in 1995 during a long-lasting heat wave

Eric Klinenberg wrote a book diving into the specifics of the heat wave. His book, detailing the stories and context fueling more than 700 deaths during just one summer week, helps readers understand how social infrastructure lapses, power outages, and ineffective heat responses led to so many deaths.

Dr. William Gorgas eradicated yellow fever in Panama, crucial to canal construction

The disease was one of the factors hampering the French effort to build the canal. Gorgas' experience elsewhere in the Caribbean had taught him that good drainage and quaranting patients were essential, and he would eventually apply mosquito prevention tactics on a mass scale.

One doctor argued vampires were based on a real disease

At a conference in 1985, Canadian biochemist David H. Dolphin posited that stories of vampires and werewolves had a real-world origin. He argued that porphyria could have caused sufferers to seek out blood, as well as experience light sensitivity and an aversion to garlic. More than one article in the 1990s discredited this take.

Limited transparency soon after Chernobyl made it a source of conspiracy theories

Some rumors about the event became perceived as more reliable than the Soviet mass media, which had omitted key information during the early days of uncertainty. The resulting theories included CIA involvement in the disaster, three-headed birds, aliens, and a weaponized earthquake.

Learn the history and science of influenza in 'This Podcast Will Kill You'

In their flu episode, cohosts Erin Welsh and Erin Allmann Updyke unpack influenza’s biology, history, and impact—explaining everything from past pandemics to modern vaccines, all with their trademark mix of science and storytelling.

Nonfiction books have been struggling to sell in the mid-2020s

In the early 2020s, readers sought out nonfiction books to help explain prominent current events, such as the first presidency of Donald Trump and the BLM movement. That interest has since waned, as publishers note that readers have lately shown a preference for escapism and gather their information from podcasts.

'Freakonomics' celebrated its 20th anniversary in 2025

The book 'Freakonomics' arguably changed the business landscape when it came out, and has since evolved into other forms of media and a cultural phenomenon.

'Jaws' creators regret making sharks the monsters

Both Peter Benchley, the author of the original 1974 novel, and Steven Spielberg, the director of the blockbuster film based on it, acknowledge that the film's popularity has led to the stigmatization of the mostly harmless creatures.

Six of history's most unethical human experiments, from deliberate flu exposure to withholding syphilis treatment

Some of the progress made in mental health treatment, vaccines, blood transfusions, and more came about before the advent of consent and ethics committees, resulting in serious physical and psychological harm that participants in studies were not even anticipating.

Stephen King once shelved his own book

Stephen King's "Rage" follows a high school student who kills a teacher and holds classmates hostage. Originally published in 1977, the book was later linked to several school shootings. In the late '90s, King asked his publisher to pull it from print.

Human-to-human transmission of hantavirus remains extremely rare, so the 2026 hantavirus cruise ship outbreak doesn't mean we're facing a COVID-style pandemic risk.

Most penicillin allergy diagnoses are wrong

A Freakonomics Radio episode investigates why so many people mistakenly believe they’re allergic to penicillin. This widespread misdiagnosis leads to costlier, less effective treatments and contributes to the growing problem of antibiotic resistance.

Time magazine ran a cover story titled 'The End of the World as We Know it?' in January 1999

In January 1999, Time published a dramatic Y2K cover with apocalyptic imagery and dire headlines. The portrayal likely exacerbated public fear and magnified the crisis in the popular imagination, turning a technical issue into a cultural panic.

Diving into 'The Flame and the Flower,' the book that popularized 'bodice ripper' romance

The 1972 Kathleen E. Woodiwiss novel helped create the romance subgenre featuring historical settings and intense, steamy sex scenes. It was an under-the-radar sensation, quietly selling millions of copies while simultaneously courting controversy for its portrayals of rape. In this essay, Jeannette Cooperman revisits the book to see how it reads 50 years after its publication.

A fake vaccine campaign was used to locate Osama bin Laden, fueling vaccine distrust

As part of the intelligence operation to find bin Laden in Pakistan, the US Central Intelligence Agency recruited a Pakistani doctor who ran a fake hepatitis B vaccine campaign and obtained DNA samples from bin Laden. News of this fake campaign fueled further distrust of healthcare workers, attacks on them, and stymied efforts to vaccinate against polio in the region.

The coronavirus likely came from China’s wet markets

A wet market is a type of marketplace primarily selling fresh, perishable goods such as meat, fish, and produce, often in a non-supermarket environment. The term originated in Singapore during the 1970s, and the "wet" aspect refers to the wet floors resulting from the washing of stalls and the use of ice to keep food fresh. Such markets have been identified as a major source of zoonotic outbreaks, including the COVID-19 pandemic.

Charles Darwin studied goose bumps by scaring zoo animals in London with a stuffed snake

Read the famous naturalist’s work from the late 1800s, detailing how he sought to draw comparisons between how animals and humans respond to fear. As part of that work, he exposed monkeys and a peccary to a stuffed snake and noted the animals’ hair-raising fear response.

'Saturday Night Fever,' the 1977 film that introduced disco to the mainstream, was based on a fabricated magazine story.

Elk Cloner, the first computer virus to spread in public, was written as a practical joke by Richard Skrenta, a Pittsburgh high school student.

The tragic Pulitzer Prize-winning image 'The Vulture and the Little Girl' (1993) generated controversy, raised concerns about ethics in photography, and eventually led to the photographer's death.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

See these 16 pieces of art evoking phobias of snakes, flying, spiders, and more. 

Discover the catastrophic consequences of a failure of the US electrical grid—something that is more likely than many Americans think.

The US first hosted the World Cup in 1994, a tournament that lives in soccer infamy for its poor planning and the murder of Colombian player Andres Escobar, who'd accidentally scored on his own net.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

The original copy of the Declaration of Independence is not a pristine document, and even features a smudged anonymous handprint in the bottom left corner.

The American cockroach is actually from Africa, an apparent hitchhiker aboard ships carrying enslaved people, with evidence suggesting the bug may have arrived in the New World as early as the 1600s.

The deadliest aspect of volcanic eruptions is often not lava, but pyroclastic flows—avalanches of ash, gas, and rock that can move more than half the speed of sound.

During the French Revolution, a botanist's letter asking about "dear Rhus" (poison ivy) was intercepted, leading authorities to suspect he was conspiring with the Russians.

Famed poet TS Eliot rejected the manuscript for George Orwell's political fable 'Animal Farm,' writing that its criticism of authoritarianism was not 'the right point of view.'

Hurricanes, which rely on air consistently spinning in the same direction, cannot cross the equator because air curves in opposite directions north and south of it.

Exploring the Larry Bird punch that almost changed March Madness

Explore a list of the 100 best novels of all time, compiled by some of the world's best living writers, including Salman Rushdie, Stephen King, and Jennifer Egan.