Dr. William Gorgas eradicated yellow fever in Panama, crucial to canal construction

Disney World is largely mosquito-free, thanks to civil engineer Joe Potter

As a former governor of the mosquito-prone Panama Canal zone, Potter understood the danger of standing water. At Disney, Potter built ditches to reduce moisture, designed buildings to channel water away, and more. His efforts help visitors avoid bites, adding to the perceived magic of the magical kingdom.

Roughly 25,000 workers died building the canal

For each mile of canal that was built, 500 workers lost their lives. The threats came from multiple fronts: mudslides, floods, earthquakes and disease-carrying mosquitoes. Workplace accidents became so common that artificial limb manufacturers competed for contracts with the canal builders.

Yellow fever sidelined more US troops than enemy fire during the Spanish-American War

The disease, transmitted by the Aedes aegypti mosquito, sickened more than 2,000 soldiers. Fewer than 400 American soldiers died in the 1898 war.

The canal project required the forced removal of local inhabitants

The canal displaced Panamanian communities, with towns like Gatun and Gorgona dismantled and farmlands lost, reshaping the region forever.

A French Army surgeon discovered that malaria is a parasitic disease in 1880—but scientists were initially skeptical

Charles Louis Alphonse Laveran won the Nobel Prize for his work "on the role played by protozoa" in causing diseases. His work included discovering and reporting the malaria-causing parasite in the blood of a patient suffering from malaria.

The US finished what the French had started with Panama's canal

For about two decades, Suez Canal-builder and Frenchman Ferdinand de Lesseps led the project, but financial troubles forced it into the hands of the US, who completed it in 1914. This timeline, made to accompany the definitive PBS American Experience documentary about the canal, highlights major moments in its construction.

The canal carried germs as well as goods

In 1832, North America’s first cholera epidemic spread inland by way of the Erie Canal, carried by immigrants arriving on ships. Fearful towns barred passengers from disembarking, yet cholera, smallpox, and other diseases still traveled the waterway.

Maryland required cholera researchers to fly a yellow warning flag—signifying quarantine dangers in the 1970s

University of Maryland Hospital researchers intentionally infected volunteers with the cholera bacterium in the late 1970s to further their understanding of the disease. They proceeded with this work following the recommendation of a US government panel. (Some users may encounter a paywall.)

Wolbachia: the bacteria that could eliminate dengue fever

Dengue fever, transmitted by mosquitoes, kills more people annually than all types of natural disasters combined. However, mosquitoes that host Wolbachia bacterium have their ability to transmit the virus naturally suppressed, offering a route to eliminating nearly 25,000 deaths annually.

How the 1918 pandemic spurred developments in virology and vaccines

This article provides an in-depth historical account of the 1918 Spanish Flu pandemic, including its impact on the global population and how its occurrence spurred significant advancements in the study of viruses—laying the groundwork for the...

Paris and Boston were redesigned partly to combat cholera's spread

Georges-Eugène "Baron" Haussmann, who oversaw Paris's redesign in the 1800s, replaced many of the city's narrow streets with wide boulevards. This was done at least in part to bring more air and light into the city to help control cholera. Architect Arthur Gilman redeveloped Boston's Back Bay to similarly combat cholera, among other reasons.

John Snow—not the one from 'Game of Thrones'—determined that contaminated water sickened London

His pioneering epidemiology work during an 1854 cholera outbreak mapped out the commonalities between people in London who were getting sick. He discovered that ill people were getting water from the same Broad Street pump. Before Snow's work, the prevailing theory was that bad air sickened individuals instead of cholera-causing bacteria in the water.

Cultural norms about how to handle the bodies of loved ones have hampered Ebola responses in West Africa

Awareness of local burial and grieving traditions eventually helped healthcare workers fight the spread of the virus. As healthcare workers and burial teams altered their procedures during the 2014 West African Ebola outbreak, and as community leaders pressed people to adapt traditional ceremonies, the spread of Ebola began to slow.

Jules Verne helped popularize the banana

In his 1872 book "Around the World in 80 Days," the sci-fi writer described the banana, then mostly a novelty, as "healthy as bread and as succulent as cream." That mention, along with an appearance at the 1876 World's Fair in Philadelphia, helped transform the fruit into a standard part of a healthy diet.

Oxford scientists turned Fleming’s mold discovery into medicine

In 1939, a team at Oxford—including Howard Florey, Ernst Chain, and Norman Heatley—revived Fleming’s forgotten discovery. Using makeshift equipment like bedpans and milk churns, they purified enough penicillin to prove it could treat deadly infections.

How the most famous Ebola book, The Hot Zone, which sold 3.5 million copies and was translated into 30 languages, got aspects of the disease so wrong.

Antimalarials must be taken before traveling to a malaria-endemic area

Malaria prevention involves avoiding getting bitten by mosquitoes (with bug spray and clothing choices) and taking malaria preventative drugs before, during, and after spending time in an area with malaria risk. The drug must be in the blood before the traveler is exposed to malaria parasites.

With no textbooks or antibiotics, this WWI surgeon pioneered facial reconstruction

New Zealand surgeon Dr. Harold Gillies made extraordinary advances in the field of reconstructive surgery during World War I and after. This 36-minute NPR podcast interviews historian Lindsey Fitzharris, author of Gillie's biography, The Facemaker, charting how the good doctor reconstructed the faces of numerous soldiers in an age before antibiotics and plastic surgery as we know it today.

Camus contracted tuberculosis as a teenager

There was still little understanding of treatment for the disease at the time; for most people, a tuberculosis diagnosis was a death sentence. The 17-year-old Camus was quarantined in his uncle's house, where he grew into an avid reader. Scholars note that the experience would inform his later work, including his 1947 novel "The Plague."

Watch the cumbersome, but necessary, precautions healthcare workers must take to care for and protect themselves while caring for Ebola patients.

How a worm helped give the southern US its reputation

"The germ of laziness" that blanketed the southern US for centuries with unshakable fatigue, brain fog, and distended bellies paired with emaciated frames was actually a worm. This parasitic worm lives in the gut, where it can stay up to five years, laying up to 10,000 eggs daily. Hundreds of millions of people worldwide continue to suffer from hookworm infections, often obtained by walking barefoot across infected soil.

Invasive species can harm infrastructure and threaten human health

The wildfires in Hawaii in 2022 were made worse by flammable invasive grasses introduced from Africa as livestock pasture, and Zebra mussels native to the Caspian and Black Seas have spread across Europe and the US, where they can clog power plant pipes. Invasive mosquitoes can carry diseases, such as dengue and malaria.

Hear the story of a doctor who decided to flee Cuba with his family in 1963

In this StoryCorps conversation, Gustavo Mestas reflects on leaving the island with his family in 1963 and the difficult transition that followed—from treating patients in Cuba to picking tomatoes and cleaning motels while rebuilding a life in the US.

New drugs called Gepants have been shown to improve the quality of life of many sufferers.

Journalist Eva Wiseman has had migraines since childhood. Beginning with a yawn they segue into visual auras before turning into severe pain. As it so happened, she experienced a migraine during the course of her interview with Dr. Peter Goadsby, a pioneer in understanding and treating migraines as well as getting the world to treat them seriously.

Guerilla warfare was a significant part of the success of the Americans

Francis Marion, also known as the Swamp Fox, was a Patriot general who used guerrilla warfare tactics in the Carolinas during the Revolutionary War’s southern campaigns. Also called “maneuver warfare,” the approach focuses on disorienting the enemy and exploiting their weaknesses while avoiding their strengths.

A letter about a hurricane helped launch Hamilton's life in America

After a hurricane severely damaged the Caribbean island of St. Croix, Alexander Hamilton wrote a vivid letter that was later published and impressed local business leaders, who took up a collection to send the teenager to North America for schooling.

Hear from a NYC public health official who led the first US investigation into West Nile

This podcast walks through the investigation into the first US outbreak of West Nile, and how the virus had never been seen in the Western Hemisphere. The official discusses how she thinks the origin of West Nile in the US may have been birds or other animals that were brought here illegally.

Volcanic activity may have triggered the Black Death by spewing gases that led to crop failures in Europe, thus forcing the import of grain ships with plague-infested fleas.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

Poison ivy was sent to Europe in the 1600s as an exotic, ornamental oddity, where it was purposefully grown in the English royal gardens at Kew, the Faculty of Medicine in Paris, and a few other locations.

Double world record holder Hunter Ewen helped conquer his fear of balloons, called globophobia, by training to win Guinness World Record titles for balloon inflation.

Human-to-human transmission of hantavirus remains extremely rare, so the 2026 hantavirus cruise ship outbreak doesn't mean we're facing a COVID-style pandemic risk.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

The American cockroach is actually from Africa, an apparent hitchhiker aboard ships carrying enslaved people, with evidence suggesting the bug may have arrived in the New World as early as the 1600s.

'Grand Canyon of the Yellowstone,' a work by American painter Thomas Moran, inspired Congress to establish Yellowstone National Park.

The US first hosted the World Cup in 1994, a tournament that lives in soccer infamy for its poor planning and the murder of Colombian player Andres Escobar, who'd accidentally scored on his own net.

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

In 1915, workers recovered a submarine-like vessel from the Chicago River, prompting fears of German espionage

Fish populations in the Great Barrier Reef have increased after installing waterproof speakers on the ocean floor that played recordings of sounds from healthy coral reefs.

Louisiana's 'Cancer Alley' is infamous for having some of the highest industrial pollution, toxic air emissions, and cancer risks in the US.

Hurricanes, which rely on air consistently spinning in the same direction, cannot cross the equator because air curves in opposite directions north and south of it.

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

See a 3D reconstruction of Tenochtitlan, the Aztec capital that was home to an estimated population of 200,000 to 400,000.

For centuries, Niagara Falls has been a magnet for daredevils seeking to conquer one of nature's most powerful wonders, with its 200-foot drop and water rushing at 32 feet per second with 280 tons of force.

In 1945, Surrealist artist Salvador Dalí and legendary animator Walt Disney began collaborating on a short film that was not completed until 2003, years after both men had died.

Quincy Jones' 'Big Band Bossa Nova' helped introduce bossa nova—a jazz-influenced Brazilian genre—to the US

The rivalry between Alexander Hamilton and Thomas Jefferson centered on federalism—the question of how much power the federal government should hold relative to the states.

Power lines are dotted with large, brightly colored balls to improve the visibility of these thin wires to helicopters and small planes and help prevent potential crashes.

Explore fun facts from the USPS, including unique post office buildings, a stamp that traveled past Pluto, and more.

Before the current East Wing ballroom project, only two White House renovations in the past 100 years cost more than $10M.