The canal carried germs as well as goods

Cholera went global thanks to global trade

The first cholera pandemic grew from an outbreak in India, in 1817. Scientists suggest it spread from there throughout the continent and onward to Africa, Russia and Europe through the poop of traders.

The Erie Canal fueled a surge in westward settlement

By providing cheap, reliable transport to the interior, the canal made western lands more accessible. Farmers, traders, and immigrants moved into the Great Lakes region, accelerating population growth.

The canal became a highway for American reform movements

Beyond goods, the canal carried ideas. Its corridor hosted Second Great Awakening revivals and became a center for activism—fueling abolitionist networks, women’s suffrage organizing, and other reform movements.

The Erie Canal was opened Oct. 25, 1825, with a group of boats from Buffalo to NYC

The unlikely engineering project connecting the Midwest to the Atlantic saw a ceremonious opening as Governor Dewitt Clinton rode with a flotilla of boats from Buffalo on Lake Erie to New York City.

The Appalachian Mountains blocked east–west boat travel until the Erie Canal

The Appalachian Mountains, spanning from Alabama to Canada, long hindered inland commerce. The Erie Canal created the first reliable water route through the range by leveraging the natural valley of the Mohawk River, revolutionizing trade and migration.

In 1892, two scientists purposefully infected themselves with cholera bacteria

When they became ill—one with mild diarrhea and the other with severe cholera—researchers pointed to that as proof that the pathogen caused the disease.

The Erie Canal transformed New York City into America’s banking capital

By redirecting western trade through New York Harbor, the canal turned New York into the nation’s commercial hub. This surge in commerce shifted financial power from Philadelphia to Wall Street, establishing the city as America’s banking capital.

Grosse Île, the quarantine island of the Port of Quebec

As tens of thousands of Irish emigrated to North America to escape the Great Famine in the mid-19th century, many port cities set up quarantine areas amid an epidemic of cholera. In Quebec City on the St. Lawrence River, one island became a mass graveyard where over 3,000 Irish immigrants died over a decade as they waited in quarantine. Listen to the history here.

Europeans' arrival to America brought disease to Indigenous populations

Indigenous people lived in the Americas for centuries before the arrival of the first Europeans in the 15th century. Their arrival was disastrous for Native tribes; in addition to being enslaved and losing their land, they had no natural immunity to the diseases brought by colonists. Eventually, up to 95% of the Native American population was killed by illnesses including typhus, chickenpox, and cholera, an event now known as the Great Dying.

The original canal had 83 different hand-operated locks

Locks are gated chambers that raise and lower boats between stretches of water at different levels. On the Erie Canal, 83 such locks managed a 565-foot elevation change from the Hudson River to Lake Erie.

Roughly 25,000 workers died building the canal

For each mile of canal that was built, 500 workers lost their lives. The threats came from multiple fronts: mudslides, floods, earthquakes and disease-carrying mosquitoes. Workplace accidents became so common that artificial limb manufacturers competed for contracts with the canal builders.

Dr. William Gorgas eradicated yellow fever in Panama, crucial to canal construction

The disease was one of the factors hampering the French effort to build the canal. Gorgas' experience elsewhere in the Caribbean had taught him that good drainage and quaranting patients were essential, and he would eventually apply mosquito prevention tactics on a mass scale.

Paris and Boston were redesigned partly to combat cholera's spread

Georges-Eugène "Baron" Haussmann, who oversaw Paris's redesign in the 1800s, replaced many of the city's narrow streets with wide boulevards. This was done at least in part to bring more air and light into the city to help control cholera. Architect Arthur Gilman redeveloped Boston's Back Bay to similarly combat cholera, among other reasons.

Amateur engineers built America’s first great infrastructure project

With no engineering schools in the US, the Erie Canal was designed and built by self-taught amateurs who improvised new methods and became known as the “Erie School of Engineering.”

Container ships are just a fraction of total traffic via the canal

While more container ships traverse the canal than any other type of ship, vessels carrying dry bulk goods, vehicle carriers, chemical tankers, passenger ships, and more also pass through the Central American passageway.

The ancient Egyptians built prototypes of the modern Suez Canal

The idea to facilitate trade between the Mediterranean Sea and the Red Sea and connect the Eurasian continent was apparent even to pharaohs in the second millennium BCE. Though no physical traces remain, contemporary accounts attest to early, shorter versions of the canal, including from Herodotus.

How a polluted New York City waterway created extremophiles hungry for 'black mayonnaise'

In the 19th century, coal processing plants, oil refineries, a tannery, and other industries lining the Gowanus Canal contaminated its waters with coal tar, sewage, and other pollutants, forming the toxic sludge. Samples taken from the site before clean-up efforts revealed over 450 species of microbes with metabolisms adapted to break down these contaminants.

Budweiser pioneered refrigerated rail transport for its beer in the 1870s

This enabled Budweiser to achieve national distribution long before competitors, fundamentally transforming the US beer industry. It was also among the earliest large-scale adopters to use pasteurization, allowing it to be shipped long distances without going bad.

Volcanic activity may have triggered the Black Death by spewing gases that led to crop failures in Europe, thus forcing the import of grain ships with plague-infested fleas.

Swimmer's ear is America's most common waterborne illness

Federal government analysis of the roughly 7 million waterborne illness cases that occur annually in the US found that swimmer's ear comprises some 4.7 million, or 65%, of the annual waterborne illnesses and 20% of hospitalizations. Norovirus infection comes in second place.

In the 19th century, ice-cream-related illnesses were somewhat regular in America

Ice cream was a popular dessert, but it was also a dangerous one, with numerous reports of vomiting, diarrhea, and—in some cases—death. Historians argue this was likely due to vendors' poor hygienic practices.

Two-thirds of soldier deaths during the war were due to disease

Roughly two-thirds of all Civil War deaths resulted from disease rather than battle. Poor sanitation, contaminated water, and limited medical knowledge made camps breeding grounds for dysentery, typhoid, and other deadly infections.

Invasive species can harm infrastructure and threaten human health

The wildfires in Hawaii in 2022 were made worse by flammable invasive grasses introduced from Africa as livestock pasture, and Zebra mussels native to the Caspian and Black Seas have spread across Europe and the US, where they can clog power plant pipes. Invasive mosquitoes can carry diseases, such as dengue and malaria.

Mass transit in America began with horse-drawn omnibuses in New York City in 1827

The omnibus, a large horse-drawn stagecoach that ran a fixed route and carried a dozen riders at an affordable fare, was different from a private carriage because it carried everyone, not just the wealthy.

How a worm helped give the southern US its reputation

"The germ of laziness" that blanketed the southern US for centuries with unshakable fatigue, brain fog, and distended bellies paired with emaciated frames was actually a worm. This parasitic worm lives in the gut, where it can stay up to five years, laying up to 10,000 eggs daily. Hundreds of millions of people worldwide continue to suffer from hookworm infections, often obtained by walking barefoot across infected soil.

The American cockroach is actually from Africa, an apparent hitchhiker aboard ships carrying enslaved people, with evidence suggesting the bug may have arrived in the New World as early as the 1600s.

A letter about a hurricane helped launch Hamilton's life in America

After a hurricane severely damaged the Caribbean island of St. Croix, Alexander Hamilton wrote a vivid letter that was later published and impressed local business leaders, who took up a collection to send the teenager to North America for schooling.

This real-time tracking of the hantavirus cruise ship outbreak in May 2026 offers a unique glimpse into the global reach of the outbreak and whether the virus sickened passengers and their communities around the world.

Watch how viruses like Ebola can spill over from animals to humans—and vice-versa.

In 1915, workers recovered a submarine-like vessel from the Chicago River, prompting fears of German espionage

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

Poison ivy was sent to Europe in the 1600s as an exotic, ornamental oddity, where it was purposefully grown in the English royal gardens at Kew, the Faculty of Medicine in Paris, and a few other locations.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Budweiser stores yeast derived from the original 1800s strain in a secret bunker, which only the Head of Yeast Management can access—not even the CEO

For centuries, Niagara Falls has been a magnet for daredevils seeking to conquer one of nature's most powerful wonders, with its 200-foot drop and water rushing at 32 feet per second with 280 tons of force.

Cultural norms about how to handle the bodies of loved ones in communities in West Africa have hampered Ebola responses.

Hear about the 250-year history of the United States Postal Service, complete with some of its strangest deliveries, important innovations, and the figures that made it an American institution.

Louisiana's 'Cancer Alley' is infamous for having some of the highest industrial pollution, toxic air emissions, and cancer risks in the US.

Stanford built a Google Maps for the Roman Empire, revealing how much it cost to travel in the ancient world

After the Boston Tea Party, colonists switched to coffee, which became the main morning drink for revolutionaries.

Discover the catastrophic consequences of a failure of the US electrical grid—something that is more likely than many Americans think.

Elk Cloner, the first computer virus to spread in public, was written as a practical joke by Richard Skrenta, a Pittsburgh high school student.

The 19th-century painters of the Hudson River School were among the first American romantics, with portraits that displayed the natural beauty of the young country.

While El Niño moves warm Pacific Ocean waters east along the equator, La Niña moves them west, shifting where rainfall will become more common for months.

The Great Salt Lake's distinct dual coloration results from high-salinity organisms that only live in the northern portion and produce a purple protein.

Pure water does not conduct electricity because this flow of energy requires the movement of charged particles, and water is a neutral molecule.

20,000 letters to the advice columnist 'Dear Abby' provide insight into prevailing sex, religion, and LGBTQ fears, anxieties, and concerns from the 1950s onward.

Gerrymandering works through two techniques: cracking opposing voters across districts to dilute their power, and packing them into a few to waste their votes in lopsided majorities.

The US first hosted the World Cup in 1994, a tournament that lives in soccer infamy for its poor planning and the murder of Colombian player Andres Escobar, who'd accidentally scored on his own net.

The first horror movie is believed to be George Méliès' 1986 short 'The Haunted Castle,' which pioneered the use of special effects