Maryland required cholera researchers to fly a yellow warning flag—signifying quarantine dangers in the 1970s

In 1892, two scientists purposefully infected themselves with cholera bacteria

When they became ill—one with mild diarrhea and the other with severe cholera—researchers pointed to that as proof that the pathogen caused the disease.

Unprecedented imaging of the Vibrio bacteria, published in 2026, may highlight new treatment targets

Researchers have produced the most detailed image ever of a key part of the Vibrio bacteria—the cause of cholera—known as the sheathed flagellum, which helps it move.

Malaria case in Maryland stumped doctors in 2023—leading to the wrong treatment

When the state had its first locally acquired malaria case in over 40 years, the patient was misdiagnosed with a more common tick-borne infection, leading to weeks-long treatment for the wrong infection. The patient had symptoms that could occur with malaria or with babesiosis, a disease caused by Babesia parasites and transmitted by ticks in the US.

We're in the middle of a decadeslong cholera pandemic

In 1961, the world's seventh recorded cholera pandemic started in South Asia, and it has continued through the decades. India and Bangladesh are at particular risk. This pandemic is driven partly by conflict, population displacement, extreme weather, and poor water infrastructure.

See how cholera spreads in a community

This animated video offers a comprehensive look at how cholera spreads. It makes clear why it's so difficult to stamp out this disease in communities around the world. It also details what steps can help control cholera.

Dr. William Gorgas eradicated yellow fever in Panama, crucial to canal construction

The disease was one of the factors hampering the French effort to build the canal. Gorgas' experience elsewhere in the Caribbean had taught him that good drainage and quaranting patients were essential, and he would eventually apply mosquito prevention tactics on a mass scale.

Cholera was called the 'Blue Death'

In the mid-1800s—when John Snow identified cholera in London—the disease was known simply as the "Blue Death." That's because blood would thicken in patients' veins when they were struggling with extreme dehydration. As a result, their skin would turn a blueish hue as their blood was starved of oxygen.

Cholera vaccines can protect people from disease for months—or even years

There are three recommended cholera vaccines on the market. The number of required shots and the period of protection they provide vary, but each of them can be life-saving.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

Listen to how the 1902 'poison squad' experiments changed food safety in America

As part of government research, a group of young men were paid to eat standard American food—replete with food additives like borax and formaldehyde—which revealed the dangers of unregulated food. The work was led by the first FDA commissioner, Harvey Wiley, who helped end the "century of the great stomachache."

Using mosquitoes to vaccinate bats could curb the spread of deadly diseases

Researchers in China tested a transmissible rabies vaccine in the lab by feeding mosquitoes blood containing the vaccine and observing what happened to bats when they were either bitten by the mosquitoes or fed on them. The bats developed antibodies against rabies and survived subsequent rabies infection. (Some users may encounter a paywall.)

Wastewater testing has detected genetic evidence of polio, triggering vaccine boosters

Sampling of wastewater in London in 2022 detected fragments of polio virus, suggesting a vaccine-derived version of polio may be circulating. No one became ill, but the finding did trigger calls for a renewed booster inoculation campaign.

A moldy cantaloupe supercharged penicillin production

In 1943, a moldy cantaloupe found at a market in Peoria, Illinois, yielded a strain that produced six times more penicillin. Though often credited to lab worker “Moldy Mary” Hunt, accounts differ on who actually brought in the fruit.

Explore what it's like Inside a patient isolation unit

Containing a contagious disease like Ebola requires strict protective measures. There are several specialized medical wards to contain deadly infectious diseases at hospitals across the U.S. Emory University has one such unit, where 4 patients were treated during the 2014 outbreak.

Grosse Île, the quarantine island of the Port of Quebec

As tens of thousands of Irish emigrated to North America to escape the Great Famine in the mid-19th century, many port cities set up quarantine areas amid an epidemic of cholera. In Quebec City on the St. Lawrence River, one island became a mass graveyard where over 3,000 Irish immigrants died over a decade as they waited in quarantine. Listen to the history here.

HFMD was first reported in 1957 in New Zealand

The first clinical report involved eight kids with the characteristic sores in New Zealand, and then in the years that followed there were dozens more cases there and also reports of outbreaks in England and Scotland, among other settings, including the US.

Explore what it's like inside a patient isolation unit, used in situations such as treating a patient or suspected patient with Ebola.

Experimental hantavirus vaccines and therapies, still under development, have long been funded by the US military.

Hippocratic doctors treated severe mental illness with the poisonous plant hellebore

Since symptoms like hallucinations were believed be due to an imbalance of black bile, yellow bile, blood, and phlegm, the treatment at the time was to bring those humors back into balance. That meant standard treatments could include bleeding a patient or using substances like hellebore to induce vomiting or diarrhea.

Read a history of how oral rehydration solution was created

Experiments dating back to the 1940s eventually led to the creation and standardization of a mixture of sugar, salt, and clean water that is now widely used globally.

Play 17th-century death roulette

Before modern science and medicine, death was much harder to escape. Using real mortality records from London's Dreadful Visitation–a collection of all the Bills of Mortality from 1665–this interactive game gives you an idea of what may have possibly killed you during the Great Plague. Grow your appreciation for life today as you stumble upon causes of death like “livergrown” and “drowned at St. Katharine’s by the Tower”.

An LSD scientist's role in a US mind control project

Within a decade of LSD's discovery, the US government had launched a secret initiative involving hypnosis and hallucinogens. LSD researcher Louis Jolyon West conducted experiments for the CIA's MKUltra project, which focused on the potential of mind control. He later took part in a criminal trial that hinged on testimony whose sourcing was seemingly inspired by MKUltra experiments. This article explores light shed by West's personal archive.

Reporting food poisoning aids in limiting outbreaks

If you suspect you were sickened by meat or poultry or by other food products (or your pet was sickened), the US has different voluntary online reporting forms and hotlines you can call. There’s even one for concerns about potentially contaminated pet food products. If you were potentially sickened at a restaurant, however, you report that directly to state and local health departments, not the federal government.

Harvard drowned rats for this?

Harvard's 1950s rat study was ethically questionable, but scientifically profound. One rescue attempt made rats swim 40x longer. The finding: hope isn't poetic, it's biological.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

How microbes limited the damage and helped clean up the Deepwater Horizon oil spill

A bloom estimated to contain about 100 sextillion microbial cells broke down much of the 4.1 million barrels of spilled crude oil into nontoxic compounds in what was one of the most significant bioremediations of a human-made disaster. The microbes involved acted similarly to the first patented genetically modified organism in US history: an oil-eating bacterium engineered in 1971.

During the COVID-19 pandemic, readers returned to Camus' 'The Plague'

The 1947 novel, about a city in Algeria that enacts a city-wide quarantine to battle a deadly outbreak, captured readers' attention in the early months of 2020. In the UK, over 2,000 copies of the book were sold in March of that year, over six times what it had sold the month before.

Explore demonstrations of hundreds of viruses and other malware in action

On their YouTube channel, Malware historian Daniel White has documented what happens when various types of malware—mostly from the 1980s and 90s—run on a computer or Nokia cell phone. The demonstrations were safely conducted within virtual machines—older operating systems run within contained windows of modern software, resembling a picture-in-picture setup.

An investigation suggests a Scottish island became awash in forever chemicals via seafoam and seaspray—raising questions about what that means for the safety of other coastal areas.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

In 1915, workers recovered a submarine-like vessel from the Chicago River, prompting fears of German espionage

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Budweiser stores yeast derived from the original 1800s strain in a secret bunker, which only the Head of Yeast Management can access—not even the CEO

Volcanic activity may have triggered the Black Death by spewing gases that led to crop failures in Europe, thus forcing the import of grain ships with plague-infested fleas.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

The American cockroach is actually from Africa, an apparent hitchhiker aboard ships carrying enslaved people, with evidence suggesting the bug may have arrived in the New World as early as the 1600s.

During the French Revolution, a botanist's letter asking about "dear Rhus" (poison ivy) was intercepted, leading authorities to suspect he was conspiring with the Russians.

A researcher recently discovered an interview from 1967 between groundbreaking journalist Joan Didion and the Grateful Dead, years before the band became an institution.

Elk Cloner, the first computer virus to spread in public, was written as a practical joke by Richard Skrenta, a Pittsburgh high school student.

Louisiana's 'Cancer Alley' is infamous for having some of the highest industrial pollution, toxic air emissions, and cancer risks in the US.

Coral reefs get their colors from zooxanthellae—microorganisms that line corals' digestive tracts and provide them with sugars in exchange for a home within this protective tissue.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

See 33 images that became central to huge scandals, including a young Charles and Camilla, Michael Jackson's baby on a hotel balcony, and Hugh Grant's mugshot.

Sunflowers have long been a symbol of nuclear disarmament because they can extract large amounts of radioactive cesium from soil.

In 2018, 26-year-old missionary John Allen Chau was killed by tribesmen after attempting to reach and evangelize on India's isolated North Sentinel Island

Mid-century modern graphic designers, known for their bright colors and bold lines in advertising, also found success with children's books.

When you complete a CAPTCHA on a website to prove you are human, you may be unknowingly training algorithms for self-driving cars, whose systems require training data to help identify crosswalks, bicycles, and other outdoor objects.

Discover the catastrophic consequences of a failure of the US electrical grid—something that is more likely than many Americans think.

Stanford built a Google Maps for the Roman Empire, revealing how much it cost to travel in the ancient world

Double world record holder Hunter Ewen helped conquer his fear of balloons, called globophobia, by training to win Guinness World Record titles for balloon inflation.