An LSD scientist's role in a US mind control project

How Western psychedelics research fell to the wayside

Psychedelics' modern era began when LSD was discovered in the 1930s. By the 1950s, clinical trials were underway. US user experimentation outside of medical settings (and high-profile violence, like the Manson murders) inspired negative attitudes toward psychedelics, leading to use restrictions that prohibited companies from patenting psychedelic compounds. This strangled psychedelics' profitability until the 1990s when the government loosened its grip and psychedelics research began seeing a resurgence.

LSD was discovered accidentally after its inventor touched his face and hallucinated

Unlike many drugs, the first time a human ever tripped on acid was recorded first-hand by a scientist. Swiss chemist Albert Hofmann, curious about the "not unpleasant intoxicated-like condition" that overcame him after an accidental exposure, set up a rigorous experiment to test the drug's effects on himself.

A psychedelic hamburger led one member of the Manson Family, the murderous cult led by Charles Manson, to testify against the group's leader.

How a dose of MDMA transformed a white supremacist

A man leading a faction of the US white nationalist movement took part in a psychedelic trial on the pleasantness of social touch and came away from it with his beliefs reportedly upended. He left researchers a note on a form, stating, "this experience has helped me sort out a debilitating personal issue. Google my name. I now know what I need to do."

In 1957, a vice president at JPMorgan became an outspoken evangelist for psychedelic mushrooms

R. Gordon Wasson wrote "Seeking the Magic Mushroom" for Life magazine in 1957. It was a groundbreaking piece of journalism that introduced mainstream society to psychedelic mushrooms. He retired from JPMorgan in 1963 and continued researching and writing about psychedelic experiences for the rest of his life.

After her fellow cult members tried to kill her with an LSD-infused hamburger, one member of the Manson Family, the murderous cult led by Charles Manson, decided to testify against the group's leader.

The history of brainwashing in America

"Brainwashing" refers to a coerced shift in worldview, often associated with cults or oppressive totalitarian governments. Though such processes are not well understood on a neurological level, they hold an outsized role in public imagination, particularly in science fiction and dystopias. This article reviews the history of the term, first popularized by Edward Hunter in 1950, and the subsequent use of the approach in pop psychology, the CIA, and more.

'Brave New World' author Aldous Huxley turned to LSD on his deathbed

As "Brave New World" author Aldous Huxley lay dying of cancer in 1963, he asked his wife Laura to dose him with the hallucinogen LSD. A month later, Laura Huxley wrote a letter detailing the author's final trip, which she notes ended "so slowly, so gently, like a piece of music just finishing in a sempre piu piano dolcemente."

Only a fraction of LSD reaches the brain, but it concentrates in key regions

When taken, LSD is absorbed quickly (often within an hour of ingestion) and exerts its effects primarily by binding to serotonin receptors. While only a small amount enters the brain, it's active in regions controlling the visual and auditory senses, potentially driving its psychedelic effects. The drug doesn't linger in the body, and is typically undetectable within a day.

Watch veterans experience psilocybin at a Mexican clinic and discuss the aftermath

This "60 Minutes" episode from 2025 follows nine veterans attending a week-long psychedelic retreat to treat their PTSD. Most of the vets say the experience at the Mexican clinic was life-changing. But results were mixed: One veteran reported he was scared and that the experience worsened his mental health overall.

The FBI ran a covert campaign to discredit Dr. Martin Luther King Jr.

From 1963 to 1968, the FBI surveilled Dr. King with wiretaps, hotel bugs, informants, and anonymous threats, citing concerns about Communist influence—an effort later revealed through declassified files and documented in the film MLK/FBI.

US secrets: Project Paperclip

The US launched Project Paperclip in 1946, covertly recruiting over 1,500 German scientists to advance American military and space programs. Among them was Wernher von Braun, a key architect of the V-2 rocket who later became instrumental in NASA’s Apollo missions. While these scientists accelerated technological breakthroughs, their recruitment raised moral debates about overlooking wartime affiliations in the name of progress—questions that remain unresolved today.

The psychedelic playlist inspired by a Johns Hopkins experiment

Dating back to 1967, the playlist is over seven hours long and organized in such a manner as to echo users’ experiences as their trips rise, crest, and fall. According to the initial creator of the playlist, the music is a “nonverbal support system” that keeps users from prematurely returning to normal consciousness.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

The CIA tried to poison Castro’s milkshake

During the Cold War, the CIA engaged in a series of "creative" attempts to assassinate Cuban leader Fidel Castro—including poisoning his daily chocolate milkshake with botulinum toxins. It was not successful.

A US Department of Defense research lab developed the technology for the dark web

Although encryption existed to mask the content of communications across the internet before the 1990s, those managing overseas network infrastructure could determine a spy's affiliation based on where they saw data sent to and received from. To keep this information secret, the US Naval Research Laboratory developed onion routing, which enabled anonymized web browsing. The release of the technology to the public obscured sensitive communications further by growing the volume of anonymous data.

Listen to how the 1902 'poison squad' experiments changed food safety in America

As part of government research, a group of young men were paid to eat standard American food—replete with food additives like borax and formaldehyde—which revealed the dangers of unregulated food. The work was led by the first FDA commissioner, Harvey Wiley, who helped end the "century of the great stomachache."

US intelligence allegedly pursued more than 600 schemes to assassinate Cuban revolutionary Fidel Castro.

Meet a government agent who laundered millions of dollars for Pablo Escobar

Robert Mazur went undercover for years inside the Medellín cartel, which was sending more than 15 tons of cocaine into the United States every single day. Mazur created more than 30 jewelry stores to create business fronts before he finally got through to the cartel.

JJ Schildkraut theorized depression is linked to brain chemical imbalances—in 1965

Schildkraut was one of the first to put forward this idea, which stemmed from lab animal research. A decade later, researchers published the first landmark paper on fluoxetine—better known by trade name Prozac—which increases serotonin levels in the brain.

How your subconscious influences your decisions

How much of your desires and daily choices are truly yours? One of the most effective ways to influence someone's subconscious is when they're asleep. To study this possibility, researchers trained participants to be able to dream lucidly, a phenomenon that occurs when a dreamer knows they're dreaming.

The reptilian conspiracy theory posits that humanoid lizards run the world

Conspiracy theorists believe shape-shifting reptiles have taken human form and gained authority to manipulate human populations. From US politicians to British royalty, could lizard people be holding positions of power?

The Texas Ranger turned 'serial killer whisperer'

Texas Ranger James Holland earned a reputation for squeezing confessions from suspected serial killers, including the country's most prolific serial killer, Samuel Little. This reputation led the LA Times to declare him "a serial killer whisperer of sorts." With methods ranging from hypnotism to lies, this award-winning article dives into the question of whether this ranger's legal lasso ever ensnared innocents and diluted witness testimony.

The theory of chemtrails originated from misinterpreting a US Air Force paper

The document proposed a future weather modification system to achieve military objectives, but clarified that such a system "does not reflect current military policy, practice, or capability." Past testing of biological and chemical weapons has accelerated conspiracies about streaks of condensation trailing aircraft to be harmful chemical agents.

Watch a former CIA deputy director rate spy gadgets from movies and television

Dawn Meyerriecks, former CIA deputy director of science and technology, examines the realism of gadgets, including James Bond's weaponized Aston Martin, climbing gloves from the Mission: Impossible franchise, and the briefcase and listening device from "The Americans."

The story of the 1945 Minnesota Starvation Experiment

Amid the severe conditions of World War II, researchers were eager to learn the effects of starvation in a controlled study. This podcast dives into a yearlong study of 36 men at a Minneapolis college who endured a six-month period of semi-starvation, where their caloric intake was halved. Results from the experiment became a landmark study in human starvation.

The ‘paranormal activity’ lab at the University of Virginia

Near-death experiences aren’t the only thing they study at Greyson’s Division of Perceptual Studies. The lab approaches a host of “paranormal” phenomena—like past lives and out-of-body experiences—with the same academic rigor as the physics or economics department.

The origin of LASIK eye surgery, from a lab incident to federal funding and widespread use

After a University of Michigan engineering student suffered retinal burns from an ultrashort pulse laser, researchers realized it could be used to reshape the cornea and improve a person's vision with greater precision than a scalpel and earlier laser technologies. Agencies, including the National Science Foundation, the National Institutes of Health, and the Department of Energy, provided funding to develop and commercialize the procedure.

Experimental hantavirus vaccines and therapies, still under development, have long been funded by the US military.

Researchers believe the brain consolidates memories, processes emotions, and plans for the future during dream states

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

The story of Dollree Mapp, whose legal challenge over her 1957 conviction for possessing "obscene material" led to a major strengthening of the Fourth Amendment

In 2009, the nation was gripped by the story of a missing young boy who was believed to be floating over Colorado in a homemade balloon, until it was revealed that he was at home the whole time.

The US first hosted the World Cup in 1994, a tournament that lives in soccer infamy for its poor planning and the murder of Colombian player Andres Escobar, who'd accidentally scored on his own net.

In recent years a child anxiety expert has created and tested a novel phobia and anxiety treatment approach for children, focused on changing how parents respond to the fears.

In 2025, four executives from large tech companies were given positions in the US Army Reserves—including Palantir Chief Technology Officer Shyam Sankar, which reinforced Palantir's ties with the US military and its role as a leading defense partner.

Clever Hans was a 1900s horse that was believed to be able to solve math equations, tell time, and read and comprehend German, until a psychology student discovered how he got his answers.

During the French Revolution, a botanist's letter asking about "dear Rhus" (poison ivy) was intercepted, leading authorities to suspect he was conspiring with the Russians.

Against his wishes, Albert Einstein's brain was removed before his cremation, and the pathologist responsible stored it for decades in mason jars within a beer cooler.

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

A 2019 Facebook event called on attendees to "Storm Area 51, They Can't Stop All of Us," resulting in countless memes, the creation of a music festival, and eventually the arrests of those who did try to approach the area.

The Mona Lisa's celebrity status and repeated restorations have obscured what made the painting so revolutionary for its time

Explore what it's like inside a patient isolation unit, used in situations such as treating a patient or suspected patient with Ebola.

One disco producer saw 'Star Wars' four times on its opening weekend and was so inspired that he recorded the album 'Star Wars and Other Intergalactic Funk,' which produced a chart-topping single.

Before humans, the Soviet Union and the United States sent animals—including apes, dogs, and cats—to space during the Space Race.

In 1963, a basement renovation in Turkey revealed a passageway to a hidden, multilevel underground city that once housed as many as 20,000 people

Legendary architect Frank Lloyd Wright designed the SC Johnson headquarters in Wisconsin, aiming to make a cathedral-like workplace

The Great Salt Lake's distinct dual coloration results from high-salinity organisms that only live in the northern portion and produce a purple protein.

Objects can be 3D printed with light by projecting 2D computerized tomography (CT) scans onto rotating cylinders of resin, which solidify upon exposure.