How a dose of MDMA transformed a white supremacist

This is the human brain on the world's strongest psychedelic

Within seconds of inhaling a high dose of vaporized synthetic 5-MeO-DMT—a lab-produced substance that otherwise is naturally derived from the glands of the Colorado River toad—it induced slow brain waves. Such waves are typically associated with unconsciousness due to a coma or anesthesia, perhaps explaining why users describe feeling like everything falls away. The compound is currently in clinical trials for treating depression.

Watch veterans experience psilocybin at a Mexican clinic and discuss the aftermath

This "60 Minutes" episode from 2025 follows nine veterans attending a week-long psychedelic retreat to treat their PTSD. Most of the vets say the experience at the Mexican clinic was life-changing. But results were mixed: One veteran reported he was scared and that the experience worsened his mental health overall.

An LSD scientist's role in a US mind control project

Within a decade of LSD's discovery, the US government had launched a secret initiative involving hypnosis and hallucinogens. LSD researcher Louis Jolyon West conducted experiments for the CIA's MKUltra project, which focused on the potential of mind control. He later took part in a criminal trial that hinged on testimony whose sourcing was seemingly inspired by MKUltra experiments. This article explores light shed by West's personal archive.

The neurobiology of meaningfulness: the benefits of psychedelics

Psychedelics produce powerful emotions in its users, including a profound sense of meaningfulness. The philosopher William James called this sense "noetic" in the late 19th century, but for decades researchers avoided studying the effects of such drugs on the brain. However, the recent resurgence in psychedelic research has heightened interest in the relationship between this noetic sense resulting from the therapeutic use of drugs. Learn what researchers have found out here.

The FDA rejected MDMA-assisted therapy for PTSD in 2024, calling for more research

The decision was considered to be a major setback for moving psychedelics into the mainstream for mental health treatment. Pharmaceutical company Lykos, who had applied for the approval, had already attracted significant support from patients, politicians on both sides of the aisle, and leaders in the mental health field.

Can microdosing improve mental health?

Animal studies involving microdoses of psilocybin, the psychoactive component in magic mushrooms and ketamine, found it helped to alleviate anxiety and inflammation, an immune response that can cause damage when chronically active. Human studies are ongoing. In at least one double-blind study, where researchers and patients don't know who got a placebo versus the real thing, about half of the participants incorrectly guessed they had been given placebos.

An account of unethical behavior by psychedelic guides

Ethical guidelines and protections have a gossamer grasp in the underground psychedelics movement. This 34-minute podcast episode delves into patterns of deception and abuse by movement leaders through one source's deeply personal tale. This episode, which involves descriptions of sexual violence, is one of many in New York Magazine's Power Trip series, a nine-part investigation into the darker side of the psychedelic renaissance.

Merck developed MDMA in the early 1900s as part of its effort to create a blood clotting drug

The company's chemists were attempting to synthesize a substance that could compete with an existing patent for the best clot medicine of that time, hydrastinine. MDMA was the byproduct of that effort.

After her fellow cult members tried to kill her with an LSD-infused hamburger, one member of the Manson Family, the murderous cult led by Charles Manson, decided to testify against the group's leader.

Psychiatrist Bruce Greyson created a scale to identify and rate NDEs

Researcher Bruce Greyson is one of the world’s leading experts on near-death experiences. This article explores what the field of NDE research has learned over the last five decades, discusses the difficulties of studying such a controversial topic, and outlines what we’ve ruled out as the cause of these events.

One US psychiatrist at Nuremberg viewed top Nazis like Göring as normal

The surviving leaders of the Nazi movement had overseen a catastrophic war and the cruel extermination of millions. US psychiatrist Douglas Kelley evaluated the 22 men ahead of their infamous trials, viewing them as intelligent, cultured men without a moral compass. Kelley would later die by suicide.

Searching for a hate crime's unknown victim

In 2004, two federal agents heard a rumor: two white men, one under investigation for an unrelated crime, had gotten away with killing a Black man 15 years earlier as a requirement to join a white supremacist group. One of the men confessed to the crime, though he didn't know who was killed. This series dives into the search for the slain man and the justice he deserved.

The 'overview effect' heightens one's sense of unity and connectedness

Coined by space philosopher Frank White in 1987, the term refers to the paradigm-shifting experience a person undergoes upon viewing Earth from space. Commercial spaceflights aim to bring this perspective to a broader audience, inspiring changes in behavior and worldview among participants.

A mescaline-induced hallucination stayed with Jean-Paul Sartre throughout his life

In 1935, Sartre was injected with mescaline, a psychedelic drug that was then used to treat alcoholism and depression, by his friend at the Hôpital Sainte-Anne in Paris. It was not a good trip: Sartre saw nightmarish crabs for days and suffered a mental breakdown. For the rest of his life, crustaceans like the ones he saw during the hallucination appeared in his works.

'Burners' say their time spent at Burning Man changed their life

A first-hand account from habitual burner Theresa Christine gives insight into the unique festival offering endless art, entertainment, parties, and genuine interactions with strangers.

Examining self-diagnosed synesthesia

A growing number of people on social media claim to have a perceptual condition that lets them smell colors, see music, or taste sounds. But do they really?

Memes can turn regular people into unwitting celebrities

When Charles Ramsey heard loud banging from his neighbor's house, he peeked outside and saw a woman trying to escape. After helping the abducted woman get free, he gave an interview that became a viral autotuned meme. This podcast explores the unintended consequences of that relationship and its racial overtones.

A comic book-style review of attending a biohacking conference

When Andrew Greenstone attended a biohacking conference in Austin, Texas, he didn't expect to walk away a newly implanted member of the techy cadre. Partway through the event, he paid $150 to have an NFC chip inserted into his right hand.

The Beatles' visit with Maharishi Mahesh Yogi helped inspire Western interest in Eastern spirituality

The Fab Four met with the guru—the creator of Transcendental Meditation—in 1968 in Rishikesh, India. The band's George Harrison and his wife had been interested in Indian culture for several years, but the meeting with Maharishi signified a meeting of Western popular culture with Eastern spirituality that would inspire the rising hippie movement.

Dylan was born Robert Zimmerman

The name change was just one facet of his self-created myth. From the moment he arrived in Greenwich Village’s folk scene, he was crafting tall tales about his life, including a claim that he'd spent the previous six years working for a carnival.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

Tattoos suppressed during colonization are experiencing a revival

A few decades ago, the distinct facial tattoos worn by Maori people were on the brink of disappearing. Then, Maori artists brought the cultural practice back into the spotlight. This TVNZ story follows one reporter’s mother as, at 59 years old, she receives tā moko from a Maori artist.

How a Nazi leader became known as the 'living Buddha' of Nanjing

Nazi party leader John Rabe helped Chinese civilians and soldiers survive Japan’s World War II invasion, earning the title living Buddha of Nanjing, previously anglicized as Nanking. Read more about his efforts in this article.

At-home genetic testing results commonly led users to healthier lifestyles

Italian research that aimed to investigate what people do longer-term after receiving direct-to-consumer genetic test results indicated that whether the results were positive or negative, people tended to adopt a healthier diet after receiving the results, and they'd still maintained it a year after receiving their results. Some users also reported an overall reduction in stress over their health concerns. (Some users may encounter a paywall.)

The anthropological origins of modern race science

The year 1961 saw the launch of The Mankind Quarterly, a new scientific journal of anthropology that hid its political propaganda behind a veneer of academia, expecting readers to assume whatever lay in its pages was scientifically proven. This in-depth article details how this journal pushed race science in the hopes of blocking racial integration in the US and preventing the immigration of those outside of Western Europe.

Psychology research shows that conspiracy theorists tend to have a desire to be unique

While conspiracy theorists are often understood to have feelings of powerlessness in their lives, research suggests they may also be inclined to set themselves apart from the masses.

Existentialism inspired Franklin Roosevelt and Martin Luther King Jr.

The Danish philosopher, sometimes called “the father of existentialism,” believed that individuals needed to resist the temptation of conformity and instead discover their authentic selves. His work became remarkably influential in the 20th century. In 1944, Roosevelt said that reading Kierkegaard made him understand how the Nazis could’ve enacted so much violence. In 1959, King wrote that existentialism was “especially meaningful for our time.”

The story of Dollree Mapp, whose legal challenge over her 1957 conviction for possessing "obscene material" led to a major strengthening of the Fourth Amendment

In 2018, 26-year-old missionary John Allen Chau was killed by tribesmen after attempting to reach and evangelize on India's isolated North Sentinel Island

A 2019 Facebook event called on attendees to "Storm Area 51, They Can't Stop All of Us," resulting in countless memes, the creation of a music festival, and eventually the arrests of those who did try to approach the area.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

After 25 people used virtual reality headsets to practice flying with virtual wings—flapping their arms—their visual cortex responded to the wings almost as if they were real arms, treating them as body parts.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

See 33 images that became central to huge scandals, including a young Charles and Camilla, Michael Jackson's baby on a hotel balcony, and Hugh Grant's mugshot.

Explore an interactive map built from more than 100,000 survey responses on where people find joy in their lives

Prince's sexually explicit 1984 track 'Darling Nikki' attracted the ire of the Parents Music Resource Center, an advocacy group that inspired the Parental Advisory sticker, even though the song ends with a Christian message.

Against his wishes, Albert Einstein's brain was removed before his cremation, and the pathologist responsible stored it for decades in mason jars within a beer cooler.

The use of fungi to detoxify land and water—a process known as mycoremediation—has been used to clean up natural resources affected by the 2025 California wildfires.

Doctors differentiate between a phobia and fear by asking patients whether their fear interferes with their day-to-day activities.

NBA superstar Victor Wembanyama spent the 2025 summer training with monks in central China to enhance his body and mind.

The identity of the Tank Man in the iconic photo from the 1989 Tiananmen Square protests remains unknown and was possibly killed.

See images of medical cases of firework injuries shared on this 'Instagram for doctors.' (Warning: Graphic content)

During the French Revolution, a botanist's letter asking about "dear Rhus" (poison ivy) was intercepted, leading authorities to suspect he was conspiring with the Russians.

In 2009, the nation was gripped by the story of a missing young boy who was believed to be floating over Colorado in a homemade balloon, until it was revealed that he was at home the whole time.

In 1984, Operation Smash Hit intentionally crashed a 239-ton train into a nuclear waste canister at 100 miles per hour to prove the canister's safety, which remained completely intact and lost just 0.29 of its 100 pounds of pressure.

American dance legend Martha Graham, sometimes called 'the Picasso of dance,' refused to perform at the 1936 Olympics in Berlin and conceived the piece 'Chronicle' in response to the experience.

A Yale student wrote a profound essay about the consulting industry's influence on elite college students that was published in a book of her writing after she died in a post-graduation car accident.

The US first hosted the World Cup in 1994, a tournament that lives in soccer infamy for its poor planning and the murder of Colombian player Andres Escobar, who'd accidentally scored on his own net.

The Great Salt Lake's distinct dual coloration results from high-salinity organisms that only live in the northern portion and produce a purple protein.

A vending machine run with Anthropic's AI went out of business after it was convinced to give away items for free and sell a video game console.