JJ Schildkraut theorized depression is linked to brain chemical imbalances—in 1965

See how antidepressants were discovered

The decadeslong journey to the three major types of antidepressants began with medications designed to treat other maladies. Watch to learn more about how attempts to treat tuberculosis and blood pressure disorders led to new insights about neural chemistry and mood.

How depression affects the brain

Treatment for depression has historically hinged on the theory that the condition was caused by underactive or abnormal neurotransmitters, specifically serotonin and norepinephrine. This four-minute video by Yale Medicine details how these neurotransmitters didn't explain the symptoms of depression but, two other neurotransmitters involved in regulating mood and emotion did. GABA and glutamate, some of the brain's most plentiful neurotransmitters, may possibly be the source of depressive symptoms.

LSD-like drugs may inspire new antidepressants

LSD and psilocybin have shown promise as antidepressants. Using a virtual library of similar chemical compounds, researchers determined via animal studies that two molecules inspired by LSD have antidepressant effects without any associated hallucinogenic experience. These molecules were found to be 40 times more potent than the common antidepressant fluoxetine, also known as Prozac, with antidepressant effects lasting up to 21 days.

How psilocybin could transform mental health treatment

How magical are magic mushrooms, at least where depression is concerned? Some 24 volunteers participated in a study to evaluate the efficacy of using psilocybin in combination with psychotherapy to treat individuals suffering from depression. While some controversies remain about its use—psilocybin is known to cause psychosis sometimes—some scientists think the benefits outweigh the risks.

Inflammation appears to cause specific symptoms of depression

A large analysis of existing studies published in 2021 found that systemic inflammation is associated with fatigue, appetite changes, and sleep disruption, rather than some of depression's broader symptoms including hopelessness about the future, or feeling fearful. This may suggest that inflammation influences specific symptoms of the condition, rather than the disease as a whole.

Can the gut microbiome influence personality?

New research suggests the bacteria in our gut—through the hormones and molecules they produce—can contribute to conditions ranging from depression to anxiety, and much more. The findings suggest diets have a direct impact on mental health and may lead to new therapies.

Explore this deep dive into how SSRIs work

This 101-style explainer on selective serotonin reuptake inhibitors explains how they work in the brain—complete with classroom-style whiteboard drawings. It covers common SSRIs, why someone might try this medication, and a deeper discussion about potential side effects.

Roughly 10% of the world has SSAD—SAD’s milder, nonclinical cousin

Subsyndromal affective disorder is diagnosed when someone exhibits two of the nine major criteria for depression (but not more than five) as a result of seasonal changes. While it is milder than primary SAD, SSAD is still significant and impacts millions.

An engineer tracked his moods for decades and helped researchers identify SAD

Civil engineer Herb Kern had bipolar and would record his moods dating back to 1967. He noticed the seasons were a major factor in the increase and severity of his episodes. By reaching out to researchers at the National Institute of Mental Health, Kern became the first human to confirm increased melatonin levels during winter and to receive bright light therapy.

A mescaline-induced hallucination stayed with Jean-Paul Sartre throughout his life

In 1935, Sartre was injected with mescaline, a psychedelic drug that was then used to treat alcoholism and depression, by his friend at the Hôpital Sainte-Anne in Paris. It was not a good trip: Sartre saw nightmarish crabs for days and suffered a mental breakdown. For the rest of his life, crustaceans like the ones he saw during the hallucination appeared in his works.

The term schizophrenia was coined by Swiss psychiatrist Eugen Bleuler in 1908

He launched the word during a lecture at the German Psychiatric Association in Berlin. In his talk he focused on the splitting of psychic functioning as a defining feature of the disease and noted it wasn't associated with dementia or factors like early puberty onset.

1 in 10 US adults are taking medication for depression

A US government report indicates that about 10% of US adults took prescription medication for this disorder in 2023. Women, at 15.3%, were more than twice as likely to take one of these medications than the 7.4% of men.

Existentialism has been used as a therapeutic tool

Psychologists became interested in existentialism in the 1940s, with two Swiss psychiatrists—Ludwig Binswanger and Medard Boss—particularly taken with Martin Heidegger’s “Being and Time.” The existential approach to therapy emphasized a patient’s personhood and experiences, using them to help that patient face their problems head-on.

Psychedelics set off a flurry of brain activity that may permanently alter it

The brain seems to experience a sharp increase in communication between areas that generally don't interact. New research suggests a thin, sheet-like gray matter structure tucked deep within the brain, between the insular cortex and striatum, may be the key to this change. The area is centrally located and home to many of the receptors that psychedelics target, potentially rewiring the brain and rewriting thought patterns.

Some data shows cold showers can help with depression

An icy water exposure can lead to the release of norepinephrine, cortisol, dopamine, and other stress hormones that are beneficial, among other potential effects. Some data shows that this type of exposure can help combat depression symptoms among some patients, but more research is still needed. (Some users may encounter a paywall.)

Could all mental health disorders have a unifying 'p-factor'?

Some researchers have argued in the past couple decades that all mental health disorders may have a unifying dimension—a theoretical "p-factor" that is common across mental illness, but life experiences and behaviors influence if and how illness manifests. Proponents point to similarities across different disorders, while detractors argue that such connections are largely exaggerated.

Stress and the brain

While an acute stress response is a normal bodily function, the effects of chronic stress can be extremely damaging to the human body. This is particularly true with regard to the brain. This article explores the effects of stress on the human brain, including how chronic stress may lead to psychological conditions such as depression and memory loss.

How new research sheds light on why we dream

The theory of where dreams originate began shifting from ancient mystical explanations to modern scientific ones at the beginning of the 20th century. Now, scientists have the ability to track electrical activity in the brain, solidifying some of the field's softer science into observable data and giving rise to sleep labs.

Schizophrenia is being studied with pea-sized 'mini-brains'

Brain organoid research is enabling researchers to study distinct electrical firing patterns associated with schizophrenia. These "mini-brains" that are constructed in the lab from patients' cells could lead to better diagnosis approaches and drug development.

Some data links schizophrenia to older paternal age and birth complications

Yet both associations are not yet considered firm enough to definitively be causative. Schizophrenia is a multi-causal syndrome and a mixture of factors, including genetics, are widely believed to be behind its development.

'Melancholia' was the ancient Greek term for depression

"Melancholia" in Hippocrates's time was derived from the Greek word for black bile. This term made sense in its context since the Greeks believed that depression stemmed from an improper balance of the four humors.

Who was Freud and what did he say?

Sigmund Freud is one of the most famous psychologists and is widely cited—but do you really know the basics of what he taught? Here's a super brief breakdown of his major insights.

Learn about the neuroscience and psychology of why we crave comfort foods

The term was coined in 1966, when psychologist Joyce Brothers suggested humans turn to food associated with the feelings of comfort from their childhoods when experiencing emotional distress. Since then, studies have shown that the familiarity, reliability, and convenience of certain foods from one's upbringing can become tied to feelings of nostalgia.

William James laid the foundation for psychology as a scientific discipline in the US

Though initially trained in painting, James would help establish Harvard's psychology department as a distinct science rather than an extension of philosophy. He taught one of the first psychology courses in America and is credited as one of the founders of American Pragmatism.

The scientists trying to prove Jackson Pollock's symbolism

Jackson Pollock is one of the most famous American artists in history. He is well-known for his Abstract Expressionist "drip paintings," which seemed to defy interpretation. But following the artist's posthumous bipolar diagnosis, a team of scientists attempted to prove that his symptoms, including mania and psychosis, caused Pollock to embed images under his thrown paint.

In recent years a child anxiety expert has created and tested a novel phobia and anxiety treatment approach for children, focused on changing how parents respond to the fears.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

Against his wishes, Albert Einstein's brain was removed before his cremation, and the pathologist responsible stored it for decades in mason jars within a beer cooler.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

An investigation suggests a Scottish island became awash in forever chemicals via seafoam and seaspray—raising questions about what that means for the safety of other coastal areas.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

Clever Hans was a 1900s horse that was believed to be able to solve math equations, tell time, and read and comprehend German, until a psychology student discovered how he got his answers.

A researcher recently discovered an interview from 1967 between groundbreaking journalist Joan Didion and the Grateful Dead, years before the band became an institution.

Volcanic activity may have triggered the Black Death by spewing gases that led to crop failures in Europe, thus forcing the import of grain ships with plague-infested fleas.

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

In 1945, Surrealist artist Salvador Dalí and legendary animator Walt Disney began collaborating on a short film that was not completed until 2003, years after both men had died.

Coral reefs get their colors from zooxanthellae—microorganisms that line corals' digestive tracts and provide them with sugars in exchange for a home within this protective tissue.

Explore an interactive map built from more than 100,000 survey responses on where people find joy in their lives

Chaos theory—informally known as the butterfly effect—is the reason why weather forecasts are presented with probabilities rather than certainties.

Sunflowers have long been a symbol of nuclear disarmament because they can extract large amounts of radioactive cesium from soil.

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

The word 'jazz' evolved from 'jasm,' 19th-century American slang for 'energy'

The 19th-century painters of the Hudson River School were among the first American romantics, with portraits that displayed the natural beauty of the young country.

Existentialist writer Jean-Paul Sartre coined the famous phrase 'Hell is—other people' in his play 'No Exit'

Warren Buffett's former professor Benjamin Graham is known as the 'father of value investing,' a strategy in which investors seek to buy stocks trading below their intrinsic worth.

SpaceX's S-1 or 'prospectus' revealed many previously unknown details about the company, including its unprofitability despite doing $18.7B in revenue in 2025, exactly how many voting shares Elon Musk will have in the company (roughly 85%), and more.

The most expensive ad of all time was for Chanel No. 5 perfume and cost roughly $33M to produce in 2004—about $57M in today's dollars.