Hit show 'The Last of Us' was based on the real-life Cordyceps fungus

Cordyceps: the fungi that turn ants into zombies

The hit show (and video game) "Last of Us" was inspired partly by real-life species of fungi that have been known to turn ants into zombies. Spores of the Cordyceps fungi are capable of penetrating the exoskeletons of arthropods, after which they break into enzymes and proliferate within the body. The fungal cells then hack the ant's nervous system and trigger compulsive climbing.

Mapping the spread of a dangerous fungus growing in US healthcare facilities

Explore the data showing how the fungus C. auris has spread in the US, with more than 10,000 reported cases since 2016. Recommended steps to prevent infections and limit their spread have been successful in some areas, but infection control remains complicated because the fungus is often now multidrug-resistant.

Mycotoxins are toxic compounds produced by fungi—some show up in food

About a quarter of the world’s agricultural products are contaminated with mycotoxins. Some of these compounds can cause serious health problems, including cancer, so the US government has set up monitoring programs to detect them in our food and in animal feed. Humans can become ill if they eat contaminated food, but also if they ingest products from animals that had previously consumed these toxic compounds, such as milk from a cow that ate contaminated corn.

How the most famous Ebola outbreak book got aspects of the disease so wrong

Richard Preston's 1994 book The Hot Zone brought knowledge of Ebola to the masses. But, beyond the poor portrayals of the science and the scientists, the book fostered fearmongering about Ebola, with portrayals of "liquefying," "dissolving," and "bleeding out." These falsehoods about Ebola have persisted for decades and appear to be reinvigorated with every new emergence of the disease.

The mushrooms in 'Super Mario Bros.' are modeled after a real mushroom

Almost every mushroom in "Super Mario Bros." is based on the Amanita muscaria, sometimes referred to as the fly agaric, because it is known to attract flies. It's also the basis for the original mushroom emoji and the mushrooms from the popular game "Minecraft."

Mapping fiction's imagined breakdowns of the US after apocalypse

Post-apocalyptic fiction in the US is at least a century old, and how the future is envisioned reflects contemporary anxieties and divisions. This piece examines the various creative maps birthed from the tradition from Jack London's 1912 "The Scarlet Plague," a pandemic novel set in 2073, through Stephen King's "The Stand", dystopian "The Hunger Games," and visions of civil war.

How the most famous Ebola book, The Hot Zone, which sold 3.5 million copies and was translated into 30 languages, got aspects of the disease so wrong.

The use of fungi to detoxify land and water—a process known as mycoremediation—has been used to clean up natural resources affected by the 2025 California wildfires.

One doctor argued vampires were based on a real disease

At a conference in 1985, Canadian biochemist David H. Dolphin posited that stories of vampires and werewolves had a real-world origin. He argued that porphyria could have caused sufferers to seek out blood, as well as experience light sensitivity and an aversion to garlic. More than one article in the 1990s discredited this take.

'Love on the Spectrum,' a popular Netflix reality show, is following people on the autism spectrum as they navigate romantic relationships

This is one of Netflix's biggest shows, something this podcast says is due partly to the fact that the series both scratches the itch for people who enjoy reality dating viewing and the program is conducted in a nonexploitative, sensitive way that makes viewers truly want the best for the people navigating these situations.

See 16 art pieces that were inspired by or evoke elements of top phobias

CBC News informally polled readers about their fears and then found works of art either inspired by or nodding to those topics.

Orson Welles' 1938 broadcast of 'War of the Worlds' invoked real panic

The raconteur's teleplay of HG Wells' 1898 science fiction novel presented the plot as a news broadcast, leading some listeners to believe that New Jersey was being invaded by Martians. This retrospective from the National Endowment for the Humanities unpacks how he made it happen, and the media fallout that ensued.

How to prevent a worst-case scenario with synbio

Author and entrepreneur Rob Reid reviews the risks of a world where more and more people have access to the technology needed to create a doomsday bug that could wipe out humanity.

Land use changes in Connecticut may have helped to enable Lyme's leap into humans

Forest clearing and fragmentation, alongside suburban development, may have contributed to the emergence of Lyme disease in humans in the 1970s. Those changes brought mice, carriers of the disease, into greater contact with people. Climate change is also facilitating Lyme's spread as tick populations survive milder winters and move northward.

The Japanese folklore that inspired Pokémon

Characters from the popular video game series appear to reference the yōkai from Japanese folklore, which first became popular during the country's Edo period, when art and literature became mass-produced.

Horror video games rely on terrifying sound design

Horror has become a popular gaming genre, which designers say is due, in large part, to the games' soundtracks. Don Veca, the audio director for the game Dead Space, said, “Sound and music prepare the player to be scared – it’s all about the buildup, the tension, and then the release when something jumps out at you.”

See an analysis of the similarities between the characters in 'Silicon Valley' and the real people who inspired them

The HBO show "Silicon Valley" follows the story of an engineer who is trying to get his startup to take off in Silicon Valley. While one tech CEO said the show is like a documentary, many speculate the show is based on real life tech figures like Mark Zuckerberg and Peter Thiel.

Slenderman is the most infamous example of creepypasta

In 2014, two teens playing in the woods at the edge of a suburban park turned on their third friend, stabbing her 19 times in an attack they claimed was compelled by Slenderman, a meme-turned-urban legend.

Some Pokémon have been named after real and fictional organisms, while some real-world species have been named after Pokémon, such as Chilicola charizard and Binburrum zapdos.

The 'Chernobyl' miniseries is one of the most critically acclaimed TV shows ever

The five-episode historical drama earned near-universal acclaim for its historical detail and haunting portrayal of the 1986 disaster, winning 10 Emmys and topping IMDb's all-time TV rankings upon its release.

The FBI was thrilled with 'The Silence of the Lambs' and its portrayal of the agency

The film's ultimate purpose was to terrify, but the FBI made it clear that they appreciated the accurate, professional portrayals of its agents. "It never hurts to see the organization we all care about and know to be good well-depicted on the big screen," special agent Walter B. Stowe, Jr., wrote in a letter to director Jonathan Demme.

Actresses Christina Applegate and Jamie-Lynn Sigler describe MS ignorance and stigma

Applegate discusses with Conan O'Brien how ignorance about the disease and fake cure information continue to proliferate. Sigler, known for her role on HBO's Sopranos, also discusses how she is now prioritizing roles that will have a disability, like her.

'Dr. Death' (4 Seasons)

Taking a unique angle on the true crime genre, this series explores medical professionals whose lust for fame and success stops at nothing—even others’ lives. Each season explores a different doctor and the systems that enabled them. Begin with the season one and the story of Christopher Duntsch, accused of maiming or killing several patients, including leaving one quadriplegic and another brain-dead.

Biological terraforming studies have been conducted at Biosphere 2

The experiments involve populating barren hillslopes within the Landscape Evolution Observatory with microbes that react with air and rock to produce molecules needed by more complex organisms. Mosses and other simple plants can then grow in these spaces, gradually making them more hospitable to humans.

'The Simpsons' show-within-a-show was based on a real cartoon

Most "Simpsons" fans assume "The Itchy and Scratchy Show," the violent cartoon Bart Simpson loves, is a disturbing inversion of "Tom and Jerry." In reality, it's based on "Herman and Katnip," a "Tom and Jerry" knockoff that was similarly grotesque.

Rachel Carson's 'Silent Spring' exposed the harmful effects of pesticides on food

The 1962 book warned against the use of DDT, a pesticide often sprayed over fields of crops, cautioning that it could be harmful if ingested in excessive amounts by humans. Some credit Carson’s book with inspiring the modern environmental movement and with encouraging the US to establish the Environmental Protection Agency in 1970 and ban the domestic sale of DDT in 1972. (Some readers may experience a paywall.)

In 2019, videos on TikTok convinced children they had Tourette syndrome

Right before the COVID-19 pandemic, an "outbreak" of Tourette syndrome was attributed to videos from a German TikToker who documented his life with the condition. The children experiencing the symptoms all had the same tics, which experts say was a case of mass sociogenic illness, also referred to as mass hysteria.

US FDA recently approved the first new schizophrenia drug in decades

Though other antipsychotics block dopamine receptors, a new drug, Cobenfy, influences dopamine levels via a different pathway—it stimulates a pair of specialized receptors in the brain that control the release of a substance called acetylcholine. This alternative approach may help patients avoid serious side effects like weight gain. (Some users may experience a paywall.)

Experimental hantavirus vaccines and therapies, still under development, have long been funded by the US military.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

Fear or disgust related to clusters of holes and cracks, called trypophobia, may stem from evolutionary processes to help us avoid pathogens.

Discover the catastrophic consequences of a failure of the US electrical grid—something that is more likely than many Americans think.

Elk Cloner, the first computer virus to spread in public, was written as a practical joke by Richard Skrenta, a Pittsburgh high school student.

The Dracula character, now seen as the vampire archetype, was inspired by a seafood-induced nightmare its creator experienced.

Netflix profits when you're not watching, and its movies are designed that way—read a detail-rich critical essay exposing lesser-known Netflix takes

Volcanic activity may have triggered the Black Death by spewing gases that led to crop failures in Europe, thus forcing the import of grain ships with plague-infested fleas.

Massive blooms of microscopic plankton called dinoflagellates produce the neon blue light seen in glowing tides.

In 2009, the nation was gripped by the story of a missing young boy who was believed to be floating over Colorado in a homemade balloon, until it was revealed that he was at home the whole time.

The US first hosted the World Cup in 1994, a tournament that lives in soccer infamy for its poor planning and the murder of Colombian player Andres Escobar, who'd accidentally scored on his own net.

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

Poison ivy's characteristic rash is caused by an allergic response to an oily compound in the plant called urushiol.

A 2019 Facebook event called on attendees to "Storm Area 51, They Can't Stop All of Us," resulting in countless memes, the creation of a music festival, and eventually the arrests of those who did try to approach the area.

After NASA's Voyager 1 captured Earth as a single pixel as it left the solar system in 1990, astronomer Carl Sagan used the image to reflect on humanity's fragility and the responsibility to protect 'the only world we've ever known.'

'Shogun,' a 1980s TV series, helped popularize sushi in the US by stimulating an American interest in Japanese culture.

Crows are believed to have intelligence on par with a seven-year-old child and demonstrate complex behaviors, from problem-solving with tools to recognizing human faces.

After her fellow cult members tried to kill her with an LSD-infused hamburger, one member of the Manson Family, the murderous cult led by Charles Manson, decided to testify against the group's leader.

The 1987 Nintendo video game 'Stadium Events' isn't known for being particularly fun, but its scarcity has made it a highly sought-after item that has sold for up to $35K at auction.

In 2018, 26-year-old missionary John Allen Chau was killed by tribesmen after attempting to reach and evangelize on India's isolated North Sentinel Island

Budweiser stores yeast derived from the original 1800s strain in a secret bunker, which only the Head of Yeast Management can access—not even the CEO