How to prevent a worst-case scenario with synbio

Is synbio really cool, really scary, or both?

There’s always been a divide between technology, the inanimate stuff that we build, and biology, the living stuff that nature builds. Synthetic biologists are trying to figure out how to close the gap by building living things.

Challenges for synthetic biology

Can engineering approaches tame the complexity and unpredictability of living systems? An exploration of five challenges for the field and how they might be resolved.

Will AI kill us all? A debate

As AI becomes a bigger part of our lives, what does that mean for the future of humanity? The podcast Entanglements hosts a pessimistic former OpenAI employee and an optimistic Princeton professor to discuss whether AI brings dystopia or a brighter future.

How Anthropic's frontier red team assesses the dangers of its AI tools

The team of researchers deliberately attempts to breach the safeguards in Claude to determine whether the large language model can be used to commit cyberattacks, develop biological weapons, or enable other harmful behavior. Unlike many other red teams, Anthropic shares its findings and how it resolved them publicly to help build transparency and credibility.

Synthetic biology can prevent extinction by creating create disease-resilient plants and animals

Through gene editing and the deployment of artificial cells, scientists can leverage learnings from the genetic sequencing of animals with known resistances to protect endangered species. Gene editing of certain species, such as mosquitoes, can also reduce their ability to spread diseases like malaria between humans.

Meet six commercially available synbio products

An article exploring the science behind synbio products currently on the market, and projecting the products that can be expected over the next 10 years.

More than 39 million people are expected to die from antimicrobial resistance by 2050

In 2024, researchers published an incredibly detailed study aimed at predicting the real-world impact of antimicrobial resistance over the next 25 years. The key findings were clear: the superbug crisis is poised to get much worse and needs to be addressed. This article offers a clear, concise overview of the study, which was published in The Lancet.

Hacking the body for a future that didn't happen

Journalist Adi Robertson experimented with one of the most accessible biohacks: magnets. Having a tiny magnet in their right ring finger meant they could sense magnetic fields, attract small metal objects, and more. But magnets weaken over time, eroding this new sense. Such implants do more than offer a new way of interacting with the world, they also pose new complications, such as the inability to get an MRI.

The risks of bioremediation, from intermediate products to ecological disruption

A step in the series of complex biochemical reactions involved in the implemented bioremediation process may produce dangerous molecules—sometimes more toxic than the initial pollutants—that require ongoing monitoring to ensure optimal conditions for processing these intermediates toward the eventual, safe outputs. Introducing non-native nutrients or species, including GMOs, may alter existing food webs and gene pools.

The crypto city home to biohacking experiments

The DIY nature of biohacking gives the work an entrepreneurial feel, as seen by the emergence of community labs, at-home testing kits, and corporation-backed cities that don't necessarily require government-approved testing standards. Próspera, Honduras, created by a business of the same (first) name, was born from legislation that allowed international businesses to shave off a slice of the country to establish their own micronations.

Tracing the history of the philosophy of human extinction

Global catastrophe is at the center of much contemporary debate over climate, war, science, technology, and more, and our period is marked by a lurking sense everything we know—including the human species—could end overnight. It wasn't always...

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

Discover the catastrophic consequences of a failure of the US electrical grid—something that is more likely than many Americans think.

Minor technology failures can spiral into massive internet outages

A mix of centralized cloud infrastructure and legacy protocols leaves the internet susceptible to downtime from minor cyberattacks or software bugs, infrastructure damage caused by extreme weather, and human error if a DNS service provider—the internet's phone book—or a backend system, such as Amazon Web Services, were compromised.

The promises and perils of using at-home genetic tests for your health

A primer on genetic testing, personalized medicine, and the promise of pharmacogenomics–the use of genetics to predict an individual's response to a drug.

How to prepare for cyberattacks

An easy-to-digest checklist on the many ways you want protect yourself from a cyberattack before it happens, if it happens, and after it happens.

Read an oral history of the Y2K panic

This oral history brings together programmers, engineers, and officials who first identified the date flaw and then spent years alerting the public to the danger and racing to repair millions of lines of code.

A scientist debunks theories for why aliens might invade Earth

While TV and films offer common tropes for why aliens would invade Earth, many of those reasons aren't actually feasible. For example, a species with technology advanced enough to allow it to travel between planets likely doesn't need to enslave flawed humans to carry out its labor.

The 2024 Synapse collapse took $90M of people’s life savings with it

In 2024, a banking middleman called Synapse declared bankruptcy. Unfortunately, it also locked roughly 100,000 Americans out of their own money, which prompted a class action lawsuit.

Dispose of invading viruses while learning about the CRISPR immune system

In this free, easy-to-play game, defend the city of Bacterium by playing the role of Cris Perotein. As you play, you'll learn microbiology and the workings of the mechanisms that CRISPR uses to protect bacteria. (desktop recommended)

Sci-fi writer Jeff VanderMeer writes dystopian fiction about the environment

Noted science fiction writer Jeff VanderMeer discusses his 2014 novel "Annihilation," which uses climate change as a dystopian frame. VanderMeer notes that he’s not interested in cynicism, even though that’s how most people view dystopian literature. “I’m not a fan of fiction that’s totally hopeless,” VanderMeer says. “You find ways of documenting the world as it is and you wind up redefining utopia and dystopia.”

Malware has transitioned from notoriety-driven to profit- and data-driven

Many of the first researchers and hobbyists who created viruses and worms showed a natural curiosity in experimenting with and designing such software to make a name for themselves and advance the field of computer science. In the future, AI-augmented malware may adapt in real-time or design enhanced cryptojackers, infostealers, and ransomware for cybercriminals.

Average citizens may be the greatest liability to smart cities

Smart cities utilize massive datasets to enhance mobility, resource utilization, and public safety. However, this data can also be compromised if mishandled by residents, making citizen awareness of risks a key component of cybersecurity efforts.

According to Bill Nye, science is under threat from an erosion in critical thinking

He states that conducting research online cannot replace consulting with scientific experts who have spent their entire lives intimately studying a field. The former science education show host argues that deepening cynicism towards scientific institutions has been fueled by leaders embracing debunked and unsupported claims.

A modern-day version of the dinosaur-killing asteroid would kill billions of people

Such an asteroid would level Central America, trigger tsunamis, spark global fires, and plunge the planet into an artificial winter lasting over a decade. Bunkers would be insufficient for survival without years of provisions.

3-parent baby technique fuels worries of future 'designer babies'

Some critics of this approach worry that any genetic manipulation will both culturally and technologically normalize the idea of "designer babies"—embryos that are manipulated or selected based on physiological characteristics including height, eye color, athletic ability, and intelligence.

As an experiment, the first B2 mission highlighted the challenges of isolated systems

Some argue that isolation from the outside world was compromised—making the experiment a failure—when a crew member was taken from Biosphere 2 for surgery and returned hours later. This position was strengthened when it was revealed that oxygen had been pumped into the facility.

Watch how viruses like Ebola can spill over from animals to humans—and vice-versa.

After NASA's Voyager 1 captured Earth as a single pixel as it left the solar system in 1990, astronomer Carl Sagan used the image to reflect on humanity's fragility and the responsibility to protect 'the only world we've ever known.'

Indefinite cloning of some endangered species may not sustain their longevity because cloning success rates decrease as genetic mutations accumulate.

Radioactive elements can introduce software errors because the ionizing radiation they produce can detach electrons from atoms, and computer code relies on the distribution of electrons.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

A vending machine run with Anthropic's AI went out of business after it was convinced to give away items for free and sell a video game console.

Watch how algorithms can be designed to train themselves and self-improve without human input, to the point where the optimized code is too complex for programmers to understand.

In 2019, a laptop loaded with six of the worst malware in history and described as 'an exhibit of historical weaponry' sold for $1.3M.

Apeirophobia is an overwhelming fear of living forever, perhaps stemming from the brain's inability to conceptualize an infinite life.

The name 'Silicon Valley' arose from the founding of Shockley Semiconductor Laboratory in Fairchild Semiconductor in 1956-57, founded near Stanford University in Palo Alto

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

In 2018, 26-year-old missionary John Allen Chau was killed by tribesmen after attempting to reach and evangelize on India's isolated North Sentinel Island

The use of fungi to detoxify land and water—a process known as mycoremediation—has been used to clean up natural resources affected by the 2025 California wildfires.

SpaceX's S-1 or 'prospectus' revealed many previously unknown details about the company, including its unprofitability despite doing $18.7B in revenue in 2025, exactly how many voting shares Elon Musk will have in the company (roughly 85%), and more.

About 2,000 US babies are born annually without some portion of their limbs, potentially leading to a lifetime of pricey prosthetics.

Chaos theory—informally known as the butterfly effect—is the reason why weather forecasts are presented with probabilities rather than certainties.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

A Yale student wrote a profound essay about the consulting industry's influence on elite college students that was published in a book of her writing after she died in a post-graduation car accident.

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

The Dracula character, now seen as the vampire archetype, was inspired by a seafood-induced nightmare its creator experienced.

Legendary architect Frank Lloyd Wright designed the SC Johnson headquarters in Wisconsin, aiming to make a cathedral-like workplace

A 2019 Facebook event called on attendees to "Storm Area 51, They Can't Stop All of Us," resulting in countless memes, the creation of a music festival, and eventually the arrests of those who did try to approach the area.