Challenges for synthetic biology

Is synbio really cool, really scary, or both?

There’s always been a divide between technology, the inanimate stuff that we build, and biology, the living stuff that nature builds. Synthetic biologists are trying to figure out how to close the gap by building living things.

How to prevent a worst-case scenario with synbio

Author and entrepreneur Rob Reid reviews the risks of a world where more and more people have access to the technology needed to create a doomsday bug that could wipe out humanity.

Making industrial chemicals with synthetic biology

A new report forecasts that synthetic biology will transform from creating niche, environmentally friendly products to creating new molecules within the next decade.

Synthetic biology can prevent extinction by creating create disease-resilient plants and animals

Through gene editing and the deployment of artificial cells, scientists can leverage learnings from the genetic sequencing of animals with known resistances to protect endangered species. Gene editing of certain species, such as mosquitoes, can also reduce their ability to spread diseases like malaria between humans.

Inside the community movement behind DIY synthetic biology

Margaret Talbot spotlights the rise of DIY biology in community labs, where amateur scientists—often outside formal institutions—create everything from insulin to prosthetic prototypes. These grassroots biohackers challenge traditional science by pursuing open, accessible innovation, raising questions about credibility, ethical oversight, and acceptance by mainstream researchers.

Explaining CRISPR at five levels of technical detail

CRISPR is a new area of biomedical science that enables gene editing and could be the key to eventually curing diseases like autism or cancer. WIRED challenges biologist Neville Sanjana to explain this concept to 5 different people; a 7-year-old, a 14-year-old, a college student, a grad student and a CRISPR expert.

Visualization of printing synthetic DNA

Ever wonder how synthetic DNA is made? Discover how GenScript uses innovative technology to synthesize precise, high-quality DNA at a larger scale than ever before.

The risks of bioremediation, from intermediate products to ecological disruption

A step in the series of complex biochemical reactions involved in the implemented bioremediation process may produce dangerous molecules—sometimes more toxic than the initial pollutants—that require ongoing monitoring to ensure optimal conditions for processing these intermediates toward the eventual, safe outputs. Introducing non-native nutrients or species, including GMOs, may alter existing food webs and gene pools.

What's next for gut microbiome science?

A Stanford microbiologist explores what we don't yet know about the gut microbiome—such as whether we can engineer the bacterial species within it—and the current scientific advances in the field.

Why the bioremediation of plastic and other synthetic materials is challenging

Ideonella sakaiensis, a bacterium found in recycling plant sludge in 2016, was the first organism seen to possess enzymes that could break down PET, a type of plastic. Researchers continue to search for microbes to expand bioremediation efforts to other types of plastic, but weakening the chemical bonds in many of these materials requires temperatures lethal to most microbes.

As of 2025, perfect synthetic replication of natural organs remains elusive

Advancements such as 3D printing muscles, performing vaginal reconstruction with colon tissue, and growing organs in a lab have shown promise, but artificial options and transplanting substitutions continue to exhibit functional and performance limitations compared to their natural equivalents.

What is cancer bioengineering?

While new treatments for cancer are under continuous development, researchers are increasingly using engineering principles to find wholly new strategies to combat the disease. Directions include nanoparticle drug delivery, advanced imaging tools, developing new materials to interact with cells, tissue engineering, robotic surgeries, and more. Such interdisciplinary efforts are expected to unlock new tools and therapies beyond traditional drug formulation.

Efforts to build touch-enabled machines highlight the complexity of human touch

The challenges that engineers are facing as they try to reproduce a human's ability to touch and also give robots the ability to interpret that kind of sensory flow are furthering our understanding of the myriad intricacies of human touch—and the challenges in emulating it.

Anthropic's interpretability team discusses how AI models' thinking mimics biology

Just as humans engage in complex behaviors to survive and reproduce, teams of experts in neuroscience, virology, mathematics, and other disciplines argue that large language models develop complex mechanisms to achieve their goals. These mechanisms can be manipulated to assess how they modify outputs—much like stimulating individual neurons—to uncover how LLMs "think."

Learn how natural systems exhibit characteristics of chaos theory

In biology, some mathematical models of ecosystem populations and heart irregularities show strong sensitivity to initial conditions, which scientists can simulate to determine quantitative tipping points at which these systems become unstable. Within the social sciences, crowd behavior and the virality of social media posts have shown how human behavior fits within the framework of chaos theory.

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

Swarms of mechanical bees may one day support natural pollination

Engineers are racing to create tiny robot bees that can be programmed to mimic natural bee behavior, helping in specific scenarios such as indoor farming and space agriculture. Battery life challenges may be solved by having these robots accompanied by a nearby "mother" drone power supply.

Breaking down the challenges of alkaline environments and how extremophiles survive them

These areas are far less acidic than the interiors of most organisms' cells, and this imbalance draws protons that are needed for various metabolic processes, including energy production, out of cells. To counter these effects, some alkaliphiles have developed stronger proton regulation across their cellular membranes and proteins that drive these processes with greater stability amid such acidity imbalances.

It can take 10 to 15 years and more than $1B to develop a new antibiotic.

Why don't we just develop new antibiotics? In part, it's a complex scientific challenge, but market incentives also play a significant role. It can be time consuming, expensive, and most notably, we should use as little as possible to avoid driving further antibiotic resistance.

The research pipelines being explored by the RIPE Project to improve photosynthesis

These include engineering plants with faster stomata, which would allow photosynthesis to resume more quickly amid fluctuations in available light due to clouds or shading from other plants, and resolving bottlenecks in the regeneration of RuBP, the molecule to which carbon dioxide is fixed during photosynthesis to initiate the Calvin cycle. (Some readers may experience a paywall.)

Many issues facing urban environments cannot be solved by smart technologies

Although connecting systems to the Internet of Things can provide improved efficiency in municipal systems, problems such as limited affordable housing are driven by larger socioeconomic factors. Some experts suggest that local governments should focus resources on practical solutions to these issues rather than investing in smart technologies.

The key ingredients to life on Earth—and elsewhere

Life can only arise in incredibly specific conditions, an abundance of certain substances like water and phosphorus, lots of time, and the right proximity to a heat-and-light-providing star. These two experts on evolution of life say above all, life requires luck. Here's a list of eight ingredients to life.

Why the nature of consciousness is such a difficult problem

David Chalmers is one of the leading philosophers of consciousness. In this video, he outlines some of the major questions in this field, including the "hard problem of consciousness," which seeks to find neural correlate for every conscious experience.

Universal limit to technological development may prevent finding alien civilizations

Given the vastness of the Universe, detecting alien life may require technological progress beyond the limits of what is sociologically viable and physically possible. Although interstellar civilizations are unlikely, messaging techniques and probes may improve the odds of successful communication with other intelligent life.

Scientists explore innovative solutions to protect coral reefs

As coral reefs are under increasing stress due to climate change, pollution, and other factors, scientists are employing creative solutions to save these crucial marine ecosystems. This National Geographic article explores the various scientific...

How to build curiosity

Change and uncertainty induce stress, but reframing the unknown into an opportunity for discovery has tangible benefits. Approaching change with curiosity enhances activity in the hippocampus and promotes neuroplasticity, promoting learning and serving as a barrier against anxiety. A neuroscientist explains how embracing the unknown, trying small experiments, and other techniques build curiosity.

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

Indefinite cloning of some endangered species may not sustain their longevity because cloning success rates decrease as genetic mutations accumulate.

Watch how algorithms can be designed to train themselves and self-improve without human input, to the point where the optimized code is too complex for programmers to understand.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

Discover the catastrophic consequences of a failure of the US electrical grid—something that is more likely than many Americans think.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

The use of fungi to detoxify land and water—a process known as mycoremediation—has been used to clean up natural resources affected by the 2025 California wildfires.

Chaos theory—informally known as the butterfly effect—is the reason why weather forecasts are presented with probabilities rather than certainties.

How fusion—which releases energy when two lighter atoms combine to form a heavier atom—differs from fission

This site reaches millions of visitors who are tired of AI chatbots and seeking human connection. Pretend to be an AI chatbot and ask questions, provide answers, and draw for people in real time.

Watch how viruses like Ebola can spill over from animals to humans—and vice-versa.

Some Pokémon have been named after real and fictional organisms, while some real-world species have been named after Pokémon, such as Chilicola charizard and Binburrum zapdos.

After NASA's Voyager 1 captured Earth as a single pixel as it left the solar system in 1990, astronomer Carl Sagan used the image to reflect on humanity's fragility and the responsibility to protect 'the only world we've ever known.'

Radioactive elements can introduce software errors because the ionizing radiation they produce can detach electrons from atoms, and computer code relies on the distribution of electrons.

The name 'Silicon Valley' arose from the founding of Shockley Semiconductor Laboratory in Fairchild Semiconductor in 1956-57, founded near Stanford University in Palo Alto

Crows are believed to have intelligence on par with a seven-year-old child and demonstrate complex behaviors, from problem-solving with tools to recognizing human faces.

Explore the history, structure, and species of Australia's Great Barrier Reef with this interactive journey narrated by Sir David Attenborough.

Apeirophobia is an overwhelming fear of living forever, perhaps stemming from the brain's inability to conceptualize an infinite life.

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

SpongeBob exemplifies Aristotle's philosophy for living well because he understands that happiness doesn't come from external factors like money, recognition, or power.

Play the role of a student in a game where you try to navigate college and remain debt-free, selecting different income levels, high school experience, race, ethnicity, and more.

Budweiser stores yeast derived from the original 1800s strain in a secret bunker, which only the Head of Yeast Management can access—not even the CEO

Legendary architect Frank Lloyd Wright designed the SC Johnson headquarters in Wisconsin, aiming to make a cathedral-like workplace

Hear 50 years of iconic hip-hop samples, the genre's foundational looped tracks