Breaking down the challenges of alkaline environments and how extremophiles survive them

An overview of extremophiles and the biochemical adaptations employed by various types

These organisms thrive in environments that would normally be inhospitable to most living things by using molecules that help counter deadly environmental factors. These include antifreeze-like proteins that prevent psychrophiles from freezing and rupturing in polar regions, and osmoprotectants that prevent some extremophiles from losing water to salty environments.

Read a technical review of extremophile categories, including the habitats of each

Acidophiles can survive in environments with acidity greater than that of the human stomach, and some radiophiles can live in places with radiation exposure hundreds of times higher than what is lethal to humans. Piezophiles—formerly known as barophiles—have been found in the Mariana Trench, where pressures are over 1,000 times larger than those on Earth's surface.

Learn about endoliths, the polyextremophiles that thrive inside rocks

These organisms include species that live in Antarctica, where they perform photosynthesis using light and water that makes it through pores in sandstone. Others residing in Earth's crust can survive temperatures reaching 60 degrees Celsius (140 degrees Fahrenheit) while generating energy through chemical reactions involving nutrients and gases trapped in rocks.

View the industrial applications of extremozymes, from food safety to antibiotic production

Extremophiles possess unique enzymes and organic molecules that have enabled them to adapt to and thrive in otherwise lethal environments. Because these conditions resemble those found in various areas of manufacturing and production plants, these organisms and their macromolecules can optimize industrial processes where conventional catalysts would lose their ability to speed up reactions.

How scientists are using molecules found in acidophiles to develop new medical treatments

The Berkeley Pit, an open-pit copper mine in Butte, Montana, that ceased operations in 1982 and is now filled with highly acidic water, is home to various species of fungi and yeast. These extremophiles produce unique compounds that may have anti-inflammatory benefits and have already been used to create an antibiotic for staph infections.

A look at hydrothermal vents, where barophiles and hyperthermophiles survive boiling water

Discovered in 1977 during an exploration of the Galapagos Rift, these seafloor openings spew hot magma and chemicals that heat seawater to hundreds of degrees. Without the sunlight found at depths of less than 1,000 meters (3,281 feet), extremophiles in these environments convert released chemicals into energy to survive, alongside surviving extreme pressures.

Legacy electronics have prevented significant advancements in alkaline batteries

While lithium-ion batteries have increased in energy density multiple times since their commercialization in 1991 and can be sized to various capacities by connecting numerous electrochemical cells, disposable alkaline batteries have been forced to maintain their 1.5-volt standard and form factors for compatibility with existing devices.

Learn how environmental conditions are optimized to increase bioremediation efficacy

Through biostimulation, Indigenous microbes are provided with moisture, nutrients, or oxygen to prevent their death and ensure optimal progression of their biochemical reactions. Bioaugmentation can introduce new microbial cultures to target specific compounds not natively found in the environment, while landfarming can spread or aerate contaminated soil to improve access to contaminants.

A Death Valley shrub optimizes its cells' organelles to photosynthesize in extreme heat

Examining the cellular structure of the plant under heat, scientists observed the formation of novel, cup-shaped chloroplasts and mitochondrial relocation, which shifted the plant's optimal photosynthesis temperature to 45 degrees Celsius (113 degrees Fahrenheit) as it tripled in mass over 10 days. Engineering these mechanisms in crops may help optimize them for hotter environments.

A look at anoxygenic photosynthetic bacteria, which do not produce oxygen

Rather than using water to produce organic compounds and release oxygen, purple and green sulfur bacteria take up hydrogen sulfide, carbon dioxide, and light to produce water, elemental sulfur, and a carbohydrate. Other organisms can take up various molecules and elements, such as iron, which can replenish the electrons in pigments involved in light-dependent reactions.

Deep sea fish rely on a molecular strengthener to prevent being crushed

Trimethylamine N-oxide (TMAO) stabilizes hydrogen bonds and prevents water and proteins within organisms from being misshapen under immense pressure. Compounds called piezolytes protect cellular membranes from being crushed in regions like the Mariana Trench, where pressures are 1,100 times greater than surface atmospheric pressure.

Batteries store energy in chemical bonds that can be turned into electricity

To achieve a more stable, nonreactive state, many elements in nature are reactive and will seek to lose electrons via oxidation or gain electrons through reduction reactions. By pairing an oxidizing chemical with a reducing chemical in a battery, electrons will naturally flow between them, producing an electric current.

The key ingredients to life on Earth—and elsewhere

Life can only arise in incredibly specific conditions, an abundance of certain substances like water and phosphorus, lots of time, and the right proximity to a heat-and-light-providing star. These two experts on evolution of life say above all, life requires luck. Here's a list of eight ingredients to life.

Challenges for synthetic biology

Can engineering approaches tame the complexity and unpredictability of living systems? An exploration of five challenges for the field and how they might be resolved.

Some organelles are believed to have once been independent cells

Mitochondria and chloroplasts, which are both responsible for energy production in cells, have DNA distinct from that of their host cells and are surrounded by cellular membranes resembling those of bacteria. Through symbiogenesis, these and other specialized structures were absorbed into larger cells, forming the modern-day biological units.

Breaking down the different types of drinking water, from alkaline to sparkling

While tap water is regulated by the EPA, environmental and infrastructural factors can introduce contaminants, which filtering can help to remove. Distilled water has had all of its mineral contaminants removed and may be used in laboratory settings, but mineral water has them added in for taste or to promote health.

Alkaline hydrolysis—dissolving the body—is one 'green' burial option

This approach, which is sometimes called flameless cremation, involves dissolving the body with water and chemicals. The remaining bone fragments can then be spread like ashes. It was reportedly incorporated into the funeral industry in 2011.

Cells modify their internal spacing to improve biochemical reaction efficiencies

Studies involving microscopy and genetic engineering tools in yeast and human cells show ribosomes act as crowding agents—much like packing peanuts—and their concentrations are actively tuned to alter the rate of cellular functions. However, these concentrations and cell crowding levels vary across different tissues and cell types.

Bacteria use chemical signals to communicate and coordinate with one another

Through a system called quorum sensing, bacteria produce and absorb compounds from their environment to identify allies or competitors and adjust their behavior accordingly. Some bacteria produce food-digesting enzymes only in the presence of similar bacteria, thereby preventing competitors from consuming their meal.

Explore the efficiency of photosynthesis under various conditions

In this simulation, users can track how the cellular concentrations of ATP, NADPH, glucose, and oxygen vary over time in response to changes in temperature, acidity, carbon dioxide concentration, and the properties of incoming light. Through multiple trials, users can identify the optimal conditions for photosynthetic reactions.

How climate change threatens coral reefs, including via warming and acidification

Increasing ocean temperatures disrupt the symbiotic relationship of corals and algae, causing the former to bleach and weaken, and strengthen storms that can destroy reef structures. Higher greenhouse gas emissions increase dissolved carbon dioxide levels in ocean water, triggering a series of reactions that consume carbonate, a key ingredient in coral reef construction.

'Gram-negative' bacteria: Bugs with extra defenses along their cell walls

The term 'Gram-negative' bacteria refers to bugs which react a certain way under a Gram stain test. These bacteria are harder to kill due to their double-layer cell walls with a thin peptidoglycan layer in between. This structure makes the delivery of drugs into the bacterial cell substantially more difficult.

Explaining how water's movement between different salt concentrations can generate electricity

Water naturally moves from regions of low salinity, such as freshwater, to regions of high salinity, such as ocean water, across a semipermeable membrane. This movement produces pressure that can be harnessed in osmotic power systems to drive turbines and generate electricity, much like in hydroelectric plants.

Cholera can persist in the environment, unlike smallpox, which needs a human host

Vibrio cholerae is the pathogen that causes cholera. It can reproduce in the environment without a human host, which means it's formally called a facultative pathogen. Obligate pathogens need a host to reproduce. Examples of obligate-based diseases include leprosy and smallpox.

Catalysts increase chemical reaction rates by providing a lower energy pathway

All chemical reactions must overcome an energy barrier, called an activation energy, to proceed. If insufficient thermal energy exists in the system to overcome the barrier, catalysts can effectively lower the activation energy, increasing the likelihood of reactions occurring.

Coral reefs get their colors from zooxanthellae—microorganisms that line corals' digestive tracts and provide them with sugars in exchange for a home within this protective tissue.

Pure water does not conduct electricity because this flow of energy requires the movement of charged particles, and water is a neutral molecule.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

Watch what the Ebola virus does inside our cells and organs in order to spread and survive.

The Great Salt Lake's distinct dual coloration results from high-salinity organisms that only live in the northern portion and produce a purple protein.

Radioactive elements can introduce software errors because the ionizing radiation they produce can detach electrons from atoms, and computer code relies on the distribution of electrons.

How fusion—which releases energy when two lighter atoms combine to form a heavier atom—differs from fission

Indefinite cloning of some endangered species may not sustain their longevity because cloning success rates decrease as genetic mutations accumulate.

Watch how deep-sea mining equipment collects and processes polymetallic nodules—metal-rich, potato-shaped rocks—from the ocean floor and creates environmentally damaging plumes of sediments.

SpongeBob exemplifies Aristotle's philosophy for living well because he understands that happiness doesn't come from external factors like money, recognition, or power.

The use of fungi to detoxify land and water—a process known as mycoremediation—has been used to clean up natural resources affected by the 2025 California wildfires.

Sony set the standard for cylinder-shaped batteries when it repurposed manufacturing equipment used to make rolls of magnetic recording tape.

Budweiser stores yeast derived from the original 1800s strain in a secret bunker, which only the Head of Yeast Management can access—not even the CEO

Bone marrow (soft tissue found inside certain bones) generates roughly 500 billion new blood cells each day

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

Doctors differentiate between a phobia and fear by asking patients whether their fear interferes with their day-to-day activities.

Scientists can determine Earth's past climate conditions by analyzing air trapped in microscopic bubbles within ice cores—columns of compressed snow layers that build up over hundreds of thousands of years.

Volcanoes 'die' when their supply of magma runs out, if they are shifted away from their underlying magma reservoir, or if they get clogged by collapsing or their magma cooling back into rock.

Electrical grids worldwide must double their power delivery capacity by 2050 to meet surging demand from AI and electric vehicles.

Watch how algorithms can be designed to train themselves and self-improve without human input, to the point where the optimized code is too complex for programmers to understand.

Louisiana's 'Cancer Alley' is infamous for having some of the highest industrial pollution, toxic air emissions, and cancer risks in the US.

Massive 3D printers have been used to build homes by stacking layers of 'concrete toothpaste,' a fire-resistant material that effectively insulates against outside noise.

Hedge funds, the private investment firms that trade a wide swath of financial assets, make money by imposing steep fees on investors and from the fund's investment performance.

After her fellow cult members tried to kill her with an LSD-infused hamburger, one member of the Manson Family, the murderous cult led by Charles Manson, decided to testify against the group's leader.

See photos of Meteora, a mountainous site in central Greece, home to 14th-century monasteries perched atop soaring outcroppings.