What's next for gut microbiome science?

A technical review of what researchers know about the gut microbiome

This overview from the National Institutes of Health provides a deeper (but still accessible) look at the different bacteria in the gut, how the microbiome develops through life, its purpose, and more.

What is the gut microbiome?

The gut microbiome is a microscopic ecosystem that runs off the work of microbes in the digestive tract. These workers make getting energy from food possible. What and how that energy manifests depends on what building blocks these microbes have to work with, meaning their composition and functions are strongly influenced by diet. Gut microbes have their own genes, which affect how a person's genes act.

What is the gut virome?

The gut microbiome's community of viruses is collectively known as the virome. It has been found to affect immune system development—important to the gut-brain axis—and has been implicated in the development of inflammatory bowel disease and Type 2 diabetes. As of early 2023, less than half of the viral sequences in the gut had been identified. Further study is needed to understand the virome's influence and therapeutic potential.

Scientists from the frontline discuss the future of antibiotics and superbugs

Superbugs are a very real problem, but researchers around the world are working to advance our understanding of these pathogens and develop new medicines. This podcast talks with several scientists on the frontier of superbug research, offering insight into what we know—and what the future of medicine may look like.

Some animals have little or no bacterial populations in their gut

Gut microbiomes are essential to human health, but many animals have a much smaller, transient, or even nonexistent microbiome. The discoveries have advanced our understanding of the evolution of the human microbiome.

Can the gut microbiome influence personality?

New research suggests the bacteria in our gut—through the hormones and molecules they produce—can contribute to conditions ranging from depression to anxiety, and much more. The findings suggest diets have a direct impact on mental health and may lead to new therapies.

Gut microbiome rewrites may help reduce allergies

Researchers are investigating different strategies to determine if one day they could give people a combination of gut microbes to set them up for fewer allergies. In animal research, scientists have already prevented severe allergic responses in allergy-prone mice—supplying them with gut microbes from healthy, non-allergic human babies.

Some dementia cases may be linked to microorganisms in the brain

Researchers now know that, much like the gut, the brain is home to an ecosystem of microorganisms—the brain microbiome. While this area of study is still new, some scientists believe 50% of bacteria-caused dementia cases could be treated. (Some users may encounter a paywall.)

Challenges for synthetic biology

Can engineering approaches tame the complexity and unpredictability of living systems? An exploration of five challenges for the field and how they might be resolved.

Scientists seeking gut insights are attaching flatulence sensors to volunteers' underwear

This fart-tracking device detects gas generated in the gut, providing insights about gut microbial activity. The underwear sensors measure a component of what is technically called flatus—digestive system gas.

Genetic engineering will change everything forever

Designer babies, the end of diseases, genetically modified humans that never age. Outrageous things that used to be science fiction are suddenly becoming reality. As scientists increasingly understand how specific genes cause disease, the possibility of engineering our genes to not only "fix" problems but enhance our natural ability grows.

Are probiotics a scam?

Probiotics are microbes meant to benefit the gut microbiome's health when consumed. This internal cityscape is packed with thousands of species of microbes whose roles and impacts have yet to be untangled. The odds are low that the probiotics have the effects they're marketed to have, and most of the gut helpers on grocery shelves have little to no evidence of impacting gut microbiome health.

Microbial research suggests shifts in diverse populations may help an invasive species establish itself

In 1958, English ecologist Charles Elton suggested that diverse ecosystems should be more resistant to invasive species because gaining a foothold would be more challenging when resources are more thinly spread. However, in lab-grown microbial ecosystems with greater biodiversity, population volatility opened more ecological roles that invasive species could easily fill.

Fecal transplants can help treat infections

Fecal transplants aim to transplant healthy gut bacteria into ill patients by transferring (literally) samples of human waste from a healthy patient to a sick patient. The technique has been shown to cure otherwise deadly Clostridioides difficile (C. diff) infections and is being studied for a range of other uses.

Meet six commercially available synbio products

An article exploring the science behind synbio products currently on the market, and projecting the products that can be expected over the next 10 years.

Research on bacterial cultures used in yogurt production led to CRISPR's discovery

Scientists learned it was a microbial immune system that could be repurposed to protect dairy cultures from viruses. Today, nearly all yogurt is made with CRISPRized bacteria, as are genetically modified crops like herbicide-resistant corn, wheat, and soy.

How scientists are using molecules found in acidophiles to develop new medical treatments

The Berkeley Pit, an open-pit copper mine in Butte, Montana, that ceased operations in 1982 and is now filled with highly acidic water, is home to various species of fungi and yeast. These extremophiles produce unique compounds that may have anti-inflammatory benefits and have already been used to create an antibiotic for staph infections.

Scientists are experimenting with ways to probe the multiverse theory

Researchers are simulating vacuum bubbles—the theorized starting points of universes—using quantum computers, digital models, and exotic lab setups to study how they form, expand, and possibly collide. One experiment aims to "blow" artificial universe-like bubbles inside ultra-cold quantum gases, potentially capturing real-time glimpses of cosmic birth processes in a lab.

From soil to beer, microplastic pollution is all around us

Marine plastic pollution has been studied for decades, but the extent and effects of plastic pollution elsewhere is only just beginning to be explored.

Lining up every microbe on Earth would stretch to about 105,000 light-years

There are about 10²⁷ such organisms on the planet, many of which are adapted to produce energy through uncommon reactions in unconventional environments, such as within rocks or near volcanoes on the ocean floor. Studies of these organisms have reframed astrobiologists' search for life beyond Earth by broadening the parameters under which life can exist.

The history of molecular gastronomy, from thickening yolks with alcohol to making art with food

Before understanding why they worked, humans used scientific principles, including designing solutions and analyzing outcomes, to develop preservation methods like curing meat and fermenting vegetables. By the 20th century, the application of industrialized food preparation to smaller kitchens set the stage for the subdiscipline of food science.

What's next for surgical robots?

Since robots were introduced into the operating room in 2001, their patients have seen improved recovery times and decreased risks of infection. This article describes what's next for surgical robots, which, so far, have remained under human...

What is galactic archaeology?

In the same way that archaeologists excavate and analyze artifacts of human civilization, galactic archaeologists observe the light in the universe to glean lessons on its age, evolution, and more. Learn about this niche area of study with this 10-minute podcast.

How do you sequence a genome?

If the genome is made up of microscopic chromosomes, how do scientists actually sequence it? Here's a 5-minute video explaining one of the most common processes.

Svante Pääbo's life work was to discover the Neanderthal in our genes

Geneticist Svante Paabo reconstructed the genome of long-extinct human relatives, showing we have more in common with Neandertals than previously thought. Read up on his research and its impact on the wider scientific community.

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

The use of fungi to detoxify land and water—a process known as mycoremediation—has been used to clean up natural resources affected by the 2025 California wildfires.

An investigation suggests a Scottish island became awash in forever chemicals via seafoam and seaspray—raising questions about what that means for the safety of other coastal areas.

Indefinite cloning of some endangered species may not sustain their longevity because cloning success rates decrease as genetic mutations accumulate.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Watch how algorithms can be designed to train themselves and self-improve without human input, to the point where the optimized code is too complex for programmers to understand.

Explore the history, structure, and species of Australia's Great Barrier Reef with this interactive journey narrated by Sir David Attenborough.

After NASA's Voyager 1 captured Earth as a single pixel as it left the solar system in 1990, astronomer Carl Sagan used the image to reflect on humanity's fragility and the responsibility to protect 'the only world we've ever known.'

The name 'Silicon Valley' arose from the founding of Shockley Semiconductor Laboratory in Fairchild Semiconductor in 1956-57, founded near Stanford University in Palo Alto

The 2026 Ebola outbreak in the DRC is spurring new Ebola vaccine development for the Bundibugyo species.

Most of the observable universe's volume consists of voids and supervoids—enormous regions of space with little to no galaxies, stars, or light.

SpaceX's S-1 or 'prospectus' revealed many previously unknown details about the company, including its unprofitability despite doing $18.7B in revenue in 2025, exactly how many voting shares Elon Musk will have in the company (roughly 85%), and more.

Learn how your body is, scientifically, like a firework with its own slow, controlled burn.

Explore an interactive map built from more than 100,000 survey responses on where people find joy in their lives

Against his wishes, Albert Einstein's brain was removed before his cremation, and the pathologist responsible stored it for decades in mason jars within a beer cooler.

In recent years a child anxiety expert has created and tested a novel phobia and anxiety treatment approach for children, focused on changing how parents respond to the fears.

Hear about the 250-year history of the United States Postal Service, complete with some of its strangest deliveries, important innovations, and the figures that made it an American institution.

Explore the archaeological treasures of Pompeii, the city buried under volcanic ash when Mount Vesuvius erupted in 79 CE.

One disco producer saw 'Star Wars' four times on its opening weekend and was so inspired that he recorded the album 'Star Wars and Other Intergalactic Funk,' which produced a chart-topping single.

Some Pokémon have been named after real and fictional organisms, while some real-world species have been named after Pokémon, such as Chilicola charizard and Binburrum zapdos.

Crows are believed to have intelligence on par with a seven-year-old child and demonstrate complex behaviors, from problem-solving with tools to recognizing human faces.