How do you sequence a genome?

Breaking the genome into random segments accelerated the Human Genome Project

Hierarchical shotgun sequencing is a method for determining an organism's genome by fragmenting DNA before sequencing. By creating fragments with overlapping nucleotide bases, the DNA is reassembled by matching fragment ends.

Watch how DNA is packaged to a 10,000th of its original size in a cell

In humans, the 2-meter (6.56-foot) molecule wraps around spool-like proteins called histones, forming beads—nucleosomes—that fold up into fibers. These fibers—chromatin—form loops through folding that compress into larger fibers, which tightly coil together to form a chromosome.

Watch how Sanger sequencing kickstarted the first generation of DNA sequencing

Sanger sequencing is a foundational DNA sequencing technology developed in 1977. The Nobel Prize-winning discovery uses fluorescent dyes at the end of DNA chains, which are sorted by length through electrophoresis, to determine the order of nucleotide bases.

An overview of the Human Genome Project

The Human Genome Project was a groundbreaking global scientific effort to sequence the genome of humans and several organisms used in scientific research. The sequenced genome was created by combining the DNA of 20 people from Buffalo, New York.

A fascinating look at how our DNA is built and replicated

This easy-to-understand 13-minute video dives into the wondrous molecule deoxyribonucleic acid – also known as DNA – and explains how it replicates itself in our cells.

Visualization of printing synthetic DNA

Ever wonder how synthetic DNA is made? Discover how GenScript uses innovative technology to synthesize precise, high-quality DNA at a larger scale than ever before.

Here’s how different genetic disorders get passed on

The human genome is complex, as identified by the Human Genome Project. This article digs in to genetic disorders, the most common ones, and how they are diagnosed.

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

Think we decoded the genome in 2000? Nope. It was 2022.

Two decades after the draft sequence of the human genome was unveiled to great fanfare, a team of 99 scientists has finally deciphered the entire thing. They have filled in vast gaps and corrected a long list of errors in previous versions, giving us a new view of our DNA.

Cells translate genetic information into proteins using RNA messengers

Genes are segments of DNA, each composed of a sequence of nitrogenous bases. Within the nucleus, these sequences are copied into a single strand of ribonucleic acid during transcription. This strand leaves the nucleus and is translated by ribosomes into a chain of amino acids that folds into a functional protein.

What is a cell? A great quick overview.

YourGenome.org furnishes a collection of information on cells and how they work. Every body has trillions of cells, each serving a specific function: making proteins, processing chemicals, and creating energy. Every cell contains a genome, a set of instructions for the cell's function. Brush up on your cells for a better grasp on genetics.

The gut microbiome, explained

This video from 1440 takes a high-level look at what populates the gut microbiome, its purpose, how it affects our health, and much more.

Explaining CRISPR at five levels of technical detail

CRISPR is a new area of biomedical science that enables gene editing and could be the key to eventually curing diseases like autism or cancer. WIRED challenges biologist Neville Sanjana to explain this concept to 5 different people; a 7-year-old, a 14-year-old, a college student, a grad student and a CRISPR expert.

What is genetics?

What is a genome, and how are traits passed from generation to generation? Learn how pea plants helped launch the study of genetics and how the field of genetics research has evolved over time.

All publicly available DNA sequences are available at GenBank

The National Institutes of Health's database stores comprehensive, annotated DNA sequences as part of the International Nucleotide Sequence Database Collaboration. It encourages unrestricted data access within the scientific community while allowing submitters to retain intellectual property rights over their data.

A scale of the universe, from atoms to cosmos

Can you really appreciate just how small protons are, or how massive the universe is? To attempt to grasp it, watch this short video which zooms out from a young woman in California to the very limits of the cosmos using established scales. Then, dive deep into the atoms of her white blood cells for a fully-rounded effect.

How do brain scans work?

There’s only one thing in our solar system sophisticated enough to study itself: the human brain. But this self-investigation is challenging because a living brain is shielded by skull, swaddled in tissue, and made up of billions of tiny cells. How do we study living brains without harming their owners? Two experts explain how the various techniques like EEGs, fMRIs, and PETs work in this TedEd talk.

A technical look at the measles virus and its life cycle

The measles virus is made up of a single strand of RNA, packaged inside an envelope that varies in shape and size. A negative-sense paramyxovirus—the same family as mumps—the virus is encased in proteins that help it attach to immune cells inside the body.

Making Champagne from start to finish

This video from wine educator Amelia Singer covers everything from grape to glass. She’ll walk you through pressing the fruit, fermentation, aging, disgorgement, and, of course, drinking.

The US Mint created a video to show kids how coins are made

The video, made simple for children (or anyone who wants an easy-to-understand 101 video about the process coins go through to get in your wallet), outlines the entire process that a coin goes through in its lifetime, from Congress voting on new coins, to how coins are stamped, to their journey to a Reserve Bank.

Model organisms like yeast, mice, and flies help scientists decode the human body

Some species are used to quickly study the effects of human diseases and treatments because they are short-lived and have similar systems to those found in humans. Bacteria, like E. coli, have been used as human proxies given their rapid growth and ease of genetic manipulability.

A timelapse of sprouting seeds

Germination is the process where an organism sprouts from a seed or spore. This timelapse captures the process in an inspiring, two-minute video so you can see the whole story of the seed quickly.

Watch a crystal undergo X-ray diffraction to determine its internal geometry

In the early days of X-ray crystallography, getting photos of a single sample could take dozens of hours, followed by months of mathematical analysis. Today, automation and computer software can complete such tasks in a few hours.

Chronological versus biological age

Science has come to understand different types of aging. What we call age is simply the number of years since birth, or chronological age. At the cellular level, biological aging happens at different rates for different people, and explains why some seem to age more quickly (or slowly).

A simple explanation of semiconductors

Semiconductor chips are electronic devices that store and process information. Today they can contain billions of microscopic switches on a chip smaller than a fingernail. The article provides a quick overview of how the devices work and how they've provided the backbone of the computer age.

Watch 1 billion years of tectonic plate movement in 40 seconds

Researchers at the University of Sydney developed the model, incorporating changing plate boundaries rather than just moving continents, to better understand the changes to biological and climatic systems throughout Earth’s history.

See how each of the more than two million known species relates to each other—and to common ancestors—in this zoomable tree of life.

Learn how your body is, scientifically, like a firework with its own slow, controlled burn.

Ebola is a filovirus, meaning it resembles a thread under a microscope, though it sometimes twists and can resemble a bowl of spaghetti.

Explore the history, structure, and species of Australia's Great Barrier Reef with this interactive journey narrated by Sir David Attenborough.

Watch how algorithms can be designed to train themselves and self-improve without human input, to the point where the optimized code is too complex for programmers to understand.

While atoms are normally made of protons, neutrons, and electrons, exotic ones have been built with antimatter—alternate versions of normal matter that live for fractions of a second and are about a billion times as rare.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

Hear 50 years of iconic hip-hop samples, the genre's foundational looped tracks

Sony set the standard for cylinder-shaped batteries when it repurposed manufacturing equipment used to make rolls of magnetic recording tape.

Watch how deep-sea mining equipment collects and processes polymetallic nodules—metal-rich, potato-shaped rocks—from the ocean floor and creates environmentally damaging plumes of sediments.

Learn how to read a prospectus, the juicy document that any company must file with the SEC before going public.

Explore chaos in this simulation of two double pendulums, where small differences in the release angles produce wildly different outcomes.

Scientists can determine Earth's past climate conditions by analyzing air trapped in microscopic bubbles within ice cores—columns of compressed snow layers that build up over hundreds of thousands of years.

Long before Major League Baseball began allowing instant replay for balls and strikes, an umpire reluctantly used the technology to determine whether a hit was a home run, a move that inadvertently ushered in a new era for the sport.

According to the physics of black holes, our 4D reality may be a hologram—a projection of information coded on a 2D surface on the edge of the universe.

The syncytiotrophoblast is the outer layer of the placenta and the largest human cell, spanning an area about twice that of a king-sized bedsheet.

Discover the catastrophic consequences of a failure of the US electrical grid—something that is more likely than many Americans think.

Gerrymandering works through two techniques: cracking opposing voters across districts to dilute their power, and packing them into a few to waste their votes in lopsided majorities.

Track the location of the Voyager probes, currently between 13 and 15 billion miles away from Earth.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

US housing costs have risen by roughly 175% between 1991 and 2026—but a growing number of Gen Zers are becoming homeowners anyway. In 2025, 4% of homebuyers were Gen Z, up from 3% the year before.

The term 'algorithm' originated from the Latinized name of al-Khwārizmī, a 9th-century mathematician whose works introduced Arabic numerals and the decimal-based numeral system to Europe and whose treatise 'Al-Jabr' gave algebra its name.

To reduce wrinkles in clothing, research recommends gentle wash cycles with more water and tumble drying with smaller loads and longer times.