Watch how Sanger sequencing kickstarted the first generation of DNA sequencing

See the history of DNA sequencing

DNA sequencing evolved from manual methods to automated, high-throughput technologies. The Human Genome Project was possible in the first generation of gene sequencing technology with the "chain termination method," which won developer Fredrick Sanger a Nobel Prize.

Glowing chemicals allow scientists to read DNA like a barcode

The process of determining the order of nitrogenous bases in DNA involves first cutting the DNA into fragments, which are duplicated multiple times using bacteria. Fluorescently labeled terminator bases are added to fragments, which are sorted by length and read via laser to reconstruct the sequence.

How do you sequence a genome?

If the genome is made up of microscopic chromosomes, how do scientists actually sequence it? Here's a 5-minute video explaining one of the most common processes.

Breaking the genome into random segments accelerated the Human Genome Project

Hierarchical shotgun sequencing is a method for determining an organism's genome by fragmenting DNA before sequencing. By creating fragments with overlapping nucleotide bases, the DNA is reassembled by matching fragment ends.

See a timeline of landmark discoveries in the field of genetics

From the first genetic map of fruit fly genes in 1911 through the completion of the Human Genome Project in 2003, scientists have built upon each other's discoveries to further our knowledge of the human body and the genetic instructions that inform our traits and disease risks.

Visualization of printing synthetic DNA

Ever wonder how synthetic DNA is made? Discover how GenScript uses innovative technology to synthesize precise, high-quality DNA at a larger scale than ever before.

Modern genetic testing stems from a 1950s discovery about the cause of Down syndrome

Scientists found that an additional copy of chromosome 21 causes the disease and developed an approach to stain chromosomes so they could be manually sorted and counted, which is called karyotyping. The breakthrough discovery by Marthe Gautier, a young French doctor and cytogenetics researcher, was appropriated by a male colleague, who listed himself as the lead author of the study reporting the finding.

Rosalind Franklin’s work led to Nobel Prize-winning discoveries in DNA and virology

Her X-ray diffraction imaging helped uncover the structure of DNA, which earned James Watson, Francis Crick, and Maurice Wilkins a Nobel Prize. The same techniques enabled virus imaging, contributing to Aaron Klug's Nobel Prize in chemistry.

All publicly available DNA sequences are available at GenBank

The National Institutes of Health's database stores comprehensive, annotated DNA sequences as part of the International Nucleotide Sequence Database Collaboration. It encourages unrestricted data access within the scientific community while allowing submitters to retain intellectual property rights over their data.

The discovery of the first extremophile and how it revolutionized DNA analysis

While investigating samples taken from within and around the hot springs at Yellowstone National Park, microbiologist Thomas Brock discovered Thermus aquaticus, a microorganism that thrived in hot water. It contained an enzyme called Taq polymerase, a critical molecule in polymerase chain reaction—a molecular photocopier that amplifies genetic signals to improve medical diagnostics.

Watson and Crick revealed DNA's double-helix structure using others' key findings

Their 1953 model, made from cardboard cutouts, explained how DNA stores genetic information through base pairing. Rather than experimenting and collecting their own data, they incorporated patterns and data from other scientists through trial and error.

The first criminal conviction through the use of DNA evidence was in 1988

Chromosomes contain markers where short DNA sequences repeat a variable number of times from person to person. A DNA profile is constructed by identifying the number of repeats across 20 regions throughout a genome, which can be compared against a database. DNA paternity tests work similarly by comparing markers between children and their fathers. (Some readers may experience a paywall.)

Bacteria helped scientists realize that DNA was the hereditary molecule, not proteins

Until the mid-1900s, most scientists believed genes were made of proteins, which were known to act as enzymes, hormones, and other chemicals that mediated an organism's traits. The Avery-MacLeod-McCarty and that benign bacteria could be made lethal, where the inherited factor that caused bacterial transformation contained DNA.

The pharmaceutical industry evolved, in part, from the discovery of synthetic dyes

In 1856, a chemist accidentally discovered mauveine, the world’s first synthetic dye, while trying to make quinine to treat malaria. The synthetic dyes that followed helped reveal germs under microscopes, paving the way for modern imaging techniques and breakthrough treatments, such as antibiotics.

The oldest DNA recovered so far is 2 million years old

The oldest DNA recovered so far is about 2 million years old and has given scientists an unadulterated peek into ancient history. This nine-minute video explores the findings and implications of the DNA, which was pulled from frozen soil in...

CRISPR is a gene-editing tool that lets scientists cut out and replace damaged DNA

One of the most significant advances in modern medical science, CRISPR is a molecular tool for making precise changes to a gene's DNA. The technology has already been approved for treating sickle-cell disease.

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

RNA may have allowed life to exist before DNA

The emergence of living organisms from non-living matter—abiogenesis—requires both a molecule that encodes genetic information and proteins that perform biochemical processes. However, because DNA and protein depend on one another, some biologists theorize that RNA, which can both store information and perform functions, preceded both and originated life.

Inside the community movement behind DIY synthetic biology

Margaret Talbot spotlights the rise of DIY biology in community labs, where amateur scientists—often outside formal institutions—create everything from insulin to prosthetic prototypes. These grassroots biohackers challenge traditional science by pursuing open, accessible innovation, raising questions about credibility, ethical oversight, and acceptance by mainstream researchers.

How the National Science Foundation helped cement the use of American Sign Language

Before the 1960s, deaf students were taught to read lips and pronounce words without signing, which was not considered a true language. After noticing that students nonetheless signed when communicating, American linguist William Stokoe conducted NSF-funded research that showed that signing met the definition of oral languages, thus establishing ASL.

Jonas Salk developed the first successful polio vaccine—and tested it on himself

The American medical researcher developed the inactivated virus vaccine from 1952 to 1955 and proved that it could prevent disease. He tested the virus on himself and his family in 1954 and then carried out formal clinical trials on more than 1.3 million children.

How Seabiscuit's DNA made him a winner

Seabiscuit's sudden success in the sport has been framed as a classic against-the-odds sports story. One Binghamton University molecular physiologist wanted to go a bit deeper, though, to see how much genetics played a role in the horse's legendary career. Using the horse's silvered hooves, his research team discovered that Seabiscuit's genotype was typically associated with late bloomers, a finding confirmed by the horse's track record.

Scientists first observed a sperm and an egg uniting in 1876

Throughout human history, scholars and researchers have speculated on the origin of human reproduction. It wasn't until the late-19th century that the physical process of egg fertilization via sperm cells was observed (in sea urchins), forming the basis for modern fertility research.

Efforts to create disease-sniffing capabilities for phones still can't match dogs

In this video, a scientist explains why dogs remain leaders in olfactory capabilities, outpacing technology. Scientists have attempted to create artificial "e-noses" for phones to detect early signs of disease, but so far they have not been successful.

How the US first installed an electronic fence along the southern border

The US Border Patrol's first automated surveillance system launched in 1970 with 177 ground sensors installed along a single section in California. The sensors had already been used in Vietnam, along the so-called McNamara Line, and were connected by radio transmitters to magnetic-tape computers. They were implemented to target people defined by law and deportable aliens.

The first practical silicon solar cell was developed at Bell Labs

In 1953, scientists at Bell Labs attempted to develop a power source for phone systems in remote locations, as the dry battery cells lacked the necessary longevity. They experimented with solar power, but the selenium solar cells of the time were too inefficient, eventually leading to the usage of silicon.

The name 'Silicon Valley' arose from the founding of Shockley Semiconductor Laboratory in Fairchild Semiconductor in 1956-57, founded near Stanford University in Palo Alto

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

Hear 50 years of iconic hip-hop samples, the genre's foundational looped tracks

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

English mathematician Ada Lovelace wrote the first computer algorithm a century before computers existed and hypothesized that computing devices would one day be able to compose music—foreseeing the generative AI systems of today.

'Shogun,' a 1980s TV series, helped popularize sushi in the US by stimulating an American interest in Japanese culture.

In its famous catalog, Sears sold $600 DIY house kits from 1908 through the 1940s, resulting in an estimated 100,000 'Sears and Roebuck homes.'

Sony set the standard for cylinder-shaped batteries when it repurposed manufacturing equipment used to make rolls of magnetic recording tape.

After NASA's Voyager 1 captured Earth as a single pixel as it left the solar system in 1990, astronomer Carl Sagan used the image to reflect on humanity's fragility and the responsibility to protect 'the only world we've ever known.'

Massive blooms of microscopic plankton called dinoflagellates produce the neon blue light seen in glowing tides.

Long before Major League Baseball began allowing instant replay for balls and strikes, an umpire reluctantly used the technology to determine whether a hit was a home run, a move that inadvertently ushered in a new era for the sport.

See how each of the more than two million known species relates to each other—and to common ancestors—in this zoomable tree of life.

Jimmy Carter signed a 1978 bill that legalized home brewing, a move credited with kick-starting the craft beer industry.

The first horror movie is believed to be George Méliès' 1986 short 'The Haunted Castle,' which pioneered the use of special effects

'Saturday Night Fever,' the 1977 film that introduced disco to the mainstream, was based on a fabricated magazine story.

Radioactive elements can introduce software errors because the ionizing radiation they produce can detach electrons from atoms, and computer code relies on the distribution of electrons.

Ebola is a filovirus, meaning it resembles a thread under a microscope, though it sometimes twists and can resemble a bowl of spaghetti.

A researcher recently discovered an interview from 1967 between groundbreaking journalist Joan Didion and the Grateful Dead, years before the band became an institution.

While the first exchange-traded fund (a 'basket' of different assets that can be bought and sold on a stock exchange) in the US only launched in 1993, the global ETF market has grown to more than $10T in the short time since.

Meet the 56 signers of the Declaration of Independence—most of whom didn't put pen to paper until August 2, 1776—and see their original signatures.

Hear about the 250-year history of the United States Postal Service, complete with some of its strangest deliveries, important innovations, and the figures that made it an American institution.

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

The most expensive ad of all time was for Chanel No. 5 perfume and cost roughly $33M to produce in 2004—about $57M in today's dollars.