Watson and Crick revealed DNA's double-helix structure using others' key findings

X-ray data from Rosalind Franklin was key to discovering DNA’s double-helix structure

Although unpublished, the data reached James Watson and Francis Crick, who worked at another institution. Incorporating her data allowed them to validate their model of DNA, which they published without crediting her.

Photo 51's distinct 'X' pattern and spacing provided data to validate DNA's model

Rosalind Franklin and Raymond Gosling captured the photo after bombarding DNA fibers with X-rays and observing how the beams were deflected. The photo had a 62-hour exposure time and indicated a helical structure for DNA.

Nature simultaneously published three papers on DNA—only the first made history

Papers by Watson and Crick, Wilkins, and Franklin were fast-tracked without peer review, and their order was arranged between lab heads and editors. Franklin's appeared last, making her paper read as though supporting Watson and Crick—because they'd already incorporated her data before it was published.

Watson's book was described as misleading when detailing Franklin's role in DNA

Despite working together to win the Nobel Prize for their discovery of the structure of DNA, Francis Crick and Maurice Wilkins objected to the publication of James Watson's account of DNA's discovery. Those involved describe how he villainized Rosalind Franklin and downplayed her work.

Stacking nucleotide molecules like toy blocks helps build DNA's structure

Each nucleotide is made up of a sugar—deoxyribose—a phosphate group, and one of four bases that contain nitrogen. Like building a two-tone, spiral staircase from the ground up, nucleotides are linked one on top of another so that sugars and phosphates alternate. The twisted strands are held together by hydrogen bonds between base pairs.

Bacteria helped scientists realize that DNA was the hereditary molecule, not proteins

Until the mid-1900s, most scientists believed genes were made of proteins, which were known to act as enzymes, hormones, and other chemicals that mediated an organism's traits. The Avery-MacLeod-McCarty and that benign bacteria could be made lethal, where the inherited factor that caused bacterial transformation contained DNA.

The structure of DNA helices comes in three major varieties

The hereditary molecule can take the form of A-DNA, B-DNA, or Z-DNA based on environmental conditions such as ion concentration and humidity—a characteristic identified by Rosalind Franklin. A-DNA is the shortest and widest of the three, while Z-DNA is the longest and narrowest. B-DNA—the most common variety in living cells—is the intermediate.

DNA's four-letter blueprint makes the variety of all living things possible

The proteins responsible for cellular functions and an organism's traits are built outside of a cell's nucleus from RNA—single-stranded molecules created by reading the information in DNA. DNA's double-stranded structure makes it more stable and allows RNA to be made from either of its complementary strands.

Watch how DNA is packaged to a 10,000th of its original size in a cell

In humans, the 2-meter (6.56-foot) molecule wraps around spool-like proteins called histones, forming beads—nucleosomes—that fold up into fibers. These fibers—chromatin—form loops through folding that compress into larger fibers, which tightly coil together to form a chromosome.

A fascinating look at how our DNA is built and replicated

This easy-to-understand 13-minute video dives into the wondrous molecule deoxyribonucleic acid – also known as DNA – and explains how it replicates itself in our cells.

Watch how Sanger sequencing kickstarted the first generation of DNA sequencing

Sanger sequencing is a foundational DNA sequencing technology developed in 1977. The Nobel Prize-winning discovery uses fluorescent dyes at the end of DNA chains, which are sorted by length through electrophoresis, to determine the order of nucleotide bases.

Ernest Rutherford's gold foil and nitrogen experiments revealed nuclear structure

Observing high-angle deflections when alpha particles were fired at gold foil led to an atomic model with a dense, positively charged nucleus. Firing those particles at nitrogen resulted in the emission of hydrogen nuclei—protons—leading to the discovery of the subatomic particle.

The first criminal conviction through the use of DNA evidence was in 1988

Chromosomes contain markers where short DNA sequences repeat a variable number of times from person to person. A DNA profile is constructed by identifying the number of repeats across 20 regions throughout a genome, which can be compared against a database. DNA paternity tests work similarly by comparing markers between children and their fathers. (Some readers may experience a paywall.)

DNA computing allows for storage and processing of massive amounts of data

Although costly and less efficient for simpler tasks, as of 2025, DNA could hold 455 exabytes of data with near limitless parallel computation potential in small data centers. Every movie ever made would fit inside the volume of a single sugar cube.

The history of the periodic table and how it hinted at atoms possessing internal structure

In 1869, more than two decades before the discovery of electrons, Russian chemist Dmitrii Mendeleev organized known elements by atomic weight and chemical properties using index cards. His organization revealed previously undiscovered elements and identified patterns in the reactivity of elements, which would later be linked to each element's outermost electron shell. (Some readers may experience a paywall.)

Computational and biological systems share fundamental principles, like randomness

Proposed by Alan Turing and John von Neumann, the concept originates from how DNA and computers run by executing encoded instructions in parallel. The advent of AI and the temperature parameter has seen neural networks mimic the randomness of protein encoding.

Dsup slightly unwinds DNA and changes shape to better cling to the molecule

The damage suppressor protein, which is exclusively found in tardigrades, has also been modeled as coating DNA and shielding it from radiation and the toxic byproducts of radiation damage. Dsup may become a fundamental ingredient in future DNA storage technologies.

A fascinating look at why cucumber tendrils coil in opposite directions

The tendrils of cucumber plants coil when they hit a surface, creating a distinct telephone-cord look. Charles Darwin wrote about the mystery in the 1850s, though it wasn't until the 21st century that scientists figured out just how mysterious the coil is: its tendrils coil in opposite directions.

Their 1901 Wind Tunnel system revolutionized the study of aeronautics

Only the second to be built in the US, the wind tunnel allowed the brothers to study how air moves around more than 200 different wing shapes. This data helped them refine a key math equation, long held as the standard, that had been based only on one wing shape.

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

The basics of behaviorism and its founder John B. Watson

Watson believed he could use classical conditioning to shape the behavior of infants toward positive outcomes, culminating in his famous "Little Albert" experiment. Here's a quick overview of his life and thought.

Understanding the Diffie-Hellman key exchange, an example of public key cryptography

Published in 1976 by Whitfield Diffie and Martin Hellman, the system involves two parties combining each of their unique private keys with a public key using a mathematical function. The combinations are exchanged and mixed to establish a common key that no third party can determine. The Diffie-Hellman system underlies many encryption protocols for internet traffic.

Science is rarely a linear progression of understanding

Particularly at the frontiers, investigations conducted based on established knowledge can provide unexpected results. This opens the door to revising existing models, inspiring new lines of research, and ultimately leading to better future comprehension. For instance, experiments on the speed of light and the expansion of the universe yielded then-confusing data that led to revolutionary insights.

Human anatomy provides evidence for evolution

Throughout history, scientists have used anatomy to support the Theory of Evolution in three main ways. Homologous structures, or similar physical features in organisms that serve different functions, can help scientists understand common ancestors....

Scientists first observed a sperm and an egg uniting in 1876

Throughout human history, scholars and researchers have speculated on the origin of human reproduction. It wasn't until the late-19th century that the physical process of egg fertilization via sperm cells was observed (in sea urchins), forming the basis for modern fertility research.

The Big Bang became physically plausible thanks to Stephen Hawking’s thesis

Stephen Hawking's PhD thesis mathematically showed that singularities—points of no volume and infinite density—are an expected feature of nature. It laid the theoretical groundwork for a model of the universe where everything originates from a single point.

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

Against his wishes, Albert Einstein's brain was removed before his cremation, and the pathologist responsible stored it for decades in mason jars within a beer cooler.

The history of many kitchen appliances involves unexpected discoveries and applications, including wartime radar turned hamster defroster and replacing an 'ice king' with heat-stealing boxes.

According to the physics of black holes, our 4D reality may be a hologram—a projection of information coded on a 2D surface on the edge of the universe.

Sony set the standard for cylinder-shaped batteries when it repurposed manufacturing equipment used to make rolls of magnetic recording tape.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

Sears sold DIY house kits starting at $600 in its famous catalog from 1908 through the 1940s, resulting in roughly 10,000 'Sears and Roebuck houses' being built.

Gerrymandering works through two techniques: cracking opposing voters across districts to dilute their power, and packing them into a few to waste their votes in lopsided majorities.

The story of Dollree Mapp, whose legal challenge over her 1957 conviction for possessing "obscene material" led to a major strengthening of the Fourth Amendment

The name 'Silicon Valley' arose from the founding of Shockley Semiconductor Laboratory in Fairchild Semiconductor in 1956-57, founded near Stanford University in Palo Alto

Trace how the Bill of Rights, inspired by centuries of political theory, took shape between 1774 and 1789.

To reduce wrinkles in clothing, research recommends gentle wash cycles with more water and tumble drying with smaller loads and longer times.

Explore chaos in this simulation of two double pendulums, where small differences in the release angles produce wildly different outcomes.

Hear 50 years of iconic hip-hop samples, the genre's foundational looped tracks

How Amazon operates a 'flywheel' business model, a self-reinforcing cycle that drives continuous growth

While atoms are normally made of protons, neutrons, and electrons, exotic ones have been built with antimatter—alternate versions of normal matter that live for fractions of a second and are about a billion times as rare.

Legendary architect Frank Lloyd Wright designed the SC Johnson headquarters in Wisconsin, aiming to make a cathedral-like workplace

Many legends about George Washington, including his supposed wooden teeth and the story of cutting down the cherry tree, lack evidence.

Ebola is a filovirus, meaning it resembles a thread under a microscope, though it sometimes twists and can resemble a bowl of spaghetti.

The Dracula character, now seen as the vampire archetype, was inspired by a seafood-induced nightmare its creator experienced.

Crows are believed to have intelligence on par with a seven-year-old child and demonstrate complex behaviors, from problem-solving with tools to recognizing human faces.

The Brothers Grimm were lawyers before they were storytellers, and became interested in fairy tales as they began investigating how rules and customs had been passed down through cultures.

In 1963, a basement renovation in Turkey revealed a passageway to a hidden, multilevel underground city that once housed as many as 20,000 people

Explore an interactive map built from more than 100,000 survey responses on where people find joy in their lives