Tardigrades

Overview

Tardigrades are microscopic animals best known for their survivability in extreme environments, including the vacuum of space, pressures six times greater than Earth's deepest ocean trench, and temperatures ranging from about minus 270 to 150 degrees Celsius (-454 to 302 degrees Fahrenheit). Nicknamed "water bears," these creatures traverse using four pairs of stubby legs that end in claws or adhesive pads and are found in habitats with moist sediments, like lake bottoms.

Their resilience comes from their ability to undergo cryptobiosis, in which a tardigrade expels nearly all the water in its body and tucks itself into a dried-up cyst called a tun. During this process, protectant molecules—including Dsup, a protein that shields DNA from radiation—create a glass-like matrix to protect a tardigrade's cells and reduce its metabolism by 99.99%. Even after decades, tardigrades in a tun state have been revived through rehydration.

Research is ongoing to identify applications of tardigrade-specific proteins, including using Dsup to protect healthy cells during radiotherapy cancer treatments.

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