Stacking nucleotide molecules like toy blocks helps build DNA's structure

Nitrogenous bases connect like puzzle pieces due to their shape

There are four bases—adenine, thymine, cytosine, and guanine—which keep the two strands of DNA connected via chemical bonds between them. Connections between thymine and adenine require two hydrogen bonds, while those between cytosine and guanine need three hydrogen bonds. These differences in bond number prevent non-complementary pairings.

Storing data in DNA requires converting binary code into DNA's four-base system

Researchers have suggested that DNA's ability to form compact, dense structures justifies investigating its use for long-term, safe data archiving. This system could fit all of the world's data in a single shoebox, though processing each bit into a nucleotide base takes 2 minutes, as of 2024.

DNA's four-letter blueprint makes the variety of all living things possible

The proteins responsible for cellular functions and an organism's traits are built outside of a cell's nucleus from RNA—single-stranded molecules created by reading the information in DNA. DNA's double-stranded structure makes it more stable and allows RNA to be made from either of its complementary strands.

Watch how DNA is packaged to a 10,000th of its original size in a cell

In humans, the 2-meter (6.56-foot) molecule wraps around spool-like proteins called histones, forming beads—nucleosomes—that fold up into fibers. These fibers—chromatin—form loops through folding that compress into larger fibers, which tightly coil together to form a chromosome.

Glowing chemicals allow scientists to read DNA like a barcode

The process of determining the order of nitrogenous bases in DNA involves first cutting the DNA into fragments, which are duplicated multiple times using bacteria. Fluorescently labeled terminator bases are added to fragments, which are sorted by length and read via laser to reconstruct the sequence.

Watson and Crick revealed DNA's double-helix structure using others' key findings

Their 1953 model, made from cardboard cutouts, explained how DNA stores genetic information through base pairing. Rather than experimenting and collecting their own data, they incorporated patterns and data from other scientists through trial and error.

The structure of DNA helices comes in three major varieties

The hereditary molecule can take the form of A-DNA, B-DNA, or Z-DNA based on environmental conditions such as ion concentration and humidity—a characteristic identified by Rosalind Franklin. A-DNA is the shortest and widest of the three, while Z-DNA is the longest and narrowest. B-DNA—the most common variety in living cells—is the intermediate.

DNA may serve as a flame retardant by self-extinguishing some burning materials

When DNA burns, phosphate groups release phosphoric acid, and nitrogenous bases release ammonia. These molecules, along with the sugar in DNA's backbone, shift the combustion reaction toward the formation of intumescent char. This puffy, carbon-rich layer protects open flames from burning the material beneath.

How chemical bonds between atoms form molecules and large geometric structures

In ionic bonding, one atom transfers at least one electron to another atom, forming two atoms of opposite charge. These atoms attract one another and can stack up in a 3D grid called a lattice. Covalent bonding, where electrons are instead shared, can produce enormous molecules, such as the two found in human chromosome 13, which each contain 37 billion atoms.

Dsup slightly unwinds DNA and changes shape to better cling to the molecule

The damage suppressor protein, which is exclusively found in tardigrades, has also been modeled as coating DNA and shielding it from radiation and the toxic byproducts of radiation damage. Dsup may become a fundamental ingredient in future DNA storage technologies.

The deceptively simple proton

Take a visual deep-dive into the proton, a near-fundamental—but deceivingly simple—building block of nature. Among other beguiling characteristics, the particle can't be described by its constituent particles (quarks), but rather exists in a...

All publicly available DNA sequences are available at GenBank

The National Institutes of Health's database stores comprehensive, annotated DNA sequences as part of the International Nucleotide Sequence Database Collaboration. It encourages unrestricted data access within the scientific community while allowing submitters to retain intellectual property rights over their data.

Snowflakes form when water vapor turns directly into ice

Every water molecule has a slightly bent shape due to electron repulsion and regularly forms bonds with hydrogen molecules. When they freeze, they form a six-sided (or hexagonal) lattice, resulting in the six-sided symmetry of snowflakes. As the snowflake falls, more water molecules freeze onto its six sides, forming the unique, beautiful geometric designs.

Umami synergy—combining glutamates and nucleotides—can amplify a meal

While glutamates are known for triggering the umami taste through specific taste receptors, nucleotides like IMP and GMP can bind alongside glutamates to enhance the receptor's response. This union explains why certain classic food combinations like bacon and eggs taste exceptionally savory.

How the nuclear shell model explains the stability or radioactivity of atomic nuclei

When the number of protons and neutrons completely fills shells within the nucleus, the binding energy that prevents these particles from being pulled apart increases. These are called "magic numbers," and they produce atoms with exceptionally stable nuclear configurations.

An explanation of the Calvin cycle, including why it needs to run six times to create glucose

Each run of this second phase of photosynthesis begins with a five-carbon molecule called RuBP, which gains an additional carbon atom when carbon dioxide (CO₂) is attached. Across six cycles, the six six-carbon molecules—36 carbon atoms in total—are processed into 12 three-carbon sugars, which can be used to generate glucose, and six RuBP molecules, enough for each cycle to restart.

Building the first atomic bomb required unprecedented coordination

Creating the first atomic bombs demanded breakthroughs in physics, engineering, and logistics—uniting elite scientists with tens of thousands of workers across the US. This in-depth history explains how the Manhattan Project overcame those challenges.

Ice cream’s unfrozen consistency is thanks to sugar

Making ice cream is a complex, multistep scientific process. But the treat’s scoopable, chewable consistency is due to the product’s dissolved sugar.

Mitochondrial DNA swapping can occur before or after fertilization

Mitochondrial replacement therapy can be conducted with four different techniques, with varying genetic material transferred depending on the approach. Maternal spindle transfer, one common method, involves transplanting the nuclear DNA from a mother into an unfertilized egg from a donor. The donor egg is then fertilized and implanted into the mother's uterus using in vitro fertilization. Another major approach, pronuclear transfer, does the genetic swapping after the mother's egg has already been fertilized. This order of operations may be uncomfortable for some individuals, but the success rate with this technique is higher.

The three theories explaining how the pyramids were built

There's no consensus over how the ancient monuments were built, and no blueprints left behind. But centuries of study have produced three competing theories: a simple, massive external ramp, a more complex internal ramp, or a highly sophisticated water elevator.

Chemistry-informed advice for cooking pasta, including how to prevent clumping noodles

On a molecular level, pasta dough consists of protein structures that hold starch molecules, and the starches absorb water during cooking, forming a gel that softens the pasta. Pasta should not be rinsed after cooking. Instead, some of the pasta water should be added to the pasta sauce, as the gelatinous starch will help the sauce stick to the pasta.

Blockchain, explained in five layers of difficulty

Blockchain, the key technology behind bitcoin, is a new network that helps decentralize trade and allows for more peer-to-peer transactions. Wired challenged political scientist and blockchain researcher Bettina Warburg to explain blockchain technology to five different people: a child, a teen, a college student, a grad student, and an expert.

Transistors are the foundation of electronic signal processing

Small amounts of voltage can allow or block the flow of electrons across a transistor made from modified layers of semiconducting materials. The conducting (1) and insulating (0) states can be quickly modified as binary code is processed in a computer system.

How NATO works

NATO now includes 32 member nations—but how does the alliance actually function? This explainer breaks down its structure, decision-making process, and funding model. From its founding in 1949 to its collective response after 9/11, here’s how NATO operates on a global scale.

How do 5G base stations work?

5G relies on a combination of base stations, including macrocells, small cells, and femtocells. The differences between the three are apparent in size, coverage, and cost—but, small cells in particular are key to providing the high millimeter wave frequencies 5G promises. Learn more in this three-minute video.

Massive 3D printers have been used to build homes by stacking layers of 'concrete toothpaste,' a fire-resistant material that effectively insulates against outside noise.

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

How fusion—which releases energy when two lighter atoms combine to form a heavier atom—differs from fission

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

Some coin denominations have ridges etched on their sides, partly to prevent counterfeiting, in a practice called 'reeding.'

Ebola is a filovirus, meaning it resembles a thread under a microscope, though it sometimes twists and can resemble a bowl of spaghetti.

Sony set the standard for cylinder-shaped batteries when it repurposed manufacturing equipment used to make rolls of magnetic recording tape.

Radioactive elements can introduce software errors because the ionizing radiation they produce can detach electrons from atoms, and computer code relies on the distribution of electrons.

The Nasdaq's 'Magnificent 7' companies are responsible for roughly 40% of the Nasdaq 100 index's gains, while the remaining 93 companies account for the other 60%.

Explore fun facts from the USPS, including unique post office buildings, a stamp that traveled past Pluto, and more.

Bone marrow (soft tissue found inside certain bones) generates roughly 500 billion new blood cells each day

Watch this video that uses Lego bricks to explain how venture capital works.

Trace how the Bill of Rights, inspired by centuries of political theory, took shape between 1774 and 1789.

According to the physics of black holes, our 4D reality may be a hologram—a projection of information coded on a 2D surface on the edge of the universe.

Scientists can determine Earth's past climate conditions by analyzing air trapped in microscopic bubbles within ice cores—columns of compressed snow layers that build up over hundreds of thousands of years.

Corals are themselves not coral reefs—the term refers to the tiny marine invertebrates that build the rigid reef.

For centuries, Niagara Falls has been a magnet for daredevils seeking to conquer one of nature's most powerful wonders, with its 200-foot drop and water rushing at 32 feet per second with 280 tons of force.

Power lines are dotted with large, brightly colored balls to improve the visibility of these thin wires to helicopters and small planes and help prevent potential crashes.

The Great Salt Lake's distinct dual coloration results from high-salinity organisms that only live in the northern portion and produce a purple protein.

To reduce wrinkles in clothing, research recommends gentle wash cycles with more water and tumble drying with smaller loads and longer times.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

English mathematician Ada Lovelace wrote the first computer algorithm a century before computers existed and hypothesized that computing devices would one day be able to compose music—foreseeing the generative AI systems of today.

Some Pokémon have been named after real and fictional organisms, while some real-world species have been named after Pokémon, such as Chilicola charizard and Binburrum zapdos.

Hear 50 years of iconic hip-hop samples, the genre's foundational looped tracks

Gerrymandering works through two techniques: cracking opposing voters across districts to dilute their power, and packing them into a few to waste their votes in lopsided majorities.