Scientists first observed a sperm and an egg uniting in 1876

The history of ectogenesis and artificial wombs

While the science of artificial wombs is new, the idea goes back to a 1923 Heretics Society of the University of Cambridge lecture where an English biologist was one of the first people to propose an egg could be fertilized outside the womb. This...

View an illustrative journey of sperm cells navigating toward fertilization

In this series of comic-style panels, a "fellowship" of sperm cells travels through fictionalized versions of reproductive anatomy on their way to an egg cell. Each panel includes informative commentary on each step of the adventure, with research insights provided by a reproductive biologist, a biomedical scientist, and an andrologist.

Scientific advances are unlocking a wide range of alternatives to IVF

From refined artificial insemination and microsurgical sperm extraction to experimental uterine transplants, scientific innovation is rapidly advancing potential fertilization technologies. But they come along with costly trials, some ethical dilemmas, regulatory issues, and more.

The first successful IVF pregnancy was in the United Kingdom in 1978

Gynecologist Patrick Steptoe and his collaborator Robert Edwards, a biologist, attempted to fertilize a human egg cell in a petri dish 101 times before finally succeeding. This resulted in the birth of Louise Brown—at the time referred to as a "test tube" baby—in 1978, who was born into the spotlight.

Only about 0.0001% of sperm, on average, successfully reach the uterine cavity

We've evolved to make pregnancy a complex and difficult process. From the initial development of the blastocyst, to the energy and nutrients needed to grow a new human, our bodies are both fighting and supporting fetal development.

Ancient Egyptians developed the first pregnancy test—and scientists tested it in the 1960s

A papyrus from about 1350 B.C.E. discusses a test in which a woman would urinate on wheat and barley seeds over the course of several days. If the barley grows, she's having a male child; if the wheat grows, it's a female child; and if nothing grows, she's not pregnant. Scientists went on to test this theory in 1963 and found that about 70% of the time, the urine of pregnant women did promote growth whereas the urine of nonpregnant women didn't—perhaps due to estrogen levels in the urine.

Watch a salamander grow from fertilization to hatching

New microscopy techniques have allowed scientists to image the development of animal embryos with unprecedented detail. This six-minute time-lapse reveals the development of a salamander from initial fertilization to hatching from an egg.

Has anyone had sex in space?

Reproduction is a basic human function, and while we've spent decades in space, no research has been done into the process. With many discussing the possibility of human-occupied bases on the moon, Mars, and more, understanding how sex works outside...

Cell theory originated from microscopic observations of cork and dental plaque

In the mid-1600s, Robert Hooke identified compartment-like structures—which he called cells—in cork, and Anton van Leeuwenhoek discovered bacteria in samples of his dental scrapings. Almost 200 years later, Matthias Schleiden and Theodor Schwann showed that plants and animals, respectively, are composed of cells, proving that cells are the foundation of all living things.

Women are born with all the eggs they will ever produce in their lifetime

Girls are born with an estimated 1 million to 2 million eggs in their bodies, but around 10,000 die monthly before puberty. Scientists have not yet figured out why there's such an excessive number of eggs prior to menstruation, but they've calculated that there are roughly 300,000 to 400,000 eggs left at puberty.

How the heart achieves its first beat

Scientists observed zebrafish embryos as they grew and isolated the several-second-long initial heartbeats to better understand this crucial moment in every heart's life. The zebrafish's heart starts beating 20 hours into their existence. Each heart cell activates electrically at random, without rhythm. As these cells mature, they become more sensitive to electrical charges; as they all fire, a rhythm is established and a pulse is born.

Stem cells become specialized cells through the activation or silencing of specific genes

After fertilization, when a sperm cell fuses with an egg, the resulting stem cell is described as totipotent—capable of transforming into any type of body cell or embryonic structures (e.g., placenta). Once differentiated into multipotent cells, they can only specialize further within specific cell type families, such as hematopoietic cells that become platelets and red and white blood cells.

Humans have speculated about alien life since ancient times

Around 50 B.C.E., Roman poet and philosopher Lucretius shared the idea that alien life was possible, which was put forth by Greek philosopher Epicurus. The writing is believed to be the first straightforward assertion in Western literature that aliens must exist.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

Read about coral reef restoration efforts, from coral IVF and cryopreservation

Researchers have collected coral eggs and sperm from healthy reefs, grown baby corals in lab pools, and released them to help repopulate damaged or lost reefs. Devices such as Coralclip® help attach these corals to existing structures, promoting growth without the use of chemical bonding agents. Corals near extinction can be frozen using liquid nitrogen for future restoration efforts.

Extremely rarely, there can be twins with different dads—but fewer than 20 such cases are documented worldwide

The non-identical twins, who would also be half-siblings, result from a rare biological phenomenon called heteropaternal superfecundation. Britain's first known twins with different dads, featured in this article, learned of each other's existence in recent years, when they were both 45. They discovered each other after taking DNA tests from Ancestry, a genealogy company.

Half of human DNA is inherited from each parent

Within most cells reside 23 pairs of chromosomes made of tightly wound DNA, and half of each pair is inherited from each parent. The 23rd pair consists of two X-shaped chromosomes, or one such chromosome paired with a Y chromosome, and determines biological sex.

Blood evolved many times over hundreds of millions of years

The earliest evidence of a blood-like substance comes from ancient arthropods, which appear to have had copper-based blood. In the 500 million years since then, some creatures have grown to rely on other variants, such as humanity's iron-based blood.

When did humans start kissing romantically?

This article explores the ancient roots of romantic kissing. Current archaeological evidence dates sexual and romantic lip kissing to about 2,500 BCE. A Mesopotamian clay tablet from the time shares a tale of two deities locking lips. There's also...

The Easter Bunny traces to German folklore, not ancient paganism

The rabbit's connection to Easter is well-documented from the 17th century onward, but the deeper origins remain unclear (particularly why a mammal that does not lay eggs became the egg-loving holiday's secular mascot). German immigrants brought the tradition in the 1700s, introducing the mythical egg-laying rabbit known as the "Osterhase," whose nests became the Easter basket.

Why humans survived and smarter species did not

This interview with Joseph Henrich, a renowned professor of human evolutionary biology, unpacks human history. Henrich shares interesting information about why humans succeeded as a species (the answer isn't IQ), how cultural evolution works, why the human brain is shrinking, and how the Catholic Church played a role in the Industrial Revolution. Listen and watch for a deep dive into human evolution.

How new research sheds light on why we dream

The theory of where dreams originate began shifting from ancient mystical explanations to modern scientific ones at the beginning of the 20th century. Now, scientists have the ability to track electrical activity in the brain, solidifying some of the field's softer science into observable data and giving rise to sleep labs.

The history of chemistry, from alchemists to probing atoms before World War I

Those involved in the predecessor of the modern scientific discipline engaged in experimentation to develop recipes that would transform ordinary matter into gold and to create medicines, cosmetics, dyes, and alloys. Over the course of centuries, scientists identified unique elements, organized them based on their properties in the periodic table, and eventually developed the technology to discover the internal structure of atoms.

The science of symmetry | The Royal Society

Nature is full of symmetries, from spiral galaxies to florets of broccoli. So why do complex creatures break the pattern?This short video discusses why symmetry came to dominate life on Earth, and how many complex life forms, such as humans, transitioned from radial to lateral symmetry.

Coral polyps reproduce via broadcast spawning, where entire reefs simultaneously release reproductive cells for about one hour, once a year.

Watch how Sanger sequencing kickstarted the first generation of DNA sequencing

Sanger sequencing is a foundational DNA sequencing technology developed in 1977. The Nobel Prize-winning discovery uses fluorescent dyes at the end of DNA chains, which are sorted by length through electrophoresis, to determine the order of nucleotide bases.

Biologist Richard Dawkins coined the term 'meme'

His 1976 book "The Selfish Gene" proposed that units of culture could be replicated, passed on, and evolve as they were transmitted, similar to human genes. He called this unit a "meme," to be pronounced like "cream."

Learn more about the history of fireworks, which dates back to an accidental invention during an alchemist's quest for information about immortality.

The syncytiotrophoblast is the outer layer of the placenta and the largest human cell, spanning an area about twice that of a king-sized bedsheet.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

While atoms are normally made of protons, neutrons, and electrons, exotic ones have been built with antimatter—alternate versions of normal matter that live for fractions of a second and are about a billion times as rare.

Watch how viruses like Ebola can spill over from animals to humans—and vice-versa.

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

Scientists can determine Earth's past climate conditions by analyzing air trapped in microscopic bubbles within ice cores—columns of compressed snow layers that build up over hundreds of thousands of years.

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

English mathematician Ada Lovelace wrote the first computer algorithm a century before computers existed and hypothesized that computing devices would one day be able to compose music—foreseeing the generative AI systems of today.

Long before Major League Baseball began allowing instant replay for balls and strikes, an umpire reluctantly used the technology to determine whether a hit was a home run, a move that inadvertently ushered in a new era for the sport.

The name 'Silicon Valley' arose from the founding of Shockley Semiconductor Laboratory in Fairchild Semiconductor in 1956-57, founded near Stanford University in Palo Alto

The American cockroach is actually from Africa, an apparent hitchhiker aboard ships carrying enslaved people, with evidence suggesting the bug may have arrived in the New World as early as the 1600s.

Salvador Dalí believed he was his own dead brother, who had died nine months before he was born

The Brothers Grimm were lawyers before they were storytellers, and became interested in fairy tales as they began investigating how rules and customs had been passed down through cultures.

In its famous catalog, Sears sold $600 DIY house kits from 1908 through the 1940s, resulting in an estimated 100,000 'Sears and Roebuck homes.'

Some Pokémon have been named after real and fictional organisms, while some real-world species have been named after Pokémon, such as Chilicola charizard and Binburrum zapdos.

The Great Salt Lake's distinct dual coloration results from high-salinity organisms that only live in the northern portion and produce a purple protein.

After 25 people used virtual reality headsets to practice flying with virtual wings—flapping their arms—their visual cortex responded to the wings almost as if they were real arms, treating them as body parts.

While the first exchange-traded fund (a 'basket' of different assets that can be bought and sold on a stock exchange) in the US only launched in 1993, the global ETF market has grown to more than $10T in the short time since.

See the most iconic photos from four decades of LIFE magazine

For centuries, it was common to sleep in two shifts: a few hours at the beginning of the night, and a longer period beginning around midnight

The US Constitution is widely regarded as the longest-standing written national constitution still in force—see how it has influenced rights worldwide.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.