The first successful IVF pregnancy was in the United Kingdom in 1978

Eight British children have been born via mitochondrial replacement therapy

In July 2025, a decade after British lawmakers signed off on allowing three-parent IVF, scientists announced that eight healthy babies had already been born using this approach. The news was included in a pair of research articles published in a peer-reviewed journal that noted the oldest kids were already more than two years old, and that they were hitting developmental milestones as expected. (Some users may encounter a paywall.)

The history of ectogenesis and artificial wombs

While the science of artificial wombs is new, the idea goes back to a 1923 Heretics Society of the University of Cambridge lecture where an English biologist was one of the first people to propose an egg could be fertilized outside the womb. This...

A step-by-step overview of the IVF process

In-vitro fertilization involves a sequence of complex steps to move from egg production to birth. This include stimulating egg production in the ovaries, egg harvesting and fertilization outside the body, embryo culturing and transfer, and methods to support in and increase the likelihood of full-term pregnancy.

Scientists first observed a sperm and an egg uniting in 1876

Throughout human history, scholars and researchers have speculated on the origin of human reproduction. It wasn't until the late-19th century that the physical process of egg fertilization via sperm cells was observed (in sea urchins), forming the basis for modern fertility research.

In vitro gametogenesis: using induced stem cells to fertilize eggs

Using stem cells from skin and mouth cells could save hopeful parents time and money and spare egg donors from significant amounts of discomfort throughout the process. There are potential consequences, not just for infertility treatment, but for the ability to create customized cells of any type.

Ancient Egyptians developed the first pregnancy test—and scientists tested it in the 1960s

A papyrus from about 1350 B.C.E. discusses a test in which a woman would urinate on wheat and barley seeds over the course of several days. If the barley grows, she's having a male child; if the wheat grows, it's a female child; and if nothing grows, she's not pregnant. Scientists went on to test this theory in 1963 and found that about 70% of the time, the urine of pregnant women did promote growth whereas the urine of nonpregnant women didn't—perhaps due to estrogen levels in the urine.

The first successful organ transplant was performed in 1954

The successful kidney transplant procedure, at what's now-called Brigham and and Women's Hospital, ushered in a new medical era and gave hope to patients with organ failure. The recipient, 23-year-old Richard Herrick, lived eight more years after receiving the donated organ from his living twin brother, Ronald.

An 18th-century woman tricked doctors into believing she gave birth to rabbits

Mary Toft was a poor servant in Surrey who reportedly sought fame and money by perpetuating the story of her "monstrous birth." After having a miscarriage a month earlier, Toft claimed to still be pregnant and called obstetrician John Howard to witness her give birth to animal parts, including a cat without a liver, a rabbit’s head, the legs of a cat, and nine dead baby rabbits. Eventually, after fooling the court physicians of King George I, she confessed to orchestrating the births.

Scientists have demonstrated IVF to help critically endangered rhinos

Scientists have used the technique to create embryos from eggs harvested from captive southern white rhinos and implanted into a southern white rhino. They hope to use this proof of concept to eventually use IVF to revive the population of northern white rhinos, which are extinct in the wild and have no living males left, using a precious reserve of frozen embryos and a surrogate southern white rhino mother.

Edward Jenner, the father of vaccinations

The British physician was the first to attempt to inoculate someone from smallpox using its milder cousin, cowpox. His innovations and documentations would prove crucial to the deployment of widespread vaccinations.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

The first prenatal screen for disease was developed in 1961

Scientist Robert Guthrie created a method to test newborns for a metabolic defect called phenylketonuria, or PKU. This blood test didn't look for gene variants—it hunted for excess phenylalanine in the blood. The disorder is caused by an inability to digest the amino acid phenylalanine, leading to excess phenylalanine in the body. PKU results in intellectual disability, seizures, and other symptoms if it isn't caught early and treated with a specialized diet.

Find fertility clinics and their success rates in your state

This database from the Centers for Disease Control and Prevention provides a searchable portal of fertility clinics across the US, with reported data on services, total procedures performed, and live births recorded for as recently as 2022.

In 1933, the influenza virus was first identified through “ferret flu” experiments

In 1933, British researchers dripped filtered nasal fluids from a sick colleague into ferrets, which quickly developed “ferret flu.” This experiment proved influenza was viral, not bacterial, and established the basis for modern flu vaccines.

The 'Penicillin Girls' made mass production possible

In Oxford during the early 1940s, six female technicians—later dubbed the “Penicillin Girls”—worked long hours tending mold cultures and extracting tiny amounts of penicillin.

The pregnancy test industry is worth roughly $769M

The inventor of the at-home pregnancy test, Margaret Crane, largely hasn't taken credit for her invention until recently.

The first criminal conviction through the use of DNA evidence was in 1988

Chromosomes contain markers where short DNA sequences repeat a variable number of times from person to person. A DNA profile is constructed by identifying the number of repeats across 20 regions throughout a genome, which can be compared against a database. DNA paternity tests work similarly by comparing markers between children and their fathers. (Some readers may experience a paywall.)

Indefinite cloning of some endangered species may not sustain their longevity because cloning success rates decrease as genetic mutations accumulate.

The first official Formula One World Championship race was in 1950

On May 13, 1950, Formula 1 held its first race at Silverstone in the UK. Over 150,000 people, including the British monarch (and future Queen Elizabeth II), turned out to watch the field of 28 cars over the 70-lap race. The race wasn’t very competitive, but it’s still a fascinating artifact to observe.

The first 3D printing patent was filed in 1967

Wyn Swainson, an English literature graduate student, filed a patent in Denmark for a system that scans an object and uses the scanning data to rebuild it using lasers that harden light-sensitive plastic. However, he never developed a working prototype. The idea originated from wanting to produce recreations of sculptures.

The earliest known country recording is Louis Vasnier's 'Thompson's Old Gray Mule'

This BBC documentary offers a brief history of the recording, explaining how the wax cylinder recording was transferred to vinyl and how the singer was identified. Interestingly, it also suggests why this recording might have been overlooked for over a century.

The first private equity fund was launched in 1960

At the time, the industry—and the public's understanding of it—was rather limited, and few private equity firms existed until the 1980s. The first leveraged buyout is thought to have taken place in 1955.

Meet Icarus the Second, the first English pig to fly

"When pigs fly" is an ironic phrase meant to express disbelief or impossibility, though it isn't as true today as it may once have been. This article details how a piglet dubbed "Icarus the Second" took flight in November 1909. Stashed in a basket...

Cosmetic surgery during the Edwardian era

This 23-minute video explores cosmetic surgery in the United Kingdom during the Edwardian era, from about 1901 to 1914. Reconstructive surgery already existed by then, though it wasn't considered elective as it was used to repair damage suffered...

King Henry VIII's first divorce is likely the most famous divorce of all time

How often does a divorce change the course of a nation? When English King Henry VIII wanted to divorce his first wife, Catherine of Aragon, in the 1500s, Catholicism was the national religion. Even though Catherine didn't produce a male heir, religious leaders refused to grant his wish. In response, King Henry turned his country upside down for the chance to marry the second of his six wives.

How David Attenborough's work in color television gave tennis balls their color

As controller of BBC Two, Attenborough wanted the BBC to achieve the first full-color broadcast in Europe and saw Wimbledon as the perfect event to make it happen. Noticing that the white tennis balls used then would stain green and become less visible on color broadcasts as matches progressed, he suggested fluorescent balls, which were eventually adopted.

Double world record holder Hunter Ewen helped conquer his fear of balloons, called globophobia, by training to win Guinness World Record titles for balloon inflation.

Before humans, the Soviet Union and the United States sent animals—including apes, dogs, and cats—to space during the Space Race.

See the evolution of Ebola vaccine and treatment development.

The history of many kitchen appliances involves unexpected discoveries and applications, including wartime radar turned hamster defroster and replacing an 'ice king' with heat-stealing boxes.

English mathematician Ada Lovelace wrote the first computer algorithm a century before computers existed and hypothesized that computing devices would one day be able to compose music—foreseeing the generative AI systems of today.

The syncytiotrophoblast is the outer layer of the placenta and the largest human cell, spanning an area about twice that of a king-sized bedsheet.

While the first exchange-traded fund (a 'basket' of different assets that can be bought and sold on a stock exchange) in the US only launched in 1993, the global ETF market has grown to more than $10T in the short time since.

Elk Cloner, the first computer virus to spread in public, was written as a practical joke by Richard Skrenta, a Pittsburgh high school student.

Budweiser stores yeast derived from the original 1800s strain in a secret bunker, which only the Head of Yeast Management can access—not even the CEO

Poison ivy was sent to Europe in the 1600s as an exotic, ornamental oddity, where it was purposefully grown in the English royal gardens at Kew, the Faculty of Medicine in Paris, and a few other locations.

The Beatles' US label rejected the band's first two singles, 'Please Please Me' and 'From Me to You,' with one executive calling the band 'dead in the water.'

The first image of a black hole was captured by creating an Earth-sized virtual observatory from a network of eight radio telescopes.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

After 25 people used virtual reality headsets to practice flying with virtual wings—flapping their arms—their visual cortex responded to the wings almost as if they were real arms, treating them as body parts.

See 33 images that became central to huge scandals, including a young Charles and Camilla, Michael Jackson's baby on a hotel balcony, and Hugh Grant's mugshot.

Long before Major League Baseball began allowing instant replay for balls and strikes, an umpire reluctantly used the technology to determine whether a hit was a home run, a move that inadvertently ushered in a new era for the sport.

Coral polyps reproduce via broadcast spawning, where entire reefs simultaneously release reproductive cells for about one hour, once a year.

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

Brandi Chastain, the star of the 1999 US victory over China in the 1999 Women's World Cup, was a last-second choice to take the penalty kick that sealed the victory.

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

Dorothy's famous entrance into Oz in 'The Wizard of Oz' relied on analog tricks, including a body double and sepia-toned paint, as much as it did on technology

Children are now three times more likely to say they want to be a YouTuber when they grow up than an astronaut, with some even attending 'YouTube camps' that teach kids how to create content for the platform.

In 2026, Finland was named the world's happiest country for the ninth consecutive year based on its wealth, social safety network, and high life expectancy, among other factors.