See the evolution of Ebola vaccine and treatment development.

An Ebola vaccine was developed during the 2018 west African Ebola outbreak, but the 2026 Ebola outbreak is with a different species of the virus, not the one that the vaccine is approved to treat.

The 2026 Ebola outbreak in the DRC is spurring new Ebola vaccine development for the Bundibugyo species.

An Ebola vaccine was developed during the 2018 west African Ebola outbreak

A study found that Merck's rVSV-ZEBOV Ebola vaccine (called Ervebo) was 84% effective against infection during the 2018-2020 Ebola outbreak in the DRC. This effect was observed for both sexes and among children and adults. The vaccine is approved to help provide protection against one specific species of the Ebola virus. The 2026 Ebola outbreak is with a different species of the virus—not the one that the vaccine is approved to treat.

The 2026 Ebola outbreak in the DRC is spurring new Ebola vaccine development for the Bundibugyo species

An experimental vaccine candidate from Moderna will use the company's mRNA vaccine platform—the same one which enabled the COVID-19 vaccine to be rapidly developed during the pandemic.

The 2026 Ebola outbreak is hampered by a lack of vaccine against the species of the virus, heightening the need for rapid tests to aid in disease control.

The 2026 Ebola outbreak is hampered by a lack of vaccine against the species of the virus, heightening the need for rapid tests to aid in disease control

Clinics in the Democratic Republic of Congo saw patients with Ebola symptoms months before the disease was identified. The identification lag was due to inadequate diagnostics that could not accurately or quickly identify the virus's myriad species. Contact tracing and better diagnostics will be required to tamp down the outbreak.

Three Ebola species are responsible for most large outbreaks of the disease, yet the only approved Ebola vaccine is known to work against just one of them.

See how Ebola tore through Guinea, Sierra Leone, and Liberia in 2014-2016.

See how Ebola tore through Guinea, Sierra Leone, and Liberia in 2014-2016

Frontline traced how the outbreak started and spread across West Africa. documenting first-hand accounts and patient experiences. This Ebola outbreak was the deadliest to date, resulting in over 11,000 deaths.

There have been close to 40 Ebola outbreaks since 1976

Ebola is a rare but deadly virus that causes severe illness, organ damage, and sometimes internal bleeding. It spreads through contact with infected bodily fluids and is most common in parts of sub-Saharan Africa. This explainer covers its symptoms, transmission, and treatment options.

Watch what the Ebola virus does inside our cells and organs in order to spread and survive.

Learn how monoclonal antibodies, which mimic the body's antibodies, can fight diseases like Ebola.

Learn how monoclonal antibodies, which mimic the body's antibodies, can fight diseases like Ebola

Monoclonal Antibodies mimic the antibodies produced naturally by the immune system. These molecules target specific parts of the virus, preventing them from entering cells or interfering with their ability to cause harm or infection.

Marburg virus, related to Ebola, is also extremely deadly

Discovered nine years before Ebola, Marburg is part of the same filovirus family. While this virus is less contagious, it can still be deadly. Currently, no vaccines exist against this disease. (Some users may encounter a paywall.)

Watch the cumbersome, but necessary, precautions healthcare workers must take to care for and protect themselves while caring for Ebola patients

Treating someone with Ebola involves a painstaking process of suiting up (donning) and peeling off (doffing) protective gear. Doctors follow detailed CDC guidelines. Properly suiting up is key to protecting against fluids that transmit Ebola, and correctly removing a suit that could be contaminated with the virus is also critical.

Watch the cumbersome, but necessary, precautions healthcare workers must take to care for and protect themselves while caring for Ebola patients.

Scientists have struggled to pin down Ebola's natural reservoir species for decades, but the available evidence suggests that it's very likely fruit and insect-eating bats found in Africa.

Watch how viruses like Ebola can spill over from animals to humans—and vice-versa.

Explore what it's like inside a patient isolation unit, used in situations such as treating a patient or suspected patient with Ebola.

Cultural norms about how to handle the bodies of loved ones have hampered Ebola responses in West Africa

Awareness of local burial and grieving traditions eventually helped healthcare workers fight the spread of the virus. As healthcare workers and burial teams altered their procedures during the 2014 West African Ebola outbreak, and as community leaders pressed people to adapt traditional ceremonies, the spread of Ebola began to slow.

Marburg virus, related to Ebola, is also extremely deadly, and has no available vaccine.

Experimental hantavirus vaccines and therapies, still under development, have long been funded by the US military.

Ebola species have historically been named after the places where they were discovered, stigmatizing residents of those areas, including Bundibugyo, in Uganda

This occurred with Ebola Zaire (now the DRC), Sudan, and Bundibugyo, a region in western Uganda composed largely of cocoa farmers. Uganda's link to the Bundibugyo virus is that the species was discovered there almost 20 years ago, in a November 2007 outbreak.

The US military, concerned about potential deployments worldwide, has long funded experimental hantavirus vaccines and therapies.

Collaborations between the military, biotech, and academic researchers led to an experimental antibody treatment for the Andes hantavirus strain—the one that more readily passes between humans. As of spring 2026, it had only been tested in animals. The US Army has also tested a potential hantavirus vaccine in people. It published early findings in 2023 that seemed promising, eliciting some immune system response. (Some users may encounter a paywall.)

Ebola species have historically been named after where they were discovered, stigmatizing residents who live there, including Bundibugyo, in Uganda.

Ebola is a filovirus, meaning it resembles a thread under a microscope

Filovirus is derived from the Latin word 'filum', meaning 'thread.' That term describes its thin, flexible, threadlike appearance. Originally isolated in 1976, the microscopic image of the Ebola virus is now famous, even portrayed in the movie Outbreak. In fact, Ebola's threadlike appearance can vary in both length and degree of twisting, sometimes resembling a bowl of spaghetti.

Ebola is a filovirus, meaning it resembles a thread under a microscope, though it sometimes twists and can resemble a bowl of spaghetti.

Ebola's natural reservoir species are likely bats

But the virus doesn't seem to sicken the animals, so capturing an infected bat and performing necessary tests has remained challenging. Though many scientists believe fruit bats are the reservoir species for the virus, Ebola viral RNA fragments were detected in a greater long-fingered bat captured in 2016 in Liberia. The species isn't a fruit bat—it roosts in caves and feeds on insects. The scientist behind the discovery states that he believes the virus likely infects multiple host species and that the hosts may differ regionally. (Some users may encounter a paywall.)

How the most famous Ebola outbreak book got aspects of the disease so wrong

Richard Preston's 1994 book The Hot Zone brought knowledge of Ebola to the masses. But, beyond the poor portrayals of the science and the scientists, the book fostered fearmongering about Ebola, with portrayals of "liquefying," "dissolving," and "bleeding out." These falsehoods about Ebola have persisted for decades and appear to be reinvigorated with every new emergence of the disease.

The flu vaccine has evolved alongside discoveries of new virus strains

After influenza B was identified in 1940, researchers created a two-strain vaccine by 1942. The WHO later built a global surveillance system to track mutations, enabling vaccines to be updated annually to target the strains most likely to circulate.

Cultural norms about how to handle the bodies of loved ones in communities in West Africa have hampered Ebola responses.

How the most famous Ebola book, The Hot Zone, which sold 3.5 million copies and was translated into 30 languages, got aspects of the disease so wrong.

View this timeline of polio milestones and vaccine development

Polio has a long history in art and medicine, dating back centuries. It includes a representation of an apparent polio survivor with a shriveled leg in ancient Egyptian art. See milestones in the history of polio in this timeline.

The business models behind vaccines

Watch experts weigh in on the prevailing business models of vaccine production, including how the Covid-19 pandemic has disrupted the industry for good in this 20-minute video from Financial Times.

A timeline of major pandemics from 1899–2025

Modern pandemics have been defined by the race between globalization (which increases risk) and the development of new medicines. The Great Influenza epidemic claimed some 50 million lives, and the COVID-19 pandemic killed more than 7 million. In between, diseases like Ebola, cholera, AIDS, and more have devastated communities.

A 1954 outbreak at a Boston boarding school allowed scientists to isolate the measles virus

While measles was described as early as the 9th century, humanity lacked the medical technology to fight the disease until the mid-20th century. Vaccine development from the Boston outbreak in the 1960s and 1970s led to one of the most effective inoculation campaigns in history.

A heatmap showing the drop in infectious diseases post-vaccine deployment

The number of infected people, measured over 70-some years and across all 50 states and the District of Columbia, declined significantly after vaccines were introduced.

Timeline of cancer research milestones

While cancer remains incurable, there's been so much progress in its treatment over the last two decades. Nature provides an abridged history of milestones and major triumphs in cancer research and treatment. Start in the year 2000, and see how much has changed in the first quarter of the new millennium

Understanding vaccine side effects

A vaccine is a medical intervention, and as with any medical intervention, may have side effects. This article discusses side effects and adverse events related to vaccination.

See how cholera spreads in a community

This animated video offers a comprehensive look at how cholera spreads. It makes clear why it's so difficult to stamp out this disease in communities around the world. It also details what steps can help control cholera.

See how antidepressants were discovered

The decadeslong journey to the three major types of antidepressants began with medications designed to treat other maladies. Watch to learn more about how attempts to treat tuberculosis and blood pressure disorders led to new insights about neural chemistry and mood.

Superbugs are bacteria and pathogens that rapidly evolve defenses against medication

Superbugs, or antibiotic-resistant bacteria, infect millions and pose a threat to global health. Developing new antibiotics is costly, offers limited profits, and struggles to outpace bacteria’s rapid evolution.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

Indefinite cloning of some endangered species may not sustain their longevity because cloning success rates decrease as genetic mutations accumulate.

In recent years a child anxiety expert has created and tested a novel phobia and anxiety treatment approach for children, focused on changing how parents respond to the fears.

Poison ivy was sent to Europe in the 1600s as an exotic, ornamental oddity, where it was purposefully grown in the English royal gardens at Kew, the Faculty of Medicine in Paris, and a few other locations.

NBA superstar Victor Wembanyama spent the 2025 summer training with monks in central China to enhance his body and mind.

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

While the first exchange-traded fund (a 'basket' of different assets that can be bought and sold on a stock exchange) in the US only launched in 1993, the global ETF market has grown to more than $10T in the short time since.

Watch this video that uses Lego bricks to explain how venture capital works.