The business models behind vaccines

The basics behind mRNA vaccines

In this video, Yale experts Saad Omer, MBBS, MPH, PhD; Onyema Ogbuagu, MBBCh; and Akiko Iwasaki, PhD, explain the science behind COVID-19 mRNA vaccines.

Breaking down the different types of vaccine technologies

There are several different types of vaccines. Each type is designed to teach your immune system how to fight off germs—and the serious diseases they cause. This short overview breaks down the differences between the types.

Understanding TikTok-owner ByteDance's business model

ByteDance has ridden TikTok's major success to become the world's most valuable startup. This deep dive showcases some of the company's smartest moves and tactics, and where it's headed next.

See the evolution of Ebola vaccine and treatment development

The recently approved vaccine and treatments against Ebola are the result of many years of investments and have reshaped how the world addresses Ebola outbreaks. Four drugs were tested in the midst of the 2014 outbreak. Two proved to be so effective the clinical trial ended early. The vaccine proved effective during the 2018-2020 outbreak in the DRC.

See the evolution of Ebola vaccine and treatment development.

Flu vaccines are reformulated each year based on global predictions

Twice a year, health agencies analyze circulating influenza strains and select those most likely to spread in the coming season. Because vaccines must be produced months ahead, they represent the best available forecast.

How the 1918 pandemic spurred developments in virology and vaccines

This article provides an in-depth historical account of the 1918 Spanish Flu pandemic, including its impact on the global population and how its occurrence spurred significant advancements in the study of viruses—laying the groundwork for the...

How chaos helps explain why small market corrections can produce major economic instability

Oxford University complex systems professor Doyne Farmer discusses how predictions from many economic models are overly weighted toward simple relationships, such as supply and demand, and external shocks, such as the COVID-19 pandemic. However, real-world macroeconomic systems involve public and private actors interacting, producing feedback loops and cascading effects that resemble the oscillatory behavior seen in chaotic systems.

A history of vaccine rollouts

History tells us the public will tolerate risk of harm from a vaccine if their fear of the disease exceeds their fear of the vaccine.

Governments are arguably very dependent on consulting firms like McKinsey and Deloitte

This podcast episode discusses the consultancy industry’s rise and how these firms make billions of dollars, even amid significant scandals.

How the World Bank's pandemic bonds were triggered during COVID-19

In 2017, the World Bank raised a chunk of emergency funds through bonds to help developing countries cover funds in the event of a pandemic. Had no pandemic occurred, investors would have received returns of 6% to 11%. But the global pandemic meant they lost all their money.

Show business is increasingly leaving Hollywood

Using tax incentives, states like Georgia, New Jersey, and New Mexico are luring studios to produce their films and television shows outside of California. Changing business models after COVID-19 largely influenced this change.

Read about Palantir's role in the COVID-19 vaccine rollout

Palantir developed Tiberius, a software service that supported the public-private partnership spearheaded by then-President Trump to roll out COVID-19 vaccines. The software tracked state-by-state vaccine allocations, as well as COVID-related hospitalizations.

The plasma-selling industry is expected to reach $50B by the end of the decade

About 55% of your blood volume is plasma, the liquid part of blood created from water, proteins, minerals, and salts absorbed through the digestive tract. This 49-minute podcast episode explores the business of plasma—part of a global industry expected to be worth $50B by 2029.

Menopause may become a $600B industry

Companies marketing products and supplements to alleviate menopause symptoms and make life easier during this life stage have become a gold mine. This 2022 article explores how and why companies have swooped into this space, and whether you should trust them or not.

Biotech is trying to boost drug production efficiency—using chicken eggs

A company called Neion Bio is genetically engineering birds in a bid to produce medical compounds, a herculean task that scientists have struggled with for decades. The US FDA has approved only one chicken-derived drug in the past—an expensive treatment for a rare liver disorder. (Some users may encounter a paywall.)

Visualizing the global supply chain of medicine

The typical medicine we consume is the end result of a complex global supply chain involving highly specialized compartmentalization. Most medicine was made locally until open trade policies enabled global trade in the 1980s. This visual essay is...

In 2023, venture capital firms invested $170B in over 15,000 US companies

That's a significant drop from 2022’s $242B, reflecting market uncertainty but continuing VC’s role in scaling transformative ideas. Rooted in early risk-sharing models, venture capital took off with firms like ARDC in 1946, later evolving into today’s influential players like Sequoia Capital and Andreessen Horowitz.

Breaking down how and why 5G will change the world

The jump from 3G to 4G networks was pretty huge, and 4G to 5G is many times greater and is almost difficult to comprehend. This nine-minute video dives into how 5G will transform our world.

The firms running America's voting systems

Three companies make up over 90% of the US market share around voting systems, and like any company, they're priorities aren't always aligned with the public's. Dive into the industry of voting machines in this investigation piece from the Guardian.

F1 is a billion-dollar industry

...but that money doesn't come easily. Team principals have to constantly ensure money is coming in to fund their million-dollar cars every weekend. This CNBC video explores all the costs of running a team. It also shows how team principals woo sponsors and find ways to maximize their technology with a cost cap.

Go behind the scenes of Davos with ‘60 Minutes’

In 2010, "60 Minutes" gained rare, near-unprecedented access to the World Economic Forum, with Scott Pelley roaming Davos’ exclusive meetings and elite spaces. See how global power brokers mingle, negotiate, and shape agendas offstage at the event.

See how DOJ prosecutors took down a pharmaceutical company's executives over the opioid crisis

This FRONTLINE documentary follows federal prosecutors as they used anti-racketeering laws to convict executives at Insys Therapeutics, a pharmaceutical company that bribed doctors to overprescribe a fentanyl painkiller.

The ABCs and FAQs on GMOs from the WHO.

GMOs (or genetically modified organisms) are a subject of great debate in the food world…but how come? GMOs are organisms whose genetic materials have been altered in a way that does not occur naturally in order to create a product that has a...

The NFL is so successful because it is perfectly suited for television

The predictable weekly cadence of football games ritualizes the experience of watching together, and their relative scarcity makes every game meaningful. With the stop-and-go play of the sport, there are predictable, repeating stoppages to allow broadcasters to sell lots of advertising inventory. The league sits in the sweet spot compared to MLB (many games) and NBA and soccer (continuous play with fewer ads). This Acquired episode distills fascinating insights into the NFL's business and history.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

The plastics industry spent decades promoting recycling while privately doubting it would ever work

This FRONTLINE investigation reveals that plastic makers publicly championed recycling for years despite internal doubts about its viability, and that no more than 10% of the plastic ever produced has been recycled.

Watch this video that uses Lego bricks to explain how venture capital works.

How Amazon operates a 'flywheel' business model, a self-reinforcing cycle that drives continuous growth

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

Hedge funds, the private investment firms that trade a wide swath of financial assets, make money by imposing steep fees on investors and from the fund's investment performance.

SpaceX's S-1 or 'prospectus' revealed many previously unknown details about the company, including its unprofitability despite doing $18.7B in revenue in 2025, exactly how many voting shares Elon Musk will have in the company (roughly 85%), and more.

Netflix profits when you're not watching, and its movies are designed that way—read a detail-rich critical essay exposing lesser-known Netflix takes

Up to a million Girl Scouts sell about 200 million cookie boxes every spring, generating $800 million, largely because refusing a child is frowned upon

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

A vending machine run with Anthropic's AI went out of business after it was convinced to give away items for free and sell a video game console.

The most expensive ad of all time was for Chanel No. 5 perfume and cost roughly $33M to produce in 2004—about $57M in today's dollars.

About 2,000 US babies are born annually without some portion of their limbs, potentially leading to a lifetime of pricey prosthetics.

Larger animals like giraffes, elephants, and blue whales have developed a unique defense against cancer, a phenomenon known as Peto's Paradox

Roughly 43 million US borrowers owe roughly $1.7T in student debt, the second-largest source of consumer debt behind mortgages.

Discover the catastrophic consequences of a failure of the US electrical grid—something that is more likely than many Americans think.

Massive 3D printers have been used to build homes by stacking layers of 'concrete toothpaste,' a fire-resistant material that effectively insulates against outside noise.

In recent years a child anxiety expert has created and tested a novel phobia and anxiety treatment approach for children, focused on changing how parents respond to the fears.

Sony set the standard for cylinder-shaped batteries when it repurposed manufacturing equipment used to make rolls of magnetic recording tape.

The idea for the Federal Reserve was conceived in secret in 1910—with bankers donning duck hunt gear for disguise while traveling to a remote country club on Georgia's Jekyll Island

Budweiser stores yeast derived from the original 1800s strain in a secret bunker, which only the Head of Yeast Management can access—not even the CEO

A Yale student wrote a profound essay about the consulting industry's influence on elite college students that was published in a book of her writing after she died in a post-graduation car accident.

How fusion—which releases energy when two lighter atoms combine to form a heavier atom—differs from fission

Chaos theory—informally known as the butterfly effect—is the reason why weather forecasts are presented with probabilities rather than certainties.

Volcanic activity may have triggered the Black Death by spewing gases that led to crop failures in Europe, thus forcing the import of grain ships with plague-infested fleas.