Breaking down the different types of vaccine technologies

How do vaccines work? Watch this brief 101

Watch this under-3-minute video explaining how vaccines use the body's immune system to prepare our bodies against viral and bacterial threats to our health.

Attenuated vaccines introduce a weakened version of the virus into the body

Some vaccines, like those for measles, rely on weakened versions of a virus. These weakened pathogens are introduced into the body, triggering an immune response and helping the immune system learn to protect itself against stronger versions of the virus. (This also explains why some vaccines make you feel under the weather.)

What are universal vaccines?

As viruses mutate and develop, vaccines have to adapt, leading to regular recommended injections like flu shots. Researchers are working to develop universal vaccines that aim to protect against multiple virus variants if not entire virus families. These vaccines work by creating broadly neutralizing antibodies (bnAbs) that target aspects of viruses that don't typically mutate and are integral to the virus' survival.

Before vaccines, there was 'variolation': what was it?

Before the technology behind vaccinations was discovered, some keen observers of medicine around the globe noticed how previous infections could impact future ones. Learn about the techniques early physicians used before they had vaccines.

Understanding vaccine side effects

A vaccine is a medical intervention, and as with any medical intervention, may have side effects. This article discusses side effects and adverse events related to vaccination.

The difference between standard cancer treatments and emerging immunotherapies

If you've ever wondered what the difference was between immunotherapy and chemotherapy, this short video takes you through the steps. Briefly, chemotherapy attacks cancer in tumor cells directly, while immunotherapy encourages your immune system to fight it. There's more to it than that, but this delightful two-and-a-half-minute video provides a good primer.

How mRNA vaccines work

mRNA COVID-19 vaccines were developed faster than any vaccine ever made. Even more enticing, the underlying technology may unlock preventive treatments for a wide-range of diseases.

The business models behind vaccines

Watch experts weigh in on the prevailing business models of vaccine production, including how the Covid-19 pandemic has disrupted the industry for good in this 20-minute video from Financial Times.

Most flu vaccines are still produced using chicken eggs

For decades, influenza vaccines have been made by growing viruses inside fertilized chicken eggs. Though newer methods using cell cultures or recombinant technology exist, egg-based production remains the primary global manufacturing process.

See the evolution of Ebola vaccine and treatment development.

What are 'antibodies'? Read this quick overview

Antibodies are protective proteins produced by your immune system. They attach to antigens (foreign substances) and remove them from your body. Understand this important element of the immune system with this quick overview.

Every virus is classified into 7 groups based on genetic differences

Viruses infecting humans have been named based on symptoms ("chickenpox") or the location or animal in which they were first discovered ("Bolivian Haemorrhagic Fever" and "Monkeypox"). For clarity among scientists and to reduce stigma, virologists classify the 15,000 known viruses (270 of which infect humans) by their basic genetic material.

Learn how monoclonal antibodies, which mimic the body's antibodies, can fight diseases like Ebola.

See the differences between the Wegovy pill and injection

Examine this chart that compares and contrasts the oral and injectable Wegovy formulations. The differences include how they are absorbed by the body (through the digestive tract versus subcutaneously), their dosages, and the required timing (the pill is taken daily and has specialized timing requirements, while the injected form is administered once a week). Importantly, the pill form is also approved to treat fewer conditions.

See the differences between chickenpox and hand, foot, and mouth

This helpful explainer breaks down the differences between these two contagious, viral diseases, which both present with fevers and sores. It includes photos of the sores that are characteristic of both diseases, showing how they have appeared across different skin tones to better inform people looking for information about their own loved one's symptoms.

Explaining CRISPR at five levels of technical detail

CRISPR is a new area of biomedical science that enables gene editing and could be the key to eventually curing diseases like autism or cancer. WIRED challenges biologist Neville Sanjana to explain this concept to 5 different people; a 7-year-old, a 14-year-old, a college student, a grad student and a CRISPR expert.

Various types of memory, each serving unique functions, create a complex brain system

These forms of memory, which can overlap in daily life, have been sorted into broad categories, such as short-term and long-term memory, and subtypes such as implicit memory, which uses saved information without conscious awareness that it’s being recalled.

An interactive explanation of blood transfusion

The antigens and Rh factors of blood cells (which determines your blood type) must be compatible with your immune system—which is why blood transfusions between patients must have matching types. In a mismatch, the immune system will attack and destroy donor blood cells, triggering a potentially fatal reaction.

The HPV vaccine reduces cervical cancer rates by 90% or more

Cervical cancer is the fourth most common cancer in women globally. Almost all cases (99%) are linked to infection with high-risk human papillomaviruses. However, cervical cancer is both treatable and preventable—and we may be able to prevent most cases through vaccination.

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

There are three types of stem cells, each with different properties

Embryonic stem cells are "blank slates" that can change into any other type of cell. Adult stem cells can become specialized cells to replenish the supply or repair injury, while induced pluripotent cells are "reset" by scientists and used in clinical and medical applications.

View a gallery of diagrams for each volcano type with glossaries

The three major types of volcanoes—cinder cone, composite, and shield—each exhibit unique, lesser-known subterranean and surface features, including lava bombs, lahars, and spatter. Other types of volcanoes include lava domes, calderas, fissure volcanoes, and Maars and tuff rings.

Explore a visual of 16 different types of trusts

While all trusts fit into one of two categories (revocable or irrevocable), many other types of trusts exist for more specific circumstances. Think: pet trusts and special needs trusts.

There are multiple types of multiple sclerosis—they differ by attack patterns

When your immune system targets the nervous system, this can cause new or worsening symptoms and the development of scarring or damage within the central nervous system. Relapsing-remitting MS is the most common type of the disease—it includes progressive bouts of attacks that occur months or years apart.

The two main types of life insurance are term and permanent

The biggest difference between the two is how long they cover the life of the insured person and how much they cost. This guide can help you learn more about term and permanent life insurance, plus their different variations, to choose the right policy for you.

Tattoos, explained

Tattoos last because immune cells trap ink beneath the skin—but there's more to the story. This overview looks at how ancient cultures used tattoos for status, spirituality and punishment; how technology like the electric tattoo machine transformed the art form, and where innovations like smart tattoos could take it next.

How generative AI differs from machine learning

Compared to machine learning - which is sort of like teaching a toddler how to recognize what a dog looks like by showing them images of one - generative AI is like teaching that same child how to actually draw a dog. Unlike machine learning, generative AI can actually generate. Read this article for a more in-depth comparison between these two types of artificial intelligence.

Immersive technologies include virtual reality, augmented reality, and mixed reality

Virtual reality relies on technologies that use screens to generate every pixel, immersing a user in an entirely digital world. In contrast, augmented reality overlays digital content onto views of the real world. Mixed reality combines both to allow real-time interaction with virtual objects.

This poison ivy knowledge quiz—accompanied by photos of the plant's varied forms—may help you identify this common rash-inducing growth.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

How fusion—which releases energy when two lighter atoms combine to form a heavier atom—differs from fission

Watch how algorithms can be designed to train themselves and self-improve without human input, to the point where the optimized code is too complex for programmers to understand.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Tattoos remain visible on your skin thanks to immune cells called macrophages

The United States is one of only around two dozen countries with a fully federal system of government, in which power is divided between national and state governments.

See how fireworks are made and learn how metals like magnesium and copper are responsible for different colors.

After 25 people used virtual reality headsets to practice flying with virtual wings—flapping their arms—their visual cortex responded to the wings almost as if they were real arms, treating them as body parts.

Venture capital is a form of funding provided to early-stage companies with high growth potential, typically in exchange for an equity (or ownership) stake

Children are now three times more likely to say they want to be a YouTuber when they grow up than an astronaut, with some even attending 'YouTube camps' that teach kids how to create content for the platform.

Some Pokémon have been named after real and fictional organisms, while some real-world species have been named after Pokémon, such as Chilicola charizard and Binburrum zapdos.

Elk Cloner, the first computer virus to spread in public, was written as a practical joke by Richard Skrenta, a Pittsburgh high school student.

Lesser-known phobias include turophobia, or the fear of cheese, and nomophobia, the fear of being without your cell phone.

Memecoins are a type of cryptocurrency—a form of digital currency with a wide variety of uses—created around popular 'memes,' or viral internet jokes.

Volcanoes 'die' when their supply of magma runs out, if they are shifted away from their underlying magma reservoir, or if they get clogged by collapsing or their magma cooling back into rock.

Gerrymandering works through two techniques: cracking opposing voters across districts to dilute their power, and packing them into a few to waste their votes in lopsided majorities.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

Budweiser stores yeast derived from the original 1800s strain in a secret bunker, which only the Head of Yeast Management can access—not even the CEO

Massive 3D printers have been used to build homes by stacking layers of 'concrete toothpaste,' a fire-resistant material that effectively insulates against outside noise.

Chaos theory—informally known as the butterfly effect—is the reason why weather forecasts are presented with probabilities rather than certainties.

Calculate how much of your tax dollars go to each federal program based on your income, filing status, and number of children