Eight British children have been born via mitochondrial replacement therapy

Four frozen embryos in the US were created via 3-parent IVF technique

Columbia University researchers created four embryos using mitochondrial replacement therapy for four female patients who didn't want to pass on mitochondrial diseases to their children. Yet US law restricts the researchers from implanting the embryos so they remain frozen. (Some users may encounter a paywall.)

The first child born via mitochondrial replacement therapy was born in 2016

The healthy baby boy's mother carried genes for a rare mitochondrial disease called Leigh syndrome and after multiple miscarriages the family opted to try the controversial procedure. It was conducted by a US doctor in Mexico. The procedure is prohibited in the United States.

See how to make a baby with 3 parents, a process called mitochondrial replacement therapy

This primer video dives into the science of mitochondrial disease risks, how this controversial mitochondrial replacement technique can work, and why proponents say this reproductive advance—already legalized in the UK and Australia—is needed in the United States.

Australia legalized 3-parent IVF in 2022

It was the second country, after the UK, to legalize the procedure, which is still prohibited in the US. There are more than 300 rare mitochondrial diseases that can be passed from a mother to her offspring.

The US FDA considered mitochondrial replacement therapy during 2014 hearings

An agency committee assessed if this approach could have undesirable ripple effects across multiple generations and whether a clinical trial involving this approach would be appropriate. As of 2026, the US has continued to prohibit this procedure though it is legal in other settings including the UK and Australia.

3-parent IVF removes most—but not all—faulty mitochondria

The process scoops out about 99% of the mother's mitochondrial DNA—replacing it with that of a donor woman—but because that roughly 1% is still in the system there is still a small chance of disease for the resulting child or future generations. (Some users may encounter a paywall.)

3-parent baby approach may help women with infertility

Though the topline promise of this approach is avoiding passing on mitochondrial diseases, some researchers and companies have been eyeing its potential for helping with female infertility, since faculty mitochondria may contribute to the condition. Recent research suggests this approach could be promising.

Without 3-parent IVF, women carrying faulty mitochondrial DNA have few options for children

Women who are carriers of mitochondrial diseases that wish to have children without those conditions cannot be biological parents without three-parent IVF. The alternatives are to adopt or have a child via egg donation.

Mitochondrial DNA swapping can occur before or after fertilization

Mitochondrial replacement therapy can be conducted with four different techniques, with varying genetic material transferred depending on the approach. Maternal spindle transfer, one common method, involves transplanting the nuclear DNA from a mother into an unfertilized egg from a donor. The donor egg is then fertilized and implanted into the mother's uterus using in vitro fertilization. Another major approach, pronuclear transfer, does the genetic swapping after the mother's egg has already been fertilized. This order of operations may be uncomfortable for some individuals, but the success rate with this technique is higher.

The first successful IVF pregnancy was in the United Kingdom in 1978

Gynecologist Patrick Steptoe and his collaborator Robert Edwards, a biologist, attempted to fertilize a human egg cell in a petri dish 101 times before finally succeeding. This resulted in the birth of Louise Brown—at the time referred to as a "test tube" baby—in 1978, who was born into the spotlight.

Scientific advances are unlocking a wide range of alternatives to IVF

From refined artificial insemination and microsurgical sperm extraction to experimental uterine transplants, scientific innovation is rapidly advancing potential fertilization technologies. But they come along with costly trials, some ethical dilemmas, regulatory issues, and more.

About 250,000 patients accessed assisted reproductive technologies in 2022

In 2022, 251,542 patients tried assisted reproductive technologies—most commonly IVF—resulting in more than 98,000 infants. Those children represent around 2.6% of the babies born in the US.

Triplet birth numbers are dropping—and that may be a good thing

Pregnancies involving three kids or more have dropped 62% from 1998 to 2023, a trend that the Centers for Disease Control and Prevention links to fewer embryo transfers during assisted reproduction procedures—a transition prompted by more refined techniques and technical advances. Though multiple births can occur naturally, often pregnancies involving multiple births have been the result of efforts to ensure pregnancy success by transferring multiple embryos.

How personalized gene-editing saved a baby's life

KJ Muldoon had a 50% chance of surviving a genetic mutation until doctors developed a one-of-a-kind gene-editing therapy. In an interview with one of the researchers behind the treatment, learn what it will take to make personalized genetic medicine possible for everyone.

‘Hope for Healing’: The first-ever use of an in utero stem cell treatment

In 2023, researchers at UC Davis performed the first-ever fetal stem cell transplant, attempting to cure a case of spinal bifida prior to childbirth using stem cells derived from the placenta. The trial, and others including an effort to treat muscular dystrophy, highlight the potential power of stem cell therapy.

Using artificial wombs to improve preterm infant health outcomes

Researchers at a hospital in the US have successfully used artificial wombs to care for preterm lambs and are now looking at the possibility of human trials. This nine-minute video includes interviews with the researchers and explains the reasoning...

One dad, one hundred babies

A look at the companies offering surrogacy to the ultrarich—including Chinese men taking their reproductive cues from Elon Musk.

In 1984, a dying infant lived for three weeks with a baboon heart

Pediatric-sized hearts are very hard to find. They're about the size of a walnut. When a premature baby girl was born with a fatal heart defect in 1984 her care team transplanted a 7-month-old baboon's heart into the patient. The organ was not genetically modified but still the infant lived for several weeks. This roughly hour-long documentary from the medical institution, features the patient's mother, clinician, and more discussing the controversial procedure and aftermath.

Indefinite cloning of some endangered species may not sustain their longevity because cloning success rates decrease as genetic mutations accumulate.

Extremely rarely, there can be twins with different dads—but fewer than 20 such cases are documented worldwide

The non-identical twins, who would also be half-siblings, result from a rare biological phenomenon called heteropaternal superfecundation. Britain's first known twins with different dads, featured in this article, learned of each other's existence in recent years, when they were both 45. They discovered each other after taking DNA tests from Ancestry, a genealogy company.

Indefinite cloning of some endangered species may not sustain their longevity because cloning success rates decrease as genetic mutations accumulate.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

Pregnancy at older ages increases the chances of fetal abnormalities

Chromosomal irregularities are more likely at older maternal ages so genetic testing for a fetus of mothers-to-be at age 35 and older is often recommended. Conditions that can be screened for in utero include cystic fibrosis, Tay-Sachs disease, sickle cell disease, Down syndrome, spina bifida, Duchenne muscular dystrophy, and more.

See a list of all of Elon Musk's known children as of April 2026

Although it's possible that these numbers could be larger than the public realizes, as of April 2026, it was believed that Elon Musk had fathered 14 children with four different women. While he has six children with his ex-wife Justine Musk, he has three with the musician Grimes, including a son named X Æ A-12.

England changed to an organ donation opt-out system in May 2020

A law that went into effect in May 2020 in England changed the country's organ donation regulations, reflecting public support for organ donation. Now, adults are typically presumed to have agreed to donate their own organs upon death unless they declare they're refusing to donate organs (or their family opts them out).

Connecticut recently became the first state to create and launch a baby bond program

The program invests $3.2K for a baby born after July 2023, who is covered by the state's Medicaid program. When the child turns 18, they can use the funds for college, retirement, to buy a home, or invest in a business.

A pediatric journal ran 138 fictional case studies, and 61 were cited as real stories

The Canadian journal Paediatrics & Child Health issued corrections to 138 case studies published since 2000, acknowledging the cases were entirely fictional—a practice intended to protect patient privacy that was never disclosed to readers. At least 61 of the fabricated reports were cited as fact in other peer-reviewed journals a combined 218 times, including a 2006 Lancet article alleging an infant died from opioid-laced breast milk.

About 2,000 US babies are born annually without some portion of their limbs, potentially leading to a lifetime of pricey prosthetics.

Astronauts have repaired genetic damage in space using CRISPR—a molecular tool that can make precise changes to DNA and is used in single-celled organisms to attack invasive viruses.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

Experimental hantavirus vaccines and therapies, still under development, have long been funded by the US military.

In recent years a child anxiety expert has created and tested a novel phobia and anxiety treatment approach for children, focused on changing how parents respond to the fears.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

The syncytiotrophoblast is the outer layer of the placenta and the largest human cell, spanning an area about twice that of a king-sized bedsheet.

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

After 25 people used virtual reality headsets to practice flying with virtual wings—flapping their arms—their visual cortex responded to the wings almost as if they were real arms, treating them as body parts.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

Massive 3D printers have been used to build homes by stacking layers of 'concrete toothpaste,' a fire-resistant material that effectively insulates against outside noise.

Fish populations in the Great Barrier Reef have increased after installing waterproof speakers on the ocean floor that played recordings of sounds from healthy coral reefs.

In 2026, Finland was named the world's happiest country for the ninth consecutive year based on its wealth, social safety network, and high life expectancy, among other factors.

See 33 images that became central to huge scandals, including a young Charles and Camilla, Michael Jackson's baby on a hotel balcony, and Hugh Grant's mugshot.

While atoms are normally made of protons, neutrons, and electrons, exotic ones have been built with antimatter—alternate versions of normal matter that live for fractions of a second and are about a billion times as rare.

English mathematician Ada Lovelace wrote the first computer algorithm a century before computers existed and hypothesized that computing devices would one day be able to compose music—foreseeing the generative AI systems of today.

In 2018, 26-year-old missionary John Allen Chau was killed by tribesmen after attempting to reach and evangelize on India's isolated North Sentinel Island

While the first exchange-traded fund (a 'basket' of different assets that can be bought and sold on a stock exchange) in the US only launched in 1993, the global ETF market has grown to more than $10T in the short time since.

Salvador Dalí believed he was his own dead brother, who had died nine months before he was born

The Beatles' US label rejected the band's first two singles, 'Please Please Me' and 'From Me to You,' with one executive calling the band 'dead in the water.'

Long before Major League Baseball began allowing instant replay for balls and strikes, an umpire reluctantly used the technology to determine whether a hit was a home run, a move that inadvertently ushered in a new era for the sport.

Fast-casual restaurant Chili's is experiencing a resurgence, with its parent company recently reporting a nearly 32% increase in sales, thanks to passionate Gen Z fans on TikTok.

Poison ivy was sent to Europe in the 1600s as an exotic, ornamental oddity, where it was purposefully grown in the English royal gardens at Kew, the Faculty of Medicine in Paris, and a few other locations.