RNA may have allowed life to exist before DNA

Peptides may have predated ribosomes—the cell's protein factory

Some scientists have hypothesized that peptides and RNA molecules may have coevolved as a single, mixed "chimeric" molecule, fueling the beginning of protein production and predating a primitive version of the ribosome. All life today uses ribosomes to make peptides. (Some users may experience a paywall.)

DNA's four-letter blueprint makes the variety of all living things possible

The proteins responsible for cellular functions and an organism's traits are built outside of a cell's nucleus from RNA—single-stranded molecules created by reading the information in DNA. DNA's double-stranded structure makes it more stable and allows RNA to be made from either of its complementary strands.

Abiogenesis explains how Earth's natural processes could have formed organic matter

The theory details how chemical interactions in hydrothermal vents and shallow ponds billions of years ago could have created lipids, proteins, and RNA. As these interactions involve water, life is thought to have started in oceans.

Watch how proteins are created from DNA

When a DNA sequence—a gene—is activated, a copy of the activated portion is created in the form of RNA, a single-stranded version of DNA, in a process known as transcription. This RNA, called messenger RNA, leaves the nucleus and travels to a ribosome, a structure within a cell, which uses it to build a chain of organic compounds that fold into a protein.

Bacteria helped scientists realize that DNA was the hereditary molecule, not proteins

Until the mid-1900s, most scientists believed genes were made of proteins, which were known to act as enzymes, hormones, and other chemicals that mediated an organism's traits. The Avery-MacLeod-McCarty and that benign bacteria could be made lethal, where the inherited factor that caused bacterial transformation contained DNA.

Computational and biological systems share fundamental principles, like randomness

Proposed by Alan Turing and John von Neumann, the concept originates from how DNA and computers run by executing encoded instructions in parallel. The advent of AI and the temperature parameter has seen neural networks mimic the randomness of protein encoding.

View a collection of historical documents about molecular biology's history

The collection features materials related to those involved in the discovery of DNA and provides historical context for the discoveries of RNA, various viruses, and important bioproteins. The items include photographs, business correspondence, manuscripts, and scientific instruments.

Before discovering cells, life was believed to emerge suddenly from inorganic matter

Popularized by Aristotle in the 4th century BCE, spontaneous generation was used to explain phenomena like mice appearing in seemingly sealed grain storage. The invention of the compound microscope in the late 16th century led to the identification of cells as the basic unit of life, but it was not until 1855 that their origin from preexisting cells was established.

Some organelles are believed to have once been independent cells

Mitochondria and chloroplasts, which are both responsible for energy production in cells, have DNA distinct from that of their host cells and are surrounded by cellular membranes resembling those of bacteria. Through symbiogenesis, these and other specialized structures were absorbed into larger cells, forming the modern-day biological units.

Where do genes come from?

There are many more genes on Earth today than when microbial life first spawned on the planet about four billion years ago. Many of these newer genes grew from genetic mutations, misprints that slowly drift from the original blueprint via cellular division. If these mutations drift far enough, they can establish a new family of genes, though this process can take well over a million years.

The discovery of the first extremophile and how it revolutionized DNA analysis

While investigating samples taken from within and around the hot springs at Yellowstone National Park, microbiologist Thomas Brock discovered Thermus aquaticus, a microorganism that thrived in hot water. It contained an enzyme called Taq polymerase, a critical molecule in polymerase chain reaction—a molecular photocopier that amplifies genetic signals to improve medical diagnostics.

Watch how Sanger sequencing kickstarted the first generation of DNA sequencing

Sanger sequencing is a foundational DNA sequencing technology developed in 1977. The Nobel Prize-winning discovery uses fluorescent dyes at the end of DNA chains, which are sorted by length through electrophoresis, to determine the order of nucleotide bases.

The messy story of humanity's genealogical past

For decades, scientists viewed the human fossil record and concluded Neanderthals, an early hominin, came before homo sapiens, or modern humans. The story became more complicated as technology advanced and ancient DNA samples were analyzed. This video breaks down the evidence, concluding the development of humanity was a lot messier than previously believed.

Biologist Richard Dawkins coined the term 'meme'

His 1976 book "The Selfish Gene" proposed that units of culture could be replicated, passed on, and evolve as they were transmitted, similar to human genes. He called this unit a "meme," to be pronounced like "cream."

CRISPR-Cas9 enables precise genome editing using a simple RNA-guided system

Jennifer Doudna's research uncovered how bacteria use the tool as an immune defense by cutting viral DNA. She and Emmanuelle Charpentier received the 2020 Nobel Prize in chemistry for showing how this mechanism could be engineered to target and edit genes in living cells.

DNA computing allows for storage and processing of massive amounts of data

Although costly and less efficient for simpler tasks, as of 2025, DNA could hold 455 exabytes of data with near limitless parallel computation potential in small data centers. Every movie ever made would fit inside the volume of a single sugar cube.

A technical look at the measles virus and its life cycle

The measles virus is made up of a single strand of RNA, packaged inside an envelope that varies in shape and size. A negative-sense paramyxovirus—the same family as mumps—the virus is encased in proteins that help it attach to immune cells inside the body.

Lyme disease-causing bacteria predate any suspected biological weapons testing

Borrelia bacteria existed long before any US biological weapons program—or human presence in North America. One study comparing genomes of the bacteria behind Lyme disease collected samples of the bacteria over three decades and calculated that the bacterium has been in North America longer than humans, at least 60,000 years. Other work found related bacteria preserved in amber from millions of years ago.

Critical organic molecules have been found on an asteroid

NASA's OSIRIS-REx mission returned samples containing amino acids and nucleobases from asteroid Bennu. Without Bennu having been destroyed—as is common for asteroids that enter Earth's atmosphere—its samples serve as a time capsule of the solar system's early chemistry.

Noam Chomsky believed it might be possible to communicate with aliens

The father of modern linguistics argued that there is a genetic component to language, and that the ability to acquire and comprehend language is innate. If aliens existed, he believed they could potentially observe the same "universal grammar" rules as humans.

Why did the Big Bang produce something, rather than nothing?

One of the more remarkable things—among many remarkable things—about the big bang is how matter seemingly won out over antimatter. Int that initial moment of creation and annihilation, it turns out, neutrinos may well have pushed the universe toward forming matter over antimatter. This New York Times article delves deeply, asking several scientists for their input.

Why the abundance of RuBisCO in photosynthetic cells may come from its inefficiency

Despite pulling about 115 billion tons of carbon dioxide from the atmosphere to build organic molecules each year, the enzyme instead binds oxygen at least one in five times, needlessly costing cells energy. To compensate for this and its processing of no more than 10 molecules per second—versus thousands processed by a typical enzyme—it's become the most abundant enzyme on Earth.

How mRNA vaccines work

mRNA COVID-19 vaccines were developed faster than any vaccine ever made. Even more enticing, the underlying technology may unlock preventive treatments for a wide-range of diseases.

Tardigrades’ intrinsically disordered proteins may help preserve biological matter

Researchers have attempted to create more drought-resistant crops by introducing proteins that help protect tardigrades in their dehydrated tun state. The proteins’ ability to stabilize molecular degradation may allow scientists to develop refrigeration-free storage for vaccines, insulin, and blood.

Flowers have been around for 123 million years

Fossilized pollen grains reveal that flowering plants have existed on Earth for 123 million years, and their emergence considerably enriched the planet's biological diversity. They may also have been more widespread than initially thought—prior assumptions were that the eudicots, the first flowering plants, appeared 121 million years ago.

Radioactive elements can introduce software errors because the ionizing radiation they produce can detach electrons from atoms, and computer code relies on the distribution of electrons.

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

English mathematician Ada Lovelace wrote the first computer algorithm a century before computers existed and hypothesized that computing devices would one day be able to compose music—foreseeing the generative AI systems of today.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

See how each of the more than two million known species relates to each other—and to common ancestors—in this zoomable tree of life.

Before humans, the Soviet Union and the United States sent animals—including apes, dogs, and cats—to space during the Space Race.

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

Long before Major League Baseball began allowing instant replay for balls and strikes, an umpire reluctantly used the technology to determine whether a hit was a home run, a move that inadvertently ushered in a new era for the sport.

How fusion—which releases energy when two lighter atoms combine to form a heavier atom—differs from fission

Budweiser stores yeast derived from the original 1800s strain in a secret bunker, which only the Head of Yeast Management can access—not even the CEO

Massive blooms of microscopic plankton called dinoflagellates produce the neon blue light seen in glowing tides.

According to the physics of black holes, our 4D reality may be a hologram—a projection of information coded on a 2D surface on the edge of the universe.

Apeirophobia is an overwhelming fear of living forever, perhaps stemming from the brain's inability to conceptualize an infinite life.

Scientists can determine Earth's past climate conditions by analyzing air trapped in microscopic bubbles within ice cores—columns of compressed snow layers that build up over hundreds of thousands of years.

A researcher recently discovered an interview from 1967 between groundbreaking journalist Joan Didion and the Grateful Dead, years before the band became an institution.

Studies suggest when you sleep is as important as how much you get, and syncing with your circadian rhythms may lead to less fatigue and improved long-term health outcomes

Ebola is a filovirus, meaning it resembles a thread under a microscope, though it sometimes twists and can resemble a bowl of spaghetti.

The word 'jazz' evolved from 'jasm,' 19th-century American slang for 'energy'

The name 'Silicon Valley' arose from the founding of Shockley Semiconductor Laboratory in Fairchild Semiconductor in 1956-57, founded near Stanford University in Palo Alto

'Saturday Night Fever,' the 1977 film that introduced disco to the mainstream, was based on a fabricated magazine story.

Memecoins are a type of cryptocurrency—a form of digital currency with a wide variety of uses—created around popular 'memes,' or viral internet jokes.

Graffiti dates back to at least ancient Pompeii, where citizens scrawled messages to one another on public walls

During the French Revolution, a botanist's letter asking about "dear Rhus" (poison ivy) was intercepted, leading authorities to suspect he was conspiring with the Russians.

Trace how the Bill of Rights, inspired by centuries of political theory, took shape between 1774 and 1789.

Prince's sexually explicit 1984 track 'Darling Nikki' attracted the ire of the Parents Music Resource Center, an advocacy group that inspired the Parental Advisory sticker, even though the song ends with a Christian message.