Robert Koch won the Nobel for his tuberculosis work, but he also pioneered cholera research

The cholera bacteria was first isolated in 1854—but the discovery was largely ignored

The pathogen was isolated by the Italian physician Filippo Pacini in Florence, Italy, though his discovery was largely ignored in favor of the popular miasma—bad air—theory of disease at the time. The pathogen was separately isolated about three decades later by German microbiologist Robert Koch.

In 1892, two scientists purposefully infected themselves with cholera bacteria

When they became ill—one with mild diarrhea and the other with severe cholera—researchers pointed to that as proof that the pathogen caused the disease.

John Snow—not the one from 'Game of Thrones'—determined that contaminated water sickened London

His pioneering epidemiology work during an 1854 cholera outbreak mapped out the commonalities between people in London who were getting sick. He discovered that ill people were getting water from the same Broad Street pump. Before Snow's work, the prevailing theory was that bad air sickened individuals instead of cholera-causing bacteria in the water.

A French Army surgeon discovered that malaria is a parasitic disease in 1880—but scientists were initially skeptical

Charles Louis Alphonse Laveran won the Nobel Prize for his work "on the role played by protozoa" in causing diseases. His work included discovering and reporting the malaria-causing parasite in the blood of a patient suffering from malaria.

Cholera went global thanks to global trade

The first cholera pandemic grew from an outbreak in India, in 1817. Scientists suggest it spread from there throughout the continent and onward to Africa, Russia and Europe through the poop of traders.

Oxford scientists turned Fleming’s mold discovery into medicine

In 1939, a team at Oxford—including Howard Florey, Ernst Chain, and Norman Heatley—revived Fleming’s forgotten discovery. Using makeshift equipment like bedpans and milk churns, they purified enough penicillin to prove it could treat deadly infections.

An overview on germ theory, the crucial framework developed by Louis Pasteur

Germ theory of disease is based on the concept that many diseases are caused by infections with microorganisms, typically only visualized under high magnification. Read this general overview to understand the basic framework which allowed for development of vaccines.

Read more about the backstory on the 2025 Nobel Prize for immune system work

A trio of scientists won the Nobel in Physiology or Medicine that year, but they performed their award-worthy work beginning about two decades before winning the prize. This announcement includes details about the science and notes that the three scientists will equally share the 11 million Swedish kronor (almost $1.2M).

Edward Jenner, the father of vaccinations

The British physician was the first to attempt to inoculate someone from smallpox using its milder cousin, cowpox. His innovations and documentations would prove crucial to the deployment of widespread vaccinations.

Listen to how the 1902 'poison squad' experiments changed food safety in America

As part of government research, a group of young men were paid to eat standard American food—replete with food additives like borax and formaldehyde—which revealed the dangers of unregulated food. The work was led by the first FDA commissioner, Harvey Wiley, who helped end the "century of the great stomachache."

The discovery of the first extremophile and how it revolutionized DNA analysis

While investigating samples taken from within and around the hot springs at Yellowstone National Park, microbiologist Thomas Brock discovered Thermus aquaticus, a microorganism that thrived in hot water. It contained an enzyme called Taq polymerase, a critical molecule in polymerase chain reaction—a molecular photocopier that amplifies genetic signals to improve medical diagnostics.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

Rosalind Franklin’s work led to Nobel Prize-winning discoveries in DNA and virology

Her X-ray diffraction imaging helped uncover the structure of DNA, which earned James Watson, Francis Crick, and Maurice Wilkins a Nobel Prize. The same techniques enabled virus imaging, contributing to Aaron Klug's Nobel Prize in chemistry.

Alfred Nobel invented dynamite and later used his fortune to fund peace prizes

Nobel stabilized dangerous nitroglycerin to create dynamite, revolutionizing construction and mining in the 19th century. Despite his success with explosives, he was deeply disturbed by their destructive potential and redirected his legacy toward rewarding human progress.

Diphtheria was once a leading childhood killer before antibiotics and vaccines

In 18th- and 19th-century outbreaks, some New England families lost as many as eight children to diphtheria, and fatality rates in hospitals often topped 60%. The invention of antitoxins, penicillin, and vaccines dramatically reduced deaths.

Camus contracted tuberculosis as a teenager

There was still little understanding of treatment for the disease at the time; for most people, a tuberculosis diagnosis was a death sentence. The 17-year-old Camus was quarantined in his uncle's house, where he grew into an avid reader. Scholars note that the experience would inform his later work, including his 1947 novel "The Plague."

How the Supreme Court established biotechnology patent law with an oil-eating microbe

While working at General Electric, microbiologist Ananda Chakrabarty engineered a strain of Pseudomonas that could break down multiple types of hydrocarbons and filed a patent on the bioremediation organism. Despite challenges over whether living things could be patented, the 5-4 decision held that genetically modified organisms could be patented because they were human-made inventions.

The history of molecular gastronomy, from thickening yolks with alcohol to making art with food

Before understanding why they worked, humans used scientific principles, including designing solutions and analyzing outcomes, to develop preservation methods like curing meat and fermenting vegetables. By the 20th century, the application of industrialized food preparation to smaller kitchens set the stage for the subdiscipline of food science.

How scientists earned themselves a Nobel Prize by discovering what destroyed ozone

In 1974, chemists Mario Molina and F. Sherwood Rowland showed that chlorofluorocarbons—then used as aerosol propellants, refrigerants, and industrial solvents—rise into the stratosphere and, upon being struck by ultraviolet radiation, release chlorine atoms, which break apart ozone molecules. Their work earned them the Nobel Prize in chemistry in 1995.

Marie Curie pioneered radioactivity research, for which she won two Nobel Prizes

Marie Curie and her husband isolated polonium and radium despite poor lab conditions and financial hardship. President Harding, on behalf of the women of America, presented her with one gram of radium in 1921 in recognition of her service to science.

Before Dawkins, other biologists proposed the power of mutating ideas

Nobel Prize winner Jacques Monod proposed, “Ideas have retained some of the properties of organisms. Like them, they tend to perpetuate their structure and to breed; they too can fuse, recombine, segregate their content; indeed they too can evolve, and in this evolution selection must surely play an important role.”

Before launching his cereal company, John Harvey Kellogg promoted natural food at a sanitarium

Kellogg was the director of the Battle Creek Sanitarium, a health resort in Michigan, where he served patients vegetarian dishes, including early experiments with meat substitutes. Kellogg espoused a philosophy of "Biologic Living," which suggested consuming natural food would lead to "racial hygiene" for white Americans, a tenet of the eugenics movement.

A collective effort from multiple scientists and inventors led to the light bulb

While Thomas Edison's thin carbon filament design made light bulbs commercially viable, prior contributions, such as Joseph Swan's development of the first successful incandescent filament electric lamp, made its eventual invention possible.

Read a history of how oral rehydration solution was created

Experiments dating back to the 1940s eventually led to the creation and standardization of a mixture of sugar, salt, and clean water that is now widely used globally.

Budweiser pioneered refrigerated rail transport for its beer in the 1870s

This enabled Budweiser to achieve national distribution long before competitors, fundamentally transforming the US beer industry. It was also among the earliest large-scale adopters to use pasteurization, allowing it to be shipped long distances without going bad.

The term 'cancer' is 3,000 years old

Around 400 BCE, Hippocrates is said to have named masses of cancerous cells "karkinos"—the Greek word for crab. Science and medical historian Dr. Howard Markel discusses a few hypotheses on why Hippocrates named the disease after a crab and how well cancer was understood in the ancient world.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

In 1915, workers recovered a submarine-like vessel from the Chicago River, prompting fears of German espionage

Three Ebola species are responsible for most large outbreaks of the disease, yet the only approved Ebola vaccine is known to work against just one of them.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

Budweiser stores yeast derived from the original 1800s strain in a secret bunker, which only the Head of Yeast Management can access—not even the CEO

Volcanic activity may have triggered the Black Death by spewing gases that led to crop failures in Europe, thus forcing the import of grain ships with plague-infested fleas.

Against his wishes, Albert Einstein's brain was removed before his cremation, and the pathologist responsible stored it for decades in mason jars within a beer cooler.

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

During the French Revolution, a botanist's letter asking about "dear Rhus" (poison ivy) was intercepted, leading authorities to suspect he was conspiring with the Russians.

Elk Cloner, the first computer virus to spread in public, was written as a practical joke by Richard Skrenta, a Pittsburgh high school student.

Louisiana's 'Cancer Alley' is infamous for having some of the highest industrial pollution, toxic air emissions, and cancer risks in the US.

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

The American cockroach is actually from Africa, an apparent hitchhiker aboard ships carrying enslaved people, with evidence suggesting the bug may have arrived in the New World as early as the 1600s.

The term 'algorithm' originated from the Latinized name of al-Khwārizmī, a 9th-century mathematician whose works introduced Arabic numerals and the decimal-based numeral system to Europe and whose treatise 'Al-Jabr' gave algebra its name.

The first robot in literature may have been a 'mechanical man' in 1907's 'Ozma of Oz,' a book in L Frank Baum's 'Wizard of Oz' series.

Coral reefs get their colors from zooxanthellae—microorganisms that line corals' digestive tracts and provide them with sugars in exchange for a home within this protective tissue.

Before writing 'Walden,' transcendentalist Henry David Thoreau nearly burned down his hometown with a campfire that grew out of control.

SpongeBob exemplifies Aristotle's philosophy for living well because he understands that happiness doesn't come from external factors like money, recognition, or power.

Double world record holder Hunter Ewen helped conquer his fear of balloons, called globophobia, by training to win Guinness World Record titles for balloon inflation.

Mid-century modern graphic designers, known for their bright colors and bold lines in advertising, also found success with children's books.

The US first hosted the World Cup in 1994, a tournament that lives in soccer infamy for its poor planning and the murder of Colombian player Andres Escobar, who'd accidentally scored on his own net.

Pure water does not conduct electricity because this flow of energy requires the movement of charged particles, and water is a neutral molecule.

'Grand Canyon of the Yellowstone,' a work by American painter Thomas Moran, inspired Congress to establish Yellowstone National Park.