How a government chemist founded the FDA—by poisoning people

Listen to how the 1902 'poison squad' experiments changed food safety in America

As part of government research, a group of young men were paid to eat standard American food—replete with food additives like borax and formaldehyde—which revealed the dangers of unregulated food. The work was led by the first FDA commissioner, Harvey Wiley, who helped end the "century of the great stomachache."

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

Teddy Roosevelt was given a daily dose of saccharin

America's 26th president was prescribed a sugar-free diet by his clinician, so when the chief chemist for the US Department of Agriculture approached him with concerns about the product's safety in the early 1900s, the duo clashed over how to regulate it.

Who was behind the fatal 1982 Tylenol poisonings?

In 1982, an unknown suspect laced Tylenol packages with potassium cyanide in a Chicago pharmacy. Seven people were killed, and the case led to a nationwide panic, as well as the development of tamper-resistant packaging. No one was ever charged with the deaths, and the lead suspect died in 2023 after serving time in prison for trying to extort $1 million from a manufacturer to "stop the killing."

Reporting if supplements make you ill helps FDA know what products to investigate

The US Food and Drug Administration regulates supplements like foods and can only take action about a supplement if they learn that there are problems with it after it's on the market. This website allows consumers, industry, and others to file a complaint about a product that made them ill or raised other concerns.

See how DOJ prosecutors took down a pharmaceutical company's executives over the opioid crisis

This FRONTLINE documentary follows federal prosecutors as they used anti-racketeering laws to convict executives at Insys Therapeutics, a pharmaceutical company that bribed doctors to overprescribe a fentanyl painkiller.

Food poisoning investigations have led to more than 1 billion pounds of food recalls

PulseNet is the US government’s real-time foodborne illness tracking system for leading causes of food poisoning. There, a network of labs and scientists share DNA sequences for pathogens collected from contaminated food and also from sickened individuals, looking for patterns in the pathogens’ genome sequences that will help them hopefully finger a certain food, warehouse, producer, or restaurant.

How a single company hooked the world on herbicides

How harmful are today’s herbicides for us humans, and for the environments they’re seeping into? And do we really need weedkillers to feed the world?

Explore the history of antibiotics with 'This Podcast Will Kill You'

The show blends medical history with storytelling and science. In Episode 50, the hosts trace the dramatic origins of antibiotics—from Fleming’s moldy petri dish to Florey’s wartime labs—and explore their lasting impact on health.

Monsanto got its start in the early 1900s producing saccharin

The company was originally called Monsanto Chemical Works and was founded in 1901 by John Francis Queeny who was then a wholesale drug buyer. He named the company Monsanto for his wife's maiden name. At first, the company began producing saccharin with borrowed equipment and secondhand machines, aiming to produce domestically what was then being imported from Germany. (Some users may encounter a paywall.)

The history of chemistry, from alchemists to probing atoms before World War I

Those involved in the predecessor of the modern scientific discipline engaged in experimentation to develop recipes that would transform ordinary matter into gold and to create medicines, cosmetics, dyes, and alloys. Over the course of centuries, scientists identified unique elements, organized them based on their properties in the periodic table, and eventually developed the technology to discover the internal structure of atoms.

The lack of guidance on getting off GLP-1s leaves patients at risk

Dr. David Kessler, former FDA Commissioner and public health leader, explores how these drugs override the brain’s reward-driven eating habits but have notable side effects. These include developing eating disorders, muscle loss, and intestinal obstruction.

Revelations that apples were sprayed with the chemical Alar led to its ban in the 1980s

Almost three decades after Rachel Carson’s “Silent Spring,” a “60 Minutes” segment on the use of Alar, a chemical sprayed on apples, drew national attention and inspired supermarkets and schools to remove apples from their shelves and cafeterias. That same year, the Environmental Protection Agency took action against the use of the chemical in food.

'Last Week Tonight' explores the risks of forever chemicals (warning: language)

Per- and polyfluoroalkyl substances (PFAS) are a group of man-made chemicals used in a wide range of products due to their unique properties. However, because they can persist in the body and environment for thousands of years, they’ve earned the moniker “forever chemicals”—and have been linked with numerous health risks.

The CIA tried to poison Castro’s milkshake

During the Cold War, the CIA engaged in a series of "creative" attempts to assassinate Cuban leader Fidel Castro—including poisoning his daily chocolate milkshake with botulinum toxins. It was not successful.

Dr. Bernard Fisher pioneered lumpectomy as a treatment for breast cancer

Dr. Bernard Fisher was a surgeon-scientist who developed and discovered cancer treatments that changed the way we treat and understand breast cancer. Despite these contributions, Fisher was also the subject of a congressional investigation that tarnished his reputation. Listen to the "Less Radical" six-episode podcast series covering the complex story of this influential doctor.

The Office of Chemical Safety and Pollution Prevention regulates toxic substances

This office evaluates and manages risks from industrial chemicals and pesticides. It reviews new chemicals before they enter the market, restricts hazardous substances, and promotes safer alternatives to protect human health and the environment.

The story of the Radium Girls, who exposed the dangers of radioactive paint

After radium was discovered in 1898, companies began using radium-based paints on watch and clock dials to create a glow-in-the-dark effect. Women who worked to apply the paint were encouraged to use their lips and tongues to help create the fine point needed to draw small numbers, unknowingly poisoning themselves.

A fake vaccine campaign was used to locate Osama bin Laden, fueling vaccine distrust

As part of the intelligence operation to find bin Laden in Pakistan, the US Central Intelligence Agency recruited a Pakistani doctor who ran a fake hepatitis B vaccine campaign and obtained DNA samples from bin Laden. News of this fake campaign fueled further distrust of healthcare workers, attacks on them, and stymied efforts to vaccinate against polio in the region.

During the French Revolution, a botanist's letter asking about "dear Rhus" (poison ivy) was intercepted and led to authorities' suspicions he was conspiring with the Russians

The 1794 incident involved André-Ignace-Joseph Dufresnoy, a French army physician researching the plants' potential medicinal properties. Rhus radicans is a scientific name for the plant, though it's commonly called Toxicodendron radicans.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

During the French Revolution, a botanist's letter asking about "dear Rhus" (poison ivy) was intercepted, leading authorities to suspect he was conspiring with the Russians.

'Most of man's problems upon this planet, in the long history of the race, have been met and solved either partially or as a whole by experiment based on common sense and carried out with courage.'

-Frances Perkins (1880-1965), first female member of US Cabinet

Coca-Cola was created during a patent medicine boom

A "patent medicine" is a proprietary medicine that is ostensibly created and marketed under a patent, and, crucially, is available without prescription.

Learn more about the history of fireworks, which dates back to an accidental invention during an alchemist's quest for information about immortality.

The federal agents who followed Billie Holiday

After the success of "Strange Fruit," the Federal Bureau of Narcotics began surveilling Holiday on suspicion that she was using heroin. Jimmy Fletcher, an agent tasked with following her to clubs and parties, later said that they became quite close. "She was the type who would make anyone sympathetic because she was the loving type," he was reported as saying.

‘The Substance’ is a great food film

"The Substance" has received numerous accolades, including five Academy Award nominations, for its satirical horror story about celebrity. This writer argues that it's also one of the best food movies in recent memory.

Richard Feynman exposed NASA's safety failures on the Rogers Commission

The Nobel Laureate served on the Rogers Commission investigating Challenger, famously demonstrating O-ring failure with ice water and eventually criticizing NASA's culture of risk normalization and management pressure in the final report.

Advertising powerhouse Mary Wells Lawrence was the first female CEO of a public company listed on the NYSE

The TV show “Mad Men’s” character Peggy Olson is inspired by Wells Lawrence, who founded ad agency Wells Rich Greene in 1966. Wells Lawrence is also known for her famous Alka-Seltzer campaign slogan, “plop plop fizz fizz.”

US intelligence allegedly pursued more than 600 schemes to assassinate Cuban revolutionary Fidel Castro.

After her fellow cult members tried to kill her with an LSD-infused hamburger, one member of the Manson Family, the murderous cult led by Charles Manson, decided to testify against the group's leader.

When a Paris department store hesitated to sell Estée Lauder's perfume, she 'accidentally' broke a bottle, causing the smell to spread throughout the store and shoppers to start asking to buy the scent.

The use of fungi to detoxify land and water—a process known as mycoremediation—has been used to clean up natural resources affected by the 2025 California wildfires.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

See a ranking of the best (and worst) Federal Reserve Chairs since 1914 out of the 16 men and women who have held the office since.

The Dracula character, now seen as the vampire archetype, was inspired by a seafood-induced nightmare its creator experienced.

The story of Dollree Mapp, whose legal challenge over her 1957 conviction for possessing "obscene material" led to a major strengthening of the Fourth Amendment

In 1915, workers recovered a submarine-like vessel from the Chicago River, prompting fears of German espionage

Jimmy Carter signed a 1978 bill that legalized home brewing, a move credited with kick-starting the craft beer industry.

Louisiana's 'Cancer Alley' is infamous for having some of the highest industrial pollution, toxic air emissions, and cancer risks in the US.

How the most famous Ebola book, The Hot Zone, which sold 3.5 million copies and was translated into 30 languages, got aspects of the disease so wrong.

Many legends about George Washington, including his supposed wooden teeth and the story of cutting down the cherry tree, lack evidence.

Mark Twain spent decades feuding with the US Postal Service, convinced its costs and regulations were bureaucratic overreach.

Discover the catastrophic consequences of a failure of the US electrical grid—something that is more likely than many Americans think.

In 2025, four executives from large tech companies were given positions in the US Army Reserves—including Palantir Chief Technology Officer Shyam Sankar, which reinforced Palantir's ties with the US military and its role as a leading defense partner.

Double world record holder Hunter Ewen helped conquer his fear of balloons, called globophobia, by training to win Guinness World Record titles for balloon inflation.

Legendary architect Frank Lloyd Wright designed the SC Johnson headquarters in Wisconsin, aiming to make a cathedral-like workplace

Pure water does not conduct electricity because this flow of energy requires the movement of charged particles, and water is a neutral molecule.

Netflix profits when you're not watching, and its movies are designed that way—read a detail-rich critical essay exposing lesser-known Netflix takes

Gerrymandering works through two techniques: cracking opposing voters across districts to dilute their power, and packing them into a few to waste their votes in lopsided majorities.