Monsanto got its start in the early 1900s producing saccharin

Saccharin was widely used in WWI when sugar was rationed

The substance was discovered by chemists in 1878, but its use became more common during World War I and also afterward as a result of sugar rationing. It had become a typical household item in the US and Europe by 1917. During World War II, the artificial sweetener again saw significant popularity.

The pharmaceutical industry evolved, in part, from the discovery of synthetic dyes

In 1856, a chemist accidentally discovered mauveine, the world’s first synthetic dye, while trying to make quinine to treat malaria. The synthetic dyes that followed helped reveal germs under microscopes, paving the way for modern imaging techniques and breakthrough treatments, such as antibiotics.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

Listen to how the 1902 'poison squad' experiments changed food safety in America

As part of government research, a group of young men were paid to eat standard American food—replete with food additives like borax and formaldehyde—which revealed the dangers of unregulated food. The work was led by the first FDA commissioner, Harvey Wiley, who helped end the "century of the great stomachache."

How a single company hooked the world on herbicides

How harmful are today’s herbicides for us humans, and for the environments they’re seeping into? And do we really need weedkillers to feed the world?

A moldy cantaloupe supercharged penicillin production

In 1943, a moldy cantaloupe found at a market in Peoria, Illinois, yielded a strain that produced six times more penicillin. Though often credited to lab worker “Moldy Mary” Hunt, accounts differ on who actually brought in the fruit.

A New York farmer established the first cheese factory and revolutionized the industry

Jesse Williams, a farmer in New York state, had a passion for cheese but didn’t have the resources to produce it at the scale he desired. So, in 1851, Jesse and his son opened the first cheese factory, sourcing milk from multiple local farms and producing 100,000 pounds of cheddar—in their first season. Soon, Williams had hundreds of factories and created the prototype for cheesemaking as we know it today.

The word ‘coupon’ comes from a French word meaning ‘to cut’

The history of coupons starts in the US with the Coca-Cola coupon that was mailed to consumers, offering them a chance to come try the soda for free in a nearby pharmacy. A coupon created by cereal company Post is one of the earliest widely cited follow-ups—it offered a penny off a box of Grape Nuts in 1909.

Cyrus McCormick invented the mechanical reaper—and a territory-based sales force

In the 1830s, farmers were skeptical of new technology, so McCormick demonstrated the machine—described as a cross between a plow, a chariot, and a flying object—to prospective buyers. Long before modern sales norms existed, he divided the market into territories operated by agents who provided service on the machines, financing to expand the customer base, and product iteration based on feedback from regional agents.

The story of the Sackler empire behind highly addictive OxyContin

This investigative report examines how the Sackler family built its fortune through Purdue Pharma’s aggressive marketing of OxyContin, a highly addictive painkiller. Through 2017, the drug had generated more than $30B in sales for Purdue Pharma, controlled by the Sacklers.

An antiperspirant ad campaign in the early 1900s dubbed body odor "B.O."

The product was marketed toward women and framed excessive sweating as a medical disorder that needed to be addressed with the product.

Natural food stores began sprouting up in the US in the 1960s and 1970s

Health food stores began opening in the ‘50s, though they were primarily focused on vitamins and holistic supplements. Natural food stores, however, provided pesticide-free produce and often relied on local farmers for their products. One of the first was New Age Natural Foods, in San Francisco’s Haight-Ashbury neighborhood, which opened in 1965.

There’s some confusion over who founded the Bavarian Brewery that later became Budweiser

While many traditional histories credit German immigrant George Schneider with founding the Bavarian Brewery in 1852, an investigation from St. Louis Magazine found that it was actually started in 1857 by a fascinating German physician named Dr. Adam Hammer.

Monosodium glutamate is a sodium salt form of a naturally occurring amino acid

Monosodium glutamate myths originate from a 1968 letter to the New England Journal of Medicine, in which unpleasant symptoms after eating Chinese food were dubbed Chinese restaurant syndrome without medical data. Subsequent studies show this savory flavor enhancer—found in tomatoes, mushrooms, and other foods—is safe in moderation.

Jane Maas was one of the first prominent female ad executives on Madison Avenue

Jane Maas started as a copywriter at the advertising agency Ogilvy & Mather in 1964. She’s known for working on the famous "I Heart NY" tourism campaign alongside artist Milton Glaser. This interview provides a glimpse into what life was like for women like her on Madison Avenue.

Budweiser stores yeast derived from the original 1800s strain in a secret bunker, which only the Head of Yeast Management can access—not even the CEO

Mister Softee started as two brothers in a Chevy van

The company began on St. Patrick's Day in 1956, when James and William Conway made their way across Philadelphia, selling green-hued ice cream. They weren't the first to sell ice cream from a truck, but they perfected it—thanks to the know-how they acquired working for the Sweden Freezer Manufacturing Company.

The unexpected origin story of the snow globe

In 1900, a Vienna tradesman named Erwin Perzy I was attempting to invent an inexpensive way to improve light amplification in hospital operating rooms. After experimenting with a glass globe filled with water, the idea for the snow globe struck. Industrious as well as inventive, Perzy eventually turned his idea into a successful business. Read the full article to learn how the invention grew to become recognized globally.

Explore a Macy's historical timeline

From its founding as RH Macy & Co. in 1858, to its 150th birthday in 2008, Macy’s has a long and storied history. Luckily, the store has chronicled many of its major milestones on its website, including key Macy’s Thanksgiving Day Parade milestones.

'The Great Onion Corner:' Hear how short-selling onions ended with a ban on onion futures

In the early 1950s, onion farmer and produce trader Vince Kosuga cornered the onion market, resulting in a 1958 ban on onion futures from Congress. After stockpiling onions and buying onion futures, Kosuga then began shorting them. Then, he released his accumulated surplus of onions, driving the price down to essentially zero, and cashed in his short positions.

A look inside one of Napa Valley's oldest wineries

Prussian migrant Charles Krug established a winery in Napa Valley in 1861, pioneering the growth of European rootstocks and helping legitimize the region's wine-making ambitions. Today, the estate is owned and operated by the Mondavi family, who purchased it in 1943 and helped elevate it to international renown. A dramatic, brief look at the winery illuminates its legendary past and larger-than-life present.

Monopoly was based on the satirical Landlord's Game, which criticized the abilities Monopoly rewarded.

Tiny solar-powered tags can now track monarch butterflies across North America

Monarch tracking began in 1935, utilizing low-tech methods to gain a better understanding of migration patterns as monarchs travel to central Mexico during the winter. Each tag weighs 60 milligrams and can be tracked via an app to provide insights into butterfly life cycles.

Richard Cadbury invented the heart-shaped chocolate box in 1868

Richard's father, John Cadbury, founded the Cadbury Brothers chocolate company (now known simply as Cadbury) in 1824. Richard recognized the popularity of ornamental designs (especially for Valentine's Day gifts) and designed the heart-shaped box for the company's chocolates, which became a staple of the holiday.

The name 'Silicon Valley' arose from the founding of Shockley Semiconductor Laboratory in Fairchild Semiconductor in 1956-57, founded near Stanford University in Palo Alto

Superman first appeared in 1938

The Man of Steel debuted in the first issue of "Action Comics." The original cover price was 10 cents. In 2024, a copy of the comic sold at auction for $6M.

Standard Oil used vertical integration to create an empire

“Vertical integration” is a modern business phrase that refers to a company taking on multiple stages of production—but John D. Rockefeller pioneered it with his Standard Oil company, employing its own plumbers and handling its own oil transportation.

There's a myth that Al Capone coined the term 'money laundering'

Al Capone owned multiple dry cleaning businesses in Chicago that were believed to be a front for his extensive bootlegging empire, but that's most likely not where the term "money laundering" actually came from. The word didn't appear in popular lexicon until the 1970s, and there aren't recorded references to Al Capone as a money launderer until much later.

Learn more about the history of fireworks, which dates back to an accidental invention during an alchemist's quest for information about immortality.

Sears sold DIY house kits starting at $600 in its famous catalog from 1908 through the 1940s, resulting in roughly 10,000 'Sears and Roebuck houses' being built.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

Poison ivy was sent to Europe in the 1600s as an exotic, ornamental oddity, where it was purposefully grown in the English royal gardens at Kew, the Faculty of Medicine in Paris, and a few other locations.

The most expensive ad of all time was for Chanel No. 5 perfume and cost roughly $33M to produce in 2004—about $57M in today's dollars.

Legendary architect Frank Lloyd Wright designed the SC Johnson headquarters in Wisconsin, aiming to make a cathedral-like workplace

After the Boston Tea Party, colonists switched to coffee, which became the main morning drink for revolutionaries.

Sunflowers have long been a symbol of nuclear disarmament because they can extract large amounts of radioactive cesium from soil.

Mark Twain spent decades feuding with the US Postal Service, convinced its costs and regulations were bureaucratic overreach.

The first horror movie is believed to be George Méliès' 1986 short 'The Haunted Castle,' which pioneered the use of special effects

Mid-century modern graphic designers, known for their bright colors and bold lines in advertising, also found success with children's books.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

The Brothers Grimm were lawyers before they were storytellers, and became interested in fairy tales as they began investigating how rules and customs had been passed down through cultures.

SpaceX's S-1 or 'prospectus' revealed many previously unknown details about the company, including its unprofitability despite doing $18.7B in revenue in 2025, exactly how many voting shares Elon Musk will have in the company (roughly 85%), and more.

Quincy Jones' 'Big Band Bossa Nova' helped introduce bossa nova—a jazz-influenced Brazilian genre—to the US

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

Louisiana's 'Cancer Alley' is infamous for having some of the highest industrial pollution, toxic air emissions, and cancer risks in the US.

The US first hosted the World Cup in 1994, a tournament that lives in soccer infamy for its poor planning and the murder of Colombian player Andres Escobar, who'd accidentally scored on his own net.

Domino's Pizza's 30-minute delivery guarantee was responsible for the chain's 1980s surge, but it was discontinued after the company was found liable for delivery driver accidents.

Warren Buffett's former professor Benjamin Graham is known as the 'father of value investing,' a strategy in which investors seek to buy stocks trading below their intrinsic worth.

The term 'algorithm' originated from the Latinized name of al-Khwārizmī, a 9th-century mathematician whose works introduced Arabic numerals and the decimal-based numeral system to Europe and whose treatise 'Al-Jabr' gave algebra its name.

While atoms are normally made of protons, neutrons, and electrons, exotic ones have been built with antimatter—alternate versions of normal matter that live for fractions of a second and are about a billion times as rare.