Monosodium glutamate is a sodium salt form of a naturally occurring amino acid

MSG was first isolated from seaweed in Japan in 1908

The compound monosodium glutamate has been identified in dairy, meats and vegetables, and provides an "umami"—Japanese for "tasty"—flavor to food. Studies in the late 1960s characterized MSG as harmful, but only when testing doses hundreds of times greater than what would be consumed in a typical diet.

Umami synergy—combining glutamates and nucleotides—can amplify a meal

While glutamates are known for triggering the umami taste through specific taste receptors, nucleotides like IMP and GMP can bind alongside glutamates to enhance the receptor's response. This union explains why certain classic food combinations like bacon and eggs taste exceptionally savory.

Ammonium may be the sixth basic taste

Researchers have proposed various candidates for the sixth official taste, including "fat." But research published in 2023 posits that ammonium should be considered the sixth taste since they found humans can apparently detect ammonium chloride, which the scientists describe as "bitter, salty, and a little sour." Detecting ammonia could be a survival mechanism to help detect when certain foods, including seafood, are no longer safe to eat. The work hinged on experiments with human cells exposed to ammonium chloride as well as rodent research.

GMOs sound scary, but you eat them every day

Why are GMOs bad? They aren’t. We’ve been eating them for decades with no ill effects, which makes sense, because a genetically modified organism is simply an organism, like every other organism, produces hundreds of thousands of proteins, but one or two of them are proteins that were chosen specifically by humans. Watch this 11-minute video for more.

Michael Sveda discovered cyclamate by accident

When this lab researcher brought his hands to his lips to smoke his cigarette in 1937, he tasted something sweet, which he called cyclamate. It was quickly used in diet sodas, but it was banned from the US in 1969 after being linked to rodent bladder cancer in lab experiments.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

Artificial sweeteners are considered safe for most people

These sugar substitutes are generally preferred because they are sweeter than sugar and can be used in smaller amounts while still getting a sugary taste. Though generally regarded as safe, sugar substitutes can cause flare-ups for individuals with bowel disease, and researchers are investigating how these substances affect gut microbiome health. Aspartame can also cause health issues for individuals with a rare genetic disease called phenylketonuria.

The five most common chemicals found in modern food

Most modern processed foods rely on a number of preservatives to stay fresh from production to our plates. The most common include citric acid (preservative and flavor), sodium benzoate (preservative), xanthan gum (thickening and stabilizing), carrageenan (thickening), and red dyes 3 and 4 (for color).

LSD's molecular structure closely resembles the neurotransmitter serotonin

Lysergic acid diethylamide (C20H25N3O) is a colorless, odorless, and flavorless chemical compound that can induce altered perception, mood, and cognition. One of its roles in the brain is as a serotonin agonist, meaning it enters serotonin receptors and triggers a fraction of the response the neurotransmitter would typically warrant.

Acrylamide forms naturally during high-heat cooking through the Maillard reaction

While studies have shown it can damage DNA and potentially cause cancer in mice, humans absorb and metabolize acrylamide at different rates, introducing uncertainty in the research's applicability to humans. Some international health agencies have nonetheless recommended avoiding darker roasts when cooking starchy foods.

Read a deep dive on the 'all-purpose healing' peptide BPC-157

The unapproved peptide—which has received glowing testimonials from bodybuilders, biohackers, popular podcasters, and some in the MAHA movement— is often sourced from China. It has been used for myriad conditions. But scientific questions about the substance abound, including whether it's truly a natural substance produced by the human body, since genetic material that codes for its unique amino acid sequence hasn't been found in the human genome or the gut microbiome. Other unknowns include how it works in the body, which receptors it targets, and its safety, since evidence beyond anecdotes remains scant in humans.

GLP-1 drugs, first used to manage diabetes, were derived from Gila monster saliva

Scientists studying the barely-there feeding frequency of the Gila monster found its saliva had a hormone regulating blood sugar and appetite. Further research revealed this hormone resembled a human one known as GLP-1, giving rise to the modern wave of diabetes and weight-management drugs.

Neural replays in mice help explain food aversions

Princeton University scientists published research in 2025 analyzing how mice learn to associate certain foods or flavors with feeling ill—even when there’s a time gap between eating something and feeling sick. The work, performed with grape Kool-Aid and injections of a substance that made mice sick, traced the literal “gut reaction” of how gut distress signals are linked to neural replays of what the mouse ate.

Food allergies were first documented more than 4,000 years ago

Although food allergies are on the rise in modern times, they have been documented in written records for thousands of years. More than 3,000 years ago, Chinese emperors advised patients to avoid certain foods, and Hippocrates noted in his work that food could cause serious harm to certain individuals, and even lead to death.

Explaining why salt should be used to season food early in the cooking process

Experiments involving the same dishes, with salt added at the start of cooking versus at the end, have been shown to yield drastically different taste outcomes because salt takes time to diffuse into foods, particularly vegetables, whose cells are surrounded by cellular membranes and walls. Salting at the end will produce a concentrated surface coating, rather than even seasoning.

Tick bites can fuel an allergy to a sugar molecule in red meat

Alpha-gal syndrome is on the rise globally as ticks spread due to climate shifts. Bites from some ticks can trigger a sensitivity to a sugar molecule called alpha-gal found in mammal meat, which can lead to allergic responses to hamburgers and steak, among other products. Listen to an expert’s tips for avoiding this allergy, including quickly removing any ticks to limit exposure to their saliva or vomit.

Ketchup, 101

Ketchup is a tomato-based condiment mixed with vinegar, salt, and spices. The word likely originates from Southeast Asia, where it was used for a common fish brine sauce in the 18th century. For a brief period in the early 19th century, ketchup was viewed and marketed as a medicine. Henry John Heinz formulated a standard recipe in the late 1800s.

Eating too much salt can worsen vertigo

High salt intake can cause fluid retention in the inner ear, worsening vertigo. Slashing sodium amounts (and caffeine and alcohol consumption) are particularly recommended for those suffering from Ménière's disease to help stabilize inner ear fluid levels.

'Tomato flu' outbreak in India turned out to be HFMD

An illness initially dubbed "tomato flu" in 2022 that sickened children in Kerala, India, with symptoms typical of hand, foot, and mouth disease turned out to be that—not a new ailment. A letter published in the prestigious journal The Lancet had initially described the illness as "a new virus" but at least some of the children ultimately tested positive for one of the viruses that causes HFMD, so it wasn't a new condition after all. (Some users may encounter a paywall.)

It seems like we shouldn’t have to say this: Cheese is not like crack

While news reports may claim cheese is addictive, the facts behind the research show cheese and crack have little in common. It appears that highly processed foods with high levels of sugars and fat, rather than cheese specifically, are most closely associated with addictive-like behaviors. In fact, cheese ranked lower than foods like pizza, chocolate, and fries in terms of its addictiveness.

Watermelons were once neither red nor sweet

The gargantuan summer picnic staple has a fascinating story: 100 million tons are produced worldwide and they take up the most space of any vegetable crop in the world. But not long ago, the flesh of the melon was white and it had a bitter taste.

Rome's herbal panacea may not be as extinct as we thought

Silphion: cure-all, aphrodisiac, birth control, tasty seasoning. Nero allegedly ate the last of this miracle plant. This article details how a researcher may have found more. Seven centuries after the yellow-flowered plant was first documented growing in what's now Libya, it vanished. Historians proposed that the loss of Silphion may have been the first recorded extinction of any species.

No one's sure why it's spelled 'sundae'

There are several different folktales explaining the origins of the popular ice cream dish and its curious name. One claims an enterprising pharmacy used chocolate syrup instead of soda, which was banned on Sundays. Another claims the dish's unique spelling was to avoid offending religious folks who might object to an unholy reference to the Sabbath.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

The Great Salt Lake's distinct dual coloration results from high-salinity organisms that only live in the northern portion and produce a purple protein.

Reporting if supplements make you ill helps FDA know what products to investigate

The US Food and Drug Administration regulates supplements like foods and can only take action about a supplement if they learn that there are problems with it after it's on the market. This website allows consumers, industry, and others to file a complaint about a product that made them ill or raised other concerns.

The Great Salt Lake's distinct dual coloration results from high-salinity organisms that only live in the northern portion and produce a purple protein.

American medical organizations rescind recognition of diagnosis cited in police custody deaths

American medical organizations have rescinded their recognition of a syndrome whose theory stemmed from discredited research. This article explores the history and implications of "excited delirium syndrome," a medical condition that can reportedly...

'Shogun,' a 1980s TV series, helped popularize sushi in the US by stimulating an American interest in Japanese culture.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

After her fellow cult members tried to kill her with an LSD-infused hamburger, one member of the Manson Family, the murderous cult led by Charles Manson, decided to testify against the group's leader.

While atoms are normally made of protons, neutrons, and electrons, exotic ones have been built with antimatter—alternate versions of normal matter that live for fractions of a second and are about a billion times as rare.

Lesser-known phobias include turophobia, or the fear of cheese, and nomophobia, the fear of being without your cell phone.

Poison ivy is in the same family as mangoes, cashews, and pistachios—and they all produce oily urushiol in their raw, unprocessed state—but they are typically prepared in ways to avoid causing human discomfort.

Sunflowers have long been a symbol of nuclear disarmament because they can extract large amounts of radioactive cesium from soil.

The Dracula character, now seen as the vampire archetype, was inspired by a seafood-induced nightmare its creator experienced.

NBA superstar Victor Wembanyama spent the 2025 summer training with monks in central China to enhance his body and mind.

Graffiti dates back to at least ancient Pompeii, where citizens scrawled messages to one another on public walls

Memecoins are a type of cryptocurrency—a form of digital currency with a wide variety of uses—created around popular 'memes,' or viral internet jokes.

Domino's Pizza's 30-minute delivery guarantee was responsible for the chain's 1980s surge, but it was discontinued after the company was found liable for delivery driver accidents.

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

Human-to-human transmission of hantavirus remains extremely rare, so the 2026 hantavirus cruise ship outbreak doesn't mean we're facing a COVID-style pandemic risk.

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

The word 'jazz' evolved from 'jasm,' 19th-century American slang for 'energy'

A small portion of The Winstons' 'Amen, Brother,' an obscure '60s gospel record, is the basis for thousands of hip-hop tracks, making it one of the most sampled records ever that's informally known as 'the Amen break.'

See this overview of the firework rules across all 50 states, ranging from a complete ban on non-professional fireworks in Massachusetts to states with more lax rules like Indiana.

A pickleball's loud 'pop' sound can reach 120 decibels, which is equivalent to a hammer hitting a nail

The Nasdaq's 'Magnificent 7' companies are responsible for roughly 40% of the Nasdaq 100 index's gains, while the remaining 93 companies account for the other 60%.

El Niño, Spanish for 'the boy,' was named after Jesus Christ because the phenomenon resembled the weather changes observed around Christmastime.