MSG was first isolated from seaweed in Japan in 1908

Monosodium glutamate is a sodium salt form of a naturally occurring amino acid

Monosodium glutamate myths originate from a 1968 letter to the New England Journal of Medicine, in which unpleasant symptoms after eating Chinese food were dubbed Chinese restaurant syndrome without medical data. Subsequent studies show this savory flavor enhancer—found in tomatoes, mushrooms, and other foods—is safe in moderation.

How science came to understand umami

Before Dr. Kikunae Ikeda sat down in 1907 and pondered the taste of dashi, scientists typically agreed upon four types of taste: sweet, salty, bitter, and sour. He boiled 90 pounds of kelp into a resin that he then stripped of different compounds until he was left with a single ounce of brown crystals. Testing later revealed these crystals were glutamate, an amino acid and one of the protein's building blocks.

Umami synergy—combining glutamates and nucleotides—can amplify a meal

While glutamates are known for triggering the umami taste through specific taste receptors, nucleotides like IMP and GMP can bind alongside glutamates to enhance the receptor's response. This union explains why certain classic food combinations like bacon and eggs taste exceptionally savory.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

Aspartame was a surprise discovery from a lab working on gastric ulcers

As with saccharin and cyclamate, the aspartame discovery arose from its discoverer tasting something sweet from his workplace. In 1965, American chemist James Schlatter licked a white powder off his finger as he picked up a piece of paper and was startled to discover it tasted sweet. He applied for a patent for the substance, and received it in 1970. It is now one of the most popular artificial sweeteners. (Some users may experience a paywall.)

Norway is responsible for salmon sushi

Japanese sushi did not include salmon until the mid-1990s because Pacific salmon was known to contain parasites. Norway, meanwhile, had an abundance of Atlantic salmon, which was safe to eat raw. The country smelled an opportunity and launched Project Japan, which successfully convinced the country that Atlantic salmon was safe to include in its cuisine.

Globalization is increasing the demand for cheese

The increased popularity of Western cuisine has affected the cheese market in historically cheese-averse regions like East Asia. Japan has gotten particularly excited about exploring what cheese has to offer, with festivals and creative fusion dishes featuring the versatile ingredient.

Mycotoxins are toxic compounds produced by fungi—some show up in food

About a quarter of the world’s agricultural products are contaminated with mycotoxins. Some of these compounds can cause serious health problems, including cancer, so the US government has set up monitoring programs to detect them in our food and in animal feed. Humans can become ill if they eat contaminated food, but also if they ingest products from animals that had previously consumed these toxic compounds, such as milk from a cow that ate contaminated corn.

Neural replays in mice help explain food aversions

Princeton University scientists published research in 2025 analyzing how mice learn to associate certain foods or flavors with feeling ill—even when there’s a time gap between eating something and feeling sick. The work, performed with grape Kool-Aid and injections of a substance that made mice sick, traced the literal “gut reaction” of how gut distress signals are linked to neural replays of what the mouse ate.

LSD was derived from natural compounds produced by the ergot fungus

Ergot is a fungus that slowly infects and replaces individual grains on grasses, including rye and wheat. Ingesting ergot can cause ergotism, a form of poisoning with symptoms—including headaches, hallucinations, gangrene, and convulsions—varying by season and geography. This grain was used for medicinal purposes as early as the 1500s.

What exactly is a GMO?

A GMO, or genetically modified organism, is an organism whose DNA has been altered for specific improvement such as longer shelf life, disease resistance, or enhanced nutrition—which can benefit both farmers and consumers. While humans have used...

'Shogun,' a 1980s TV series, helped popularize sushi in the US by stimulating an American interest in Japanese culture.

The five most common chemicals found in modern food

Most modern processed foods rely on a number of preservatives to stay fresh from production to our plates. The most common include citric acid (preservative and flavor), sodium benzoate (preservative), xanthan gum (thickening and stabilizing), carrageenan (thickening), and red dyes 3 and 4 (for color).

The 'definitive' history of magic mushrooms

Where did magic mushrooms come from, and how did they get their magical reputation? This article explains the history of the psychedelic fungi from pre-history to now. The earliest concrete evidence of psychedelic mushroom use is 12,000-year-old murals in Northern Australia that portray mushroom iconography. Considering how many species seek out and consume psychoactive substances, such as Siberian reindeer, it's possible human use of these psychedelic mushrooms may predate these murals.

Feeding grazing cattle seaweed cut their methane emissions by almost 40%

The largest share of the 12% of global greenhouse gas emissions from livestock comes from methane released when cows burp. A study found that introducing a seaweed supplement in pellet form significantly reduced these emissions without affecting cattle's health or weight.

Food allergies were first documented more than 4,000 years ago

Although food allergies are on the rise in modern times, they have been documented in written records for thousands of years. More than 3,000 years ago, Chinese emperors advised patients to avoid certain foods, and Hippocrates noted in his work that food could cause serious harm to certain individuals, and even lead to death.

Japanese scientists develop an eco-friendly plastic that dissolves in saltwater

The strong and flexible plastic is made from molecules held together by saltwater-sensitive chemical bonds. The components left after the plastic breaks down within hours contain phosphorus and nitrogen, allowing them to serve as soil fertilizer.

Merck developed MDMA in the early 1900s as part of its effort to create a blood clotting drug

The company's chemists were attempting to synthesize a substance that could compete with an existing patent for the best clot medicine of that time, hydrastinine. MDMA was the byproduct of that effort.

The origin of the term 'molecular gastronomy' and its first international workshop

The 1992 event was born from a conversation between American cooking instructor Elizabeth Cawdry Thomas and Italian physicist Ugo Valdrè, who agreed on the merits of the science of cooking. The International Workshop on Molecular and Physical Gastronomy was named, in part, after the field of molecular biology to lend it prestige and greater seriousness.

GLP-1 drugs, first used to manage diabetes, were derived from Gila monster saliva

Scientists studying the barely-there feeding frequency of the Gila monster found its saliva had a hormone regulating blood sugar and appetite. Further research revealed this hormone resembled a human one known as GLP-1, giving rise to the modern wave of diabetes and weight-management drugs.

How cultured meat is made

In recent years, a number of companies have debuted meatless alternatives to traditional burgers, chicken, and more. Some are made from soy, while others use molecular formulations to recreate the flavor profile and texture of meat. Now, actual meat...

How silica gel took over the world

Silica gel packets are those sugar packet-like bags that keep packaged foods and more dry and free of mildew. First invented in the early 20th century, they saw great commercial success starting in 1927, being deployed in traded goods across the world. This simple invention allows modern supply chains to extend across the globe by extending the preservation of shipped goods.

Radioactive elements can generate electricity, sterilize products, and date artifacts

Since their discovery in the 1890s, these substances have been incorporated throughout our daily lives, from treating food packaging and improving microbial safety to their presence in smoke detectors and gauges for ice cream aeration.

The extremophilic origins of watermelon snow and its impact on glacial melting

Also known as "blood snow," the red coloration is produced by snow algae that thrive in extremely cold conditions and take the shape of red spherical cysts in winter. To protect themselves from more intense summer solar radiation, these psychrophiles accumulate red, orange, and yellow pigments, intensifying their coloration and causing glaciers to reflect less sunlight than if they were white.

The ubiquitous 1990s “Got Milk?” ad campaign was intended to fix milk’s dwindling popularity in the late 20th century

Despite its success in spreading the word about milk, the sales numbers weren’t quite as impressive. This Mental Floss article details the marketing efforts themselves, as well as how milk lobbyists didn’t necessarily succeed despite their revolutionary ads.

A 1954 outbreak at a Boston boarding school allowed scientists to isolate the measles virus

While measles was described as early as the 9th century, humanity lacked the medical technology to fight the disease until the mid-20th century. Vaccine development from the Boston outbreak in the 1960s and 1970s led to one of the most effective inoculation campaigns in history.

An investigation suggests a Scottish island became awash in forever chemicals via seafoam and seaspray—raising questions about what that means for the safety of other coastal areas.

The health benefits of matcha tea

Matcha tea has skyrocketed in popularity in recent years. Very likely due to its bright green color, which is conducive to social media post aesthetics. The tea is a powdered form of green tea, and its benefits are touted everywhere. This article examines the evidence for such health claims, finding the tea's key nutrients of theanine, chlorophyll, and caffeine did have small observable effects on study participants. Learn more here.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

The Great Salt Lake's distinct dual coloration results from high-salinity organisms that only live in the northern portion and produce a purple protein.

Poison ivy is in the same family as mangoes, cashews, and pistachios—and they all produce oily urushiol in their raw, unprocessed state—but they are typically prepared in ways to avoid causing human discomfort.

The use of fungi to detoxify land and water—a process known as mycoremediation—has been used to clean up natural resources affected by the 2025 California wildfires.

Massive blooms of microscopic plankton called dinoflagellates produce the neon blue light seen in glowing tides.

The word 'jazz' evolved from 'jasm,' 19th-century American slang for 'energy'

See how fireworks are made and learn how metals like magnesium and copper are responsible for different colors.

Volcanic activity may have triggered the Black Death by spewing gases that led to crop failures in Europe, thus forcing the import of grain ships with plague-infested fleas.

After her fellow cult members tried to kill her with an LSD-infused hamburger, one member of the Manson Family, the murderous cult led by Charles Manson, decided to testify against the group's leader.

Graffiti dates back to at least ancient Pompeii, where citizens scrawled messages to one another on public walls

Sunflowers have long been a symbol of nuclear disarmament because they can extract large amounts of radioactive cesium from soil.

The first horror movie is believed to be George Méliès' 1986 short 'The Haunted Castle,' which pioneered the use of special effects

Memecoins are a type of cryptocurrency—a form of digital currency with a wide variety of uses—created around popular 'memes,' or viral internet jokes.

A researcher recently discovered an interview from 1967 between groundbreaking journalist Joan Didion and the Grateful Dead, years before the band became an institution.

While atoms are normally made of protons, neutrons, and electrons, exotic ones have been built with antimatter—alternate versions of normal matter that live for fractions of a second and are about a billion times as rare.

Long before Major League Baseball began allowing instant replay for balls and strikes, an umpire reluctantly used the technology to determine whether a hit was a home run, a move that inadvertently ushered in a new era for the sport.

Explore an interactive map built from more than 100,000 survey responses on where people find joy in their lives

Sony set the standard for cylinder-shaped batteries when it repurposed manufacturing equipment used to make rolls of magnetic recording tape.

Up to a million Girl Scouts sell about 200 million cookie boxes every spring, generating $800 million, largely because refusing a child is frowned upon

Indefinite cloning of some endangered species may not sustain their longevity because cloning success rates decrease as genetic mutations accumulate.

Lesser-known phobias include turophobia, or the fear of cheese, and nomophobia, the fear of being without your cell phone.

The Nasdaq's 'Magnificent 7' companies are responsible for roughly 40% of the Nasdaq 100 index's gains, while the remaining 93 companies account for the other 60%.