The 'definitive' history of magic mushrooms

How psilocybin could transform mental health treatment

How magical are magic mushrooms, at least where depression is concerned? Some 24 volunteers participated in a study to evaluate the efficacy of using psilocybin in combination with psychotherapy to treat individuals suffering from depression. While some controversies remain about its use—psilocybin is known to cause psychosis sometimes—some scientists think the benefits outweigh the risks.

Psychoactive drugs found in 1,000-year-old bag made of fox noses

Archaeologists in Bolivia have uncovered an ancient bag filled with "amazing goodies" that suggests the owner or owners were well-versed in the properties of psychoactive substances and sourced goods from well-established trade routes. This article details the findings, which shed light on how ancient peoples in the region consumed and obtained psychoactive substances.

How Western psychedelics research fell to the wayside

Psychedelics' modern era began when LSD was discovered in the 1930s. By the 1950s, clinical trials were underway. US user experimentation outside of medical settings (and high-profile violence, like the Manson murders) inspired negative attitudes toward psychedelics, leading to use restrictions that prohibited companies from patenting psychedelic compounds. This strangled psychedelics' profitability until the 1990s when the government loosened its grip and psychedelics research began seeing a resurgence.

In 1957, a vice president at JPMorgan became an outspoken evangelist for psychedelic mushrooms

R. Gordon Wasson wrote "Seeking the Magic Mushroom" for Life magazine in 1957. It was a groundbreaking piece of journalism that introduced mainstream society to psychedelic mushrooms. He retired from JPMorgan in 1963 and continued researching and writing about psychedelic experiences for the rest of his life.

What do psychedelic plants look like?

Far from the drippy aesthetic often associated with psychedelics, the plants powering naturally occurring psychoactive experiences may not stand out as anything special. This database offers a visual guide to psychoactive plants and fungi. Clicking on the title of a particular plant, such as yerba mate, will bring up a secondary screen with various hyperlinked images, such as the plant itself, related botanical drawings, and molecular structures.

LSD was derived from natural compounds produced by the ergot fungus

Ergot is a fungus that slowly infects and replaces individual grains on grasses, including rye and wheat. Ingesting ergot can cause ergotism, a form of poisoning with symptoms—including headaches, hallucinations, gangrene, and convulsions—varying by season and geography. This grain was used for medicinal purposes as early as the 1500s.

The history of infographics: cave art to interactive visuals

When did humans first create infographics? This article and related infographics detail how artistic data representations have evolved alongside humans and other hominins. The roots of infographics can be traced back to cave paintings, such as...

The mushrooms in 'Super Mario Bros.' are modeled after a real mushroom

Almost every mushroom in "Super Mario Bros." is based on the Amanita muscaria, sometimes referred to as the fly agaric, because it is known to attract flies. It's also the basis for the original mushroom emoji and the mushrooms from the popular game "Minecraft."

Artificial lightning can improve the yield of shiitake mushroom growers

Researchers have found that shockwaves produced from lightning strikes homogenously break internal filaments called hyphae, transitioning the mushrooms from a vegetative growth to a fruiting phase. Repeated minor shocks near mushroom logs mimicked this effect.

The history and significance of rosemary

Rosemary is more than just an herb—it’s a powerful symbol intertwined with ancient Egypt, Christianity’s origins, Shakespeare, the culinary arts, and more. Native to the Mediterranean area, this plant has accompanied humanity for centuries, providing us with pleasant aroma, adornment, and even medicine. Explore this article for further insight into the significance of our long-standing relationship with rosemary.

Learn more about the history of fireworks, which dates back to an accidental invention during an alchemist's quest for information about immortality.

The earliest mention of time travel

Time travel has fascinated humans for centuries. It appears in myths, literature, and science fiction. One of the earliest examples comes from the 400 BCE Hindu epic Mahabharata, describing time dilation long before Einstein’s Theory of Relativity. By the 19th century, stories introduced machines enabling time travel—setting the stage for modern sci-fi.

Billion-year-old Arctic fossils suggest Earth had fungi far earlier than previously thought

Named Ourasphaira giraldae, this new species of fungus, reported in 2019, was found in the Grassy Bay Formation in the Canadian Arctic. It pushed the fossil record of fungi back by about half a billion years since the oldest previously recognized fungi fossils came from the Rhynie chert, a Scottish site that dates back roughly 400 million years. This fungal discovery also suggests that fungi may have occurred on land much earlier than plants, raising questions about what ancient fungi used for nourishment.

How winemaking has changed throughout history

Winemaking is an ancient practice, and researchers continue to find evidence that this ritual came even earlier than previously estimated. This article outlines five key turning points in wine’s history, from the fermentation of fruit by our primate ancestors to today’s increasingly popular “New World” wine. Discover the fascinating scientific and cultural factors that led to wine’s changes in flavor and increased symbolic importance.

Miracles versus magic: How early Christians distinguished their beliefs from pagan ones

This in-depth article describes how early Christians attempted to differentiate their beliefs and rituals from those that came before. One major difference? Demons. For pagans, demons could be good or bad, occupying the middle ground between gods...

The history of iconic pigments used in seven famous paintings

While art paints can be bought by the bucket at any craft store today, pigments throughout history have been difficult to come by. Art historian Kelly Grovier traces the fascinating history of pigments that make up hidden layers in masterpieces from Picasso and Hokusai’s Prussian Blue to Vermeer’s shade of red.

The history of skull modification

The ancient Maya people sometimes modified their skulls to appear more conical. Body modification has been a human pastime for literal ages, from piercings to bindings and everything in between. Modifying one's skull shape may have been a way to symbolize status, beauty, belonging, or belief. The health impacts of such practices are still debated. This article explores the history and health impacts of skull modification, also known as artificial cranial deformation.

Ancient humans settled Australia more than 50,000 years ago

Archaeological evidence shows that modern humans reached Southeast Asia about 70,000 years ago and they spread to Australia by at least 50,000 years ago. It marks the oldest evidence of open-sea migration by humans on record.

The agricultural history of the pumpkin

Pumpkin pie holds a special place in Thanksgiving traditions, but its journey from everyday produce to a seasonal treat spans over 10,000 years. Trace the history of this oversized fruit with this fascinating dive. Pumpkins belong to the species...

MSG was first isolated from seaweed in Japan in 1908

The compound monosodium glutamate has been identified in dairy, meats and vegetables, and provides an "umami"—Japanese for "tasty"—flavor to food. Studies in the late 1960s characterized MSG as harmful, but only when testing doses hundreds of times greater than what would be consumed in a typical diet.

The history of blood, as told by a hematologist

Since ancient times, blood has been seen as a semi-magical substance. Alchemists theorized it was a mixture of the four elements. Others proposed it was one of four bodily fluids whose balance dictated health. This 2019 essay by a hematologist reviews blood's reputation across cultures and centuries.

The history of the Met

From a single sarcophagus to a collection of more than a million artifacts that span nearly the entirety of human civilization, the Met and its importance have grown significantly over the last 150 years. This history of the museum hits all the highlights, including important acquisitions, new wings and galleries, and the importance of the buildings that hold and display all of the incredible artwork.

The medieval origins of Māori and Moriori culture

New Zealand, also known as Aotearoa, was one of the last large land masses inhabited by humans. This 18-minute video explores the ancient origins of Polynesian people and their medieval journey to New Zealand and the nearby Chatham Islands archipelago.

Food allergies were first documented more than 4,000 years ago

Although food allergies are on the rise in modern times, they have been documented in written records for thousands of years. More than 3,000 years ago, Chinese emperors advised patients to avoid certain foods, and Hippocrates noted in his work that food could cause serious harm to certain individuals, and even lead to death.

Learn more about the history of fireworks, which date back to an accidental invention during an alchemist's quest for information about immortality

When bamboo in China was tossed into fire in 200 BCE, there was an explosion. About 1000 years later, around 800 CE, an alchemist searching for secrets to immortality mixed sulfur, charcoal, and potassium nitrate together, leading to gunpowder. That mixture was then packed into bamboo or paper tubes, leading to fireworks.

Why some people say the moon is made of cheese

Mental Floss digs into the history behind the fable, which dates back as far as the 1500s, when it was mentioned in "The Proverbs of John Heywood." Even NASA has gotten in on the joke, tweeting a (supposedly) doctored photograph showing the moon's expiration date.

Graffiti dates back to at least ancient Pompeii, where citizens scrawled messages to one another on public walls

Poison ivy was sent to Europe in the 1600s as an exotic, ornamental oddity, where it was purposefully grown in the English royal gardens at Kew, the Faculty of Medicine in Paris, and a few other locations.

The use of fungi to detoxify land and water—a process known as mycoremediation—has been used to clean up natural resources affected by the 2025 California wildfires.

After her fellow cult members tried to kill her with an LSD-infused hamburger, one member of the Manson Family, the murderous cult led by Charles Manson, decided to testify against the group's leader.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

The first horror movie is believed to be George Méliès' 1986 short 'The Haunted Castle,' which pioneered the use of special effects

Explore the history, structure, and species of Australia's Great Barrier Reef with this interactive journey narrated by Sir David Attenborough.

Before humans, the Soviet Union and the United States sent animals—including apes, dogs, and cats—to space during the Space Race.

'Shogun,' a 1980s TV series, helped popularize sushi in the US by stimulating an American interest in Japanese culture.

Some Pokémon have been named after real and fictional organisms, while some real-world species have been named after Pokémon, such as Chilicola charizard and Binburrum zapdos.

See the 25 of the best photos of auroras from around the world.

The Brothers Grimm were lawyers before they were storytellers, and became interested in fairy tales as they began investigating how rules and customs had been passed down through cultures.

Explore an interactive map built from more than 100,000 survey responses on where people find joy in their lives

In 1963, a basement renovation in Turkey revealed a passageway to a hidden, multilevel underground city that once housed as many as 20,000 people

Clever Hans was a 1900s horse that was believed to be able to solve math equations, tell time, and read and comprehend German, until a psychology student discovered how he got his answers.

Long before Major League Baseball began allowing instant replay for balls and strikes, an umpire reluctantly used the technology to determine whether a hit was a home run, a move that inadvertently ushered in a new era for the sport.

Hear 50 years of iconic hip-hop samples, the genre's foundational looped tracks

'Grand Canyon of the Yellowstone,' a work by American painter Thomas Moran, inspired Congress to establish Yellowstone National Park.

Memecoins are a type of cryptocurrency—a form of digital currency with a wide variety of uses—created around popular 'memes,' or viral internet jokes.

While the first exchange-traded fund (a 'basket' of different assets that can be bought and sold on a stock exchange) in the US only launched in 1993, the global ETF market has grown to more than $10T in the short time since.

The US first hosted the World Cup in 1994, a tournament that lives in soccer infamy for its poor planning and the murder of Colombian player Andres Escobar, who'd accidentally scored on his own net.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

The power and influence of the American presidency have expanded significantly over time—far beyond what the founders envisioned.