Psychoactive drugs found in 1,000-year-old bag made of fox noses

The 'definitive' history of magic mushrooms

Where did magic mushrooms come from, and how did they get their magical reputation? This article explains the history of the psychedelic fungi from pre-history to now. The earliest concrete evidence of psychedelic mushroom use is 12,000-year-old murals in Northern Australia that portray mushroom iconography. Considering how many species seek out and consume psychoactive substances, such as Siberian reindeer, it's possible human use of these psychedelic mushrooms may predate these murals.

Evidence of opium use dates to as early as 5000 BCE

Archaeological evidence shows the use of the poppy plant for its pain-killing properties likely originated in the Mediterranean before making its way to the East and West via trade. It has since inspired two eponymous wars, and highly addictive derivatives of the naturally occurring substance have led to an ongoing overdose crisis.

Read the academic article explaining how ancient smells can be dissected and recreated

This paper explores how biomolecular data on past scents can be teased out and then transformed into olfactory museum experiences, adding another component to our understanding of archaeology.

Drugs 101: An interactive guide

What's the difference between opioids and psychedelics? This guide details specific drugs and their various associated effects. Drugs in this wheel fall into seven categories: stimulants, depressants, empathogens, psychedelics, dissociatives, cannabinoids, and opioids.

How can octopuses and MDMA help scientists understand the human brain?

Research shows that psychedelics may induce something called "critical periods" in the adult brain, which can make our brains more open to learning and changing, like they once were back in early childhood. Psychedelics similarly change how social creatures like octopuses behave, which demonstrates that these animals could help us better understand our own neurobiology.

Researchers believe beer was being brewed 13,000 years ago

In 2018, archaeologists discovered traces of a wheat-and-barley-based alcoholic beverage near Haifa, in modern-day Israel, and believe it was produced by the Natufian people.

Shrunken human heads were once a valuable commodity

In the Ecuadoran Amazon of the 1800s, shrunken human heads had spiritual significance. As outsiders became fascinated by the exotic practice, head shrinking became commercialized, and counterfeit shrunken heads were common. By the mid-1940s, shrunken heads could be traded for guns. (Some users may experience a paywall.)

Rome's herbal panacea may not be as extinct as we thought

Silphion: cure-all, aphrodisiac, birth control, tasty seasoning. Nero allegedly ate the last of this miracle plant. This article details how a researcher may have found more. Seven centuries after the yellow-flowered plant was first documented growing in what's now Libya, it vanished. Historians proposed that the loss of Silphion may have been the first recorded extinction of any species.

Dragon seismometers, Baghdad batteries, and more ancient artifacts

The ancients were behind us in many ways, but some inventions from the time have not been surpassed in the modern era in effectiveness, beauty, or cleverness. This quick list of bizarre ancient inventions includes a battery from Baghdad, a Molotov cocktail-like explosive in Greece, and more.

Cocainenomics

How did Pablo Escobar rise up out of the Medellin barrios to become the CEO of a $4 billion business? This immersive look at the global drug trade spawned by the notorious drug lord, who at his peak controlled 80% of the cocaine supply in the US. This deep dive includes visualizations showing how logistics of drug smuggling evolved over the years and traces the economic impact of the industry.

History finds of 2021

The year’s most exciting discoveries include a Viking “piggy bank,” a lost Native American settlement and a secret passageway hidden behind a bookshelf

Ibogaine, a psychedelic substance, can be used to treat mental illness

Although the substance is banned in the US, it's legal in Mexico. Americans who have traveled there for treatment, including the NFL's Braden Smith, say the drug helps deal with conditions like obsessive-compulsive disorder.

The iconic Aztec 'crystal skulls' were 19th-century fakes

The crystal skulls long displayed as Aztec artifacts were actually fabricated in the late 1800s, all linked to French antiquities dealer Eugène Boban. Anthropologist Jane Walsh's investigation exposed their modern origins, overturning a century of mistaken museum lore.

The chemistry of ancient tacos

This 16-minute podcast explores the chemistry of Mesoamerica's corn tortillas, which involve a 3,500-year-old chemical process called nixtamalization that releases vitamins, including niacin, one of the essential B vitamins. This process also makes the tortillas softer and more delicious. Corn tortillas were a staple in Mesoamerica, and the archaeologist interviewed in this podcast argues cultures like the Aztecs and Maya wouldn't have thrived without nixtamalization.

Ancient Romans helped develop modern cheese production techniques

The ancient Romans loved cheese and experimented with different processes to elevate its flavor, like aging. Some of their innovations, like Pecorino Romano, you can still find today. Others, like the smoked goat-milk Caseus, we only know about through historical records.

Native Americans developed pottery and religion, and experienced population growth during the Woodland period

Between 500 B.C.E. and 1100 C.E., Indigenous peoples produced pottery and practiced animism, a spiritual worldview in which animals, plants, and natural forces are believed to possess sacred power. They moved seasonally to make the most of available resources.

Silk Road, the dark web's first widely used market, proved the real-world utility of bitcoin

Named after the ancient intercontinental trade network between China and the Roman Empire, the anonymous market was active from early 2011 to October 2013. Before it was shut down, approximately 10,000 products—70% of which were illegal and controlled prescription drugs—were bought and sold using the cryptocurrency.

The pharmaceutical industry evolved, in part, from the discovery of synthetic dyes

In 1856, a chemist accidentally discovered mauveine, the world’s first synthetic dye, while trying to make quinine to treat malaria. The synthetic dyes that followed helped reveal germs under microscopes, paving the way for modern imaging techniques and breakthrough treatments, such as antibiotics.

Ancient Egyptian papyrus from 16th century BCE seems to reference tinnitus

Ancient Egyptians wrote that they treated "bewitched ear" with herbal concoctions that involved frankincense and other ingredients, which were placed in the ear.

Neanderthals commonly had surfer's ear, a potential sign of extensive seafood collection

Analysis from 2019 found that about half of the 23 Neanderthal skulls scientists examined seemed to have the bony growths in the inner ear, signifying they had surfer's ear. Those growths suggest our ancient relatives, dating back to between perhaps 100,000 and 40,000 years ago, were potentially hunting fish, mollusks, or other marine resources in chilly waters.

How scientists are using molecules found in acidophiles to develop new medical treatments

The Berkeley Pit, an open-pit copper mine in Butte, Montana, that ceased operations in 1982 and is now filled with highly acidic water, is home to various species of fungi and yeast. These extremophiles produce unique compounds that may have anti-inflammatory benefits and have already been used to create an antibiotic for staph infections.

The expedition purchased more than 260 separate items to supply their journey

Preparing for two years in the wilderness, Lewis acquired hundreds of supplies, including medicine, food, weapons, and 63 lbs of pigtail tobacco. The total bill was estimated to be around $2,324 (around $60,000 today).

Western China's millennia-old mummies

The extremely dry climate of China's western province of Xinjiang has preserved mummy-like dessicated corpses from as long as 4,000 years ago. The so-called Tarim Basin mummies were discovered in Central Asia at the start of the 20th century and have since been studied by archaeologists, genome experts, and more. Take a look at their extremely well-preserved blonde braids and other features while reading about them in this essay.

How the Inca used threads to communicate

One of the great mysteries of ancient Peru is that the Inca did not have a system of writing, but communicated with a system of strings tied with knots. This 4-minute video explores its possible uses.

Enter the Mayan underworld through this 3-mile cave

Discoveries in Belize's Actun Tunichil Muknal (ATM) cave suggest the cave was once a significant site for sacred Mayan ceremonies in antiquity. New research reveals how the Mayans conducted rituals to re-enact a specific creation myth, often staged in desperate times and aimed to invoke the gods for a "rebirth" amid drought and turmoil. Read more on the enigmatic research here.

Graffiti dates back to at least ancient Pompeii, where citizens scrawled messages to one another on public walls

Learn more about the history of fireworks, which dates back to an accidental invention during an alchemist's quest for information about immortality.

In 1963, a basement renovation in Turkey revealed a passageway to a hidden, multilevel underground city that once housed as many as 20,000 people

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

The American cockroach is actually from Africa, an apparent hitchhiker aboard ships carrying enslaved people, with evidence suggesting the bug may have arrived in the New World as early as the 1600s.

See these 16 pieces of art evoking phobias of snakes, flying, spiders, and more. 

During the French Revolution, a botanist's letter asking about "dear Rhus" (poison ivy) was intercepted, leading authorities to suspect he was conspiring with the Russians.

Volcanic activity may have triggered the Black Death by spewing gases that led to crop failures in Europe, thus forcing the import of grain ships with plague-infested fleas.

Against his wishes, Albert Einstein's brain was removed before his cremation, and the pathologist responsible stored it for decades in mason jars within a beer cooler.

After her fellow cult members tried to kill her with an LSD-infused hamburger, one member of the Manson Family, the murderous cult led by Charles Manson, decided to testify against the group's leader.

Crows are believed to have intelligence on par with a seven-year-old child and demonstrate complex behaviors, from problem-solving with tools to recognizing human faces.

The use of fungi to detoxify land and water—a process known as mycoremediation—has been used to clean up natural resources affected by the 2025 California wildfires.

For centuries, it was common to sleep in two shifts: a few hours at the beginning of the night, and a longer period beginning around midnight

Hear 50 years of iconic hip-hop samples, the genre's foundational looped tracks

In 2019, a laptop loaded with six of the worst malware in history and described as 'an exhibit of historical weaponry' sold for $1.3M.

The story of Dollree Mapp, whose legal challenge over her 1957 conviction for possessing "obscene material" led to a major strengthening of the Fourth Amendment

The most expensive ad of all time was for Chanel No. 5 perfume and cost roughly $33M to produce in 2004—about $57M in today's dollars.

Hear about the 250-year history of the United States Postal Service, complete with some of its strangest deliveries, important innovations, and the figures that made it an American institution.

Explore an interactive map built from more than 100,000 survey responses on where people find joy in their lives

In 2009, the nation was gripped by the story of a missing young boy who was believed to be floating over Colorado in a homemade balloon, until it was revealed that he was at home the whole time.

A researcher recently discovered an interview from 1967 between groundbreaking journalist Joan Didion and the Grateful Dead, years before the band became an institution.

US intelligence allegedly pursued more than 600 schemes to assassinate Cuban revolutionary Fidel Castro.

Before humans, the Soviet Union and the United States sent animals—including apes, dogs, and cats—to space during the Space Race.

Cultural norms about how to handle the bodies of loved ones in communities in West Africa have hampered Ebola responses.