Evidence of opium use dates to as early as 5000 BCE

Opium's history traces from religious use to mass-market commercial products

Religious or medical use of opium was present across Europe and Asia as early as 5000 BCE. By the 16th century, humanity had come to see opium as more than medicine: It was a marketable product. This perspective also defines today's relationship with opioids, highly addictive painkillers at the heart of an ongoing drug crisis.

Opium is a milky liquid substance extracted from unripe poppy plant seeds

It's been used for ages to reduce pain and induce euphoria, both of which are side effects of the plant's alkaloids—nitrogen-based compounds with pronounced physical effects. Isolating and synthesizing derivatives of these naturally occurring chemicals enabled the invention of morphine, heroin, and other opioids.

Morphine, heroin, codeine, and more were derived from opium

Opium reached the US at about the time early colonists were itching for ways to soothe aches and pains. The active ingredient in the substance was isolated in the early 19th century, eventually leading to the manufacture and commercial sale of morphine, heroin, and other opium-based drugs.

Synthetic opioids: a historical and clinical review

In the 19th century, researchers began synthesizing and isolating poppy plant alkaloids, leading to the invention of morphine, codeine, heroin, oxycodone, and others. These highly addictive variants eventually gave rise to illicit use and a widespread underground market, laying the foundation for the current opioid crisis.

Opioids are a class of drugs including fentanyl, heroin, oxycodone, and more

Since the dawn of pain, living things have sought ways to mitigate this evolutionary warning signal. One of nature's most effective painkillers is opium, a highly addictive, milky latex extracted from poppy plants. This forms the basis of one of the most prescribed classes of modern drugs.

Psychoactive drugs found in 1,000-year-old bag made of fox noses

Archaeologists in Bolivia have uncovered an ancient bag filled with "amazing goodies" that suggests the owner or owners were well-versed in the properties of psychoactive substances and sourced goods from well-established trade routes. This article details the findings, which shed light on how ancient peoples in the region consumed and obtained psychoactive substances.

Aspirin was the first synthesized anti-inflammatory drug

Once used by the ancient Sumarians—extracted from willow bark—but now synthesized in the lab, the active ingredient of this popular medication has been used to treat headaches and pain for thousands of years.

Food allergies were first documented more than 4,000 years ago

Although food allergies are on the rise in modern times, they have been documented in written records for thousands of years. More than 3,000 years ago, Chinese emperors advised patients to avoid certain foods, and Hippocrates noted in his work that food could cause serious harm to certain individuals, and even lead to death.

An eye-opening interactive journey into the global drug trade

POPPY Interactive reveals how drug money destabilizes entire countries, fuels global conflicts, and allows a worldwide illegal economy to grow. Navigating the site involves diving into three major routes—the Northern Route, the Balkan Route, and...

The recorded history of crude oil use, starting with Babylonians waterproofing boats

The ancient civilization located in modern-day Iraq also used crude oil as mortar in construction, while the Egyptians used it to treat human remains during the mummification process. After the invention of the first motorcar in 1885 and the introduction of the affordable Model T in 1908, demand for crude oil skyrocketed.

Ancient Egyptian papyrus from 16th century BCE seems to reference tinnitus

Ancient Egyptians wrote that they treated "bewitched ear" with herbal concoctions that involved frankincense and other ingredients, which were placed in the ear.

See a collection of ancient Roman coins used on the Silk Roads

As ancient Rome's appetite for eastern luxuries grew, long-distance trade routes linking the Mediterranean to Asia emerged along what became known as the Silk Road. Without shared language or legal systems, merchants could use the reliable Roman coins to exchange with other cultures. This exhibit features gold and silver pieces bearing the portraits of emperors and Latin inscriptions.

The term 'alcohol' has Arabic origins

Linguistic research reveals a lot about the ancient origins of alcohol. For example, studying various languages reveals that "mead," an alcoholic beverage made from honey, came even before wine.

Evidence of cancer has been found in a 1.7-million-year-old fossil

Cancer has existed as long as humans have, with some of the earliest evidence found among fossilized bone tumors, human mummies in ancient Egypt, and ancient manuscripts. The oldest example was uncovered in a toe—millions of years old—from an ancestor of modern-day humans.

​Why heroin became associated with the grunge world

The drug was popular with several Seattle acts in the early 1990s, with artists like Hole's Courtney Love even publicizing her use in a magazine profile. A 1992 New York Times story on Seattle said the city's principal drugs were "espresso, beer, and heroin."

LSD was derived from natural compounds produced by the ergot fungus

Ergot is a fungus that slowly infects and replaces individual grains on grasses, including rye and wheat. Ingesting ergot can cause ergotism, a form of poisoning with symptoms—including headaches, hallucinations, gangrene, and convulsions—varying by season and geography. This grain was used for medicinal purposes as early as the 1500s.

Poison ivy was sent to Europe in the 1600s as an exotic, ornamental oddity

The plants were grown in the English royal gardens at Kew, the Faculty of Medicine in Paris, and a few other locations.

Ancient Greece originated roughly 4,000 years ago around the Aegean Sea

From architectural feats to the Western alphabet, ancient Greece has helped shape modern life. Over centuries, the eastern Mediterranean culture grew as far as India, Egypt, and Spain. Its cultural influence has long since spread beyond any physical boundaries.

The history of coffee

From its likely origins in what is now Ethiopia to today's worldwide consumption, this video uses a map to show how coffee conquered the world. Follow along and see how pilgrimages and centuries of trade influenced the spread of the beverage we all know so well.

Poison ivy was sent to Europe in the 1600s as an exotic, ornamental oddity, where it was purposefully grown in the English royal gardens at Kew, the Faculty of Medicine in Paris, and a few other locations.

Trauma is a primary risk factor for substance use disorder later in life

Studies indicate 75% of people with substance use disorder have experienced at least one traumatic experience in their life. These experiences alter brain function, leading to heightened stress and emotional pain. Substances offer temporary relief, but this often results in dependency.

The popular myth behind the India pale ale

Legend has it that the beer style earned its name in the late 1700s and early 1800s, when one brewer realized he had to add more alcohol and hops to his beers to survive the long boat ride to India. But as this essay by one beer historian makes clear, the facts don't line up with that myth.

Oral history and artifacts suggest the Wampanoag inhabited the area for 12,000 years

By 1621, Native Americans had been interacting with European explorers along the coasts for hundreds of years. European adventurers, including Giovanni da Verrazzano, mapped the coastline as early as 1524, as this timeline from the National Museum of the American Indian explains.

The negative effects of cannabis use

After decades of criminalization, cannabis is a legalized drug in an increasing number of countries around the world. This allows for accurate, robust research on the drug's effects on humans . While weed isn't as harmful as alcohol, regular usage has its negative effects. As strains of the drug become stronger, so does its consequences. Watch this video for a lucid look at the effects of cannabis on its users.

The history and significance of rosemary

Rosemary is more than just an herb—it’s a powerful symbol intertwined with ancient Egypt, Christianity’s origins, Shakespeare, the culinary arts, and more. Native to the Mediterranean area, this plant has accompanied humanity for centuries, providing us with pleasant aroma, adornment, and even medicine. Explore this article for further insight into the significance of our long-standing relationship with rosemary.

Learn more about the history of fireworks, which dates back to an accidental invention during an alchemist's quest for information about immortality.

Graffiti dates back to at least ancient Pompeii, where citizens scrawled messages to one another on public walls

A weed from the mustard family facilitated the molecular era of botany

The small genome and rapid growth cycle of Arabidopsis thaliana have made it an ideal organism for genetic studies, with over 100,000 research papers exploring topics such as disease resistance, stress tolerance, and response to light. The first studies were done on plants that grew from seeds saved during the Hungarian Uprising of 1956.

Volcanic activity may have triggered the Black Death by spewing gases that led to crop failures in Europe, thus forcing the import of grain ships with plague-infested fleas.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

Sunflowers have long been a symbol of nuclear disarmament because they can extract large amounts of radioactive cesium from soil.

For centuries, it was common to sleep in two shifts: a few hours at the beginning of the night, and a longer period beginning around midnight

After the Boston Tea Party, colonists switched to coffee, which became the main morning drink for revolutionaries.

'Shogun,' a 1980s TV series, helped popularize sushi in the US by stimulating an American interest in Japanese culture.

The most expensive ad of all time was for Chanel No. 5 perfume and cost roughly $33M to produce in 2004—about $57M in today's dollars.

Before humans, the Soviet Union and the United States sent animals—including apes, dogs, and cats—to space during the Space Race.

One of the most famous portraits ever taken is 'Afghan Girl' (1984) by Steve McCurry, yet the subject Sharbat Gula went much of her life without being identified or benefitting from the image's success.

The US dollar is the most widely circulated currency in the world, and is involved in nearly 90% of global transactions

Cultural norms about how to handle the bodies of loved ones in communities in West Africa have hampered Ebola responses.

After her fellow cult members tried to kill her with an LSD-infused hamburger, one member of the Manson Family, the murderous cult led by Charles Manson, decided to testify against the group's leader.

The term 'algorithm' originated from the Latinized name of al-Khwārizmī, a 9th-century mathematician whose works introduced Arabic numerals and the decimal-based numeral system to Europe and whose treatise 'Al-Jabr' gave algebra its name.

Long before Major League Baseball began allowing instant replay for balls and strikes, an umpire reluctantly used the technology to determine whether a hit was a home run, a move that inadvertently ushered in a new era for the sport.

A small portion of The Winstons' 'Amen, Brother,' an obscure '60s gospel record, is the basis for thousands of hip-hop tracks, making it one of the most sampled records ever that's informally known as 'the Amen break.'

See photos of Meteora, a mountainous site in central Greece, home to 14th-century monasteries perched atop soaring outcroppings.

Budweiser stores yeast derived from the original 1800s strain in a secret bunker, which only the Head of Yeast Management can access—not even the CEO

Domino's Pizza's 30-minute delivery guarantee was responsible for the chain's 1980s surge, but it was discontinued after the company was found liable for delivery driver accidents.

Explore an interactive map built from more than 100,000 survey responses on where people find joy in their lives

Some researchers have labeled nomophobia, the fear of being without your phone, as 'the phobia of the 21st century.'

Dorothy's famous entrance into Oz in 'The Wizard of Oz' relied on analog tricks, including a body double and sepia-toned paint, as much as it did on technology