Opium's history traces from religious use to mass-market commercial products

Evidence of opium use dates to as early as 5000 BCE

Archaeological evidence shows the use of the poppy plant for its pain-killing properties likely originated in the Mediterranean before making its way to the East and West via trade. It has since inspired two eponymous wars, and highly addictive derivatives of the naturally occurring substance have led to an ongoing overdose crisis.

Morphine, heroin, codeine, and more were derived from opium

Opium reached the US at about the time early colonists were itching for ways to soothe aches and pains. The active ingredient in the substance was isolated in the early 19th century, eventually leading to the manufacture and commercial sale of morphine, heroin, and other opium-based drugs.

Synthetic opioids: a historical and clinical review

In the 19th century, researchers began synthesizing and isolating poppy plant alkaloids, leading to the invention of morphine, codeine, heroin, oxycodone, and others. These highly addictive variants eventually gave rise to illicit use and a widespread underground market, laying the foundation for the current opioid crisis.

Opium is a milky liquid substance extracted from unripe poppy plant seeds

It's been used for ages to reduce pain and induce euphoria, both of which are side effects of the plant's alkaloids—nitrogen-based compounds with pronounced physical effects. Isolating and synthesizing derivatives of these naturally occurring chemicals enabled the invention of morphine, heroin, and other opioids.

The story of the Sackler empire behind highly addictive OxyContin

This investigative report examines how the Sackler family built its fortune through Purdue Pharma’s aggressive marketing of OxyContin, a highly addictive painkiller. Through 2017, the drug had generated more than $30B in sales for Purdue Pharma, controlled by the Sacklers.

Psychoactive drugs found in 1,000-year-old bag made of fox noses

Archaeologists in Bolivia have uncovered an ancient bag filled with "amazing goodies" that suggests the owner or owners were well-versed in the properties of psychoactive substances and sourced goods from well-established trade routes. This article details the findings, which shed light on how ancient peoples in the region consumed and obtained psychoactive substances.

Silk Road, the dark web's first widely used market, proved the real-world utility of bitcoin

Named after the ancient intercontinental trade network between China and the Roman Empire, the anonymous market was active from early 2011 to October 2013. Before it was shut down, approximately 10,000 products—70% of which were illegal and controlled prescription drugs—were bought and sold using the cryptocurrency.

LSD fueled a countercultural movement before evolving into a potential therapeutic

As the use of recreational psychedelics became common, authorities were quick to claim LSD had lasting adverse effects, criminalizing the drug and halting scientific study for decades. Over time, LSD's reputation shifted from a potential source of enlightenment to a dangerous drug that could dim a person's future, and back to a possible therapeutic compound.

The International Olympic Committee banned ibogaine decades ago

Beyond use by athletes as a stimulant before the ban, the drug has a long history. The psychoactive substance was also mass produced in the mid-20th century by a French pharmaceutical company as a product called Lambarène, which was marketed as a cure for conditions including depression and lethargy. Production halted in 1966, however, when ibogaine-containing products became illegal in France.

Visualizing the global supply chain of medicine

The typical medicine we consume is the end result of a complex global supply chain involving highly specialized compartmentalization. Most medicine was made locally until open trade policies enabled global trade in the 1980s. This visual essay is...

The first ever IPO was issued by the Dutch East India Co., a spice company

It first offered shares to the public in the 1600s on the Amsterdam Stock Exchange to help finance its passages. The Dutch East India Co. succeeded in part due to its monopolistic hold over the East Indies at the time.

The recorded history of crude oil use, starting with Babylonians waterproofing boats

The ancient civilization located in modern-day Iraq also used crude oil as mortar in construction, while the Egyptians used it to treat human remains during the mummification process. After the invention of the first motorcar in 1885 and the introduction of the affordable Model T in 1908, demand for crude oil skyrocketed.

The science (and scams) behind essential oils

Essential oils are a big business, with industry estimates pegging its market size at $10B last year—a number expected to double by 2030. These distilled plant compounds have a long history of both legitimate and exaggerated uses, and many marketed oils are, as the author of this long read claims, just selling wish fulfillment. Revisit some of the history and contemporary use of essential oils with this piece.

Europe’s first recorded influenza pandemic swept the continent in 1580

The 1580 influenza pandemic, traced from Asia to Africa and into Europe, became the first flu outbreak clearly documented across the continent—killing tens of thousands and highlighting influenza’s potential for rapid global spread.

Money—not land—became Europe’s key economic driver in the Middle Age

During the medieval commercial revolution, money gradually replaced land as the primary economic commodity. Expanding trade, markets, and finance transformed Europe’s economy—laying foundations, historians argue, that were essential for the later Industrial Revolution.

In the 1600s, coffee had religious significance

In the 1600s, coffee was important in multiple religious traditions. In Yemen, it was the drink of choice for Sufi mystics to improve their focus and fuel their grueling meditations. Pope Clement VIII's approval spread coffee’s popularity from the Muslim to the Christian world, paving the way for the cappuccino.

​Why heroin became associated with the grunge world

The drug was popular with several Seattle acts in the early 1990s, with artists like Hole's Courtney Love even publicizing her use in a magazine profile. A 1992 New York Times story on Seattle said the city's principal drugs were "espresso, beer, and heroin."

What did people do before eyeglasses were invented?

An estimated two-thirds of the world's adults use a form of prescription glasses or contacts, proof spectacles were a godsend when they were invented in 1286 CE. But what did people do before that? Different tools were used for distinct vision problems, but some would use magnifying lenses, clear emeralds, and more. Watch this video for a historical explanation.

The Ouija board originated in 19th-century America

The bizarre board game that helps people communicate with the dead at sleepovers first emerged in the 19th century as a business-minded response to the growing fascination with spiritualism. The Ouija Board has since generated an abundance of sales, as well as scientific research.

Why Belgium is now the cocaine capital of Europe

Belgium has become Europe’s cocaine-trafficking capital. Recently, Belgian ports have seen record seizures of cocaine. In 2020, the port of Antwerp accounted for 40% of all cocaine seizures in the EU. And local authorities are struggling with the...

A history of Rome and wine

Wine and winemaking were integral parts of everyday Roman life. Wine was used medicinally and for religious rites, as well as for pleasure. It also contributed to the expansion of the Roman empire as wine and grapes were traded throughout the Mediterranean. Roman winemaking practices spread as the empire grew. Without Rome, wine may never have grown into what it became, and vice versa.

Anorexia as religion: from the Middle Ages to modern message boards

Humanity's interest in anorexia nervosa can be traced back to the Middle Ages and the rise of "fasting girls." This article explores the history of the eating disorder as a religion. The first recorded anorexics appeared during the 13th century...

Roughly 80% of US antibiotics sold each year go to agricultural use

Antibiotics have long been used in agriculture to treat diseases in animals and plants. However, antibiotics are also often misused, to treat non-bacterial diseases, to encourage growth in animals, and more. This expansive use of antibiotics has become one of the primary sources of the emergence of new superbugs.

Opera melodies from centuries ago still appear in TV and movies today

Even if you haven't witnessed an 18th century opera, you've likely heard melodies from one in modern media like “Apocalypse Now” and “Sesame Street.” Today, sports events, movies, and television feature operatic melodies even over a century after they were written.

Ice cream can be traced back to the 7th century

Documents from ancient China refer to a frozen milk dish, a predecessor of the treat we now know. That evolved into a blend of buffalo milk, flour, and fragrant camphor oil that more closely resembled our ice cream.

Poison ivy was sent to Europe in the 1600s as an exotic, ornamental oddity, where it was purposefully grown in the English royal gardens at Kew, the Faculty of Medicine in Paris, and a few other locations.

Learn more about the history of fireworks, which dates back to an accidental invention during an alchemist's quest for information about immortality.

Volcanic activity may have triggered the Black Death by spewing gases that led to crop failures in Europe, thus forcing the import of grain ships with plague-infested fleas.

Graffiti dates back to at least ancient Pompeii, where citizens scrawled messages to one another on public walls

For centuries, it was common to sleep in two shifts: a few hours at the beginning of the night, and a longer period beginning around midnight

After the Boston Tea Party, colonists switched to coffee, which became the main morning drink for revolutionaries.

See the evolution of Ebola vaccine and treatment development.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

The hormonal disorder PCOS was renamed PMOS in 2026, a move designed to improve care and research by shifting the focus to the hormonal causes of this condition that affects 1 in 8 women.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

The US dollar is the most widely circulated currency in the world, and is involved in nearly 90% of global transactions

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

A century of Billboard issues documenting the evolution of popular music.

The term 'algorithm' originated from the Latinized name of al-Khwārizmī, a 9th-century mathematician whose works introduced Arabic numerals and the decimal-based numeral system to Europe and whose treatise 'Al-Jabr' gave algebra its name.

Budweiser stores yeast derived from the original 1800s strain in a secret bunker, which only the Head of Yeast Management can access—not even the CEO

An initial public offering or 'IPO' is the process of a private company becoming public by putting shares of the company on the stock market for purchase.

The most expensive ad of all time was for Chanel No. 5 perfume and cost roughly $33M to produce in 2004—about $57M in today's dollars.

Georgia O'Keeffe's flower paintings are often assumed to be sexual, though the artist claimed she was simply interested in highlighting the beauty of flowers that most people neglect

A small portion of The Winstons' 'Amen, Brother,' an obscure '60s gospel record, is the basis for thousands of hip-hop tracks, making it one of the most sampled records ever that's informally known as 'the Amen break.'

'Shogun,' a 1980s TV series, helped popularize sushi in the US by stimulating an American interest in Japanese culture.

In 2019, a laptop loaded with six of the worst malware in history and described as 'an exhibit of historical weaponry' sold for $1.3M.

Before humans, the Soviet Union and the United States sent animals—including apes, dogs, and cats—to space during the Space Race.

44% of Americans say they pray at least once a day—discover how your state's religiosity stacks up against the rest of the country.

After her fellow cult members tried to kill her with an LSD-infused hamburger, one member of the Manson Family, the murderous cult led by Charles Manson, decided to testify against the group's leader.

See photos of Meteora, a mountainous site in central Greece, home to 14th-century monasteries perched atop soaring outcroppings.