Europe’s first recorded influenza pandemic swept the continent in 1580

Human records of influenza stretch back more than two millennia

Accounts of flu-like illness appear as early as 412 BCE, when Hippocrates described a sudden wave of cough and fever. Centuries of recurring outbreaks culminated in the first clearly documented pandemic in 1580, spreading from Asia into Europe and Africa.

Human records of influenza stretch back more than two millennia

Accounts of flu-like illness appear as early as 412 BCE, when Hippocrates described a sudden wave of cough and fever. Centuries of recurring outbreaks culminated in the first clearly documented pandemic in 1580, spreading from Asia into Europe and Africa.

The 1957 and 1968 influenza pandemics caused millions of deaths worldwide

The 1957 H2N2 pandemic spread from East Asia, killing more than 1M globally, while the 1968 H3N2 pandemic began in Hong Kong and caused a similar toll, with both strains rapidly moving across continents.

A novel H1N1 influenza strain sparked a 2009 global pandemic

First detected in Mexico, the 2009 “swine flu” pandemic infected up to 1.4B people worldwide. While mortality rates were lower than earlier pandemics, the outbreak still caused more than 150,000 deaths.

How the 1918 pandemic spurred developments in virology and vaccines

This article provides an in-depth historical account of the 1918 Spanish Flu pandemic, including its impact on the global population and how its occurrence spurred significant advancements in the study of viruses—laying the groundwork for the...

Why the 1918 flu killed between 50 and 100 million people

The 1918–1920 flu pandemic (once called, incorrectly, the Spanish flu) killed quickly and in huge numbers, with estimates of the global death toll ranging from 50 to 100 million people. Several factors contributed to the high mortality rate: lack of antibiotics, the global disruption of World War I, and more.

A timeline of major pandemics from 1899–2025

Modern pandemics have been defined by the race between globalization (which increases risk) and the development of new medicines. The Great Influenza epidemic claimed some 50 million lives, and the COVID-19 pandemic killed more than 7 million. In between, diseases like Ebola, cholera, AIDS, and more have devastated communities.

In 1933, the influenza virus was first identified through “ferret flu” experiments

In 1933, British researchers dripped filtered nasal fluids from a sick colleague into ferrets, which quickly developed “ferret flu.” This experiment proved influenza was viral, not bacterial, and established the basis for modern flu vaccines.

Measles reached global transmission during the 15th- and 16th-century Columbian exchange

Devastating diseases like smallpox, influenza, measles, and other viruses were largely introduced into the Western Hemisphere beginning with the 1492 arrival of Christopher Columbus and the ensuing age of exploration.

Volcanoes in the 1340s likely helped trigger the Black Death

The "bubonic plague" that wiped out roughly half of Europe and Asia originated from many factors. Recent research suggests volcanic eruptions contributed as well. The "aerosol" effects of matter released from eruptions likely prompted famine and accelerated the spread of infected fleas riding on grains avoiding spoilage.

Hear firsthand stories from Americans who lived through the 1918 flu pandemic

This video shares personal accounts from survivors of the 1918 influenza epidemic, capturing memories of sickness, loss, and resilience. Their voices offer a glimpse into how ordinary people experienced one of history’s deadliest pandemics.

The word 'influenza' comes from a 15th-century Italian belief in the stars

In Renaissance Italy, epidemics were thought to result from the influence of natural disasters or celestial bodies. The illness was named "influenza", meaning “influence” in Italian.

Volcanic activity may have triggered the Black Death by spewing gases that led to crop failures in Europe, thus forcing the import of grain ships with plague-infested fleas.

Major genetic shifts in flu viruses can spark global pandemics

Antigenic shift happens when two different influenza viruses infect the same host and swap genetic material. The result is a brand-new subtype of influenza which, if easily spread among people, can trigger a worldwide pandemic.

The virus was officially described for the first time in 1789

Michael Underwood, an English physician and surgeon, was the first to describe the disorder, noting it caused disability in the lower extremities in children. Large-scale outbreaks of the disease were not observed until the late 19th century.

Bird Flu is spreading—what does that mean for us and other species?

The rapid global spread of H5N1 bird flu—from remote Antarctic islands to US farms—shows how animal spillover, driven by human activity and ecological disruption, is accelerating pandemic risk across species long before sustained human transmission begins.

Flu spreads through droplets in the air and on surfaces

Influenza passes mainly through tiny droplets released when sick people cough, sneeze or talk. The virus can also survive briefly on surfaces, allowing it to spread when others touch contaminated objects.

See how Ebola tore through Guinea, Sierra Leone, and Liberia in 2014-2016

Frontline traced how the outbreak started and spread across West Africa. documenting first-hand accounts and patient experiences. This Ebola outbreak was the deadliest to date, resulting in over 11,000 deaths.

See how Ebola tore through Guinea, Sierra Leone, and Liberia in 2014-2016.

HIV originated in Central and West Africa from a virus in chimpanzees

Researchers believe the virus crossed from chimpanzees to humans through bushmeat practices in the early 20th century, with genetic studies suggesting the most recent common ancestor of the HIV-1 M group, which is responsible for the global AIDS pandemic, emerged around 1910–1930 in Léopoldville (now Kinshasa) in the Belgian Congo.

How royal panic led to Europe's deadliest witch hunts

This article delves into the witch "panics" and hunts that roiled across Scotland between 1590 and 1662. The witch hunts in Scotland were unusually deadly, with the country having five times the average European execution rate per capita. Their...

Pneumonia was once a leading killer before penicillin treatments

In the early 20th century, pneumonia was a top cause of death worldwide, often fatal without effective treatment. Penicillin turned a once deadly infection into one of the most treatable bacterial diseases.

Early farming created population booms—and also major busts

Europe’s ancient embrace of farming took the continent on a demographic roller-coaster ride. Regional booms and busts in human numbers occurred between 8,000 and 4,000 years ago, a new study finds.

The first ever IPO was issued by the Dutch East India Co., a spice company

It first offered shares to the public in the 1600s on the Amsterdam Stock Exchange to help finance its passages. The Dutch East India Co. succeeded in part due to its monopolistic hold over the East Indies at the time.

Europe’s first universities emerged from medieval church school

The modern university can be traced back to the Middle Ages, when schools in Italy, France, and England initially trained clergy before expanding to include lay students. By the 10th and 11th centuries, they taught law, medicine, and theology across Europe.

Who was impacted by the first world war, and how?

This interactive map from the National Archives in the UK details the global impact of World War I. Countries and territories from Aden to New Zealand were impacted by the Great War, which started in 1914 and lasted until 1918. By selecting various locations on the map, viewers can access articles and evidence on how the war's influence traveled far beyond the front lines.

The first printed Advent calendars were from Germany in the early 1900s

Printed Advent calendars originated in early-20th-century Germany, where printer Gerhard Lang created the first commercially produced versions. Inspired by his mother’s homemade countdowns, Lang added small doors in the 1920s, establishing the format that spread worldwide.

Human-to-human transmission of hantavirus remains extremely rare, so the 2026 hantavirus cruise ship outbreak doesn't mean we're facing a COVID-style pandemic risk.

Poison ivy was sent to Europe in the 1600s as an exotic, ornamental oddity, where it was purposefully grown in the English royal gardens at Kew, the Faculty of Medicine in Paris, and a few other locations.

The American cockroach is actually from Africa, an apparent hitchhiker aboard ships carrying enslaved people, with evidence suggesting the bug may have arrived in the New World as early as the 1600s.

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

Learn more about the history of fireworks, which dates back to an accidental invention during an alchemist's quest for information about immortality.

Elk Cloner, the first computer virus to spread in public, was written as a practical joke by Richard Skrenta, a Pittsburgh high school student.

The first horror movie is believed to be George Méliès' 1986 short 'The Haunted Castle,' which pioneered the use of special effects

The Russia-Ukraine conflict is the largest ground war in Europe since World War II in casualties, forces mobilized, and displacement of civilians.

Scientists can determine Earth's past climate conditions by analyzing air trapped in microscopic bubbles within ice cores—columns of compressed snow layers that build up over hundreds of thousands of years.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

Stanford built a Google Maps for the Roman Empire, revealing how much it cost to travel in the ancient world

Apeirophobia is an overwhelming fear of living forever, perhaps stemming from the brain's inability to conceptualize an infinite life.

The term 'algorithm' originated from the Latinized name of al-Khwārizmī, a 9th-century mathematician whose works introduced Arabic numerals and the decimal-based numeral system to Europe and whose treatise 'Al-Jabr' gave algebra its name.

Visualize the path of every solar eclipse from 1900 to 2099 and see what each looks like when observed from different locations on Earth.

While the first exchange-traded fund (a 'basket' of different assets that can be bought and sold on a stock exchange) in the US only launched in 1993, the global ETF market has grown to more than $10T in the short time since.

The US first hosted the World Cup in 1994, a tournament that lives in soccer infamy for its poor planning and the murder of Colombian player Andres Escobar, who'd accidentally scored on his own net.

Double world record holder Hunter Ewen helped conquer his fear of balloons, called globophobia, by training to win Guinness World Record titles for balloon inflation.

For centuries, it was common to sleep in two shifts: a few hours at the beginning of the night, and a longer period beginning around midnight

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

A century of Billboard issues documenting the evolution of popular music.

Exploring the Larry Bird punch that almost changed March Madness

The original copy of the Declaration of Independence is not a pristine document, and even features a smudged anonymous handprint in the bottom left corner.

'Shogun,' a 1980s TV series, helped popularize sushi in the US by stimulating an American interest in Japanese culture.