LSD's molecular structure closely resembles the neurotransmitter serotonin

How to make LSD

Lysergic acid diethylamide, often shortened to LSD, comes from ergot, a parasitic fungus that can be found in grains. Chemists rearrange the fungus' chemical structure or the structure of an ergot derivative through complex chemical reactions, transforming it into the hallucinogenic bicycle-shaped LSD crystal. Due to the partially synthetic drug's criminalization, many of the details of modern LSD crafting honed by "underground chemists" are kept secret.

Only a fraction of LSD reaches the brain, but it concentrates in key regions

When taken, LSD is absorbed quickly (often within an hour of ingestion) and exerts its effects primarily by binding to serotonin receptors. While only a small amount enters the brain, it's active in regions controlling the visual and auditory senses, potentially driving its psychedelic effects. The drug doesn't linger in the body, and is typically undetectable within a day.

LSD was derived from natural compounds produced by the ergot fungus

Ergot is a fungus that slowly infects and replaces individual grains on grasses, including rye and wheat. Ingesting ergot can cause ergotism, a form of poisoning with symptoms—including headaches, hallucinations, gangrene, and convulsions—varying by season and geography. This grain was used for medicinal purposes as early as the 1500s.

LSD (better known as acid) was created in 1938 by Swiss chemist Dr. Albert Hofmann

Lysergic acid diethylamide, better known as LSD or acid, was first developed synthetically in 1938 by Swiss chemist Dr. Albert Hofmann. It's since become a linchpin for an entire aesthetic, fueled a counterculture movement, and is being studied for potential therapeutic uses.

LSD-like drugs may inspire new antidepressants

LSD and psilocybin have shown promise as antidepressants. Using a virtual library of similar chemical compounds, researchers determined via animal studies that two molecules inspired by LSD have antidepressant effects without any associated hallucinogenic experience. These molecules were found to be 40 times more potent than the common antidepressant fluoxetine, also known as Prozac, with antidepressant effects lasting up to 21 days.

Psychedelics interact with neurotransmitter systems to alter one's perception

LSD, psilocybin, and MDMA can suppress the brain's default mode network and enhance connectivity. Research shows that, when paired with therapy, psychedelics may help treat mental health conditions, including depression, addiction, and PTSD.

An overview of modern clinical research on LSD

Researchers have determined that LSD, taken in a medical setting, decreases anxiety related to "life-threatening disease," reduces brain reactivity to fearful faces, increases the meaning and emotional response derived from music, and more. No complications of LSD administration have been observed in medical settings, though acute adverse effects, including exhaustion, nausea, and difficulty concentrating.

Psychedelic compounds: a visual library

However psychedelic experiences manifest, they all begin with the presence of psychoactive compounds. Learn about their various chemical compositions in this structural library of psychedelic compounds. Clicking on an entry will take readers to a new page where they can learn about the chemistry and pharmacology of each compound, as well as the drug's possible applications.

What exactly is dopamine?

Dopamine is a neurotransmitter—a chemical released by neurons that enables neural communication—that makes people want things with an "almost animalistic desire," compelling them to snack or check phone notifications. Often misrepresented as a "pleasure" chemical, dopamine is involved in motivation, learning, attention, habit formation, and more. Trends like dopamine fasting overinflate its role in mental health and often use it as part of "straw man" biohacking claims.

Monosodium glutamate is a sodium salt form of a naturally occurring amino acid

Monosodium glutamate myths originate from a 1968 letter to the New England Journal of Medicine, in which unpleasant symptoms after eating Chinese food were dubbed Chinese restaurant syndrome without medical data. Subsequent studies show this savory flavor enhancer—found in tomatoes, mushrooms, and other foods—is safe in moderation.

SAD disrupts melatonin secretion, producing it longer in the morning

The hormone is secreted from the pineal gland in the brain and is key to the timing of sleep. However, the substance does not generate sleep itself. With seasonal affective disorder, the body misperceives the photoperiod—the time with light—and the cycle of sleeping and waking gets off-phase, leading to issues with circadian rhythms.

The research that led to sour

Scientists are trying to figure out if there are unique receptors that respond to the molecules that make up flavors we associate with calcium, blood, batteries, and other items that often escape dinner menus. Taste researcher Dr. Danielle Reed says the minimum evidence for a taste category typically involves identifying dedicated receptors and then removing them to show the taste vanishes.

Opium is a milky liquid substance extracted from unripe poppy plant seeds

It's been used for ages to reduce pain and induce euphoria, both of which are side effects of the plant's alkaloids—nitrogen-based compounds with pronounced physical effects. Isolating and synthesizing derivatives of these naturally occurring chemicals enabled the invention of morphine, heroin, and other opioids.

Scent is a stronger memory trigger than sight

Smell is imbued with more emotion than visual memories, and research indicates that smell triggers a significantly greater effect on amygdala activation. Scientists believe these powerful responses occur partly because smell signals bypass the thalamus and go directly to the amygdala and hippocampus, brain areas involved in emotion and memory.

View examples of luciferin, the light-emitting molecule behind bioluminescence

Bioluminescent marine organisms rely on various unique luciferins, including Cypridina-type luciferin in seed shrimp and chlorophyll-based dinoflagellate luciferin, to react with oxygen to produce light. These chemicals require unique catalysts to help them bind with oxygen.

Sclerosis is the technical term for the lesions or plaques that form without myelin

In the absence of myelin, the body forms scar tissue called sclerosis. That scar tissue hampers nerve's abilities to transmit nerve impulses, essentially acting as a roadblock to speedy communication.

Synesthesia: when sensation in one sense triggers an unrelated sense in the brain

The first reported clinical case of synesthesia dates back to the early 1800s, though the perceptual phenomenon may be much older than surviving records imply. This article by researcher Richard Cytowic details the scientific history of synesthesia, a neurological trait that causes some senses to overlap, giving color to numbers and flavors to names.

A psychedelic hamburger led one member of the Manson Family, the murderous cult led by Charles Manson, to testify against the group's leader.

GLP-1 drugs, first used to manage diabetes, were derived from Gila monster saliva

Scientists studying the barely-there feeding frequency of the Gila monster found its saliva had a hormone regulating blood sugar and appetite. Further research revealed this hormone resembled a human one known as GLP-1, giving rise to the modern wave of diabetes and weight-management drugs.

Symptoms of DNA loss may mimic those seen in mushroom poisoning or chemotherapy

Although no organism has ever lost all its DNA, the destroying angel mushroom contains amatoxin, which disrupts DNA transcription and is known to cause death via liver and kidney failure in three days. Doxorubicin, which tangles DNA to disrupt cellular replication, compromises a person's immune system.

Linguistics professors believe memes are a language

It's generally agreed upon that languages exhibit at least some of the following characteristics: compositionality, social transmission, arbitrariness of form and meaning, and accomplishment of linguistic functions like asking questions and expressing emotions, among other qualities. Memes fulfill these basic requirements, giving them linguistic legitimacy.

AI hallucinations are inaccuracies or falsehoods in generated content

AI hallucinations are a by-product of the sequential creation of content based on patterns in text, which may not reflect the context or meaning behind a prompt. Back-end issues like biased datasets and overfitting of model data contribute to hallucinations.

The mushrooms in 'Super Mario Bros.' are modeled after a real mushroom

Almost every mushroom in "Super Mario Bros." is based on the Amanita muscaria, sometimes referred to as the fly agaric, because it is known to attract flies. It's also the basis for the original mushroom emoji and the mushrooms from the popular game "Minecraft."

After her fellow cult members tried to kill her with an LSD-infused hamburger, one member of the Manson Family, the murderous cult led by Charles Manson, decided to testify against the group's leader.

What it means to call something 'Lynchian'

David Lynch was one of American cinema's most influential directors. He brought a singular, unsettling vision to the silver screen. Critics, however, have trouble pinning down what it means when other artists try to recreate that vision. This essay untangles his influence, tracing the word "Lynchian" back to its earliest utterances and attempting to define a notoriously slippery term.

Itching is caused by stimulated nerve cells in the skin

Scratching produces low-level pain signals to the brain, distracting from the itch. Scratching also releases serotonin, a neurotransmitter that creates a happy sensation, which resets the itch signal. This can cause a cyclical itch-scratch cycle.

Researchers believe the brain consolidates memories, processes emotions, and plans for the future during dream states

The Great Salt Lake's distinct dual coloration results from high-salinity organisms that only live in the northern portion and produce a purple protein.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

See how fireworks are made and learn how metals like magnesium and copper are responsible for different colors.

Ebola is a filovirus, meaning it resembles a thread under a microscope, though it sometimes twists and can resemble a bowl of spaghetti.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

Fear or disgust related to clusters of holes and cracks, called trypophobia, may stem from evolutionary processes to help us avoid pathogens.

Browse a detailed visual analysis of over 200,000 similes—comparisons that often use 'like' or 'as'—from popular fiction to see how frequently writers the same idiomatic expressions.

All rainbows are 'raincircles' caused by water droplets separating white sunlight into a spectrum of colors, but Earth's surface blocks the bottom half of the circle from our line of sight.

Objects can be 3D printed with light by projecting 2D computerized tomography (CT) scans onto rotating cylinders of resin, which solidify upon exposure.

While atoms are normally made of protons, neutrons, and electrons, exotic ones have been built with antimatter—alternate versions of normal matter that live for fractions of a second and are about a billion times as rare.

When a Paris department store hesitated to sell Estée Lauder's perfume, she 'accidentally' broke a bottle, causing the smell to spread throughout the store and shoppers to start asking to buy the scent.

Sony set the standard for cylinder-shaped batteries when it repurposed manufacturing equipment used to make rolls of magnetic recording tape.

Some Pokémon have been named after real and fictional organisms, while some real-world species have been named after Pokémon, such as Chilicola charizard and Binburrum zapdos.

The Dracula character, now seen as the vampire archetype, was inspired by a seafood-induced nightmare its creator experienced.

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

Explore an interactive map built from more than 100,000 survey responses on where people find joy in their lives

Poison ivy's rash-causing compound is found in the plant's roots, stem, and leaves—so coming into contact with any part of the plant can lead to rashes for the 85% of people who are allergic to it.

In 1945, Surrealist artist Salvador Dalí and legendary animator Walt Disney began collaborating on a short film that was not completed until 2003, years after both men had died.

Georgia O'Keeffe's flower paintings are often assumed to be sexual, though the artist claimed she was simply interested in highlighting the beauty of flowers that most people neglect

Learn how to read a prospectus, the juicy document that any company must file with the SEC before going public.

English mathematician Ada Lovelace wrote the first computer algorithm a century before computers existed and hypothesized that computing devices would one day be able to compose music—foreseeing the generative AI systems of today.

The word 'jazz' evolved from 'jasm,' 19th-century American slang for 'energy'