Poison ivy's rash-causing compound is found in the plant's roots, stem, and leaves—so coming into contact with any part of the plant can lead to rashes for the 85% of people who are allergic to it.

Poison ivy's characteristic rash is caused by an allergic response to an oily compound in the plant called urushiol.

Poison ivy's characteristic rash is caused by an allergic response to an oily compound in the plant called urushiol.

Poison ivy can cause rashes year-round since all parts of the plant contain urushiol, the oil that triggers our allergic response.

Between 10 million and 50 million people in the US develop rashes from poison ivy, poison sumac, and poison oak each year.

Between 10 million and 50 million people in the US develop rashes from poison ivy, poison sumac, and poison oak annually

If someone is exposed to one of these plants for the first time, it can take several weeks to develop a rash.

This poison ivy knowledge quiz—accompanied by photos of the plant's varied forms—may help you identify this common rash-inducing growth.

Poison ivy can cause rashes any time of the year

This myth-busting article about poison ivy notes that all parts of the plant contain urushiol, the oil that triggers our allergic response, so if you are in the woods in winter you may be still encounter the plant—and urushiol.

Poison ivy's characteristic rash is caused by an allergic response to an oily compound in the plant called urushiol

Chinese lacquer tree sap also contains urushiol, yet the sap was widely used as a lacquer in Asian lacquerware for thousands of years. The word "urushiol" is derived from the Japanese word "usushi," which is the word for the lacquer tree.

Urushiol, the oily toxin in poison ivy, can remain allergenic on clothing for years

The substance can still cause rashes even after being on shoelaces, clothing, sleeping bags, boots, or other clothing for multiple years—some reports say five years on surfaces—so they all need to be washed after outdoor adventures with the plants.

Poison ivy is projected to be larger and more resilient due to climate change

Elevated atmospheric carbon dioxide boosts the growth rate of the plant and the resulting leaf area. These larger plants contain more uroshiol—the substance most humans are allergic to—and are hardier, recovering from damage more quickly than their smaller counterparts.

See if you know how to recognize poison ivy

This quiz, accompanied by photos of the varied forms of the plant, may help you identify the plant when it counts.

Poison ivy is in the same family as mangoes, cashews, and pistachios—and they all produce oily urushiol in their raw, unprocessed state—but they are typically prepared in ways to avoid causing human discomfort.

Urushiol, the oily toxin in poison ivy, can remain allergenic on clothing for years.

Poison ivy is in the same family as mangoes, cashews, and pistachios—and they all produce oily urushiol in their raw unprocessed state, and chewing mango skin can produce blister rashes

Poison ivy only seems to lead to allergic responses in humans, other primates, and guinea pigs. Other animals can both interact with the plant and eat it without becoming sickened.

Poison ivy will likely become both larger and more resilient due to climate change.

During the French Revolution, a botanist's letter asking about "dear Rhus" (poison ivy) was intercepted and led to authorities' suspicions he was conspiring with the Russians

The 1794 incident involved André-Ignace-Joseph Dufresnoy, a French army physician researching the plants' potential medicinal properties. Rhus radicans is a scientific name for the plant, though it's commonly called Toxicodendron radicans.

Poison ivy was sent to Europe in the 1600s as an exotic, ornamental oddity, where it was purposefully grown in the English royal gardens at Kew, the Faculty of Medicine in Paris, and a few other locations.

Poison ivy was sent to Europe in the 1600s as an exotic, ornamental oddity

The plants were grown in the English royal gardens at Kew, the Faculty of Medicine in Paris, and a few other locations.

Scientists testing how climate change affects plants found, in a years-long simulation study, that poison ivy grew 70% faster with the resulting extra carbon dioxide.

During the French Revolution, a botanist's letter asking about "dear Rhus" (poison ivy) was intercepted, leading authorities to suspect he was conspiring with the Russians.

You can be allergic to grass—but there are other reasons it can make you itch

Allergies occur when our immune system mistakenly considers a substance a threat

Immunoglobulin E antibodies, or IgE antibodies, may bind to an allergen, effectively labeling it as a threat. That triggers a cascade of actions in the body, including the release of histamine, which causes the characteristic itching and hives of allergies. Sometimes a cooked version of an allergen—like a cooked carrot—may look different enough from its raw form to the immune system that antibodies ignore it, and no allergic response takes place.

Natural toxins produced on plants or consumed by animals may cause food poisoning

When humans eat plants with certain natural toxins on them—including a family of toxins called aflatoxins that fungi produce on crops like peanuts and corn— they can become ill with food poisoning. Toxins can still harm humans even if animals or plants appear fine to the human eye. The World Health Organization advises that we should throw away moldy or discolored foods, refrain from eating wild plants or mushrooms that aren’t definitively nonpoisonous, and remember that just because something is “natural” it’s not always safe to eat.

Plants use physical and chemical defenses to protect themselves

Tree bark is difficult to chew and resistant to pathogens, while the waxy cuticle on the surface of leaves deters insects and microbes. Some plants possess thorns, spines, and prickles to discourage predators. Plant cells can also produce antimicrobial toxins or release compounds to alert parasitic wasps to lay eggs in attacking insects.

Erythema migrans rash is common in Lyme—but it often doesn't look like a bull's-eye

The US Centers for Disease Control and Prevention states that this rash occurs in roughly 70% or more of Lyme disease patients, and typically occurs at the site of a tick bite. The rash may expand slowly over several days and feel warm to the touch, but it's rarely itchy or painful. As it grows, areas of it may clear—creating a target or "bull's-eye" appearance.

About 95% of people are naturally immune to leprosy

Contracting it requires prolonged contact with someone with the disease, meaning you'd have to be living with them. You cannot get leprosy from hugging someone with leprosy or sitting next to them. It's not known to pass from mother to fetus. The risk of transmission from armadillos is also likely low, but people should avoid touching wild animals for general safety.

Many patients with psoriasis develop other autoimmune diseases, too

A small study published in 2024 found that nearly three-quarters of patients with psoriasis—a condition in which the body attacks healthy skin cells—also developed autoimmune disorders including thyroid diseases, connective tissue diseases, and more, suggesting such connections between these autoimmune disorders warrant further exploration.

The legacy of Agent Orange: a photo gallery

An herbicide sprayed over the Vietnamese jungles during the war had a far greater impact than its supposed role as a defoliant, a chemical used to remove greenery. Agent Orange’s deleterious nature quickly impacted exposed people – and their children. This photo gallery, which includes graphic images, follows a photographer as they report on those affected by the chemical.

Beyond burns, fireworks can harm respiratory, auditory, and visual health

While mishandling fireworks can cause severe burns and loss of appendages, there are also risks for viewers of displays. Released particulate matter can cause the surrounding air to resemble wildfire smoke, and the explosions can cause hearing loss and damage to the corneas.

A 101 on the 'Death Cap,' the world's deadliest mushroom

The Death Cap, also known as amanita phalloides, is the most fatal mushroom on the planet, responsible for roughly 90% of the world's mushroom deaths per year. Ingestion of the mushroom wreaks havoc on the liver and kidneys, frequently leading to...

Learn about ionizing radiation and see the most radioactive places on Earth

The average person is exposed to radiation every day, though most of it is either harmless non-ionizing radiation or ionizing radiation at doses too small to significantly affect an individual. The highest doses of ionizing radiation are received by smokers due to the radioactive polonium and radioactive lead in tobacco products.

The oral, live virus vaccine is the most robust but carries more risks

The live virus vaccine, delivered via oral drops, induces the best protection in the body. Because it includes a live, weakened form of the virus there's an extremely small risk it can sicken recipients and potentially cause paralysis. Recipients also shed the virus in their stool, which can rarely lead to vaccine-derived cases of the virus if the virus mutates. (Some users may experience a paywall.)

What is the rarest color in nature?

Plants, animals, or minerals found in nature bear almost every color imaginable. There are two factors that influence what hues you see in the wild: physics and evolution. So, which colors are you least likely to see in the natural world? Victoria Hwang explores one of nature’s rarest spectacles.

There are no outdoor locations that are safe from lightning

If your hair stands up amid an approaching storm, seek shelter immediately, as a local buildup of charge imbalance precedes cloud-to-ground lightning. If you are stuck outside, move to a lower altitude, such as a valley or ravine, and avoid open fields, water, and isolated tall objects. Do not lie down or crouch.

Tattoo inks are largely unregulated by the FDA

With hundreds of ink manufacturers, all unregulated by the FDA, it’s hard to determine the exact ingredients in tattoo inks. Some pigments may contain carcinogenic chemicals, such as heavy metals and aromatic hydrocarbons, or even bacterial contaminants. Red ink often causes allergic reactions and may even contain lead or mercury.

Opioids are a class of drugs including fentanyl, heroin, oxycodone, and more

Since the dawn of pain, living things have sought ways to mitigate this evolutionary warning signal. One of nature's most effective painkillers is opium, a highly addictive, milky latex extracted from poppy plants. This forms the basis of one of the most prescribed classes of modern drugs.

The use of fungi to detoxify land and water—a process known as mycoremediation—has been used to clean up natural resources affected by the 2025 California wildfires.

Firework or sparkler burns, even if they cover a relatively small area of skin, can significantly affect our range of motion.

Louisiana's 'Cancer Alley' is infamous for having some of the highest industrial pollution, toxic air emissions, and cancer risks in the US.

Listen to an in-depth conversation on the links between Parkinson's disease and herbicide exposure and the challenging pace of scientific investigation.

Watch what the Ebola virus does inside our cells and organs in order to spread and survive.

The deadliest aspect of volcanic eruptions is often not lava, but pyroclastic flows—avalanches of ash, gas, and rock that can move more than half the speed of sound.

Animal phobias are likely the most common type of phobias, followed by an extreme fear of heights.

Radioactive elements can introduce software errors because the ionizing radiation they produce can detach electrons from atoms, and computer code relies on the distribution of electrons.

All rainbows are 'raincircles' caused by water droplets separating white sunlight into a spectrum of colors, but Earth's surface blocks the bottom half of the circle from our line of sight.

The Great Salt Lake's distinct dual coloration results from high-salinity organisms that only live in the northern portion and produce a purple protein.

After her fellow cult members tried to kill her with an LSD-infused hamburger, one member of the Manson Family, the murderous cult led by Charles Manson, decided to testify against the group's leader.

Prince's sexually explicit 1984 track 'Darling Nikki' attracted the ire of the Parents Music Resource Center, an advocacy group that inspired the Parental Advisory sticker, even though the song ends with a Christian message.

Iran's Revolutionary Guard Corps is independent of Iran's regular army and is one of the most powerful and influential military-political organizations in the Middle East.

An initial public offering or 'IPO' is the process of a private company becoming public by putting shares of the company on the stock market for purchase.