A 101 on the 'Death Cap,' the world's deadliest mushroom

Symptoms of DNA loss may mimic those seen in mushroom poisoning or chemotherapy

Although no organism has ever lost all its DNA, the destroying angel mushroom contains amatoxin, which disrupts DNA transcription and is known to cause death via liver and kidney failure in three days. Doxorubicin, which tangles DNA to disrupt cellular replication, compromises a person's immune system.

19 fungal pathogens are of key concern to world health officials

In 2022, this global health body issued its first-ever list of top fungal threats to human health. It said fungal threats are spreading and occurring more frequently. The WHO’s list included 19 fungal pathogens to watch, and said that the most dangerous ones to public health are Cryptococcus neoformans, Aspergillus fumigatus, Candida albicans, and Candida auris. There are only a handful of classes of medication currently available to combat fungal pathogens, with few others in the pipeline even though antimicrobial resistance is growing.

Natural toxins produced on plants or consumed by animals may cause food poisoning

When humans eat plants with certain natural toxins on them—including a family of toxins called aflatoxins that fungi produce on crops like peanuts and corn— they can become ill with food poisoning. Toxins can still harm humans even if animals or plants appear fine to the human eye. The World Health Organization advises that we should throw away moldy or discolored foods, refrain from eating wild plants or mushrooms that aren’t definitively nonpoisonous, and remember that just because something is “natural” it’s not always safe to eat.

Mosquitoes top the ranking of the world's deadliest animals

Mosquitos kill about 760,000 people every year. The vast majority of those deaths are caused by malaria, which is transmitted and spread by the Anopheles mosquito. The second-place deadliest animal title goes to snakes, with an estimated human death toll of around 100,000 annually.

The ‘humongous fungus’ may be the largest organism on Earth at more than 2,300 acres

Discovered in 1988, when it was only covering 400 acres, this massive colony of Armillaria ostoyae, based in Oregon, has taken hold among the tree roots of the Malheur National Forest. It consists of a vast network of unique long black filaments of fungal tissue called rhizomorphs that grow under the soil and infect tree roots, nourishing the fungus but killing the trees. Researchers believe this fungal growth dates back more than 8,000 years and currently weighs approximately 35,000 tons.

The mushrooms in 'Super Mario Bros.' are modeled after a real mushroom

Almost every mushroom in "Super Mario Bros." is based on the Amanita muscaria, sometimes referred to as the fly agaric, because it is known to attract flies. It's also the basis for the original mushroom emoji and the mushrooms from the popular game "Minecraft."

How Alzheimer’s disease becomes fatal

Despite more than 100,000 people with Alzheimer's dying each year, the specific cause of death is not the disease itself. Often, secondary diseases arise from complications with the disease, including pneumonia, severe falls, malnutrition, or infection. Read more about the range of complications caused by Alzheimer’s here.

Watch Cordyceps, a parasitic fungus, turn an ant into a ‘zombie’

This National Geographic TV clip shows how a parasitic Cordyceps species—sometimes colloquially called the “zombie ant fungus”—controls an ant’s behavior and kills its host. The fungus can rapidly wipe out entire insect colonies.

Why bananas are in trouble

The average American eats over 25 pounds of bananas every year, but we won't for long if a deadly soil fungus continues to spread. Learn what scientists are doing to save the popular fruit.

Fentanyl can be up to 100 times more potent than morphine

A synthetic opioid, fentanyl is highly addictive and incredibly fast-acting—a fatal dose is equal to a few grains of table salt. Once it enters the body, fentanyl floods naturally occurring opioid receptors, which can cause the body to shut down its breathing reflex, leading to a fatal overdose.

Chocolate can be deadly in humans, but only after consuming extraordinary quantities

Based on tests with mice, the lethal dose of chocolate is estimated to be no more than 1,000 mg/kg. This means that the lethal dose of dark chocolate for the average US adult is about 6.5 kilograms (14.33 pounds), or about 8,300 Hershey's kisses, in one sitting.

An interactive trek up Mount Everest

At just over 29,000 feet, Mount Everest is the highest summit on Earth and the premiere destination for serious climbers. The imposing peak has also claimed at least 322 lives over the past century, or between four and five victims per year. This...

Mapping where the drug captagon is seized worldwide

In the 1960s, Captagon was patented in Germany as a stimulant similar to amphetamines. It was prescribed for a time to address narcolepsy, ADHD, and other conditions. As its addictiveness and psychosis-inducing quality became more apparent, the drug has been banned in many countries. A robust illicit manufacturing of the drug endures in the Middle East, especially in Syria and Lebanon. Track locations where the drug has been seized on this updated map.

In 1951, a small French town was overtaken by the fungus that ultimately led to LSD

During the summer of 1951, the French town of Pont-Saint-Esprit appeared to go mad. Hundreds were treated for hallucinations and delirium, with some reporting ongoing hallucinations a month after the LSD-like symptoms appeared. Some historians argue it was a case of ergotism, better known in the Middle Ages as "burning disease" and "St. Anthony's Fire."

'Blackout challenge' can cause brain damage or death in under 5 minutes

A social media trend that encourages viewers to asphyxiate themselves until they lose consciousness in the hopes of feeling "high" or euphoric has garnered the interest of teens and adolescents, with dangerous results. Variations of this deadly challenge have been adolescent trends every few years.

What can psychedelics teach us about dying?

Psychedelics have made their way into the world of licensed mental healthcare, and the drugs have been proven to help people process and lessen anxiety and depression. What does this mean for people with terminal illnesses who are afraid of death?

The world's weirdest flowers

We mostly marvel at the beauty of flowers, but some kinds of flowers are incredibly weird. This video highlights 15 of the world's strangest flowers, from the massive Titan Arum to the rare Lady Slipper Orchid.

View the 10 biggest volcanic eruptions in recorded history

The Mount Tambora eruption in 1815 was the deadliest and released so much sun-blocking ash and gas that 1816 became known as “the year without summer.” The resulting global food shortages are estimated to have killed over 71,000 people.

Marburg virus, related to Ebola, is also extremely deadly, and has no available vaccine.

What ghosts eat around the world

This Thrillist article compiles a rich assortment of cultural beliefs and practices surrounding food for the dead. From Bengali folklore to Ancient Greek mythology, peruse through the different ways in which cultures around the world use food to maintain connected to the deceased.

11 people died from firework injuries in the US in 2024

Most of those deaths involved misuse of the explosives and device malfunctions or misfires. That fatality count doesn't include the almost 15,000 people who received treatment in the emergency room due to firework-related injuries. More than a third of all the injuries in 2024 were burns, underscoring the risks of using these explosive devices.

How royal panic led to Europe's deadliest witch hunts

This article delves into the witch "panics" and hunts that roiled across Scotland between 1590 and 1662. The witch hunts in Scotland were unusually deadly, with the country having five times the average European execution rate per capita. Their...

The use of fungi to detoxify land and water—a process known as mycoremediation—has been used to clean up natural resources affected by the 2025 California wildfires.

After her fellow cult members tried to kill her with an LSD-infused hamburger, one member of the Manson Family, the murderous cult led by Charles Manson, decided to testify against the group's leader.

A cup of coffee on Earth contains about 100 proton masses worth of dark matter

The estimate is based on Earth's location within the Milky Way and the dark matter cloud it resides in. Because scientists do not know the nature of dark matter, the mass may be accounted for with any number of dark matter particles of varying mass.

Civet coffee is some of the most expensive (and bizarre) coffee in the world

Known colloquially as "cat poo coffee," the style is made from beans that have been consumed and then excreted by the Asian palm civet, a small mammal related to the mongoose. Coffee made from these beans is said to be smooth and complex, with notes of chocolate.

Test your knowledge of famous death days

Of the thousands of celebrities whose name you know, how many can you remember the year they died? This simple game tests your knowledge of celebrity death days. An exact match gets you 1,000 points, and if you select within 15 years of the right year you get some points. Go see how much you remember here.

Learn about ionizing radiation and see the most radioactive places on Earth

The average person is exposed to radiation every day, though most of it is either harmless non-ionizing radiation or ionizing radiation at doses too small to significantly affect an individual. The highest doses of ionizing radiation are received by smokers due to the radioactive polonium and radioactive lead in tobacco products.

11 people died from firework injuries in the US in 2024.

The deadliest aspect of volcanic eruptions is often not lava, but pyroclastic flows—avalanches of ash, gas, and rock that can move more than half the speed of sound.

Fear or disgust related to clusters of holes and cracks, called trypophobia, may stem from evolutionary processes to help us avoid pathogens.

During the French Revolution, a botanist's letter asking about "dear Rhus" (poison ivy) was intercepted, leading authorities to suspect he was conspiring with the Russians.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

When caught in the mouths of cardinal fish, seed shrimp release glowing, bioluminescent chemicals, which alert predators of the cardinal fish, prompting the shrimp's ejection.

The US first hosted the World Cup in 1994, a tournament that lives in soccer infamy for its poor planning and the murder of Colombian player Andres Escobar, who'd accidentally scored on his own net.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

For centuries, Niagara Falls has been a magnet for daredevils seeking to conquer one of nature's most powerful wonders, with its 200-foot drop and water rushing at 32 feet per second with 280 tons of force.

The Dracula character, now seen as the vampire archetype, was inspired by a seafood-induced nightmare its creator experienced.

The American cockroach is actually from Africa, an apparent hitchhiker aboard ships carrying enslaved people, with evidence suggesting the bug may have arrived in the New World as early as the 1600s.

In 2018, 26-year-old missionary John Allen Chau was killed by tribesmen after attempting to reach and evangelize on India's isolated North Sentinel Island

Neutron stars, the remains of some massive stars after they explode in a supernova, are the densest directly observable objects in the universe.

Indefinite cloning of some endangered species may not sustain their longevity because cloning success rates decrease as genetic mutations accumulate.

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

Explore a list of the 100 best novels of all time, compiled by some of the world's best living writers, including Salman Rushdie, Stephen King, and Jennifer Egan.

See the 25 of the best photos of auroras from around the world.

A pickleball's loud 'pop' sound can reach 120 decibels, which is equivalent to a hammer hitting a nail

The Nasdaq's 'Magnificent 7' companies are responsible for roughly 40% of the Nasdaq 100 index's gains, while the remaining 93 companies account for the other 60%.

See a 3D reconstruction of Tenochtitlan, the Aztec capital that was home to an estimated population of 200,000 to 400,000.

Art theft is the third-largest source of criminal revenues worldwide, thanks in part to the subjective nature of valuing a work of art.