Poison ivy is in the same family as mangoes, cashews, and pistachios—and they all produce oily urushiol in their raw unprocessed state, and chewing mango skin can produce blister rashes

Poison ivy's rash-causing compound is found in the plant's roots, stem, and leaves—so coming into contact with any part of the plant can lead to rashes for the 85% of people who are allergic to it.

Poison ivy's characteristic rash is caused by an allergic response to an oily compound in the plant called urushiol.

Poison ivy's rash-causing compound is found in the plant's roots, stem, and leaves—so coming into contact with any part of the plant can lead to rashes for the 85% of people who are allergic to it

Once sold as an ornamental plant, poison ivy can actually look varied—its colors change seasonally from reddish to green to yellow. It typically has three broad, shiny, tear-shaped leaves. But it sometimes may have a different number of leaves, and its edges can be serrated.

Poison ivy's characteristic rash is caused by an allergic response to an oily compound in the plant called urushiol

Chinese lacquer tree sap also contains urushiol, yet the sap was widely used as a lacquer in Asian lacquerware for thousands of years. The word "urushiol" is derived from the Japanese word "usushi," which is the word for the lacquer tree.

Urushiol, the oily toxin in poison ivy, can remain allergenic on clothing for years

The substance can still cause rashes even after being on shoelaces, clothing, sleeping bags, boots, or other clothing for multiple years—some reports say five years on surfaces—so they all need to be washed after outdoor adventures with the plants.

Poison ivy can cause rashes year-round since all parts of the plant contain urushiol, the oil that triggers our allergic response.

Urushiol, the oily toxin in poison ivy, can remain allergenic on clothing for years.

Poison ivy can cause rashes any time of the year

This myth-busting article about poison ivy notes that all parts of the plant contain urushiol, the oil that triggers our allergic response, so if you are in the woods in winter you may be still encounter the plant—and urushiol.

Between 10 million and 50 million people in the US develop rashes from poison ivy, poison sumac, and poison oak each year.

This poison ivy knowledge quiz—accompanied by photos of the plant's varied forms—may help you identify this common rash-inducing growth.

Poison ivy will likely become both larger and more resilient due to climate change.

Zoo animals have developed allergies, too

Although scientists do not know if allergies manifest among wild animals—and if animals can survive with them—in a zoo setting, veterinarians have observed zoo animals with common allergy symptoms, including itchiness, crusty skin, and runny eyes. Veterinarians have identified Asian elephants with pollen allergies and at least one jaguar with an allergy to fleas.

Natural toxins produced on plants or consumed by animals may cause food poisoning

When humans eat plants with certain natural toxins on them—including a family of toxins called aflatoxins that fungi produce on crops like peanuts and corn— they can become ill with food poisoning. Toxins can still harm humans even if animals or plants appear fine to the human eye. The World Health Organization advises that we should throw away moldy or discolored foods, refrain from eating wild plants or mushrooms that aren’t definitively nonpoisonous, and remember that just because something is “natural” it’s not always safe to eat.

Poison ivy was sent to Europe in the 1600s as an exotic, ornamental oddity, where it was purposefully grown in the English royal gardens at Kew, the Faculty of Medicine in Paris, and a few other locations.

You can be allergic to grass—but there are other reasons it can make you itch

Plants use physical and chemical defenses to protect themselves

Tree bark is difficult to chew and resistant to pathogens, while the waxy cuticle on the surface of leaves deters insects and microbes. Some plants possess thorns, spines, and prickles to discourage predators. Plant cells can also produce antimicrobial toxins or release compounds to alert parasitic wasps to lay eggs in attacking insects.

Allergies occur when our immune system mistakenly considers a substance a threat

Immunoglobulin E antibodies, or IgE antibodies, may bind to an allergen, effectively labeling it as a threat. That triggers a cascade of actions in the body, including the release of histamine, which causes the characteristic itching and hives of allergies. Sometimes a cooked version of an allergen—like a cooked carrot—may look different enough from its raw form to the immune system that antibodies ignore it, and no allergic response takes place.

Alpha-gal allergy is a problem for red meat lovers, and that same sugar is an issue for xenotransplants, too

In recent years, researchers have discovered ticks can induce spontaneous meat allergies in people they bite, a particularly problematic condition for previous meat lovers. This 18-minute podcast from RadioLab breaks down the cause.

People can—and have—contracted leprosy from armadillos

A 2011 study linked multiple human cases to the handling of armadillos or the consumption of their meat. The research couldn't document direct transmission, but did find that the animals and humans shared the same exact strain of the disease.

Cantaloupe’s textured skin boosts the risk of food poisoning

Food safety expert Darin Wetwiler says he prefers to stay clear of this fruit altogether since it’s so hard to keep the textured skin pathogen-free. He advises trying to avoid pre-cut cantaloupe in particular, since consumers won’t know when the fruit was sliced and pathogens on the outside could have been spread to the part we consume during slicing and multiplied.

Watch how viruses like Ebola can spill over from animals to humans—and vice-versa.

Neural replays in mice help explain food aversions

Princeton University scientists published research in 2025 analyzing how mice learn to associate certain foods or flavors with feeling ill—even when there’s a time gap between eating something and feeling sick. The work, performed with grape Kool-Aid and injections of a substance that made mice sick, traced the literal “gut reaction” of how gut distress signals are linked to neural replays of what the mouse ate.

The similarly named foot-and-mouth disease doesn't affect humans, unlike HFMD

Though the names are similar, foot-and-mouth disease—also known as hoof-and-mouth disease—exclusively affects animals, primarily those with hooves, such as cattle, sheep, pigs, goats, and even giraffes. It doesn't sicken humans, though both this disease and hand, foot, and mouth disease do come from the same family of viruses—Picornaviridae.

How those Pakistani Mangoes make it to shelves near you is more complicated than you think.

Customs restrictions, high transport costs, and a short shelf life have made the world’s greatest mangoes — grown in Pakistan — difficult to come by in the U.S.

Over time, people develop a resistance to spicy foods

TRPV1 is a receptor in the body that detects potentially harmful things and responds in a variety of ways, including sweating, tearing up or a runny nose. Over time, more exposure to spicy foods can build up a resistance that minimizes these reactions.

Mosquito saliva acts as an anticlotting agent

The bug's piercing mouthpart, the proboscis, is actually several tubes—one for sucking, one for spitting. But the chemicals in its spit actually help its blood meal to flow, combating its victim's ability to clot at the puncture site.

Are seed oils as bad as rumors say?

Some claim seed oils—oils extracted from seeds, such as sunflower or canola—increase inflammation and disease risk, advising consumers reach for saturated fats instead. Saturated fats, typically solid at room temperature, are found in animal products and some vegetable oils, including coconut. When adjusting for lifestyle risk factors, research shows seed oils are, on average, good for one's heart and considered healthy alternatives to saturated fat.

Humans need higher levels of water-soluble vitamins that easily pass through the body

There are two types of vitamins: lipid soluble and water-soluble. Water-soluble vitamins like B vitamins and vitamin C are in the watery parts of fruits and easily pass through the human body before being taken up by the bloodstream or exiting your body. But lipid (fat) soluble vitamins must be absorbed through the intestinal wall, carried by proteins, and then may be stored in the liver and other body parts—meaning there is greater risk of overdosing.

Typhoid smells like freshly baked brown bread

Certain ailments are associated with documented scents, including diabetes, Parkinson's disease, and typhoid. The skin of people with yellow fever, for example, can smell like a "butcher shop."

Turning some invasive species into cash crops has helped control their spread

In Mexico, some companies are transforming sargassum seaweed blooms into paper, bricks, and shoes, while in Cambodia, water hyacinths are dried and woven into baskets, rugs, and other crafts. Lionfish and green crabs have been hunted for culinary dishes, with the latter also being used to make crab whiskey in New England.

Measles attacks the body’s immune system, leaving it vulnerable to secondary complications

A measles infection begins in the lungs, where it hijacks cells known as macrophages and begins to replicate itself. It then uses a Trojan horse method to enter the lymph nodes, where it attacks vulnerable T and B cells. Symptoms include fever and rashes.

Volcanic ash is composed of fragments of volcanic rock, minerals, and glass

These abrasive particles are hazardous to aircraft. They can melt within engines and re-solidify on turbine blades, preventing forward propulsion. If inhaled, chemicals within ash can be toxic, and the particles can embed themselves into the lungs' ducts, causing suffocation.

Opium is a milky liquid substance extracted from unripe poppy plant seeds

It's been used for ages to reduce pain and induce euphoria, both of which are side effects of the plant's alkaloids—nitrogen-based compounds with pronounced physical effects. Isolating and synthesizing derivatives of these naturally occurring chemicals enabled the invention of morphine, heroin, and other opioids.

Indigenous people of the Amazon rainforest

Indigenous people have unrivalled knowledge of plants and animals and play a crucial role in conserving biodiversity. Protecting their rights preserves this unique knowledge.

Coral reefs get their colors from zooxanthellae—microorganisms that line corals' digestive tracts and provide them with sugars in exchange for a home within this protective tissue.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Firework or sparkler burns, even if they cover a relatively small area of skin, can significantly affect our range of motion.

Fear or disgust related to clusters of holes and cracks, called trypophobia, may stem from evolutionary processes to help us avoid pathogens.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

Tattoos remain visible on your skin thanks to immune cells called macrophages

Many legends about George Washington, including his supposed wooden teeth and the story of cutting down the cherry tree, lack evidence.

Louisiana's 'Cancer Alley' is infamous for having some of the highest industrial pollution, toxic air emissions, and cancer risks in the US.

Some Pokémon have been named after real and fictional organisms, while some real-world species have been named after Pokémon, such as Chilicola charizard and Binburrum zapdos.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

After her fellow cult members tried to kill her with an LSD-infused hamburger, one member of the Manson Family, the murderous cult led by Charles Manson, decided to testify against the group's leader.

Sunflowers have long been a symbol of nuclear disarmament because they can extract large amounts of radioactive cesium from soil.

Prince's sexually explicit 1984 track 'Darling Nikki' attracted the ire of the Parents Music Resource Center, an advocacy group that inspired the Parental Advisory sticker, even though the song ends with a Christian message.

Fast-casual restaurant Chili's is experiencing a resurgence, with its parent company recently reporting a nearly 32% increase in sales, thanks to passionate Gen Z fans on TikTok.

American short story writer Flannery O'Connor raised 40 peacocks, which became potent symbols for her fiction's elegant violence

Art theft is the third-largest source of criminal revenues worldwide, thanks in part to the subjective nature of valuing a work of art.