Over time, people develop a resistance to spicy foods

How bitter taste receptors help guard against infection

Receptors for "bitter" tastes evolved to detect potentially harmful plant chemicals, such as nicotine. The receptors also trigger bacteria-fighting responses, including waving hairlike projections to bat away bacteria, ordering the release of bacteria-killing nitric oxide, and calling for antimicrobial protein reinforcements.

Why the Scoville scale for measuring a pepper's heat is outdated and inadequate for sauces

Developed in 1912 by American pharmacist Wilbur Scoville, the scale is a subjective test in which testers determine the dilution at which capsaicinoids—the molecules that give peppers their heat—are no longer detectable. Modern chemical analyses can accurately quantify the amount of these molecules in peppers, which are diluted to varying degrees in sauces, thus affecting their net spiciness.

When common sounds become disturbing

Misophonia causes certain sounds to feel violating, triggering a "very visceral kind of experience" filled with extremely unpleasant emotions, including annoyance, anger, and disgust. A 2017 study found that people with misophonia have elevated activity in the brain's anterior insula—a region associated with interoception, emotional processing, and behavioral responses—when exposed to trigger sounds. Ongoing research suggests trigger sound context affects the severity and manifestation of the condition.

Humans can't smell the inside of their nose due to olfactory fatigue

Once a person is accustomed to a specific odor, their neurons have trouble continuing to respond to that smell because of that familiarity. That's why humans may not notice when their house smells like trash until they leave the house and then return to it.

The importance of volatile aroma compounds in the flavor quality of food

Processes such as air movement and heating cause food to lose aroma molecules, which studies have shown play a major role in our sense of taste. While losing these molecules to the environment leaves fewer to be processed during consumption to intensify flavor, it can also produce previously nonexistent aroma compounds or release previously trapped ones, altering or enhancing the food's flavor.

Overuse of opioids can lead to hypersensitivity to pain

Opioid misuse can lead opioid-induced hyperalgesia, where the body becomes increasingly sensitive to pain. The body produces its own opioids as a way to temporarily block pain signals. When met with external opioid use, the body ratchets up pain sensitivity to ensure it senses the pain necessary to trigger its own response.

Fevers are an immune response to create hurdles for pathogens

Substances called pyrogens prompt the brain to raise the body temperature to levels where bacteria and viruses struggle to survive. The higher temps also support immune cells fighting off the invaders.

Seasonal allergies don't always show up in childhood

The human immune system may become sensitized to pollen and develop an allergic reaction to it after prolonged exposure. Other triggers for new seasonal allergies may include exposure to new environments and changing climate conditions that affect allergy season length and conditions for various pollens.

The brains of people who experience frisson have unique neural pathways

A small 2016 study aimed to investigate the behavioral and neural differences between 10 individuals who experience goose bumps when listening to music and 10 who typically don’t. Scientists reported that individuals experiencing musical chills had greater white matter connectivity in specific auditory, emotional, and social processing areas of the brain.

Stress evolved as a survival mechanism to keep humans alive

Stress activates the “fight-or-flight” response when we face threats. It’s triggered by the hypothalamus, which signals the release of adrenaline and cortisol, heightening awareness and energy. While acute stress helps in short bursts, chronic stress—persistent over time—can harm both physical and mental health, leading to conditions like hypertension, anxiety, or depression.

CRISPR technology is removing allergens from common foods

Proteins responsible for allergies to eggs, milk, wheat, peanuts, and other foods can be genetically edited out of foods to reduce the risk of life-threatening reactions. The technique has also been used to produce caffeine-free coffee beans, spicier tomatoes, allergen-free pets, and more nutritious fish.

The idea of a tongue map has been discredited (but taste sensitivity varies across the tongue)

The original tongue map, created by German researcher DP Hanig, recorded taste sensitivities reported in psychological studies. His findings were later translated and taken out of context, possibly giving rise to the faulty tongue map. In fact, taste receptors in the oral cavity respond to all tastes regardless of their location.

A Venus flytrap's hairs convert sensory touch into electrical signals

A stretch-activated ion channel called DmMSL10 acts as an amplifier, converting grazing contact into a strong impulse that the plant uses to react and close its jaw. To distinguish prey from raindrops or other stimuli, the jaw only closes when the hairs are touched twice in quick succession.

Fear or disgust related to clusters of holes and cracks, called trypophobia, may stem from evolutionary processes to help us avoid pathogens.

Ticks are extremely hard to kill

These arachnids can transmit more than a dozen diseases to humans, and they're very resilient: Some can survive extreme heat and cold, live for years without a blood meal, and even survive multiple days underwater.

A web of sensory neurons in the skin help filter out background sensations

The somatosensory system helps us organize and navigate our surroundings, enabling us to understand our bodies in relation to our environment and also filter out minor sensations that are basically background noise so they aren't overwhelming to our bodies. Meanwhile, viscerosensation—or internal sensation—refers to the internal sensory neuron system that conveys information from internal organs to the brain.

Unlike milder fears, phobias may get in the way of proceeding with your life

Clinicians may recommend exposure therapy—exposing oneself to the thing triggering fears in some doses—as one way to help overcome a fear.

Play food science trivia along with a former state trivia champion

From limitations in panda taste receptors and a surprising food that has been forged into diamonds to the origins of chili pepper heat and the Maillard reaction, test your knowledge during a game of Super Food Science Excellence Trivia Blowout.

Tannins contribute to a wine's composition

Tannins are compounds found in many different types of food, including grape skins. When consumed, they produce a noticeable drying effect in the mouth. Because of the difference in production methods, red wines typically have tannins while white wines do not.

Stevia has been used to treat burns and indigestion

The substance, which is roughly 300 times sweeter than sugar and scientifically known as Stevia rebaudiana, comes from a plant that grows in Paraguay and Brazil. It has long been used medicinally and as a sweetener by indigenous communities in those locations.

There's no definitive test for inflammation, or a baseline for what's considered normal

Existing tests can pick up proteins that indicate an immune response—in particular C-reactive protein, which the liver produces when the body's stressed—but that won't tell you why there's inflammation nor if it's chronic or acute inflammation. (Some users may experience a paywall.)

Fungi make people sick when they invade and survive in otherwise healthy human tissue

We breathe in airborne spores frequently, but they often don't make us sick. This video details how certain concerning fungal changes can occur and discusses the role of mycologists—scientists who study fungi—in helping to improve human health.

How heatstroke—from overexertion or extreme heat—affects the body

When core body temperature soars to 104 degrees Fahrenheit or higher and remains there for about 30 minutes, it sets off a cascade of problems in the body. Proteins and cell membranes can degrade and begin to leak, potentially leading to liver damage, blood clots, GI tract damage, and organ failure, among other issues.

Most people with East Asian ancestry are genetically predisposed to be less smelly

A gene variant found in 80%-95% of individuals with East Asian ancestry reduces armpit bacteria and related odors. People with this nonfunctioning ABCC11 gene variant lack a protein that transports molecules, including sweat, across cellular membranes, so their armpits are starved of sweat that bacteria may have metabolized to help them multiply.

Poison ivy is in the same family as mangoes, cashews, and pistachios—and they all produce oily urushiol in their raw unprocessed state, and chewing mango skin can produce blister rashes

Poison ivy only seems to lead to allergic responses in humans, other primates, and guinea pigs. Other animals can both interact with the plant and eat it without becoming sickened.

Surfer's ear, from repeated cold water exposure, leads to new bony protrusions in the ear

Frequent exposure to icy cold water, typical in surfing, can cause tiny bony growths to develop in the ear canal, informally called surfer's ear. While the exact cause for these growths is unknown, it may be the body's protective response to shield the ear drum from the cold. These protrusions can heighten the risk of swimmer's ear, lead to wax buildup, and result in hearing loss.

Poison ivy is in the same family as mangoes, cashews, and pistachios—and they all produce oily urushiol in their raw, unprocessed state—but they are typically prepared in ways to avoid causing human discomfort.

Scientists testing how climate change affects plants found, in a years-long simulation study, that poison ivy grew 70% faster with the resulting extra carbon dioxide.

After 25 people used virtual reality headsets to practice flying with virtual wings—flapping their arms—their visual cortex responded to the wings almost as if they were real arms, treating them as body parts.

Learn how your body is, scientifically, like a firework with its own slow, controlled burn.

Visualize how CRISPR-Cas9—a type of immune system used by single-celled organisms to attack invasive viruses—targets and makes precise changes to a gene's DNA.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Tattoos remain visible on your skin thanks to immune cells called macrophages

Volcanoes 'die' when their supply of magma runs out, if they are shifted away from their underlying magma reservoir, or if they get clogged by collapsing or their magma cooling back into rock.

In recent years a child anxiety expert has created and tested a novel phobia and anxiety treatment approach for children, focused on changing how parents respond to the fears.

Fast-casual restaurant Chili's is experiencing a resurgence, with its parent company recently reporting a nearly 32% increase in sales, thanks to passionate Gen Z fans on TikTok.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

The boiling temperature of water decreases with increasing elevation because the molecules need less energy to overcome the lower atmospheric pressure associated with thinner air.

Experimental hantavirus vaccines and therapies, still under development, have long been funded by the US military.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

The history of many kitchen appliances involves unexpected discoveries and applications, including wartime radar turned hamster defroster and replacing an 'ice king' with heat-stealing boxes.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year

Explore an interactive map built from more than 100,000 survey responses on where people find joy in their lives

The Great Salt Lake's distinct dual coloration results from high-salinity organisms that only live in the northern portion and produce a purple protein.

Sunflowers have long been a symbol of nuclear disarmament because they can extract large amounts of radioactive cesium from soil.

Fish populations in the Great Barrier Reef have increased after installing waterproof speakers on the ocean floor that played recordings of sounds from healthy coral reefs.

Prince's sexually explicit 1984 track 'Darling Nikki' attracted the ire of the Parents Music Resource Center, an advocacy group that inspired the Parental Advisory sticker, even though the song ends with a Christian message.

In 2018, 26-year-old missionary John Allen Chau was killed by tribesmen after attempting to reach and evangelize on India's isolated North Sentinel Island

Some Pokémon have been named after real and fictional organisms, while some real-world species have been named after Pokémon, such as Chilicola charizard and Binburrum zapdos.