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Opioids mimic naturally produced endorphins to dull pain.

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Additional insights we found via TED-Ed

  1. Once in the body, opioids bind to naturally occurring opioid receptors typically used by endorphins to temper pain. They trigger the release of dopamine, a desire-related hormone, and decrease noradrenaline, a neurotransmitter involved in heart and breathing rate regulation—meaning high doses can also slow these processes to dangerous levels.

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