Coca-Cola was created during a patent medicine boom

Coca-Cola and Pepsi have a fierce rivalry

And it's been that way for a long time—both of the sodas were created in the late 1800s in the South. Pepsi was created by Caleb Bradham, and was originally called "Brad's Drink."

The drink that became Coca-Cola was originally called 'Pemberton's French Wine Coca'

When Civil War veteran John Pemberton concocted the drink, he was suffering from both a saber wound and a morphine addiction. He formulated Pemberton's French Wine Coca by copying the popular cocaine-infused Vin Mariani wine that Popes and Presidents drank at the time. This podcast episode details Coca-Cola's origin story, as well as the financial and business strategies it used to get to where it is today.

Coca-Cola began developing Diet Coke to compete with a diet cola called Tab

Launched in 1963, Tab was successful in part because of its diet-conscious branding, with the name "tab" referring to the idea of "keeping a tab on your weight." Diet Coke made its debut in 1982.

The Coca-Cola bottle was designed to be recognizable even when shattered

The contour bottle, which was designed and patented to prevent copycats in its distributed bottling system in 1915, would soon become one of the most identifiable shapes in commercial culture. The designers also made sure it could be easily identified even in the dark.

​​Andy Warhol made a Coca-Cola perfume called 'You're In'

The 100 spray-painted bottles were filled with a cheap citrusy perfume, practically begging audiences to ask if they were indeed filled with urine. The Coca-Cola Company sent a cease-and-desist letter shortly after learning of the project. IN 2017, a Japanese fashion brand remade the works without mentioning Coca-Cola.

The word ‘coupon’ comes from a French word meaning ‘to cut’

The history of coupons starts in the US with the Coca-Cola coupon that was mailed to consumers, offering them a chance to come try the soda for free in a nearby pharmacy. A coupon created by cereal company Post is one of the earliest widely cited follow-ups—it offered a penny off a box of Grape Nuts in 1909.

Patents arguably grant inventors monopolies for a short period of time

As a way to reward innovation, the government grants short-term monopolies on patented products. Patents block other companies from producing or selling that product, giving inventors the rights and opportunity to establish themselves in a market before other competitors enter.

Coca-Cola claims that only two people in the world know the full Coca-Cola formula

They are supposedly two Coca-Cola executives. Over the years, a number of handwritten formulas have surfaced to the public, but Coca-Cola has ruled all of them as inauthentic.

The Stepan Company is the only US company with legal permission to import coca leaves

The Stepan Company works closely with Coca-Cola so that the soda giant can continue to use coca leaves for its beverages. Today, the cocaine from the coca leaves is removed before they are used to create Coca-Cola.

Anheuser-Busch sold half of its real estate holdings to survive Prohibition

The Budweiser parent company also created and sold out more than 25 different nonalcoholic products during this time, including but not limited to infant formula, frozen eggs, and specialized coffees and teas.

Bottled water started as a 19th-century wellness trend

Selling drinking water in America began at resorts in New York and West Virginia, where tourists were encouraged to take the regenerative mineral water back to their homes.

Penicillin was hailed as a 'wonder drug' upon its release

When penicillin became widely available in the 1940s, newspapers and doctors alike celebrated it as a “wonder drug” that could cure infections once considered fatal.

Aspartame was a surprise discovery from a lab working on gastric ulcers

As with saccharin and cyclamate, the aspartame discovery arose from its discoverer tasting something sweet from his workplace. In 1965, American chemist James Schlatter licked a white powder off his finger as he picked up a piece of paper and was startled to discover it tasted sweet. He applied for a patent for the substance, and received it in 1970. It is now one of the most popular artificial sweeteners. (Some users may experience a paywall.)

LSD (better known as acid) was created in 1938 by Swiss chemist Dr. Albert Hofmann

Lysergic acid diethylamide, better known as LSD or acid, was first developed synthetically in 1938 by Swiss chemist Dr. Albert Hofmann. It's since become a linchpin for an entire aesthetic, fueled a counterculture movement, and is being studied for potential therapeutic uses.

Morphine, heroin, codeine, and more were derived from opium

Opium reached the US at about the time early colonists were itching for ways to soothe aches and pains. The active ingredient in the substance was isolated in the early 19th century, eventually leading to the manufacture and commercial sale of morphine, heroin, and other opium-based drugs.

How the Supreme Court established biotechnology patent law with an oil-eating microbe

While working at General Electric, microbiologist Ananda Chakrabarty engineered a strain of Pseudomonas that could break down multiple types of hydrocarbons and filed a patent on the bioremediation organism. Despite challenges over whether living things could be patented, the 5-4 decision held that genetically modified organisms could be patented because they were human-made inventions.

How a government chemist founded the FDA—by poisoning people

The Poison Squad tells the story of government chemist Dr. Harvey Wiley who, determined to banish these dangerous substances from dinner tables, took on the powerful food manufacturers and their allies.

In 2015, the FDA approved the first 3D-printed prescription tablet

Spritam, an epilepsy medication, had been too large and difficult to swallow, particularly due to its inability to dissolve easily. The new pill was designed with porous layers to enhance its dissolvability, paving the way for future 3D printing of drugs.

The birth of the multivitamin

In 1912, biochemist Kazimierz Funk, often anglicized as Casimir Funk, proposed that there existed an essential nutrient in food that could prevent deficiency diseases, such as scurvy or rickets. This article explores the origin of the multivitamin, an invention that has garnished...

Hikma v. Amarin is a case the Supreme Court is hearing in 2026 that could impact how much you ultimately pay for prescription drugs

The case explores the liability of a generic drug maker for patent infringement. Hikma Pharmaceuticals launched a generic for Amarin Pharma's Vascepa (a fish oil drug), carving out a still-patented use and instead explicitly selling its product for another unprotected use. But Hikma was sued for its marketing materials that still alluded to the patented indication without outright referencing it.

Jimmy Carter signed a 1978 bill that legalized home brewing, a move credited with kick-starting the craft beer industry.

Visualizing the global supply chain of medicine

The typical medicine we consume is the end result of a complex global supply chain involving highly specialized compartmentalization. Most medicine was made locally until open trade policies enabled global trade in the 1980s. This visual essay is...

Plastic's history began with an inventor seeking a $10,000 prize offer

In 1869, the first synthetic polymer—celluloid—was created as a substitute for ivory in billiard balls. It became the historical catalyst for the eventual manufacturing of plastics everywhere as an alternative to the depletion of other natural resources, including tortoiseshell and horns.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

The pregnancy test industry is worth roughly $769M

The inventor of the at-home pregnancy test, Margaret Crane, largely hasn't taken credit for her invention until recently.

Frisbee, Jet Ski, and Dumpster—explore a list of words you might not realize are trademarked

Many products that have become household names started out as first-of-a-kind items. As those products grew in popularity, the brand name became the default name for the product.

Thomas Edison inadvertently spurred the film industry's move to Hollywood

The inventor's patent on the motion picture camera included several stipulations that required independent movie studios to work with Edison's Motion Picture Patents Co., making the East Coast undesirable for aspiring filmmakers.

Learn more about the history of fireworks, which dates back to an accidental invention during an alchemist's quest for information about immortality.

Dozens of S&P 500 stocks, including Coca-Cola and Walmart—known as the dividend aristocrats—have increased dividends every year for 25 years

Venture capital is a form of funding provided to early-stage companies with high growth potential, typically in exchange for an equity (or ownership) stake

Telehealth demand for GLP-1s for weight loss is booming as consumers seek easier access.

After the Boston Tea Party, colonists switched to coffee, which became the main morning drink for revolutionaries.

Memecoins are a type of cryptocurrency—a form of digital currency with a wide variety of uses—created around popular 'memes,' or viral internet jokes.

The most expensive ad of all time was for Chanel No. 5 perfume and cost roughly $33M to produce in 2004—about $57M in today's dollars.

Sears sold DIY house kits starting at $600 in its famous catalog from 1908 through the 1940s, resulting in roughly 10,000 'Sears and Roebuck houses' being built.

Some Pokémon have been named after real and fictional organisms, while some real-world species have been named after Pokémon, such as Chilicola charizard and Binburrum zapdos.

The first robot in literature may have been a 'mechanical man' in 1907's 'Ozma of Oz,' a book in L Frank Baum's 'Wizard of Oz' series.

The story of Dollree Mapp, whose legal challenge over her 1957 conviction for possessing "obscene material" led to a major strengthening of the Fourth Amendment

A vending machine run with Anthropic's AI went out of business after it was convinced to give away items for free and sell a video game console.

Larger animals like giraffes, elephants, and blue whales have developed a unique defense against cancer, a phenomenon known as Peto's Paradox

Long before Major League Baseball began allowing instant replay for balls and strikes, an umpire reluctantly used the technology to determine whether a hit was a home run, a move that inadvertently ushered in a new era for the sport.

Domino's Pizza's 30-minute delivery guarantee was responsible for the chain's 1980s surge, but it was discontinued after the company was found liable for delivery driver accidents.

Mid-century modern graphic designers, known for their bright colors and bold lines in advertising, also found success with children's books.

See the evolution of Ebola vaccine and treatment development.

The word 'jazz' evolved from 'jasm,' 19th-century American slang for 'energy'

The Mona Lisa's celebrity status and repeated restorations have obscured what made the painting so revolutionary for its time

The power and influence of the American presidency have expanded significantly over time—far beyond what the founders envisioned.

'Saturday Night Fever,' the 1977 film that introduced disco to the mainstream, was based on a fabricated magazine story.

Objects can be 3D printed with light by projecting 2D computerized tomography (CT) scans onto rotating cylinders of resin, which solidify upon exposure.

A small portion of The Winstons' 'Amen, Brother,' an obscure '60s gospel record, is the basis for thousands of hip-hop tracks, making it one of the most sampled records ever that's informally known as 'the Amen break.'