Penicillin’s pioneers were awarded the Nobel Prize in 1945

Penicillin was discovered by accident

In 1928, Alexander Fleming returned from vacation to find mold contaminating a petri dish of bacteria. Around the mold, the microbes had died—an accidental observation that led to the discovery of penicillin.

Penicillin is considered one of history’s greatest medical breakthroughs

Experts widely rank penicillin’s discovery among the most important advances in medicine. It launched the antibiotic era, transformed once-deadly infections into treatable illnesses.

Penicillin was hailed as a 'wonder drug' upon its release

When penicillin became widely available in the 1940s, newspapers and doctors alike celebrated it as a “wonder drug” that could cure infections once considered fatal.

Penicillin’s discoverer predicted antibiotic resistance

Alexander Fleming’s discovery of penicillin revolutionized modern medicine. But the same man who pioneered the development of antibiotics also recognized that bacteria could make sntibiotics obsolete if they were used irresponsibly. This story sheds light on Fleming’s discovery—and on his prophetic warning about antibiotic resistance.

Oxford scientists turned Fleming’s mold discovery into medicine

In 1939, a team at Oxford—including Howard Florey, Ernst Chain, and Norman Heatley—revived Fleming’s forgotten discovery. Using makeshift equipment like bedpans and milk churns, they purified enough penicillin to prove it could treat deadly infections.

Penicillin has saved an estimated 500 million lives since its creation

Since its introduction in the 1940s, penicillin and related antibiotics are estimated to have saved around 500 million lives worldwide—making it one of the most consequential medical breakthroughs in human history.

Penicillin production was just behind the atom bomb in wartime priorities

By 1943, the US War Department made penicillin its second-highest priority—just after the Manhattan Project. Producing enough of the antibiotic for the D-Day invasion became a central mission of Allied science and industry.

The 'Penicillin Girls' made mass production possible

In Oxford during the early 1940s, six female technicians—later dubbed the “Penicillin Girls”—worked long hours tending mold cultures and extracting tiny amounts of penicillin.

Penicillin slashed battlefield pneumonia deaths during World War II

Before antibiotics, bacterial pneumonia killed about 18% of infected soldiers in World War I. By World War II, penicillin cut that death rate to less than 1%.

The discovery of insulin led to a controversial Nobel Prize in 1923

For centuries, Type 1 diabetes was fatal. The 1920s "discovery" of insulin netted two of its creators—Frederick Banting and his boss, John Macleod—a Nobel prize. Separately, the German doctor Georg Zuelzer synthesized an effective version of the life-saving drug years earlier but was interrupted by World War I.

Read more about the backstory on the 2025 Nobel Prize for immune system work

A trio of scientists won the Nobel in Physiology or Medicine that year, but they performed their award-worthy work beginning about two decades before winning the prize. This announcement includes details about the science and notes that the three scientists will equally share the 11 million Swedish kronor (almost $1.2M).

Two-thirds of antibiotic classes were made between the 1940s and 1960s

The vast majority of bacterial treatments were developed during the "Golden Age of Antibiotics," an era of rapid innovation and drug discovery that led to the reduction of millions of deaths worldwide. Since 1970, only eight new antibiotic classes have been discovered.

Rosalind Franklin’s work led to Nobel Prize-winning discoveries in DNA and virology

Her X-ray diffraction imaging helped uncover the structure of DNA, which earned James Watson, Francis Crick, and Maurice Wilkins a Nobel Prize. The same techniques enabled virus imaging, contributing to Aaron Klug's Nobel Prize in chemistry.

Penicillin works by attacking the cell walls of bacteria

Penicillin targets bacteria at their weakest point—their cell walls. By blocking wall-building, it leaves microbes unable to survive, causing them to burst and die.

The Nobel Prizes honor global achievements in science, literature, and peace efforts

Established by Alfred Nobel’s will, the Nobel Prizes have been awarded since 1901 to individuals and organizations making major contributions to humanity. Although often grouped with the five original prizes, the economics award was added later by Sweden’s central bank in 1968 and isn't technically a Nobel Prize.

Robert Koch won the Nobel for his tuberculosis work, but he also pioneered cholera research

Koch was one of the first scientists to isolate the bacterium that causes cholera while investigating an outbreak in Egypt in 1883. He went on to advise about rules to control cholera outbreaks, which formed the basis of the disease control approaches and water hygiene techniques still used today.

A French Army surgeon discovered that malaria is a parasitic disease in 1880—but scientists were initially skeptical

Charles Louis Alphonse Laveran won the Nobel Prize for his work "on the role played by protozoa" in causing diseases. His work included discovering and reporting the malaria-causing parasite in the blood of a patient suffering from malaria.

The discovery of nuclear fission was facilitated by the discovery of the neutron

The discovery of the neutron provided scientists with a particle that could penetrate the nucleus and advance atomic physics. Otto Hahn was the sole Nobel recipient for the discovery of fission, despite collaborating with Lise Meitner and Fritz Strassmann.

How scientists earned themselves a Nobel Prize by discovering what destroyed ozone

In 1974, chemists Mario Molina and F. Sherwood Rowland showed that chlorofluorocarbons—then used as aerosol propellants, refrigerants, and industrial solvents—rise into the stratosphere and, upon being struck by ultraviolet radiation, release chlorine atoms, which break apart ozone molecules. Their work earned them the Nobel Prize in chemistry in 1995.

Edward Jenner, the father of vaccinations

The British physician was the first to attempt to inoculate someone from smallpox using its milder cousin, cowpox. His innovations and documentations would prove crucial to the deployment of widespread vaccinations.

During his 'miraculous year,' Einstein published four groundbreaking papers

The 1905 "annus mirabilis" papers explained the photoelectric effect, Brownian motion, the absolutism of the speed of light, and mass-energy equivalence, revolutionizing scientists' understandings of space, time, mass, and energy. For the discovery of the photoelectric effect, Einstein won the 1921 Nobel Prize in Physics.

The 2019 Nobel Prize in Chemistry was awarded for lithium-ion battery development

Stanley Whittingham developed the first functional lithium battery in the early 1970s, while John Goodenough doubled its electrical potential in 1980 by replacing the cathode, thereby enhancing its commercial viability. Five years later, Akira Yoshino developed an anode using carbon material, reducing the risk of flammability.

The disputed inventor of the radio

Guglielmo Marconi was awarded the 1909 Nobel Prize in physics for inventing the wireless telegraph, which used radio waves to transmit Morse code. Nikola Tesla, however, was experimenting with radio waves in the 1890s, though much of his work was destroyed in a 1895 fire.

Rune Elmqvist forwent practicing medicine to invent the first inkjet printer

The Mingograph recorded real-time physiological signals from a patient's electrocardiogram, helping doctors diagnose heart and brain conditions. Eight years later, in 1958, Elmqvist worked with cardiac surgeon Åke Senning to develop the first fully implantable pacemaker.

Camus credited a teacher with his success

After winning the Nobel Prize in literature in 1957, Camus wrote a letter to Louis Germain, his former teacher, thanking the man for "the affectionate hand" he extended to Camus as a student. In the short note, he'd go on to write, "without your teaching and example, none of all this would have happened."

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

As of 2025, the most cited papers in science include a review of graphene, methods to improve image recognition, streamlining electron density calculations, and optimizing protein studies.

Poison ivy was sent to Europe in the 1600s as an exotic, ornamental oddity, where it was purposefully grown in the English royal gardens at Kew, the Faculty of Medicine in Paris, and a few other locations.

Astronauts have repaired genetic damage in space using CRISPR—a molecular tool that can make precise changes to DNA and is used in single-celled organisms to attack invasive viruses.

See the evolution of Ebola vaccine and treatment development.

The first line of 'immortal' human cells, which can divide indefinitely and are used in scientific research, was nonconsensually taken from a Black woman.

Learn more about the history of fireworks, which dates back to an accidental invention during an alchemist's quest for information about immortality.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

Elk Cloner, the first computer virus to spread in public, was written as a practical joke by Richard Skrenta, a Pittsburgh high school student.

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

Budweiser stores yeast derived from the original 1800s strain in a secret bunker, which only the Head of Yeast Management can access—not even the CEO

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

Clever Hans was a 1900s horse that was believed to be able to solve math equations, tell time, and read and comprehend German, until a psychology student discovered how he got his answers.

Walt Disney's early film 'Alice's Wonderland' was a groundbreaking innovation in the silent film era

The term 'algorithm' originated from the Latinized name of al-Khwārizmī, a 9th-century mathematician whose works introduced Arabic numerals and the decimal-based numeral system to Europe and whose treatise 'Al-Jabr' gave algebra its name.

Warren Buffett's former professor Benjamin Graham is known as the 'father of value investing,' a strategy in which investors seek to buy stocks trading below their intrinsic worth.

The most expensive ad of all time was for Chanel No. 5 perfume and cost roughly $33M to produce in 2004—about $57M in today's dollars.

Explore a list of the 100 best novels of all time, compiled by some of the world's best living writers, including Salman Rushdie, Stephen King, and Jennifer Egan.

The Mona Lisa's celebrity status and repeated restorations have obscured what made the painting so revolutionary for its time

Sony set the standard for cylinder-shaped batteries when it repurposed manufacturing equipment used to make rolls of magnetic recording tape.

The Beatles' US label rejected the band's first two singles, 'Please Please Me' and 'From Me to You,' with one executive calling the band 'dead in the water.'

Massive blooms of microscopic plankton called dinoflagellates produce the neon blue light seen in glowing tides.

Brandi Chastain, the star of the 1999 US victory over China in the 1999 Women's World Cup, was a last-second choice to take the penalty kick that sealed the victory.

Meet the 56 signers of the Declaration of Independence—most of whom didn't put pen to paper until August 2, 1776—and see their original signatures.