Penicillin slashed battlefield pneumonia deaths during World War II

Pneumonia was once a leading killer before penicillin treatments

In the early 20th century, pneumonia was a top cause of death worldwide, often fatal without effective treatment. Penicillin turned a once deadly infection into one of the most treatable bacterial diseases.

Penicillin production was just behind the atom bomb in wartime priorities

By 1943, the US War Department made penicillin its second-highest priority—just after the Manhattan Project. Producing enough of the antibiotic for the D-Day invasion became a central mission of Allied science and industry.

Penicillin supplies were ready for every wounded soldier on D-Day

By June 1944, Allied stockpiles included 2.3 million doses of penicillin—enough to ensure that every soldier wounded during the pivotal Normandy landings could receive treatment.

Penicillin was hailed as a 'wonder drug' upon its release

When penicillin became widely available in the 1940s, newspapers and doctors alike celebrated it as a “wonder drug” that could cure infections once considered fatal.

Penicillin ended scarlet fever’s deadly threat to children

Between 1840 and 1883, scarlet fever was among the leading causes of childhood death in the United States, with case fatality rates ranging from 15% to 30%. Today, thanks to antibiotics like penicillin, the mortality rate is below 1%.

Penicillin has saved an estimated 500 million lives since its creation

Since its introduction in the 1940s, penicillin and related antibiotics are estimated to have saved around 500 million lives worldwide—making it one of the most consequential medical breakthroughs in human history.

Penicillin’s pioneers were awarded the Nobel Prize in 1945

Alexander Fleming, Howard Florey, and Ernst Chain received the 1945 Nobel Prize in Physiology or Medicine for discovering and developing penicillin.

Penicillin works by attacking the cell walls of bacteria

Penicillin targets bacteria at their weakest point—their cell walls. By blocking wall-building, it leaves microbes unable to survive, causing them to burst and die.

Two-thirds of antibiotic classes were made between the 1940s and 1960s

The vast majority of bacterial treatments were developed during the "Golden Age of Antibiotics," an era of rapid innovation and drug discovery that led to the reduction of millions of deaths worldwide. Since 1970, only eight new antibiotic classes have been discovered.

Women's wartime suit features silk dyed with CRISPR-modified bacteria

Anna Dumitriu's bioart piece was created to commemorate the 75th anniversary of the first use of penicillin in a human patient and intends to raise awareness about the rapid development of antibiotic-resistant pathogens by using bacteria that have essentially been transformed into their pre-antibiotic era state.

Two-thirds of soldier deaths during the war were due to disease

Roughly two-thirds of all Civil War deaths resulted from disease rather than battle. Poor sanitation, contaminated water, and limited medical knowledge made camps breeding grounds for dysentery, typhoid, and other deadly infections.

Antibiotic resistance is a growing global health problem

Over decades, bacteria have grown increasingly resistant to antibiotics. This resistance now causes an estimated 1.27 million deaths each year and is associated with nearly 5 million deaths worldwide, according to the World Health Organization.

Exploring World War I technology on the battlefield

Industrialization brought massive changes to warfare during the Great War. Newly-invented killing machines begat novel defense mechanisms, which, in turn spurred the development of even deadlier technologies. Nearly every aspect of what we would consider modern warfare debuted on World War I battlefields. Starting with soldiers on horseback carrying lances and ending in poison gas, machine guns, and aerial battles, this gallery shows the first tools of modern warfare.

The same mold behind penicillin also flavors blue cheese

There are over 300 species of Penicillium. The mold that produces the lifesaving antibiotic is a close relative to those used to make blue cheeses like Roquefort and Stilton and to flavor some types of ham.

Why the 1918 flu killed between 50 and 100 million people

The 1918–1920 flu pandemic (once called, incorrectly, the Spanish flu) killed quickly and in huge numbers, with estimates of the global death toll ranging from 50 to 100 million people. Several factors contributed to the high mortality rate: lack of antibiotics, the global disruption of World War I, and more.

How slugs helped soldiers during WWI

Slimy, squishy, slow-moving, and heroic? Slugs are land-dwelling mollusks known mostly for causing havoc in our gardens. But during World War I, slugs saved numerous soldier's lives as poison gas detectors. Learn how the unpleasant creatures earned their stripes in the battle to protect soldiers from chlorine, phosgene, and mustard gas as organic detectors.

A WWI war helmet outperformed modern gear in this study

Your great-grandparent's World War I helmet stuffed in the back of a closet may be just as effective at preventing brain injury from some blasts as a modern-day military helmet. This article further explains a study that pitted WWI and modern helmets against each other.

Winston Churchill said he was comforted by 'Pride and Prejudice' during World War II

The prime minister was bedridden in a hospital with pneumonia in 1943. In his memoirs, Churchill recalls how Austen's "Pride and Prejudice" comforted him, especially because its characters remained calm amid the political turbulence of the time.

The Night Witches

During World War II, one of the most effective Soviet bombing units flew wooden crop dusters that maxed out at 94 mph. They had no radios, no radar, and no parachutes. And the pilots? Young Soviet women, mostly in their teens and early twenties. The Germans called them Nachthexen—Night Witches. Shooting one down earned a Nazi soldier an Iron Cross, one of the highest military honors. However, for decades, most of the world forgot they existed. In this video, we trace how the Night Witches became one of the most feared units of WWII—and why their story nearly disappeared from history.

Camus contracted tuberculosis as a teenager

There was still little understanding of treatment for the disease at the time; for most people, a tuberculosis diagnosis was a death sentence. The 17-year-old Camus was quarantined in his uncle's house, where he grew into an avid reader. Scholars note that the experience would inform his later work, including his 1947 novel "The Plague."

How World War II affects your wallet today

The world's deadliest conflict also impacted social programs extensively, including ways that still affect your money today. World War II is responsible for the practice of employers withholding tax payments and sponsoring health insurance, as well as the norm of providing school lunches for the nation's schoolchildren. Watch this brief video to learn more.

Wolbachia: the bacteria that could eliminate dengue fever

Dengue fever, transmitted by mosquitoes, kills more people annually than all types of natural disasters combined. However, mosquitoes that host Wolbachia bacterium have their ability to transmit the virus naturally suppressed, offering a route to eliminating nearly 25,000 deaths annually.

A World War I discovery about blocking ethylene, a plant hormone, now helps preserve our fruits

Listen to this in-depth podcast episode about discoveries that enabled fruits and vegetables to be preserved and appear fresh for months or longer and other scientific insights, including why iceberg lettuce was the salad staple people ate for most of the 20th century.

The highest inflation in US history was estimated at 30% in 1778

This was just after the Revolutionary War. Both World Wars also brought double-digit inflation. It's worth noting that exact inflation rates in early America are difficult to calculate precisely.

Surgery before the dawn of anesthesia

The arc toward anesthetics was painfully slow, with early pain mitigation offerings ranging from analgesics—drugs that dim pain but don't block it—and numbing surgical sites with cold water to gassing patients with carbon dioxide or bashing or bleeding them unconscious. Such treatments and the torturous surgery they preceded led many to avoid even life-saving procedures, and those who survived often kept silent about the trauma.

Hookworm infection, though risky, may help fight certain autoimmune conditions by tamping down the immune system's inflammatory response.

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

Larger animals like giraffes, elephants, and blue whales have developed a unique defense against cancer, a phenomenon known as Peto's Paradox

Volcanic activity may have triggered the Black Death by spewing gases that led to crop failures in Europe, thus forcing the import of grain ships with plague-infested fleas.

Poison ivy was sent to Europe in the 1600s as an exotic, ornamental oddity, where it was purposefully grown in the English royal gardens at Kew, the Faculty of Medicine in Paris, and a few other locations.

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

See the evolution of Ebola vaccine and treatment development.

Fireworks-related ER visits are on the rise—in 2024, they increased by 52% as compared to the prior year.

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

Astronauts have repaired genetic damage in space using CRISPR—a molecular tool that can make precise changes to DNA and is used in single-celled organisms to attack invasive viruses.

Against his wishes, Albert Einstein's brain was removed before his cremation, and the pathologist responsible stored it for decades in mason jars within a beer cooler.

Explore an interactive map of battles from the American Revolution, along with detailed summaries of each engagement

In 1939, baseball star Lou Gehrig delivered his inspirational 'Luckiest Man' speech after retiring due to the health condition that now bears his name.

Abraham Lincoln was almost assassinated weeks before his inauguration as he traveled from Illinois to DC through Baltimore in 1861; it took two independent claims for Lincoln to be convinced the threat was real

Brandi Chastain, the star of the 1999 US victory over China in the 1999 Women's World Cup, was a last-second choice to take the penalty kick that sealed the victory.

See the most iconic photos from four decades of LIFE magazine

Double world record holder Hunter Ewen helped conquer his fear of balloons, called globophobia, by training to win Guinness World Record titles for balloon inflation.

The Russia-Ukraine conflict is the largest ground war in Europe since World War II in terms of casualties, forces mobilized, and displacement of civilians.

In 1984, Operation Smash Hit intentionally crashed a 239-ton train into a nuclear waste canister at 100 miles per hour to prove the canister's safety, which remained completely intact and lost just 0.29 of its 100 pounds of pressure.

Brian Wilson wrote the Beach Boys' 'Don't Worry Baby' for the Ronettes, but the legendary girl group rejected it.

For centuries, it was common to sleep in two shifts: a few hours at the beginning of the night, and a longer period beginning around midnight

The price of gas is a composite made up of several different factors, with the federal gas tax making up less than 20% of what drivers pay at the pump.

In 2019, a laptop loaded with six of the worst malware in history and described as 'an exhibit of historical weaponry' sold for $1.3M.

Sony set the standard for cylinder-shaped batteries when it repurposed manufacturing equipment used to make rolls of magnetic recording tape.

To reduce wrinkles in clothing, research recommends gentle wash cycles with more water and tumble drying with smaller loads and longer times.