Surgery before the dawn of anesthesia

Six of history's most unethical human experiments, from deliberate flu exposure to withholding syphilis treatment

Some of the progress made in mental health treatment, vaccines, blood transfusions, and more came about before the advent of consent and ethics committees, resulting in serious physical and psychological harm that participants in studies were not even anticipating.

Brain conditions and surgery can cause some individuals to feel no fear

Fear is a survival mechanism that originates in the brain's amygdala, triggering the body's fight-or-flight response. However, in modern society, without the same natural dangers, fear can lead to anxiety and mental health issues when unnecessarily triggered. Understanding individuals without fear may help identify new methods to treat anxiety disorders.

Cosmetic surgery during the Edwardian era

This 23-minute video explores cosmetic surgery in the United Kingdom during the Edwardian era, from about 1901 to 1914. Reconstructive surgery already existed by then, though it wasn't considered elective as it was used to repair damage suffered...

Anesthetics slow brain activity by promoting inhibitory neurotransmitters

Drugs like propofol and isoflurane increase activity at the GABA receptor, which opens chloride channels. These ions enter neurons and hyperpolarize them, making them less likely to fire. Dexmedetomidine instead blocks norepinephrine receptors in the brainstem to sedate patients.

Aspirin was the first synthesized anti-inflammatory drug

Once used by the ancient Sumarians—extracted from willow bark—but now synthesized in the lab, the active ingredient of this popular medication has been used to treat headaches and pain for thousands of years.

Doctors ignored women's pain as a nurse replaced their fentanyl with saline

This five-part podcast series, produced by Serial Productions, focuses on the experiences of women undergoing fertility treatments at a Yale clinic where a nurse secretly replaced pain medication with saline solution. This led to women experiencing excruciating pain during procedures, but the clinic downplayed or ignored their complaints.

The concept of phantom limbs, the perception that amputated limbs are still present, dates back to a French military surgeon in the 16th century.

The oldest medical report of a near-death experience dates to around 1740

In 2014, Dr. Philippe Charlier, a medical doctor and archeologist, found a French medical book from 1740 that described the near-death experience of a pharmacist. Using the Greyson Scale, Charlier found that the incident would have rated at least 12/32, more than high enough to scientifically classify as an NDE by today’s standards.

What's next for surgical robots?

Since robots were introduced into the operating room in 2001, their patients have seen improved recovery times and decreased risks of infection. This article describes what's next for surgical robots, which, so far, have remained under human...

The medical profession has a dark history of 'body snatching' for education

This term originally referred to secretly removing corpses from graves for sale—usually to medical schools where they were used for education. The practice dates back at least to the 1300s but still—much more rarely—persists today.

Research advances suggest death takes much longer than we realized

Recent research indicates that organs, including the brain, are better at handling a lack of oxygen after the heart stops beating than previously known. Such findings may open up possibilities that include someday reversing certain death processes and expanding the availability of organs available for organ donations. (Some users may experience a paywall.)

The surgeon who tried to save John Lennon says he can’t forget that night

Frank Veteran was a resident in 1980 on the night John Lennon was shot in New York. For years afterward, he tried to process the sight of seeing the Beatle dying in the hospital, including through art, but he says that the memories from the experience are still vivid.

How dentistry evolved from carnival sideshow to respected medicine

The field, which has remained siloed from other medical care, also has a separate insurance system. This podcast walks through how and why dental insurance often remains capped at $1,500 primarily to cover cleanings, and it wouldn't cover catastrophes—unlike many other medical or housing insurance models.

What is the most painful thing in the world?

Pain is famously difficult to quantify, and though our response to it may be subjective, most pain does have underlying objective causes. So what's the most painful thing of all? Many say childbirth, or a broken femur, but this article lays out one case for why, of all things, kidney stones may be the most painful experience. Prepare yourself to find out here.

Pneumonia was once a leading killer before penicillin treatments

In the early 20th century, pneumonia was a top cause of death worldwide, often fatal without effective treatment. Penicillin turned a once deadly infection into one of the most treatable bacterial diseases.

New drugs called Gepants have been shown to improve the quality of life of many sufferers.

Journalist Eva Wiseman has had migraines since childhood. Beginning with a yawn they segue into visual auras before turning into severe pain. As it so happened, she experienced a migraine during the course of her interview with Dr. Peter Goadsby, a pioneer in understanding and treating migraines as well as getting the world to treat them seriously.

Reduced inflammation from cold plunges lacks scientific support

The cold water triggers immediate cold shock, increasing heart rate and blood pressure, and prolonged exposure can lead to cold-water incapacitation and hypothermia. Plungers are encouraged to enter the water slowly and manage their breathing to reduce the risk of shock. Warm baths post-plunge are discouraged, and exercise is generally better for recovery.

Skin wounds and burns heal fastest if they occur during the day

Skin cells responsible for healing wounds work more quickly during the daytime, underscoring that the timing of an injury greatly influences recovery time, according to 2017 research. Nighttime burns took an average of 11 days longer to heal than burns incurred during the day. (Some readers may experience a paywall.)

Real surgical footage reveals what arthritis looks like up close

Arthritis is a painful condition of human joints that often results from the loss or breakdown of the soft cartilage padding that naturally exists between bones. This video shows footage from an actual knee surgery that beautifully demonstrates the difference between normal cartilage and the degenerative cartilage seen in osteoarthritis.

For centuries, it was common to sleep in two shifts: a few hours at the beginning of the night, and a longer period beginning around midnight

At the beginning of the 20th century, a group of young men ate standard American food—replete with food additives like borax and formaldehyde—as part of government research to better understand food safety.

Hear the story of the first paramedic services, which grew out of a community training program in 1960s Pittsburgh

Before 911 existed, cities sent police cars or hearses from funeral homes to medical emergencies. In 1967, a group of young Black men in Pittsburgh changed that, developing the training protocols and lifesaving techniques that became the foundation of modern EMT response.

Samuel O’Reilly patented the tattoo gun in 1891

Before the tattoo gun's invention, recipients sweated while artists slowly tapped or sliced designs into their flesh. The tattoo gun changed the field, helping artists ink clients’ skin at incredible speeds. Inventor Samuel O’Reilly applied the basic idea of an electric pen invented by Thomas Edison to his tattoo gun.

10 items that could have saved your life in the trenches

Soldiers settled into trenches to defend themselves against shrapnel and bullets, but weapons such as mustard gas crawled along the ground and settled in these low-lying areas. Here are 10 items that could have helped you survive the trenches, according to this article.

How ancient Roman gladiators got ready to rumble

Before they could lay the smackdown in the arena, gladiators were professionally trained, combining a physical regimen with an education in the rules of the ring. Contrary to popular belief, archaeological evidence suggests most gladiators weren't killed in the action, and women may have fought on rare occasions. This article breaks down a life of a Roman gladiator.

Alkaline hydrolysis—dissolving the body—is one 'green' burial option

This approach, which is sometimes called flameless cremation, involves dissolving the body with water and chemicals. The remaining bone fragments can then be spread like ashes. It was reportedly incorporated into the funeral industry in 2011.

A 2,000-year history of alarm clocks

Clocks have revolutionized the way we live, structuring our days into abstract, regular units and providing quantification for those who are chronically late. The alarm clock was the next obvious step: clocks which not only tell you the time but...

The abolitionist movement long predated the Civil War

Beginning in the late 18th century, abolitionists like Frederick Douglass, William Lloyd Garrison, and Sojourner Truth campaigned through newspapers, lectures, and political action to end slavery.

See images of medical cases of firework injuries shared on this 'Instagram for doctors.' (Warning: Graphic content)

Read a deep dive on the 'all-purpose healing' peptide BPC-157.

Cultural norms about how to handle the bodies of loved ones in communities in West Africa have hampered Ebola responses.

In recent years a child anxiety expert has created and tested a novel phobia and anxiety treatment approach for children, focused on changing how parents respond to the fears.

Against his wishes, Albert Einstein's brain was removed before his cremation, and the pathologist responsible stored it for decades in mason jars within a beer cooler.

The animatronic shark from Steven Spielberg's 'Jaws,' the first modern blockbuster, was a complex underwater apparatus called 'Bruce.'

Abraham Lincoln was almost assassinated weeks before his inauguration as he traveled from Illinois to DC through Baltimore in 1861; it took two independent claims for Lincoln to be convinced the threat was real

Before humans, the Soviet Union and the United States sent animals—including apes, dogs, and cats—to space during the Space Race.

For centuries, Niagara Falls has been a magnet for daredevils seeking to conquer one of nature's most powerful wonders, with its 200-foot drop and water rushing at 32 feet per second with 280 tons of force.

After the Boston Tea Party, colonists switched to coffee, which became the main morning drink for revolutionaries.

Exploring the Larry Bird punch that almost changed March Madness

English mathematician Ada Lovelace wrote the first computer algorithm a century before computers existed and hypothesized that computing devices would one day be able to compose music—foreseeing the generative AI systems of today.

Dorothy's famous entrance into Oz in 'The Wizard of Oz' relied on analog tricks, including a body double and sepia-toned paint, as much as it did on technology

Apeirophobia is an overwhelming fear of living forever, perhaps stemming from the brain's inability to conceptualize an infinite life.

A researcher recently discovered an interview from 1967 between groundbreaking journalist Joan Didion and the Grateful Dead, years before the band became an institution.

In 2018, 26-year-old missionary John Allen Chau was killed by tribesmen after attempting to reach and evangelize on India's isolated North Sentinel Island

Stanford built a Google Maps for the Roman Empire, revealing how much it cost to travel in the ancient world

Domino's Pizza's 30-minute delivery guarantee was responsible for the chain's 1980s surge, but it was discontinued after the company was found liable for delivery driver accidents.

Objects can be 3D printed with light by projecting 2D computerized tomography (CT) scans onto rotating cylinders of resin, which solidify upon exposure.

The word 'jazz' evolved from 'jasm,' 19th-century American slang for 'energy'

Scientists can determine Earth's past climate conditions by analyzing air trapped in microscopic bubbles within ice cores—columns of compressed snow layers that build up over hundreds of thousands of years.

Alzheimer's can lead to brain shrinkage, with an average of around 2% of volume reduction per year